PIDNaziv projekta HRNaziv projekta ENID VoditeljaVoditeljID SuvoditeljaSuvoditeljVrsta natječajaRokŠifraAkronimTrajanjeStatusVrijednost financiranjaZnanstvena područjaScientific areaZnanstvena poljaScientific fieldsUstanovaInstitutionID SuradniciSuradniciKljučne riječiKeywordsSažetakSummary
1321Metode slabih convergencija i primjeneWeak convergence methods and applications58Nenad Antonić IP2013-11IP-2013-11-9780WeConMApp01.07.2014 - 30.06.2018Završio859.958,93 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science349, 72, 637, 866, 3374, 86, 1460, 628, 19188, 23449, Krešimir Burazin, Marko Erceg, Ivan Ivec, Martin Lazar, Nedžad Limić, Marin Mišur, Darko Mitrovic, Marko Vrdoljak, Boris Pawilowski, Ivana Vojnović, weak convergences, partial differential equation, homogenisation, optimal design, H-measures, semiclassical measures, transport problemsWeak convergences are the foundation of most successful methods in the investigation of partial differential equations today. The approach known as Tartar's programme proved particularly convenient for partial differential equations modelling physical laws; the basic assumption being that weak convergences of sequences of solutions model the transition from microscale to macroscale. Of importance are also mathematical objects being, in a generalised sense, accumulation points of weakly convergent sequences, such as defect measures or H-measures. The research will be directed towards improving the existing weak convergence methods, designing new mathematical objects for that purpose, as well as developing new methods, with particular attention paid to their applications to practical problems.Problems known as homogenisation are tied to properties of mixtures of materials, with important applications in optimal design. Problems related to evolutionary equations and their admissibility conditions mainly concern transport problems in free and porous media, where it is sometimes natural to include continuous time random walk variables in the model. Such problems sometimes also lead to fractional derivative equations. Some problems are related to hyperbolic conservation laws and the propagation and interaction of singularities. High-frequency waves corresponding to solutions of hyperbolic systems are governed by ODEs, allowing for final interpretation as particles. Particularly interesting are situations where the equation changes its type (like transonic fluid flow), motivating our interest in Friedrichs systems. Further results for semilinear systems could open a new approach to the Maxwell-Dirac system, with potential applications in quantum field theory. Practical computation of coefficients in specific applications is also important; as the unknown functions have the domain in multidimensional space, quite often more efficient numerical methods have to be developed.
1326Konceptualiziranje nacije i kolektivnih identiteta u Hrvatskoj: Politički rituali i kulturalna memorija trauma 20. stoljećaFraming the Nation and Collective Identity in Croatia: Political Rituals and the Cultural Memory of Twentieth Century Traumas2671Vjeran Pavlaković IP2013-11IP-2013-11-3782FRAMNAT10.06.2014 - 09.06.2018Završio516.429,48 KnHumanističke znanostiHumanitiesPovijest, History, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences6622, 6547, 4388, 7594, 17786, 7594, DAVOR PAUKOVIĆ, Ana Smokrović, Benedikt Perak, Tamara Banjeglav, Renato Stanković, Tamara Banjeglav, Cultural memory, war, discourse analysis, collective identity, mediaCommemorations and other political rituals are key components of a nation’s cultural memory, crucial for the construction and reinforcement of ideological, ethnic, economic, gender, and other identities. FRAMNAT will involve a dynamic team of young scholars and develop innovative methodologies for cultural memory research and cognitive linguistics analysis relevant for Croatia’s academic and policy-making community, as well as a much broader transnational audience. Croatia’s commemorative culture regarding the wars of the 20th century serves as a platform for politicians to operate within the nation-building narratives. Our project will analyze both top-down and bottom-up strategies of framing the nation and collective identities through commemorative practices of World War Two and the Homeland War in Croatia. These discourses will be analyzed at three levels: top-down political discourse (elites), media representation and transmission, and the reception of the narratives in Croatian society (bottom-up reactions). Seven commemorations related to World War 2 and the Homeland War will be observed and analyzed using corpus-based linguistic analysis and frame analysis. The media representations of the commemorative events and opinion poll data will likewise be analyzed in order to map how these discourses are transmitted and received in Croatian society. The project results will be disseminated via a regularly updated website (which includes a database of the collected research materials), journal articles, an edited volume, and papers presented at international conferences. Students and other members of the scholarly community will be encouraged to participate in the project through a variety of workshops to be held at the University of Rijeka. The long-term goal is to develop a Cultural Memory Research Center with scientific methods which can be applied to other regional and international case studies.
1327Pravni aspekti korporativnih akvizicija i restrukturiranje trgovačkih društava utemeljeno na znanju Legal Aspects of Corporate Acquisitions and Knowledge Driven Companies' Restructuring345Edita Čulinović-Herc IP2013-11IP-2013-11-9366LACAKDCR01.02.2015 - 31.01.2019Završio588.788,00 KnDruštvene znanostiSocial sciencesPravo, Law, Sveučilište u Rijeci, Pravni fakultetUniversity of Rijeka, Faculty of Law3403, 3741, 618, 2793, 3020, 3047, 2685, 626, 4067, Nataša Žunić Kovačević, Dionis Jurić, Ivana Kunda, Vlatka Butorac Malnar, Antonija Zubović, Mihaela Braut Filipović, Stjepan Gadžo, Danijela Vrbljanac, Nikolina Grković, corporate acquisitions, mergers, takeovers, concentrations, taxation of corporate acquisitions, knowledge based restructuring In the EU post-accession era, Croatian companies are facing the challenges of corporate acquisitions and restructurings. The latter is an inevitable result of new EU competitors entering the Croatian market. Cross-border and/or domestic corporate regrouping may take different forms depending on the chosen legal model. While being multi-layered phenomena, corporate acquisitions and restructurings are covered by several specialized legal disciplines which the contemporary legal doctrine does not observe as a whole. The aim of this research is to combine the various legal aspects of corporate acquisitions focusing on knowledge driven companies’ restructuring as the most beneficial model. Accordingly, the proposed research will analyze legal models of corporate acquisitions, financing techniques, taxation issues, intellectual property and related competition law concerns, covering thus the topic from the point of company law, capital market law, tax law, competition law and intellectual property law. The research will combine the legislative, judicial and theoretical analysis with the relevant empirical analysis. Cross-referenced results in the respective fields and their systemization will enable the creation of scientifically founded and empirically tested legislative proposals in one single-package. The aim is to enhance the level of protection of all interested parties of corporate acquisitions and knowledge driven restructurings either via strengthening ex ante and/ or ex post control. The results will be disseminated to the legislator, regulators, judiciary and companies as ultimate beneficiaries. What more, project results will enable companies to optimize their choices of restructuring and their position on the market. The dissemination of the project results will ultimately promote and develop knowledge driven restructuring that should in turn increase the competitiveness of the Croatian companies and stimulate the overall economic growth.
1329Fizika Standardnog modela i njena proširenjaPhysics of the Standard Model and Beyond2665Blazenka Melic IP2013-11IP-2013-11-5169PhySMaB01.10.2014 - 30.09.2018Završio723.799,43 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb5180, 4045, 4709, 5888, 5307, 18986, 17814, 21412, Goran Duplančić, Bruno Klajn, Fabrizio Nesti, Kornelija Passek-Kumerički, Bene Nižić, Monalisa Patra, Goran Popara, Domagoj Leljak, theoretical particle physics, Standard Model, perturbative calculations, physics beyond Standard Model, neutrinosIn high energy particle physics it is widely believed that the energy frontier experiments at LHC and the planned linear colliders, ILC and/or CLIC, together with ongoing and new experiments in neutrino and flavour physics will unravel fundamental problems in particle and astroparticle physics. A prerequisite for this progress is the complete understanding of the Standard model (SM) predictions. One of the triumphs of SM physics has been the extent to which QCD successfully describes strong interaction processes observed at colliders. More accurate QCD calculations are nowadays essential in understanding the enormous amount of available high-precision data, particularly since new physics effects are obscured by standard QCD processes. Our focus in that area will be to improve the description of hard exclusive processes by including higher-order contributions and by further developing the corresponding methods for automatic QCD calculations. Furthermore, we plan to do precision studies of top-quark production and decay observables which provide a unique view to the mechanism of electroweak symmetry breaking, important for understanding of particle mass generation. In the top-quark decay the information about its spin polarization imprinted by the production process is preserved, and can be calculated and measured in angular distributions of decay products providing other way to search for deviations from the SM expectations. Regarding new physics, the fact that neutrinos have a mass already requires an extension of the SM and calls for an understanding of the origin of neutrino masses. The seesaw mechanism, included in a theory as the one where left-right symmetry (parity) is restored at accessible LHC energies, stands out as a prominent theoretical candidate, and this theory links the origin of neutrino masses to new interactions at high energies and to the restoration of parity. A phenomenological investigation of these predictions is thus compelling and timely.
1338Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranzicijiThe Role of Wnt signaling in Epithelial to Mesenchymal Transition139Nives Pećina-Šlaus IP2013-11IP-2013-11-6625WNT4EMT01.09.2014 - 31.08.2018Završio800.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine2813, 1169, 2587, 441, 354, 445, 1170, 3553, 4751, 4287, 4859, 19002, Davor Tomas, Tomislav Vladušić, Hrvoje Ivan Pećina, Tamara Nikuševa Martić, Anja Kafka, Ljiljana Šerman, Reno Hrašćan, vili beroš, Martina Zeljko, Goran Mrak, Denys Neville WHEATLEY, Anja Bukovac, Wnt signaling, EMT, brain tumors, invasion, dishevelled, TCF/LEFIn the proposed research project we aim to determine the involvement of Dishevelled and TCF/LEF families of human genes in the process of Epithelial-to-Mesenchymal Transition (EMT) in brain tumors. We believe that the changes of structure and expression of the selected genes correlate with the phenotypic changes of tumor cells. EMT is a process very much involved in invasion and progression of tumors. Many oncogenic signaling pathways can induce EMT. The classical Wnt pathway has a particularly tight link with EMT and it has been shown that nuclear translocation of beta-catenin can induce EMT. Wnt pathway is one of the basic cellular pathways whose misregulation plays important roles in tumorigenesis and whose mediators of transcription are members of TCF/LEF family. Another important protein family is the Dishevelled considered to be the central hub of Wnt signaling since it interacts with Wnt receptors and recruits the multiprotein beta-catenin destruction complex. The experiments of the proposed research will use modern methods of molecular biology for the analyses of brain tumor samples of different malignancy grades. The genetic changes will be tracked by PCR/loss of heterozygosity, heteroduplex and Spreadex electorphoresis (Elchrom Scientific, Switzerland) methods. Expression of selected proteins will be studied by immunohistochemistry demonstrating their location in tumor cells. Besides its scientific value, results from the proposed project will have an application in medical diagnostics. Identifying changes in molecules responsible for control of cell motility will give us the preconditions for understanding the invasiveness of brain tumors and offer new disease progression markers. Our experimental evidence would also encourage the development of therapies that specifically interfere with Wnt signaling in cancer.
1340Algebarske i kombinatorne metode u teoriji verteks algebriAlgebraic and combinatorial methods in vertex algebra theory92Dražen Adamović IP2013-11IP-2013-11-2634ACMVAT01.07.2014 - 30.06.2018Završio532.515,86 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science1285, 1098, 746, 1252, 631, 636, 632, 687, 1138, 638, 4027, 17775, Goran Trupčević, Marijan Polić, Josip Vujčić, Tomislav Šikić, Gordan Radobolja, Slaven Kožić, Ozren Perše, Marijana Butorac, Miroslav Jerković, Mirko Primc, Boris Širola, Ana Kontrec, vertex algebras, W-algebras, affine Lie algebras, logarithmic CFT, combinatorial bases, Zhu's algebras, C2 cofiniteness,In the proposed project we shall study the representation theory of important classes of vertex algebras with particular emphasis on the theory of vertex algebras with origins in physics. We shall also study the affine vertex algebras and their connections with W-algebras. Based on previous research of D. Adamović and O. Perše from the papers J. Algebra 319 (2008); SIGMA 8 (2012); Algebras and Representation Theory 16 (2013) we shall apply the representation theory of vertex algebras of affine type to the structure and representation theory of W-algebras. In the last few years, C2-cofinite, irrational vertex algebras with non-semisimple representation categories attracted a lot of interest. Such vertex algebras also appear in the logarithmic conformal field theory. By using methods developed in the papers by D. Adamović and A. Milas: Adv. Math. 217 (2008), Comm. Math. Phys. 288 (2009), Adv. Math. 227 (2011) and J. Math. Phys. 73511 (2012) we shall study the representation theory of certain irrational, C2-cofinite vertex algebras and their connections with the theory of quantum groups. An emphasis will be put on the tensor categories of modules of C2-cofinite vertex algebras, the determination of fusion rules, orbifold vertex subalgebras and the explicit realization of logarithmic representations. A part of the research will be devoted to some combinatorial aspects of the representation theory of affine Kac-Moody Lie algebras. We will study the application of intertwining operators on the determination of combinatorial bases of Feigin-Stoyanovsky type subspace and the associated fermionic character formulas developed by M. Primc and collaborators. We also plan to apply the above methods on the combinatorial structures related to triplet vertex algebras and logarithmic CFT.
1341Otvaranje obrazovanja kroz učenje unutar i izvan škola i kolaboraciju na mobilnim tablet računalimaOpening up education through Seamless and COLLAborative Mobile learning on tablet computers151Ivica Botički UIP2013-11UIP-2013-11-7908SCOLLAm01.09.2014 - 31.08.2017Završio769.387,50 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing2986, 2994, 3154, 3186, 3195, 6008, 3612, Neven Drljevic, Vedran Mornar, Igor Mekterovic, Natasa Hoic-Bozic, Mia Carapina, Peter Seow, Tomislav Jagušt, seamless learning, mobile learning, technology enhanced learning, collaborative learning, informal learning, educational technologyThis project explores the potential of using mobile technology for seamless and mobile learning in Croatia and proposes a technologically innovative mobile learning platform named SCOLLAm. Being one of the first scientific mobile learning projects in Croatian schools, it explores both technology and pedagogies through two studies leveraging tablet computers in Croatian classrooms. In the first study, SCOLLAm will be deployed in a primary school to support new seamless and collaborative lessons in and across the existing subjects. In the second study, augmented mobile learning technology and the accompanying digital lessons will be used as a tool to support seamless and collaborative learning in a vocational school. These studies seek to stimulate and explore the effectiveness of mobile learning in Croatian schools in a strictly scientific manner, by engaging in digital mobile lesson co-design with the school teachers. The project will leverage experience from mobile learning research groups from Singapore, Sweden and USA in order to develop a new set of tools and lessons suitable for Croatian educational system. In order to move away from the tools typically targeting one platform and providing only limited adaptation mechanisms with virtually no learning analytics, one of the project objectives is the design, development and deployment of a scalable, adaptive and analytics driven platform SCOLLAm. Through the designed studies, produced open localizable educational resources and the SCOLLAm platform, we expect to see that the participants benefit from the introduction and use of mobile technology and applications through increased learning, collaboration skills and self-directedness, and acquire 21st century skills needed in their further education and life.
1350Uvjeti, resursi, neprijatelji i bioraznolikost: Sile koje oblikuju morske zajednice u plitkom Jadranskom moruConditions, Resources, Enemies, and Biodiversity: Forces structuring marine communities of the shallow Adriatic Sea1269Stewart Schultz IP2013-11IP-2013-11-3107COREBIO01.10.2014 - 30.09.2018Prekinut736.080,39 KnPrirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u ZadruUniversity of Zadar3702, 5004, 4486, 6648, 17825, Tatjana Bakran-Petricioli, Claudia Kruschel, Donat Petricioli, Alen Soldo, Dubravko Pejdo, community ecology, fish, Posidonia, habitat, monitoringThis project is an investigation of the major drivers of fish community structure in the shallow Adriatic Sea of Croatia. This information is crucial for the sustainable, scientific management of coastal ecosystems, as required by EU instruments such as the Habitats Directive, Marine Strategy Framework Directive, Water Framework Directive, and the Common Fisheries Policy. The major questions asked are 1) What are the ecological baselines in Croatia in community structure? 2) How does anthropogenic activity (harvesting, coastal development) shift community structure from baseline? 3) How do marine protected areas maintain functional communities? 4) How is community structure changing over time? We will investigate these questions using innovative, non-destructive techniques for quantifying fish abundance and size distribution, and benthic habitat quality. These techniques include lure-assisted, underwater visual census which was originally developed in the Schultz laboratory; baited, underwater video; and DGPS-assisted, towed underwater video. EU policies require that non-destructive methods for assessment and monitoring replace destructive harvest-based methods currently in widespread use, and these methods are among the most scientifically supported non-destructive methods currently available. These methods will be used to quantify fish community structure and benthic habitat at all major MPAs and former MPAs in Croatia, to compare communities within MPAs to matched locations outside MPAs. Matched locations will be chosen to test for specific anthropogenic drivers of community structure, such as high fishing pressure, coastal development, marine tourism, aquaculture, and terrestrial runoff. These results will advance our basic understanding of coastal ecosystems, and will be crucial for satisfying Croatia's responsibilities as an EU citizen in MPA construction, management, and monitoring of marine resources.
1352Hrvatska u 20. stoljeću: modernizacija u uvjetima pluralizma i monizmaCroatia in the 20th century: modernization in the context of pluralism and monism515Zdenko Radelić IP2013-11IP-2013-11-3481Croatia20thcentury01.07.2014 - 30.06.2018Završio206.200,00 KnHumanističke znanostiHumanitiesPovijest, History, Hrvatski institut za povijestCroatian Institute of History1344, 1060, 1350, 1375, 1361, 2545, 1357, 1345, 286, 2817, 2834, 2933, 3107, Miroslav Akmadža, Nikica Barić, Davor Kovačić, Zdravka Jelaska Marijan, Hrvoje Čapo, Josip Kajinić, Josip Mihaljević, Ivana Šubic Kovačević, Marko Zubak, Goran Mladineo, Stipe Kljajić, Mario Jareb, Nada Kisić Kolanović, Croatia, Kingdom of Yugoslavia, Independent State of Croatia, Socialist Federative Republic of Yugoslavia, democracy, dictatorship, totalitarianismThe aim of the project is to research the political, economical, social and cultural developments in Croatia from 1918 when Austro-Hungarian Empire collapsed, to 1991 when socialist Yugoslavia disintegrated. Thus the project covers the period of about 70 years, from 1914/1918 to 1991. The project will cover complete present day Croatian territory as well as neighbouring areas where necessary. The project will include various topic – ideologies and politics, national and religious questions, as well as culture, especially the role of media and sport in the social life. Research will cover a wide range of events and historical processes: formation and spreading of national and political ideas and their realization through the activities of political parties and movements; organization of state security and police; reconstruction of everyday life; the question of identity of various groups of Croatian society. The project will also cover the biographies of certain persons and how certain regimes treated them. More specifically the project will research the consequences of World War I on the population; the activities of state authorities of Kingdom of Serbs, Croats and Slovenes/Yugoslavia, Independent State of Croatia, Federal People's Republic of Yugoslavia/Socialist Federative Republic of Yugoslavia and to the present day Republic of Croatia. The research will concentrate on the question of freedom of nations and individuals and the influence of external political forces.
1358Računalna rješenja u bioznanostima: Značaj savitljivosti molekulaComputational Solutions in the Life Sciences: The Importance of Molecular Flexibility326David Smith IP2013-11IP-2013-11-8238CompSoLS-MolFlex15.07.2014 - 14.12.2018Završio900.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb2848, 854, 56, 3235, 2682, 3093, 2666, 2736, 3618, 5501, 18936, Nadja Doslic, Darko Babić, Borislav Kovačević, Danijela Barić, Ana-Sunčana Smith, Karmen Čondić-Jurkić, Momir Mališ, Jurica Novak, Zlatko Brkljača, Ivan DRAGIČEVIĆ, Marko Hanževački, Molecular Flexibility, Computational Chemistry, Peptides, Proteins, Enzyme CatalysisMolecular flexibility controls a number of key processes ranging from protein folding to the design of advanced materials. However, the detailed understanding of its impact on a given process is poorly understood. Direct investigation of this phenomenon by experimental means, is a challenging endeavour, as the microscopic details are frequently hidden from macroscopic observations. Computational simulations, on the other hand, provide detailed information regarding molecular dynamics and flexibility. The theoretical approach is thus crucial in both understanding the experimental results and in expanding the underlying conceptual framework.The present project proposes to utilize state-of-the-art computational techniques to address the importance of molecular flexibility across a range of carefully selected examples from the life sciences. The examples, which can be classified under the headings: (i) peptides and spectroscopy, (ii) protein flexibility, and (iii) enzyme related transformations, have been chosen to span multiple time and length scales and thus to highlight the diverse and wide-reaching nature of molecular flexibility. The selected examples exhibit a significant degree complementarity and synergy with one another and are all associated with their own applicative importance in different areas of (bio)chemistry.In addition to the scientific research proposed, the project aims to consolidate a highly successful and competitive platform in computational life sciences that has been established at the RBI. This platform was already recognized through the granting of an EU-FP6 project (2007-2010). The current project team is thus well equipped for the proposed work and exhibits a good balance between senior researchers, with excellent track records, and junior scientists with outstanding potential. The support of the project team by HrZZ is crucial for maintaining their competitiveness in the international scientific environment of computational life sciences.
1366SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLASYNTHESIS AND CYTOSTATIC EVALUATIONS OF NOVEL NITROGEN HETEROCYCLES LIBRARY76Silvana Raić-Malić IP2013-11IP-2013-11-5596SCIENcENTRY02.06.2014 - 31.05.2018Završio934.036,00 KnPrirodne znanosti, Biomedicina i zdravstvo, Natural sciences, Biomedicine and health sciences, Kemija, Chemistry, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology3924, 2914, 2865, 2847, 2768, 2769, 1135, 3913, 1219, 2835, 2767, 3261, 2811, 17839, Tatjana Gazivoda Kraljević, Marijana Hranjec, Livio Racané, Irena Sović, Maja Aleksić, Nataša Perin, Andrijana Meščić, Silvija Maračić, Maja Stipković Babić, Višnja Stepanić, Krešimir Pavelić, Mirela Sedić, Grace Karminski-Zamola, Andrea Bistrović, 1,2,3-triazole-heterocycles hybrids, benzimidazoles, benzothiazoles, synthesis, cytostatic activity, in silico and docking analysis, DNA bindingCancer is one of the most serious health problems of a worldwide dimension. One in three of the population develops cancer at some time in their lives and one in four dies from this disease. The main problems in antitumor chemotherapy are drug resistance and side effects on normal tissues. In the recent years a tremendous growth was witnessed in synthesis and development of vast number and types of new heterocyclic antitumor agents, with an emphasis on creation of new drugs with better selectivity or activity. The latter are indeed major requirements in development of novel anticancer drugs. The proposed scientific project is highly interdisciplinary and objective-oriented with the principal aim to develop the novel lead compounds with pronounced and selective anticancer activity that would be used for further phases of drug development.To achieve the principal aim following specific tasks are foreseen. The goal of the first one is to synthesize small-compound library (Classes A–H) comprising new conjugates of pseudopurines, coumarines and quinolines with 1,2,3-triazole scaffold, N-acyclic 5-unsaturated pyrimidine derivatives, amino-, amido- and amidino substituted benzimidazole, benzothiazole and benzo[b]thieno-2-carboxamide derivatives. Molecule library will be synthesized using modern synthetic approaches such as click chemistry, palladium mediated cross-coupling, eco-friendly microwave assisted and photochemical reactions as well as classical organic synthetic methods. The aim of the second task is to predict plausible biological targets and pharmacological activities using cheminformatics/in silico analysis. The third task is to perform cytostatic evaluations based on which hit molecules with desired biological effect will be selected for structure optimization that will be subsequently carried out. Finally, the molecular mechanism studies are anticipated for the most effective compounds from synthesized N-heterocycles library.
1367Periodički npregnuti grfen; strukturna i elektroska svojstvaPeriodically strained graphene; structural and electronic properties105Petar Pervan IP2013-11IP-2013-11-2727PerStaGra01.07.2014 - 31.08.2016Prekinut353.000,00 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut za fizikuInstitute of Physics in Zagreb3486, 3090, 3104, 6373, 6283, Vesna Mikšić Trontl, Iva Šrut Rakić, Ivo Pletikosić , Tonica Valla, Asensio Maria Carmen, graphene, strain, vicinal surface, fermi velocity, spin-orbit coupling, STM, ARPESA strained graphene offers a valuable avenue for the manipulation in altering its electronic structure. Graphene can withstand rather large elastic deformation and it appears that within the elastic response there is a range of different modifications in graphene’s electronic structure. This is a basis of what is called “strain engineering”. Recent theoretical calculations suggest that uniaxial strain or shear deformations can induce opening of the electron band gap, anisotropic modification of the Fermi velocity, spin-orbit interaction and consequently alter the transport properties. However, there is still no consensus on the mechanical conditions required to obtain a particular electronic modification. In this project we propose a systematic study of structural and electronic properties of periodically rippled graphene. We have already demonstrated that graphene conforms to the stepped (vicinal) iridium surface – Ir(332) creating periodic structure at nanometer scale. It is aim of this project to experimentally explore the dependence of the electronic structure of graphene with respect to periodicity of the graphene corrugation, orientation of the graphene with respect to the shear deformation (zig-zag with respect to armchair direction). By intercalation of different elements we will alter the graphene substrate interaction with the aim to control the structure of the underlying surface and consequently valence band structure of graphene. We shall investigate structural properties of graphene on Ir(332) by Scanning Tunneling Microscope (STM) and Atomic Force Microscope (AFM). The focus in the investigation of electronic properties will be on the ARPES study of anisotropic distortion of the Dirac cone, relation with the direction of the graphene modulation, spin-orbit interaction and on the possibility to induce electron band gap.
1371Procjena i predviđanje produktivnosti šumskog ekosustava objedinjavanjem terenskih izmjera, daljinskih istraživanja i modeliranjaEstimating and Forecasting Forest Ecosystem Productivity by Integrating Field Measurements, Remote Sensing and Modelling360Hrvoje Marjanović UIP2013-11UIP-2013-11-2492EFFEctivity01.07.2014 - 30.06.2017Završio603.400,00 KnBiotehničke znanostiBiotechnical sciencesŠumarstvo, Forestry, Hrvatski šumarski institutCroatian Forest Research Institute819, 1275, 843, 6352, 7033, 18937, 17816, Maša Zorana Ostrogović, Ivan Balenović, Elvis Paladinić, Krunoslav Indir, Zoltan Barcza, Anikó Kern, Mislav Anić, forest productivity, Quercus robur, GPP, NPP, eddy covariance, MODIS, Biome-BGC, photogrammetry, dendrometers, soil respirationForest play important role in climate regulation and secure resources vital for local economy, but the imminent climate change will affect their productivity, and for some tree species possibly even their sustainability. Thus, monitoring forest productivity and understanding effects of key environmental drivers becomes essential for forest management. This is a challenging task, particularly due to great costs related to it. Hereby we propose a research, aimed at addressing this issue, with a novel approach that could facilitate fast and cost-effective assessments of forest productivity. The research would be conducted on pedunculate oak forests (Quercus robur L.) which are economically, and ecologically, one of the most important in Croatia. Main objective of the proposed research is to develop and test methods and workflows for the estimation of annual productivity of forests at the local scale by using existing research infrastructure for measurement of carbon fluxes (EC monitoring system), freely available high temporal resolution data from remote sensing (MODIS) and state of the art process model (Biome-BGC). The proposed research will provide the first evaluation on the quality of MODIS GPP and NPP estimates for Central-European lowland forests. Field measurement campaigns combined with state of the art digital photogrammetry will be performed to parameterise Biome-BGC model, and validate data from MODIS and model simulations. Using available data on future climate scenarion, productivity of oak forests for the future 30-50 years will be simulated with Biome-BGC model. The proposed research is in line with the objectives of the EU Forest Action Plan which, among others proposes to encourage adaptation to the effects of climate change (key action 6), and to work toward a European Forest Monitoring System (key action 8).
1381PRIMJENA PLAZME STVORENE VISOKONAPONSKIM ELEKTRIČNIM PRAŽNJENJEM PRI KONZERVIRANJU TEKUĆE HRANE APPLICATION OF ELECTRICAL DISCHARGE PLASMA FOR PRESERVATION OF LIQUID FOODS206Zoran Herceg IP2013-11IP-2013-11-6248NTP0115.09.2014 - 14.09.2018Završio850.000,00 KnBiotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology456, 526, 469, 1307, 453, 448, 707, 493, 591, 590, 1002, 2653, 3170, 2917, 2609, 4033, Vesna Lelas, Selma Mededovic Thagard, Anet Režek Jambrak, Damir Stanzer, Jasna Mrvčić, Suzana Rimac Brnčić, Hrvoje Juretić, Tomislava Vukušić, Marija Badanjak Sabolović, Višnja Stulić, Ivona Elez Garofulić, Stela Križanović, Mara Banović, Ivančica Delaš, Zlatko Kregar, Vlasta Horvatić, Electrical discharge plasma, liquid-phase plasma reactor, liquid food, physico-chemical properties, nutritional and sensory propertiesWith the growing knowledge of the importance of food in maintaining the human health, the food industry is faced with increasing challenges to develop new non-thermal food treatment technologies that would prevent and mitigate food contamination while retaining nutritional and functional properties of the treated food. Electrical discharge plasma is one of these more promising techniques. Plasmas formed directly in liquid inactivate microorganisms and without significant increase in temperature during the treatment. However, knowledge gaps regarding the nature of sterilization, inactivation mechanism and the plasma reactor design have been identified as major constraints for the applicability of this technology in food industry. Thus the main goal of the proposed project is to design and develop a non-thermal plasma reactor for the treatment of fruit juices and milk and optimize it to maximize the utilization of UV light and chemical species produced by plasma. To achieve this goal, we propose to address the following research objectives (R):R1 Develop and optimize a liquid-phase plasma reactor for treatment of fruit juices and milk.R2 Characterize the chemical and electrical properties of the liquid plasmas. R3 Evaluate the ability of the liquid-phase plasma to inactivate pathogenic microorganisms in suspensions of pure culture microorganisms and suspended in fruit juices and milk respectively. R4 Determine inactivation mechanism of the plasma treatments on microorganisms R5 Determine the effect of the plasma treatments on the physico-chemical, nutritional and sensory properties of juices and milk.The significance of the proposed research lies in the development of a novel plasma reactor as well as acquires new knowledge regarding the science behind the forthcoming plasma technology which can then be applied towards introducing and potentially replacing current processing technologies with plasma.
1382Uloga receptora autofagije u selektivnom uklanjanju mitohondrijaThe role of autophagy receptors in selective removal of mitochondria62Ivana Novak Nakir UIP2013-11UIP-2013-11-5246AutoMito01.03.2015 - 30.09.2018Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine3657, 6096, 5274, 17855, Brady Nathan, Ivan Đikić, Maja Buljubašić, Mija Marinković, autophagy, mitochondria, mitophagy, receptor, neurodegeneration, cancerAutophagy is cellular degradation pathway essential for cell survival, development and differentiation. Its digestive property has been shown important in different pathologies including cancer, neurodegeneration and pathogen removal. Discoveries of specific autophagy receptors have opened a new chapter in the autophagy field. Of great interest is the removal of damaged or excess mitochondria through specialized autophagy- mitophagy. Together with colleagues, I have identified and characterized mitochondrial proteins Nix/Bnip3L and Bnip3 as a mitophagy receptors for recruiting the autophagic machinery to damaged mitochondria and help their elimination (Novak et al, 2010; Zhu et al, 2013). We demonstrated that receptors mediate mitochondrial clearance during reticulocyte differentiation. Our goal is to further study autophagy receptors and proteins associated with mitochondrial clearance to better understand the role of mitophagy and its mechanism. We will study: (1) phosphorylation and dimerization of receptors and the consequences of this events on mitophagy progression; (2)factors that regulate tight connection of apoptosis and mitophagy; (3)potential interplay between mitophagy receptors and other mitophagy-related proteins, like E3-ligase Parkin and kinase PINK1; (4)the effects of mitophagy on cancer development. To reach our goals we will use established methodology in our laboratories including protein identification and interaction techniques (Western blot, IP, GST-pull down, RNAi), immunofluorescent microscopy, mass spectrometry, ITC and NMR. All experiments will be performed using cultured cells. This project proposal has a high capacity to generate very interesting data with high possibility for publications in top scientific journals. Fundamentally, generated data will help to understand the physiological and pathological conditions, such as neurodegeneration and cancer and allow us to manipulate mitophagy to fight diseases.
1386Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemijaNotch in hematopoietic stem cell differentiation and leukaemia development 498Mariastefania Antica IP2013-11IP-2013-11-7140NOBLE10.09.2014 - 09.02.2019Završio875.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb3776, 3576, 559, 3672, 6232, 17773, Ivan Bilić, Maja Matulić, Isidoro Feliciello, Li Wu, Mladen Paradzik, Luka Horvat, hematopoietic stem cells, leukemia, Notch, Ikaros, non-coding RNA,differentiation, The relevance of adult (somatic) stem cell research is increasing steeply with a growing number of human diseases shown to be curable by stem cell therapy. The present study plan aims the research towards the gene regulatory mechanisms that control hematopoietic stem cell (HSCs) homeostasis and differentiation, which is tightly regulated by an interplay of a number of transcription factors and environmental signals mediated by a Notch signaling pathway. Our group designed an experimental approach for studying the interaction of Notch signaling pathway with transcription factor genes associated with hematopoiesis with focus on Ikaros gene family. Our laboratory has established a diagnostic technique for quick and sensitive detection of aberrant Notch and Ikaros forms by single cell multiplex qRT-PCR, which is a unique tool enabling us to dissect the contribution of different members of the Ikaros and Notch families on differentiation and survival of hematopoietic cells in a context of regulation of expression of target genes as well as non-coding RNAs, since they maintain the spatial organization of chromosome structure and regulate cell commitment. Our results will improve diagnosis and risk stratification for leukaemia patients which will be an important aid in informed clinical decisions. Therefore the proposed project will substantially advance the field towards better therapeutic options and contribute significantly to the field of stem cell medicine.
1387Bioindikatori vodenih masa u JadranuBio-tracing Adriatic water masses (BIOTA)2829Zrinka Ljubešić UIP2013-11UIP-2013-11-6433BIOTA01.10.2014 - 30.09.2017Završio938.778,05 KnPrirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science2843, 4351, 4337, 451, 1519, 17842, 1305, Damir Viličić, Petar Kružić, Sunčica Bosak, Jelena Godrijan, Marijana Miloslavić, Maja Mejdandžić, Ivana Bosnjak, Adriatic Sea, climate changes, water mass tracers, cyanobacteria, coccolithophoridsInterannual changes in the circulation patterns and water mass dynamics highly influence biogeochemical processes in the Adriatic Sea, consequently impacting the functioning of the Adriatic ecosystem. Specific phytoplankton ecological preferences drive their temporal and spatial distribution, reflecting their dependence on specific temperature ranges, light levels, nutrient availability and other environmental gradients. Hence, some phytoplankton taxa can be used as water mass tracers (biotracers). We hypothesize that picophytoplanktonic prokaryote Prochlorococcus and nanophytoplanktonic eukaryotes coccolithophores: Emiliania huxleyi and/or Gephyrocapsa oceanic are such organisms, and can be used for tracing water masses in the Adriatic. Here, we propose interdisciplinary study where oceanography, taxonomy of phytoplankton and molecular recognition are combined to detect and follow water masses. Two winter cruises in the southern Adriatic will be conducted with station positions and sampling depths defined in situ. Water mass detection will be based on pre-defined physical characteristics; however, we also plan to use optical measurements in conjunction with the proposed sampling to develop an optical based criterion for definition of the targeted water masses. Phytoplankton community will be assessed using multiple tools to confirm the presence and to determine distribution, abundance and diversity of the proposed biotracers in sampled water masses. With the variability and trends of the Adriatic circulation as well as the water mass characteristics brought on by changing climate, we believe that proposed study is timely and needed as it is offering a holistic and integrated approach to oceanography of the Adriatic. Most importantly, this study is proposing to develop a new set of interdisciplinary tools that will be essential for future research activities.
1400Dijagnostika Interakcije lasera i hladne plazmeLaser - Cold Plasma Interaction and Diagnostics140Slobodan Milošević IP2013-11IP-2013-11-2753LaCPID01.06.2014 - 31.05.2018Završio851.283,51 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut za fizikuInstitute of Physics in Zagreb2611, 2867, 1500, 3306, 2609, 4041, 4033, 1271, 17797, Marijan Bišćan, Robert Beuc, Damir Veža, Mladen Movre, Zlatko Kregar, Čedomil Vadla, Vlasta Horvatić, Nikša Krstulović, Dean Popović, low temperature plasmas, laser produced plasmas, cold plasmas, atmospherics plasmas, laser spectroscopyCold and low-density plasmas are currently in focus of basic research worldwide due to many open questions regarding their complex nature and simultaneously due to their high potential for applications in various fields of research and technology. Plasmas can be produced by bombarding matter either with energetic electrons or with energetic photons. The first kind is related to use of various discharges and the second to use of powerful lasers. Our interest is in plasmas produced in vacuum, under low-pressure gas environment, at atmospheric air or on/within liquids. Discharges which we use range from electrodeless, single electrode to various designs of two electrode systems. Lasers we use are cw or pulsed nanosecond. In our research special care will be devoted to tailoring the electron energy distribution functions as a key factor influencing plasma content and features. This is usually done by changing macroscopic plasma parameters - gas pressure, electrical fields and geometry of discharges. In this project we shall combine laser produced plasmas with discharge plasmas to achieve that goal. To understand the complex nature of plasma or processes of plasma interaction with other matter phases (gases, liquids and solids) basic approach is to perform plasma diagnostics by various types of optical and laser spectroscopies. To interpret findings we study basic atomic collision processes in plasmas and structure and spectra of various complexes formed within plasma (dimers, radicals etc). Modeling of various processes within cold plasmas and laser produced plasmas is performed in addition. In various applications in which plasma treatment of matter is used there is a need for in situ monitoring of processes both in plasma and at interfaces and therefore both spatial and temporal spectral resolution of applied detection techniques are important. We use classical emission and absorption laser spectroscopies and modern techniques such as a cavity ring-down spectroscopy.
1402Utjecaj endemskog ratovanja na zdravlje kasnosrednjovjekovnih i ranonovovjekovnih populacija HrvatskeThe effects of endemic warfare on the health of historic period populations from Croatia2788Mario Šlaus IP2013-11IP-2013-11-8100Warandhealth30.06.2014 - 29.06.2018Završio599.860,70 KnHumanističke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, Humanities, Biomedicine and health sciences, Natural sciences, Etnologija i antropologija, Ethnology and anthropology, Hrvatska akademija znanosti i umjetnostiCroatian Academy of Sciences and Arts2670, 567, 596, 2583, 2919, 3780, 1439, 19012, Mario Novak, Željka Bedić, Vlasta Vyroubal, Marin Vodanović, Emma Lightfoot, Hrvoje Brkić, Mislav Čavka, Anita Adamić, physical anthropology, bioarchaeology, paleopathology, health, war, osteological analyses, medieval period, CroatiaWarfare has afflicted humankind throughout its history, and is a phenomenon that still fundamentally affects the modern world. Despite the fact that violence -related mortality is profoundly undercounted, violent conflict represents the third most important source of mortality around the world. Analyzing the effects that war had on health through the deep time perspective that archaeological investigations afford can provide unique data on the interactions between warfare, health and the environment and provided conclusions that are particularly relevant to disadvantaged communities throughout the developing world where most wars are currently being fought. This project assembles an international and multidisciplinary team of collaborators to conduct bioarchaeological investigations on two large composite skeletal samples from Croatia. The two composite series represent individuals who inhabited Croatia throughout: a) the Late Medieval period (1100-1400 AD) a period of relative prosperity and peace prior to the arrival of Ottoman Turks, and b) individuals who inhabited Croatia in the Historic period (1400-1700 AD) during which time the Ottoman Empire gradually expanded into East and Central Europe. The research will reconstruct Historic period health, diet, weaning practices, and disease and trauma patterns by comparing them with data from the Late Medieval period using bioarchaeological, paleopathological and stable isotope analyses of human burials from Croatia. The project is a collaboration between researchers and postgraduate students who specialize in bioarchaeology, paleopathology, paleodemography, paleodontology, radiology and stable isotope analyses from four institutions: the Croatian Academy of Sciences and Arts, the School of Dental Medicine of the University of Zagreb, the Department of Diagnostic and Interventional Radiology of the University Hospital Dubrava, and the McDonald Institute for Archaeological Research of the University of Cambridge.
1404Istraživanje dinamike Jadrana pomoću naprednih mjerenja i metode asimilacije podatakaExploring the Adriatic Sea Dynamics using Advanced Data Assimilation Methods and Measurements357Ivica Janeković IP2013-11IP-2013-11-5928ADAM-ADRIA01.08.2014 - 31.07.2018Završio488.262,27 KnPrirodne znanostiNatural sciencesGeofizika, Geophysics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb1044, 2836, 1020, 1417, 2898, 3461, 3525, Milivoj Kuzmić, Igor Tomažić, Mathieu Dutour Sikirić, Zoran Pasarić, Miroslava Pasarić, Stjepan Ivatek-Šahdan, Hrvoje Mihanović, Physical Oceanography, Data Assimilation, 4D-Var, ADCP, CTD profiler, Po river dynamics, Dense Water Dynamics, Adriatic SeaUsing advanced numerical techniques and data assimilation (ROMS 4D-Var) at the same time with modern observations in a dynamically consistent way we aim to improve knowledge of the Adriatic Sea dynamics. During the project we will explore open questions in the field of physical oceanography of the Adriatic Sea: (I) dynamics of the dense water (DW), especially flow at the eastern side of the Adriatic Sea, (II) dynamics of the Po river outflow during stratified and vertically homogeneous conditions, as well as (III) generation and dynamics of the sharp Istrian temperature and salinity front. In order to capture those phenomena we plan to use advanced field observations (ADCPs, CTDs, towed CTD profiler, underway ship CTD), as well as high resolution nested numerical models. This type of measurements could arguably prove hypothesis on the importance of the East Adriatic DW contribution to the overall northern Adriatic DW budget. Measuring synchronously at all important entrances of the Kvarner Bay, we can determine time-evolving dynamics of this socio-economically important region. ROMS 4D-Var system is a powerful tool capable to provide insight into a optimal observation setup, predictability and limits of the linearized adjoint techniques for a shelf sea as the Adriatic. Results from the project could serve as basis for other research fields like ocean biology (DW bringing O2 at the bottom), chemistry or geology, or even applied like oil spills, integrated environmental planning where correct dynamics is of a crucial importance. The project team members come from the four institutions: Ruđer Bošković Institute, Faculty of Science, Croatian Meteorological and Hydrological Service, and Hydrographic Institute bringing unique competences for the proposed project to succeed.Last but not least, it is important to emphasize that after the project completion, all the insitu collected and model data will be made available to the scientific and applied research community.
1406Uloga biotičkih čimbenika na vitalnost poljskoga jasena (Fraxinus angustifolia Vahl.) u poplavnim šumama HrvatskeThe role of biotic agents on vitality of narrow-leafed ash (Fraxinus angustifolia Vahl.) in Croatian floodplain forests2886Josip Margaletić IP2013-11IP-2013-11-4250FRAXINPRO13.06.2014 - 12.06.2018Završio940.000,00 KnBiotehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, Biotechnical sciences, Natural sciences, Biomedicine and health sciences, Šumarstvo, Forestry, Sveučilište u Zagrebu, Šumarski fakultetUniversity of Zagreb, Faculty of Forestry5650, 5656, 3892, 4036, 3748, 727, 4230, 3731, 3754, 5989, 6347, 5242, 5801, 5291, 5641, 6605, 4731, 3730, 5905, 3750, 6189, 1128, 17430, 19025, Ante Tadin, Dario Baričević, Marko Vucelja, Linda Bjedov, Milivoj Franjevic, Boris Hrašovec, Kristijan Tomljanović, Marijan Grubešić, Stjepan Mikac, Daniela Pilarska, Renata Pernar, Zrinka Štritof Majetić, Nenad Turk, Josipa Habuš, Petra Svoboda, Mario Ančić, Chandelier Anne, Danko Diminić, LUCIO MONTECCHIO, Marno Milotić, Thomas Cech, Davorin Kajba, Ivan Andrić, Jelena Kranjec, Fraxinus angustifolia, vitality, biotic agents, floodplain forests, modellingClose to half of the Croatian flood plain forests (67 470 ha) are represented by narrow-leaf ash (Fraxinus angustifolia), covering 29 748 ha in major river basins. Respective welfare value of these forests amount to 6,4 billion €, 2,8 billion € being attributed exclusively to ash forests. Growing stock in narrow-leafed ash forests reaches 4,3 million m3, binding 11,8 million tons of carbon dioxide acting as an important carbon sink depository. Natural and artificial regeneration of ash stands is under direct impact of numerous biotic and abiotic factors, many of which seriously hamper the viability of ash. Insect pests, pathogenic fungi, large game ungulates and ruminantes and small rodent populations play dominant role in the complex processes of tree decline and stand deterioration. Additionally, in the course of recent Europe-wide dramatic spread of newly identified lethal disease on ashes (Chalara fraxinea), introduction of a highly damaging Emerald Ash Borer (Agrilus planipennis) on the eastern borders of Europe, and increased frequency of climatic extremes urge the need to intensify the research of this phenomena. Through an integrated, multidisciplinary approach, in the course of 4 years, the proposed research project targets on several critical aspects of aforementioned biotic detrimental factors analyzing them in the given area and time and aiming to provide a multitude of new details on the mechanisms of their impact. Modern methodological approach covers the following major research topics: presence, local impact and ash disease spread and host resistance tests; additive impact of ash defoliators in the course of recent decline and possibility to manage their populations via entomopathogenic organisms; the impact of small rodents on tree regeneration, acting also as an important human diseases reservoir; negative impact of large game in ash regeneration; geospatial and temporal analysis of major biotic influences in given forest communities.
1407Stohastičke metode u analitičkim i primijenjenim problemimaStochastic Methods in Analytical and Applied Problems145Zoran Vondraček IP2013-11IP-2013-11-3526SMAAP01.09.2014 - 31.08.2018Završio439.181,10 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science522, 790, 570, 740, 781, 987, 793, 760, 1087, 853, 635, 1447, 999, 577, 19109, 19068, Hrvoje Šikić, Bojan Basrak, Miljenko Huzak, Vjekoslav Kovač, Ante Mimica, Nikola Sandrić, Danijel Krizmanić, Ivana Geček Tuđen, Azra Tafro, Drago Špoljarić, Vanja Wagner, Tvrtko Tadić, Kristina Ana Škreb, Snježana Lubura, Hrvoje Planinić, Stjepan Šebek, stochastic methods, stochastic processes, Markov processes, martingales, heavy tails, point processes, branching processesIn this project we apply modern stochastic methods to study a number of analytical and applied problems. Many phenomena in science and everyday life exhibit inherent uncertainty. We commonly use stochastic models to describe such behaviour and rely on stochastic methods to gain insights, make forecasts or inference about them. Various stochastic methods have appeared over the years in biology, medicine, biomedicine, geology, climatology, social sciences, finance and insurance, and many other scientific fields. The area of mathematics that lies in the background is probability theory, in particular, theory of stochastic processes. It is a rich mathematical theory with proven potential to solve not only applied problems, but also some quite theoretical problems coming from other areas of mathematics.The problems that we plan to study can be broadly divided into four groups: 1. Analysis and potential theory of Markov processes, 2. Stochastic methods in modelling heavy tailed phenomena, 3. Stochastic methods in harmonic analysis, and 4. Stochastic methods in biomedical and social sciences problems. This choice of problems is influenced by importance in the current international research as well as the background and expertise of members of our team. The goal of the project is to advance understanding of the role of randomness in each of these four settings. The unifying feature behind our approach to these problems is common stochastic methods in their analysis. These methods include, but are not limited to, martingale methods, point processes and random measure methods, potential-theoretic methods (both probabilistic and analytic), Markov processes methods, methods from the Dirichlet form theory, stochastic integrals, diffusion processes, branching processes and measure-valued processes methods, time-series methods, wavelets and methods for statistical inference.
1415Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidimaDesign, synthesis and evaluation of new antidotes in nerve agent and pesticide poisoning872Zrinka Kovarik IP2013-11IP-2013-11-4307CHOLINESTERASE01.09.2014 - 31.08.2018Završio999.946,82 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut za medicinska istraživanja i medicinu radaInstitute for Medical Research and Occupational Health982, 991, 489, 1224, 601, 411, 657, 3033, 3076, 5926, 17747, Maja Katalinić, Anita Bosak, Goran Šinko, Gordana Mendaš Starčević, Vladimir Vinković, Nikolina Maček Hrvat, Nikola Maraković, Suzana Žunec, Ana Lucić Vrdoljak, Zoran Radić, Tamara Zorbaz, acetylcholinesterase, butyrylcholinesterase, bioscavengers, prophylaxis, in silico drug-design, oximes, bronchodilatatorsOur main goal is to develop new compounds to serve as more efficient antidotes and improve the treatment of highly toxic organophosphorus (OP) compound poisoning. OP compounds used as pesticides account for over 3,000,000 registered accidental or deliberate cases of poisoning per year worldwide. Furthermore, OPs known as nerve agents (soman, sarin, tabun, VX) present a threat in terrorist attacks and conflicts, as was the case recently in Syria. The main targets of OP compounds are cholinesterases: acetylcholinesterase (AChE), the essential enzyme in neurotransmission, and butyrylcholinesterase (BChE), its back-up enzyme. However, the antidotes currently in use, which act as reactivators of inhibited AChE, were empirically synthesized before the two enzyme’s crystal structures were resolved. Due to structural requirements, their binding affinity and reactivation rate have not been well-balanced. This project utilizes new compounds to gain a better understanding of the mechanistic basis of the limitations of reactivation and find new effective leads for further in vivo study. We will combine several approaches, including: a study of the finely tuned interplay between these two sister enzymes, computational and experimental studies of cholinesterase interactions with a wide range of ligands defining favourable characteristic for potential new antidotes, in silico design of novel compounds that will direct the subsequent synthesis of selected leads, and thorough in vitro and in vivo experimental evaluation guided by strict cost-benefit criteria. Such a comprehensive approach will enable us to test a wide selection of candidates in a more reliable manner and obtain unambiguous data for further enhancements of the antidotal treatment. This will also enable us to explore other possible OP treatments such as highly-effective bioscavengers. Many of the findings that would arise from this project should have an impact that reaches far beyond the level of cholinesterases.
1417MOLEKULARNI MEHANIZMI POVEĆANJA OSJETLJIVOSTI NA PROTUTUMORSKE LIJEKOVE STANICA KARCINOMA DOJKE I MELANOMA ČOVJEKA UTIŠAVANJEM INTEGRINAMOLECULAR MECHANISMS OF CHEMOSENSITISATION OF HUMAN BREAST CARCINOMA AND MELANOMA CELL LINES BY SILENCING OF INTEGRINS1211Andreja Ambriović Ristov IP2013-11IP-2013-11-2465INSILCELL01.09.2014 - 31.08.2018Završio998.571,84 KnPrirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb1380, 3536, 3713, 1263, 3899, 2888, 3147, 420, 6232, Maja Osmak, Mario Cindrić, Anamaria Brozović, Mirela Baus Loncar, Sanjica Rak, Nikolina Stojanović, Tihana De Zan, Ana Dekanić, Mladen Paradzik, breast cancer, melanoma, signalling pathways, anticancer drug resistance, focal adhesion, migration, invasionThe recognition of molecular mechanisms involved in drug resistance may improve basic knowledge of signalling pathways involved in resistance to anticancer drugs and also improve outcomes in patients with drug-resistant cancers that have poor prognosis, such as triple negative breast cancer (TNBC) and metastatic melanoma. Integrins are cell surface molecules that mediate sensitivity to anticancer drugs, migration and invasion, and therefore represent a suitable target for therapy. This proposal investigates the molecular mechanism behind knockdown of integrins alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha 3 beta 1, alpha 4 beta 1 and alpha 5 beta 1 using integrin subunit specific siRNAs (beta 3, beta 5, beta 6, alpha v, alpha 3, alpha 4 or alpha 5) and the ability of such a treatment to sensitise TNBC and melanoma cell lines to anticancer drugs paclitaxel, vincristine and cisplatin. Our next goal is to identify how specific integrin knockdown influences cell migration and invasion. The focal adhesions (FA) are sites of attachment between cells and extracellular matrix which may mediate differential cell responses by variation of FA protein composition. Therefore, the FA protein composition will be investigated before and upon integrin silencing using proteomics methodology. We will monitor formation and temporal evolution of FA in living cells during spreading or migration using reflection interference contrast microscopy (RICM). On the basis of these data, several signalling pathways will be proposed and their involvement in sensitivity to anticancer drugs, migration and invasion will be experimentally verified. Our data will contribute to the knowledge on integrin signalling pathways, structure and function of focal adhesions. The understanding of integrin pathways involved in sensitivity to anticancer drugs, migration and invasion processes may provide novel insights into biology of these cancer cells and identify new target molecules in TNBC or melanoma.
1421Transformacije kolektivnih i individualnih identiteta u Dubrovačkoj Republici od kasnog srednjeg vijeka do 19. stoljećaTransformations of the Collective and Individual Identities in the Dubrovnik Republic from the Late Middle Ages until the Nineteenth Century393Nenad Vekarić IP2013-11IP-2013-11-5106COLINDA01.07.2014 - 30.06.2018Završio590.000,00 KnHumanističke znanostiHumanitiesPovijest, History, Hrvatska akademija znanosti i umjetnostiCroatian Academy of Sciences and Arts384, 386, 389, 398, 481, 458, 726, 739, 430, 1091, 1097, 1115, 1112, 1254, 330, Ivana Lazarević, Nella Lonza, Rina Kralj-Brassard, Relja Seferović, Vesna Miović, Stanislava (Slavica) Stojan, Lovro Kunčević, Zdenka Janeković Roemer, Irena Ipšić, Antun Koncul, Kristina Puljizević, Marija Gjurašić, Marinko Marić, Štefica Curić Lenert, Zrinka Pešorda Vardić, Dubrovnik, Identity, Middle Ages, Early Modern Period, cultural historyThe proposed project is an interdisciplinary study of various forms of identity in the Republic of Dubrovnik during almost half a millennium of its independent statehood (mid 14th – early 19th century). Adopting a broad perspective it will take into account most diverse aspects of identity, such as social, political, religious, ethnic, or individual, as well as their interactions. This requires investigation of diverse historical sources which range from texts (e.g. historiography, diplomatic correspondence, notary records), to social practices (e.g. ritual) or urban topography and visual arts. Besides such comprehensiveness, another important novelty of the project is its chronological scope. It takes into account long period of almost half a millennium, thereby disregarding the conventional divide between the Middle Ages and the Early Modern Period, which will enable valuable insights into long term (dis)continuities. Yet another important novelty is that the project focuses on a premodern city-state, a type of community relatively neglected in the field of identity studies mostly focused on modern period and national states. Finally, the project will also adopt a strongly comparative perspective, investigating the (dis)similarities between Dubrovnik and other Mediterranean cities.Since the enterprise of this scope necessarily involves specialists in different fields and methodologies, the project assembles an interdisciplinary team led by the Academician Nenad Vekarić. It consists of ten scientists, two postdoctoral researchers and four doctoral students. The project proposes to publish more than 10 scientific books, numerous articles, and organize four workshops. Besides offering the answer to an important scientific problem, the main objective of the project is to present to the international audiences the less known but important case of Dubrovnik, thus contributing to the visibility and networks of Croatian scholars.
1422Aproksimacija ovisna o konfiguraciji u nelinearnoj analizi konstrukcija metodom konačnih elemenataConfiguration-dependent Approximation in Non-linear Finite-element Analysis of Structures527Gordan Jelenić IP2013-11IP-2013-11-1631CANFAS01.09.2014 - 31.08.2018Završio938.478,00 KnTehničke znanostiTechnological sciencesTemeljne tehničke znanosti, Basic engineering sciences, Sveučilište u Rijeci, Građevinski fakultet u RijeciUniversity of Rijeka, Faculty of Civil Engineering1064, 1014, 906, 856, 3167, 7310, 19011, 17756, 22702, Paulo Šćulac, Dragan Ribarić, Leo Škec, Maja Gaćeša, Edita Papa Dukić, Nenad Bićanić, Nina Čeh, Sara Grbčić, Miran Tuhtan, non-linear structural analysis, finite-element method, configuration-dependent approximation, beams, shells, dynamicsThis proposal explores the configuration-dependent interpolation as a novel, unorthodox and remarkably promising expansion of the framework within which the non-linear finite-element method has been traditionally contained. The basic idea underlying the project stems from an apparent disparity between the rather advanced extensions of the traditional linear finite-element principles to non-linear problems and the fact that the key finite-element concept – that of interpolation of the unknown functions – is surprisingly kept mostly constant, i.e. configuration-independent. Enabling the finite-element approximation to become configuration-dependent is motivated by the existing need to improve the current non-linear finite-element procedures, in particular for mechanical problems defined on non-linear manifolds. This principle is presented as the general concept providing viable novel development paradigm with obvious benefits for a wider class of mechanical problems. The configuration-dependent approximation to be designed shall obey the essential convergence requirements, with its extra flexibility (arising from the potential of the new approximation to vary with the configuration) employed to improve the solution in some clearly defined manner. In particular, during the design process, the following two basic principles will be consistently adhered to:(i) In the limiting case where the non-linear mechanical problem becomes linear, the configuration-dependent approximation sought must coincide with a known reference interpolation for linear analysis.(ii) In a general non-linear situation, the configuration-dependent approximation should preserve a set of selected mechanical or mathematical properties of equilibrium or motion defined beforehand.In this way, a variety of finite-elements for static and dynamic analysis will be derived.
1423Inovativno pametno poduzećeInnovative Smart Enterprise2921Ivica Veža IP2013-11IP-2013-11-1353INSENT01.09.2014 - 31.08.2018Završio722.000,00 KnTehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnjeUniversity of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture3561, 5080, 4743, 5276, 5799, 5752, 18966, 18965, 18956, 17852, Marko Mladineo, Željko Stojkić, Zoran Babić, Nikola Gjeldum, Stipe Čelar, Boženko Bilić, Nikola Banduka, Igor Bošnjak, Mii Turić, Ivan Peko, innovation, smart enterprise, learning factory, production systems, business modelThe introduction of the Internet of Things and Services into the manufacturing environment is ushering in a fourth industrial revolution: Industry 4.0. This new type of industry is based on Smart Factory model or Smart Enterprise. The main features of Smart Enterprise can be summarized into the following: smart personalized product, product and service provider, and high level of collaboration.Manufacturing is today, as it always has been, a cornerstone of the economy of developed nations. An important advantage of manufacturing is that it calls on the skills of everyone from entry-level factory workers to scientists, engineers, and business professionals. Hence, main focus of this project will be Manufacturing Enterprises. Vision of Innovative Smart Enterprise for next generation manufacturing can be summarized into following features: Lean, Flexible, Agile, Efficient, Responsive, Information Enabled, Predictive, and Safe. All these features result with long term sustainability.The main objective of this project is to develop Croatian model of Innovative Smart Enterprise (HR-ISE model). Hence, a profound research will be performed to describe current state of Croatian manufacturing enterprise. It will be the answer on the question: “Where are we?”Furthermore, a synthesis of analysis of Croatian manufacturing enterprises will be done through development of HR-ISE model. It will be the answer on the question: “Where we want to be?”Finally, a special learning environment will be established: Learning Factory. It will be a place in which transfer of developed HR-ISE model to the economy subjects will be achieved. It will be the answer on the question: “How can we get there?”Results of this project will be of the highest value for “fallen” Croatian industry. The development of HR-ISE model and its transfer to economy can have strong impact on recovery of Croatian industry, and it can significantly improve competencies and capabilities of Croatian enterprises.
1427Kompetencijski profil akademske profesije: između novih zahtjeva i mogućnostiAcademic Profession Competence Framework: Between New Requirements and Possibilities380Jasminka Ledić IP2013-11IP-2013-11-2004APROFRAME01.06.2014 - 31.05.2017Završio292.214,82 KnDruštvene znanostiSocial sciencesPedagogija, Pedagogy, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences2588, 500, 2686, 3032, 18914, 18911, Bojana Ćulum, Marko Turk, Vilma Kotlar, Nena Rončević, Marija Brajdić Vuković, Bojana Vignjevic, higher education, academic profession, competence framework, academic roles, higher education policyChanges in social environment indicate the need for a redefinition of the academic profession’ traditional role and for its more comprehensive understanding, which leads to the requirements for the development of new competences. Research results indicate the increased scope of workload and demands for new approaches to teaching, disharmony between teaching and research, increasing administrative duties, and the insistence on a stronger connection between the academic community and social environment.This project aims to determine how academics in Croatia assess the relevance of various competences, and how they assess, perceive and interpret possession of various competences that shape contemporary academic profession. It is expected that the research results in a proposal of the academic profession’ competence framework.In the research quantitative and qualitative methodological approach (survey and semi-structured interview) will be used. The survey consists of the competence framework elements which are to be evaluated by the participants in terms of the assessment of their (1) relevance and (2) possession. The interviews will explore the deeper perception of academics and challenging issues within the framework, and gain a ‘holistic’ (comprehensive, systemic, integrated) understanding of context, while capturing data on the participants perceptions ‘from the inside’.The final definition of an integrated competence framework which includes different dimensions of the academic profession is an original research contribution. Bearing in mind that the research of the academic profession is neglected in the national research discourse, the results of this study will also be a starting point for defining recommendations for (national) educational policies. This will particularly apply to profiling the academic profession in the context of recent strategic directions in Croatia, in accordance with the requirements of the international scientific community.
1431Anaerobni kapaciteti u udaračkim borilačkim sportovimaAnaerobic capacities in kicking combat sports784Dražen Čular UIP2013-11UIP-2013-11-6524ACIKCS15.06.2014 - 14.03.2018Završio396.760,25 KnDruštvene znanosti, Biomedicina i zdravstvo, Tehničke znanosti, Social sciences, Biomedicine and health sciences, Technological sciences, Kineziologija, Kinesiology, Sveučilište u Splitu, Kineziološki fakultetUniversity of Split, Faculty of Kinesiology2949, 3449, 1463, 3312, 4560, 3813, 4737, 17896, 18978, Danijel Vučić, Alen Miletić, mirjana milić, Goran Kuvačić, Vladimir Ivancev, TEA BEŠLIJA, Damir Zubac, Luka Pezelj, Johnny Padulo, anaerobic capacity, combat sport, test construction, taekwondo, karate, kickboxing, fitness tests, The main aim of the project is to construct and validate a measuring instrument of good metric characteristics and with high applicability that will, in a quality way, describe the level of specific anaerobic capacities in kicking combat sports (taekwondo, karate, kickboxing). Due to the complexity of the problems regarding the object of research, and in case the newly constructed test does not show satisfactory metric characteristics, a secondary aim is set which entails revalidation and selection of one or more existing “non-specific” tests which will be proven appropriate for each sport after testing the metric characteristics. The project is designed as a research in duration of 36 months. For the purposes of realization of the aims set, the research will be conducted on a sample of 300 subjects minimum, divided into subsamples according to sport, gender and age category (cadets, juniors, seniors). The project consists of three phases. In the first phase a Web page and computer application will be created for: input, storage, reviewing and monitoring of subjects and results, and, based on a pilot study and previous findings, a certain number of the existing “non-specific” measuring instruments will be selected. In the second phase of the project data will be collected on anthropometric characteristics and the level of anaerobic capacities of the subjects will be measured by field tests with confirmed metric characteristics. At the same time, the construction of a new specific measuring instrument will begin during the second phase. The third phase of the project includes the testing of metric characteristics of the newly constructed specific field test for assessing anaerobic capacities in kicking combat sports, as well as the selection of the existing tests appropriate for practical application on a specific sample. After the project is finished, selection normative according to sport, gender and age category will be created based on the obtained results.
1440Dokumentiranje i interpretiranje najstarijih razdoblja hrvatskoga jezikaDocumentation and Interpretation of the Earliest Croatian995Amir Kapetanović IP2013-11IP-2013-11-2698DOCINEC01.07.2014 - 30.06.2018Završio425.995,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Institut za hrvatski jezik i jezikoslovljeInstitute of Croatian Language and Linguistics3723, 5648, 5864, 5965, 3726, 6131, 6612, 5332, Dunja Brozović Rončević, Željka Brlobaš, Vuk-Tadija Barbarić, Saskia Elisabeth Pronk-Tiethoff, Tijmen Pronk, Dubravka Ivšić, Tatjana Vukadinović, Branimir Brgles, Old Croatian, Proto-Slavic, onomastics, earliest linguistic attestations, loanwords, issoglosesThe oldest Slavic language attestations on Croatian territory date from two periods - the first which saw the disintegration of Common Slavic (9th-11th c.), and the second which saw the beginnings of the Croatian language (12th-13th c.). This Slavic vernacular, which was the direct predecessor of present-day Croatian, coexisted with the liturgical Croatian Church Slavic, whose oldest written texts can be dated to the 11th c. The earliest attestations of the Croatian language are scattered throughout written sources of various nature, from individual words found in Latin and Church Slavic texts, glosses, and notes in the margins of medieval codices to Glagolitic epigraphs. This language has not yet been analyzed in its entirety.The backbone of the project will be formed by a corpus of the earliest attested Croatian lexical data. Such a corpus does not yet exist. This early Croatian corpus will reflect the development of the languages between the 9th and 13th centuries, some of the earliest isoglosses between Croatian and other Slavic languages, as well as some of the earliest Croatian dialectal isoglosses and interaction with western European – especially Romance and Germanic – and eastern European cultural and linguistic entities. The earliest onomastic data of Slavic origin plays an important role in this research.The research will be conducted using the traditional methods and tools of historical linguistics, such as text analysis and interpretation and the comparative method. The research team consists of four researchers and five junior researchers from a number of academic institutions (Zagreb, Zadar, Leiden).The aims of the proposed project are: (1) to create a complete collection of the oldest attestations of the Croatian language; (2) to improve our understanding of the structural changes in early Croatian and the rise of the earliest isoglosses within Croatian; (3) to place the beginnings of the Croatian language in a wider Slavic and non-Slavic context.
1442Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija A multidisciplinary approach to discover selective drugs targeting cancer stem cells: The role of potassium transport 613Marijeta Kralj IP2013-11IP-2013-11-5660MultiCaST01.10.2014 - 28.02.2019Završio991.460,00 KnBiomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, Biomedicine and health sciences, Natural sciences, Biotechnical sciences, Temeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb629, 859, 2607, 3445, 647, 3806, 1421, 698, 2992, 17804, 21401, Marko Marjanović, Katja Ester, Irena Martin-Kleiner, Ana-Matea Mikecin, Lidija Uzelac, Tomislav Šmuc, Fran Supek, Kata Majerski, Tatjana Šumanovac Ramljak, Iva Guberović, Marija Ćosić, cancer stem cells, potassium transport, salinomycin, crown ethers, ion channels, ABC transporters, predictive QSAR modeling, drug discovery, therapyTargeting cancer stem cells (CSC), rather than cancer cells in general, is a novel and highly promising strategy for cancer treatment. The defining characteristics of CSC are self-renewal, propagation into heterogeneous lineages of cancer cells, and increased resistance to chemotherapy, thus, attacking the CSC should abolish a tumor's ability to recur or metastasize. Recently, a natural potassium ionophore salinomycin was identified as one of a few available CSC-selective substances, but the precise mechanism of its selectivity remains elusive. Based on hypothesis that the potassium transport is an important process of CSC biology, the objective of the proposed research is to understand fundamental processes of CSC-resistance to therapy and to discover novel compounds with ion homeostasis-modulating properties to selectively target CSC. Project methodology orchestrates research in three principle areas and their close interactions, covering synthesis and characterization of molecules (chemistry), assessment of their activity in biological models (biology, medicine) and computer-aided drug design (computational sciences). We’ll focus on salinomycin and a series of proprietary crown ether compounds, which will be optimized and developed. Their efficacy/selectivity and influence on drug transporters P-gp- and/or ABCG2-mediated efflux of chemoterapeutics will be assessed, as well as the toxicity and in vivo activity of the most promising compound. Deploying cutting-edge techniques in cell and molecular biology, bioimaging, molecular electrophysiology and transgenic cell lines (e.g. a unique CSC model - HMLEshEcad cells) we will strive to recognize novel biomarkers for identification and enrichment of CSC, related to abnormal potassium transport regulation that promote acquisition of CSC phenotype and/or influence their proliferation, death and migratory potential. The ultimate aim is to translate this knowledge into innovative mechanism-based therapeutic approaches.
1445Kateterska denervacija pulmonalnih arterija u liječenju primarne i sekundarne plućne hipertenzijeCATHETER DENERVATION OF PULMONARY ARTERIES IN THE TREATMENT OF PRIMARY AND SECONDARY PULMONARY HYPERTENSION315Aleksander Ernst IP2013-11IP-2013-11-2505CADOPA01.07.2014 - 30.06.2018Prekinut1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesKliničke medicinske znanosti, Clinical sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine1334, 1092, 1021, 985, 3393, 3452, Jadranka Šeparović Hanževački, Mladen Vidovich, Boško Skorić, Joško Bulum, Maja Strozzi, Miroslav Samarzija, idiopathic pulmonary hypertension, secondary pulmonary hypertension, radiofrequency denervation, cryodenervation, pulmonary arteriesThe role of neural reflexes in the mediation and development of idiopathic pulmonary artery hypertension (IPAH) and secondary pulmonary artery hypertension (SPAH) has not been adequately investigated. The existence of a pulmopulmonary baroreceptor reflex that originates in the large pulmonary branches, unrelated to the vagus nerve has been reported (1,2,3).Very recently, experimentally induced acute pulmonary hypertension in 10 Mongolian dogs was completely abolished by radiofrequency pulmonary artery denervation at the main bifurcation area of the left pulmonary artery (4). Also,the effect of radiofrequency pulmonary artery denervation on functional capacity and hemodynamics showed significant reduction of mean pulmonary artery pressure (PAP) in 13 patients with IPAH not responding optimally to medical therapy(5).The aim of research proposal is to assess and compare the safety and efficacy of radiofrequency and cryodenervation of pulmonary arteries on decrease in pulmonary vascular resistance in 20 patients with IPAH (mean pulmonary artery pressure >25 mmHg) and in 20 patients with secondary pulmonary hypertension due to pulmonary disease or due to left heart disease not responding optimally to medical therapy.Already well established and aproved radifrequency and cryo ablation technology modified for pulmonary artery denervation will be utilized in proposed clinical trial of new indication. All procedures will be performed in the Clinical Hospital Center Catheterization laboratory. Proposed duration of the trial is 4 years. Expected scientific contribution of this clinical trial might provide invaluable impact on improvement of quality of life and possibly on a deacrease in mortality of patients with pulmonary hypertension. Positive results of proposed study might generate several scientific publications, doctoral theses and above all would strengthen the international scientist collaboration and reputation of Medical Faculty of University of Zagreb.
1447Otkrivanje novih genetskih lokusa uključenih u regulaciju funkcije štitne i doštitne žlijezdeIdentification of new genetic loci implicated in regulation of thyroid and parathyroid function118Tatijana Zemunik IP2013-11IP-2013-11-1498THYPARATHYFUNCTION15.09.2014 - 31.12.2018Završio850.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine137, 588, 611, 262, 3571, 4137, 17479, 19036, 23035, Maja Barbalić, Dubravka Brdar, Vesela Torlak, Bernarda Lozić, Ante Punda, Caroline Hayward, Antonela Boljat, Ivana Gunjača, Marijana Popović, thyroid function, parathyroid function, genetic variants, polymorphisms, genome-wide study, gene-environmental interaction, complex phenotypesThyroid diseases affect up to 10% of the general population creating an important public health problem. Parathyroid diseases are less frequent but not insignificant. Thyroid hormones act on every tissue regulating cellular development, differentiation and metabolism. Parathyroid hormones control the amount of calcium in the blood. The expression of thyroid and parathyroid hormones/antibodies is under polygenic control and influenced by environmental factors. The aim of this study is to identify genetic loci that are associated with levels of thyroid/parathyroid hormones and antibodies that will advance our understanding of the genetic basis of their function and thus provide additional knowledge relevant to clinical outcomes. We will perform genome-wide association analysis of thyroid and parathyroid hormones/antibodies on 1,000 individuals from Split region (participants from the 10,001 Dalmatians project). The thyroid and parathyroid hormones/antibodies that are planned to be analysed are: free triiodothyronine, free thyroxine, thyroid-stimulating hormone, thyroglobulin, thyroid microsomal antibody titer, thyroglobulin antibody titer and parathiroid hormone. In addition, detailed anamnestic data and phenotype measurements already taken from study participants will be used in realization of second and third project objectives: investigation of relevant gene-environment interactions and determination of phenotype-phenotype correlation. We plan to follow-up interesting findings in additional 2,000 individuals and in datasets sought through international collaboration.Outcomes of such comprehensive approach will be generation of a new knowledge of genetic background, gene-environment interaction and phenotype-phenotype correlation associated with thyroid and parathyroid function that will lead to better understanding of biological pathways and clinically relevant disorders related to their function. The obtained results will promote excellence of Croatian research.
1451Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjekaNew protein networks for novel therapeutic avenues in human melanoma649Neda Slade IP2013-11IP-2013-11-1615ProNetMel01.09.2014 - 31.01.2019Završio908.350,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb1107, 3089, 54, 942, 3095, 3401, 1322, 712, 1033, 2896, 2812, 1140, 1470, 17835, 15915, Maja Herak Bosnar, Sonja Levanat, Oliver Vugrek, Vesna Musani, Martina Deželjin, Mladen Jokić, Anđela Horvat, Petar Ozretić, Diana Car, Robert Belužić, Božena Šarčević, Arijana Zorić, Ivan Milas, Nikolina Hanžić, Vjekoslav Tomaić, melanoma, protein interactions, p53, p73, nm23, GliMetastatic melanoma represents a major clinical problem due to rising incidence and resistance to available therapies. Therefore, there is a necessity for developing novel molecular approaches to treat this disease. Unlike other tumors, in melanoma p53 is relatively rarely mutated. However, overexpressed p53 fails to function as a tumor suppressor and tumor cells continue to proliferate and spread. This suggests that regulation of p53 activity depends on the interplay between p53 and its binding partners. Based on current state of knowledge, we hypothesize that p53 function in malignant melanoma might be altered through the interactions with p53 small molecular weight and p73 isoforms, nm23/NDPK and Gli families of proteins. Thus we will search for p53 protein binding partners in melanoma. The interactions identified by mass spectrometry will be further confirmed using microarray-based approaches and co-immunoprecipitation techniques. Furthermore, the expression profile of genes/proteins of interest in panel of melanoma cell lines and melanoma tissue samples will be investigated. The potential impact of the identified p53 interacting partners on its transcriptional activity and the stimulation of apoptosis will be determined. The depletion of partners using siRNA technology would confirm the involvement of selected proteins on p53 activity. The subcellular localization of the proteins in complex will be revealed by advanced fluorescent microscopy methods on state-of-the-art instrumentation what would give us the insight on dynamics of their interactions. The proposed research could provide a possible explanation why p53 function in melanoma is abrogated. The aim of this project is to determine the complexity of p53 interactions and their role in the onset and progression of human melanoma and offer new, innovative solutions in diagnosis, prognosis and therapy.
1456Automorfne forme, reprezentacije i primjeneAutomorphic forms, representations, and applications820Goran Muić IP2013-11IP-2013-11-9364Automorphic forms01.07.2014 - 30.06.2018Završio378.000,00 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science863, 831, 850, 890, 1154, 1000, 1079, 901, 17779, Darija Brajković, Iva Kodrnja, Ivan Matić, Neven Grbac, Marko Tadić, Igor Ciganović, Marcela Hanzer, Nevena Jurčević Peček, Sonja Žunar, automorphic forms, representations, Eisenstein series, cuspidal forms, theta correspondenceRecent and major breakthrough in the Langlands programme is a proof of existence endoscopic transfer of representations both local and global automorphic from split classical groups to GL(n) proved mainly by Arthur. Our research proposal fits very well with this recent development. First of all, the work of Arthur has its local application in the classification of representations of discrete series that was done by Moeglin and Tadić. Based on those results we plan to pursue the following investigations in the representation theory of p-adic groups. We would like to compute the Jacquet modules of discrete series representations completely.This will help us understand representations parabolically induced from those discrete series (generalized principal series) completely. This will have consequence on the problems of determination of complementary series for classical groups a problem related to the classification of unitary representations. Results of Gan, Savin and Ichino will help us extend some of those results to metaplectic groups. This will have important consequence on the determination of theta correspondence for dual pairs consisting of odd orthogonal and metaplectic groups such as explicit determination of all theta lifts. In the theory of automorphic forms, we would like to understand the construction of Arthur and Moeglin more explicitly. This will construct new series of square integrable representations; some special cases were obtained earlier by Muić, and Muić and Hanzer.This will give locally many interesting unitary representations which are more complicated than that has appeared in earlier works of Speh, Rogawski, Tadić, Muić, Savin, and Hanzer. We will apply those methods to study cohomology and poles of automorphic L-functions.
1458Razvoj voltametrijskih metoda za karakterizaciju prirodnih antioksidansaDevelopment of voltammetric methods for the characterisation of natural antioxidants442Šebojka Komorsky-Lovrić IP2013-11IP-2013-11-2072DVMCNA01.07.2014 - 30.06.2017Završio110.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb1099, 595, 438, 17762, Ivana Novak Jovanović, Dijana Jadreško, Milivoj Lovrić, Lara Čižmek, voltammetry, antioksidans, radicals, squave wave, simulationsOxidant is an ion or a compound that reacts with a certain component of a living cell and oxidizes it. The reactive oxygen species produced in cells include hydrogen peroxide, hypochlorous acid, hydroxyl radical and superoxide anion. Antioxidant is a foreign substance that reacts with the oxidant faster than the components of the cell. An imbalance between oxidants and antioxidants in favour of the oxidants is termed oxidative stress. Antioxidants act as free radical scavengers and therefore can lower the risk of numerous degenerative diseases by preventing damages caused by free radicals. Fruits and vegetables are the major sources of antioxidants in human diet. Several natural compounds found in food, such as polyphenols, vitamins A and E, and some carotenoids, have been found to show excellent antioxidant activity. Chlorophylls and their derivatives have also been reported to possess this activity. However, literature is still scarce regarding their antioxidant properties. It is known that the amount of each antioxidant in fruits, vegetables and their derivatives is strongly influenced by numerous factors such as agro-technical processes, environmental conditions, processing factors and storage conditions. Continuous monitoring of antioxidant capacity of plant-based foods through different phases, from cultivation to storage, is needed to maintain or even improve the beneficial properties of food. The goal of this project is to develop several cyclic multi-pulse voltammetric techniques for the characterization of natural antioxidants and to apply them in routine analysis of food quality. Experimental results will be explained by the comparison with the theoretical simulation of responses of various electrode mechanisms of independent and conjugated multiple redox centers.
1459Istraživanje utjecaja na okoliš primjene nanomaterijala u pročišćavanju vodaEnvironmental Implications of the Application of Nanomaterials in Water Purification Technologies984Hrvoje Kušić UIP2013-11UIP-2013-11-7900NanoWaP20.07.2014 - 19.07.2017Završio948.964,50 KnTehničke znanosti, Prirodne znanosti, Technological sciences, Natural sciences, Kemijsko inženjerstvo, Chemical engineering, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology1122, 1123, 3191, 3845, 3168, 17765, Ana Lončarić Božić, Daria Juretić, Dionysios Dionysiou, Urska Lavrencic Stangar, Panaghiotis Karamanis, Marin Kovačić, Water treatment, Advanced oxidation technologies, Photocatalysis, Pharmaceuticals degradation, Nanocomposites, ToxicityThe water resources globally are facing tremendous pressures due to increased consumption and pollution caused by growing population and industrialization. Thus, the development of advanced treatment technologies is highly required. Technologies using nanomaterials are one of the fast-growing fields creating variety of new commercial nanoparticles. One of the innovative applications of nanomaterials with a great potential involve their usage as water treatment tools. The photocatalytic treatment using nano-TiO2 as a destructive and “zero” waste method for water purification provides a synergy of advanced oxidation technologies and nanomaterials application with a great potential to be commercialized. However, some features of TiO2 photocatalysis, its mechanical and chemical stability, have to be improved to minimize the potential negative implications.The main goal of NanoWaP project is to develop the sustainable photo-AOT with nanocomposite photocatalysts for the purification of water containing pharmaceuticals. In order to overcome the limitations of nano-TiO2 technologies: agglomeration tendency, post-separation, low activation potential under the sunlight, novel nano-TiO2-based composites with iron-exchanged zeolites and SnS2 will be investigated for degradation of pharmaceuticals in water. The efficiency will be evaluated using an innovative integral approach including: (i) pharmaceuticals removal expressed in a terms of common ecological parameters, (ii) energy consumption per decreased concentration of chosen ecological parameter for one order of magnitude, and (iii) the assessment of adverse environmental effects. Besides, the photocatalysts characterization prior and after the treatment would provide an additional insight in its stability which will be also examined through consecutive runs.
1465Lokalna proba i mezoskopska dinamika u novim fazama jako koreliranih elektronskih sustavaLocal Probe and Mesoscopic Dynamics of New Phases in Strongly Correlated Electron Systems50Miroslav Požek IP2013-11IP-2013-11-2729LOMEDY01.09.2014 - 31.08.2018Završio945.031,82 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science3145, 3099, 3159, 3165, 3109, 3116, 17735, 23833, Antonije Dulčić, Dalibor Paar, Mihael Srđan Grbić, Marko Bosiočić, Damjan Pelc, Tonči Cvitanić, Marija Došlić, Ana Najev, nuclear magnetic resonance, microwaves, cuprates, pnictides, frustrated spin systems, charge orderInvestigations of strongly correlated electron systems (SCES) attract an ever-growing scientific community, not only because of high potential for new technological applications, but also as a virtually unfailing source of new basic phenomena and theoretical concepts. The properties of such systems can be described only by taking into account collective phenomena governed by strong and competing interactions, often leading to frustrations. The subtle interplay of interactions is, in turn, a key ingredient for extraordinary complex phase diagrams exhibited by SCES. Even more interesting are regions of instabilities away from stable phases.The way a new phase emerges close to a phase boundary reveals hidden properties of the studied system. It is extremely important to understand how symmetry breaks in the transition itself and identify the space and time-scales relevant for the changes of order parameter within the transition. Sometimes an intermediate state emerges between two stable phases, bringing new physics to light. This project aims to study some of these new, mostly unexplored states that emerge between well explored stable phases in SCES, or as a consequence of some kind of frustration. In order to obtain a complete picture of new states of matter we will combine several advanced experimental methods: nuclear magnetic and quadrupolar resonance (NMR and NQR) as an atomic-scale, local probe, and nonlinear conductivity as a mesoscopic probe of electronic physics. We will be able to systematically study the many phases and transitions in SCES, provide answers to some currently burning questions, and significantly advance our knowledge about them. In particular, we will study charge order in novel superconductors, and spin liquid and spin nematic states in frustrated quantum spin systems.The project will fully employ the new broadband NMR laboratory in Zagreb, strengthen its visibility and international collaborations, and enable finishing of three PhD theses.
1473Defolijatori kao invazivni šumski štetnici u uvjetima klimatskih promjena Defoliators as invasive forest pests in changing climate conditions3209Milan Pernek IP2013-11IP-2013-11-7616DIFPEST16.06.2014 - 15.06.2017Završio394.000,00 KnBiotehničke znanosti, Prirodne znanosti, Biotechnical sciences, Natural sciences, Šumarstvo, Forestry, Hrvatski šumarski institutCroatian Forest Research Institute868, 2968, 4683, 6691, 6721, 6774, 6993, 17805, Dinka Matošević, Nikola Lacković, Andreas Linde, Christa Schafellner, Leellen Solter, George Melika, Christian STAUFFER, Ivan Lukić, invasive forest pests, climate change, biodiversity, insect pathology, Lymantria dispar, Abraxas pantaria,Cydalima perspectalisClimate change, particularly extreme weather events, can directly affect forest pests and the damage they cause by influencing the pests’ development, survival, reproduction and spread and by altering host defences and susceptibility. Basic knowledge of the identity, origin, pathway, and time of introduction of invasive species is essential for assessing the threats. Warming is expected to force species to shift their distributions by expanding into new climatic areas. Several projects have shown that genotypes have increasingly migrated to the north in the last decade, mainly caused by climate change. Records of changes as a result of pest-host-climate change interaction, including possible reasons for changes, are a crucial point of forest monitoring which forms the basis for control strategies and forest management decisions. We will build case studies to represent a specific pest-host-climate change interaction model: native and potentially invasive: i) from one isolated population to other population, (Gypsy Moth); ii) from one climate/geographic region to another (Abraxas pantaria) and non-native potentially invasive in a new climate/geographic region (Cydalima perspectalis). The study presents an extensive research on targeted insect pests in Croatia, taking into account the biology of the pest and host plants and all aspects of the bioecology of the species like genetic constitution and origin, thermal requirements, possible host plants, palatability, influence of antagonists etc.) that influence its spread in a novel environment influenced by climate change and possible serious damage. All the gained data could be used for predictive pest risk analysis models for the researched species, as well as for other native and non-native invasive species that could become a serious threat to Croatian forest ecosystems in changed climate conditions in the near future.
1478GENOMIKA I MOLEKULARNA EPIDEMIOLOGIJA HUMANIH PARAMIKSOVIRUSA U HRVATSKOJGENOMICS AND MOLECULAR EPIDEMIOLOGY OF HUMAN PARAMYXOVIRUSES IN CROATIA936DUBRAVKO FORČIĆ IP2013-11IP-2013-11-6255ParamyxoCro01.09.2014 - 31.08.2018Završio957.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u ZagrebuUniversity of Zagreb2510, 3085, 2521, 4279, 4779, 2562, 3357, 3005, 3622, 17817, 23373, Maja Šantak, Jelena Ivančić Jelečki, Tanja Košutić Gulija, Krešo Bendelja, Goran Tešović, Sunčanica Ljubin-Sternak, Maja Markušić, Ana Savić Mlakar, Mladen Jergović, Anamarija Slović, Nataša Bauk, Paramyxoviruses, molecular evolution, genomics, virus genotype, molecular epidemiologyThe family Paramyxoviridae harbors a broad spectrum of serious virus pathogens that are of importance to human health and global economics. Paramyxoviruses are RNA viruses with a single-stranded negative sense genome. They have been isolated from a wide variety of species, demonstrating a vast host range and great viral genetic diversity. These ubiquitous pathogens are among the most common causatives of respiratory tract infections and are responsible for a high degree of morbidity and mortality worldwide. The biology of RNA viruses is influenced by their high potential of continuous evolution. Because of the error-prone nature of their RNA-dependent RNA polymerases and large population sizes, RNA viruses show high levels of genetic diversity. Mutations can significantly influence virus biological properties and lead to appearance of new strains. The knowledge of viral evolution depends on the amount of genomic data available for analysis.We propose the research of viral genomics of wild type paramyxoviruses currently circulating in Croatia. It is our goal to increase the number of genetically well characterized paramyxoviral wild-type strains. The proposed work will add to knowledge about paramyxoviral ecology, variability and evolutionary capacities. As molecular epidemiologic monitoring of circulating wild type viruses enables analysis of current relations between existing viral genotypes, it is an invaluable part of virus surveillance and control, facilitating the detection of endemic areas, estimations of vaccine efficacies and predications of possible outbreaks.
1479Nano-mreže kvantnih točaka u staklima: Od samouređenja do pretvorbe energije i pohrane vodikaNano-networks of Quantum Dots in Glasses: From Self-assembly to Energy Conversion and Hydrogen Storage1362Maja Buljan UIP2013-11UIP-2013-11-2334NanoDeSign01.06.2014 - 31.05.2017Završio733.483,50 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb2755, 3498, 3526, 3509, 3556, 19015, 17815, 21151, Ivančica Bogdanović Radović, Marko Karlušić, Tihomir Car, Marko Jerčinović, Nikola Radić, Davor Galonja, Nikolina Nekić, Stefano (Antonio) Mezzasalma, Quantum dots, Self-assembly, Magnetron sputtering, Quantum dot crystal, Hydrogen storage, Energy conversion, Solar cell, Ion-beam irradiationThe main goal of the project is to investigate the capabilities of the recently developed materials based on self-assembled quantum dots organized as nano-networks in glass matrices for application in energy-conversion and Hydrogen-storage devices. Two new self-assembly processes of Ge quantum dots in dielectric amorphous matrices and consequently novel material types have been discovered recently by our group. We have performed intensive investigation of their structural properties since then, and we had found that they appear in many different shapes, internal structures and ordering types. One material can store large amounts of Hydrogen. However, only properties of Ge and SiGe quantum dots have been investigated, while all other materials and their properties are completely unknown. These materials are theoretically very suitable for applications, especially in photo-electric conversion and energy storage, so the investigations of their properties related to the applications are also very important.We intend to form a group which will be excellent in production, characterization and application of these materials. Precisely, we intend to (i) further investigate the observed self-assembly processes and develop new material types with interesting or extraordinary structural properties; (ii) determine the basic optical and electrical properties of these materials and (iii) produce simple devices based on these materials for energy conversion and storage.We expect preparation of new, applicative materials with exceptional properties, observation of unusual effects caused by specific structure, and preparation of efficient thin-film coatings for conversion and storage of Sun energy. These results could be of great relevance for the production of super-efficient energy-converting window glasses, as the method that we use for the preparation (magnetron sputtering deposition), is a standard technique for production of window coatings and low-emissivity glasses.
1483Postupci strojnog učenja za dubinsku analizu složenih struktura podatakaMachine learning algorithms for insightful analysis of complex data structures4140Strahil Ristov IP2013-11IP-2013-11-9623DescriptiveInduction16.08.2014 - 15.08.2017Završio342.000,00 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb3806, 3548, 3945, 3822, 4140, 4312, 4568, 4718, 17767, 1483, Tomislav Šmuc, Ivan Michieli, Peter Škoda, Branka Medved Rogina, Strahil Ristov, Nino Antulov-Fantulin, Matija Piškorec, Damir Korenčić, Maria Brbic, Dragan Gamberger, machine learning, knowledge discovery, structured data, rule learning, FPGA Induction is a process of knowledge extraction from information contained in data. In our work we will concentrate on descriptive induction whose goal is to construct knowledge that enables human understanding of the data. Included are techniques for construction of user-interpretable models, segmentation of the corpus of examples, and detection of outliers. The methodology is relevant for the computer science fields known as intelligent data analysis, knowledge discovery from data, and data mining. At Rudjer Boskovic Institute we are developing machine learning algorithms for more than 15 years and we have successfully applied them in various domains including chemistry, biology, medicine, social sciences, economics, and manufacturing. With this project we want to extend the existing methodology and to implement novel techniques able to cope with data contained in complex structures. The main topic will be spatio-temporal structures but we will work also with networks of data, relational databases, and data contained in ontologies. Previous experience clearly demonstrates that complete transformation of information contained in structured data into a form that may enter the induction process is not a simple task. Our goal is to develop and implement systematic and general approaches for this conversion. The consequence will be explosion of generated data that must enter into the process of induction. Therefore, the second goal will be implementation of efficient algorithms for descriptive induction. The work includes development of novel algorithms for clustering and outlier detection in sets of unclassified examples and implementation of hardware for fast execution of rule learning algorithms. The third goal is application and evaluation of implemented algorithms in various real-life domains. The success of the complete project will be measured by the quality and usefulness of knowledge obtained in these applications.
1484Bioinspirirani materijali - mehanizmi nastajanja i interakcijaBioinspired Materials - Formation Mechanisms and Interactions922Damir Kralj IP2013-11IP-2013-11-5055Bio-Mat-Form01.10.2014 - 31.01.2019Završio893.500,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb224, 339, 340, 336, 3922, 3932, 220, 425, 406, 297, 4209, 404, 17878, Maja Dutour Sikirić, Darija Jurašin, Vlasta Tomašić, Tea Mihelj, Andreja Gajović, Milivoj Plodinec, Jasminka Kontrec, Branka Njegić Džakula, Marko Ukrainczyk, Iva Buljan, Nadica Maltar Strmečki, Vida Čadež, Lara Štajner, Biomineralization, Calcium Phosphates, Calcium Carbonates, Precipitation, Model organic moleculesProsperity of modern society at large extent relies on the design of new and advanced materials. Many classes of organic, inorganic or hybrid materials are produced by process of precipitation (crystallization) in which the size, morphology, chemical and structural composition could be tuned by the strict control of formation conditions. Process by which living organisms produce hard tissues is known as biomineralization and such tissues are, actually, the organic-inorganic composites. In comparison to their geological analogues, biominerals have the superior mechanical and chemical properties that are a consequence of just a minor presence of extracellular matrix proteins or polysaccharides, as well as of the specific confined environment in which the process occur. In addition, such materials are produced from aqueous systems, chemically neutral precursors, at low temperature and pressure, thus inspiring the scientists investigating the biomimetic syntheses routes for design of functional materials for advanced application.In order to contribute to the understanding of basic interactions between the mineral phases and complex macromolecules, underlying biomineralization, we propose the investigations in which the representative inorganic salts (calcium carbonates & phosphates) will be precipitated in a presence of simple and representative organic molecules (acidic and hydrogen bonding amino acids and custom-designed small peptides) while the complexity of systems will be systematic increased by confining the precipitation in polysaccharide hydrogel or synthetic vesicular microenvironment. Particular attention will be paid on a role of the amorphous and other precursor phases on formation of stable modifications relevant for biomineralization. Besides the precipitation kinetic analyses, the advanced characterization techniques (HR-TEM, EPR, confocal microscopy) will be applied in order to reveal the mechanisms of organic molecules – mineral surface interactions.
1487Procjena ponašanja konstrukcija u graničnim uvjetima radaAssessment of structural behaviour in limit state operating conditions3256Josip Brnić IP2013-11IP-2013-11-6876STRUBECON21.07.2014 - 20.07.2018Završio969.900,00 KnTehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Rijeci, Tehnički fakultetUniversity of Rijeka, Faculty of Engineering3309, 3419, 3329, 3323, 3325, 3328, 3332, 3330, 3318, 17760, Goran Turkalj, Marko Čanađija, Domagoj Lanc, Marino Brčić, Goran Vukelić, Igor Pešić, Sanjin Kršćanski, Neven Munjas, Edin Merdanović, Damjan Banić, structures, material properties, experimental investigations, numerical investigations, limit state, assessment of structural behaviourStructures are designed according to their purpose taking into account all relevant service life requirements, which are usually related to a factor of safety, material properties, service life conditions and of course service life prediction. Structure may be sometimes exposed to unexpected conditions, let say adverse or hazard conditions. These conditions may cause failures making structure incapable to perform the function for which it has been designed. The task is to make an assessment of the structure behaviour at mentioned conditions and decide if the structure is capable for further operation. This means the assessment should provide an answer if the structure has sustained irreparable damage. Therefore, the main objective is to provide an assessment of structure behaviour, by comparing of the parameters like stress, strain, crack occurring, etc., caused by certain load level and temperature at this unexpected limit state with those allowed by material properties. To assess structural behaviour in operation at limit state, the following research sub-objectives should be accomplished: testing of material properties for the different environmental conditions; definition of impact energy as well as the determination of the crack driving force and life assessment of structural elements; evaluation of the semi-rigid structural joints/connections behaviour; development of a numerical algorithm for optimization of semi-rigid framed structures; creep buckling simulations of composite beam-type structures; proper constitutive modelling at limit operating conditions (i.e. plasticity, damage, thermomechanical coupling); application of new materials to be used at limit state – nanocomposites. Targeted structures are single and multi storey steel buildings, rigs, high-power electrical transmission towers, ship structures, etc.
1493Višeskalno numeričko modeliranje deformiranja materijala od makro do nanorazineMultiscale Numerical Modeling of Material Deformation Responses from Macro- to Nanolevel927Jurica Sorić IP2013-11IP-2013-11-2516MNumMacroNano15.07.2014 - 14.07.2018Završio959.719,20 KnTehničke znanosti, Biotehničke znanosti, Prirodne znanosti, Technological sciences, Biotechnical sciences, Natural sciences, Temeljne tehničke znanosti, Basic engineering sciences, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture1010, 263, 1039, 1028, 2803, 3044, 1012, 3311, 285, 17578, 17579, 21241, 21256, 21254, Igor Karšaj, Tomislav Jarak, Ivica Skozrit, Boris Jalušić, Tomislav Lesičar, Eduard Marenić, Lana Virag, Zdenko Tonković, Robert Pezer, Filip Putar, Ivan Trapić, Karlo Seleš, Christian Weißenfels, Joško Frančeski, Engineering materials, bilogical tissues, multiscale modeling, finite element method, meshless method, damage modeling, molecular dynamicsMany engineering materials as well as biological tissues have a heterogeneous structure particularly when they are observed at microlevel. In order to assess structural integrity as well as to predict structural lifetime, an analysis at microlevel is required. In recent years, a special attention has been directed to the investigation of relations between macroscopic properties of materials and their microstructure as well as to perform a link to atomistic scale. Since classical continuum mechanics cannot consider structural effects in the material at the micro- and nanolevel, multiscale techniques are developed that model material deformation responses at multiple levels using appropriate numerical procedures. Deformation responses of arteries will be considered by using multiscale computational strategy too. A special attention will be directed toward the mathematical modeling of arterial growth and remodeling, which could help physicians to track certain cardiovascular diseases and predict their development. For modeling of engineering materials, a new micro-macro numerical procedure based on the second-order computational homogenization approach employing nonlocal continuum theory will be proposed. Both finite element and meshless spatial discretization will be applied. The damage evaluation at the microlevel which may lead to macroscopic fracture will be modeled. Here the damage evaluation law based on the computational averaging procedure will be used and the modeling at atomistic scale will be performed in the very narrow domain of localization. In the atomistic modeling using molecular dynamics, a special attention will be directed to the coupling of atomistic domain with the discretized continuum domain. An approach inspired by the quasicontinuum and bridging domain will be proposed. All results of the research will be tested by the modeling deformation responses of realistic materials.
1497Djelovanje progesterona u reproduktivnim i ne-reproduktivnim tkivimaProgesterone action in reproductive and non-reproductive tissues1286Biserka Mulac-Jeričević IP2013-11IP-2013-11-3432reproduction201301.09.2014 - 30.11.2018Završio996.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesJavno zdravstvo i zdravstvena zaštita, Public health and health services, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine3456, 3448, 3903, 3361, 3467, 5756, 4733, 5775, Sandra Šućurović, Zdravko Jotanović, Tamara Nikolić, Jagoda Ravlić-Gulan, Gordan Gulan, Jan Brosens, Neda Smiljan Severinski, Hrvoje Jakovac, Progesterone, progesterone receptors, uterus, bone, physiology, pathophysiology, animal model, humanProgesterone (P) is an indispensable regulator of female reproductive function, but also has an important role in non-reproductive tissues. Aberrant P signaling has been associated with reproductive conditions, cancer, metabolic disorders, cardiovascular defects, and neurological defects. In humans and mice the physiological effects of P are mediated by two intracellular receptors, termed PR-A and PR-B, expressed in subset of cells in target tissues. PR-A and PR-B isoforms are transcribed from a single gene by alternative promoter usage. PR-A (94 kD) isoform differ from PR-B (120 kD) by lacking 164 amino acids at the N terminus . Analyses to date have shown that PR-A and PR-B mediate mostly distinct but partially overlapping reproductive tissue selective physiological responses to P. The overall objective of this research is to establish the selective physiological roles of each of the individual PR isoforms in their natural physiological context. For this research we will use a genetically modified mouse in which gene targeting was used to knockout expression of either the PR-A or PR-B isoform in mice. The specific aims of this application are as follows: 1. To examine the isoform-selective molecular mechanisms by which PR-A and PR-B differentially regulate uterine epithelial proliferation, uterine receptivity and stromal decidualization. 2. To examine the selective contributions of the PR-A and PR-B isoforms to the P dependent immunomodulatory activity during early pregnancy. 3. To identify progesterone-regulated genes in musculoskeletal tissue using a genetically altered mouse models lacking progesterone receptors. 4. To determine whether differential signaling pathways of PR isoforms are conserved from rodent to human. It is expected that this research will contribute to understanding the molecular mechanisms of P in reproductive tissues and musculoskeletal and could lead to new strategies for disease prevention and treatment.
1503Genetika i fiziologija tolerancije na višestruki stres kod kukuruzaGenetics and physiology of multiple stress tolerance in maize3305Domagoj Šimić IP2013-11IP-2013-11-5707MUST-MAIZE16.06.2014 - 15.06.2018Završio810.000,00 KnBiotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Poljoprivredni institut OsijekAgricultural Institute Osijek4241, 4812, 5221, 5133, 3283, 6391, 4899, 6193, 4907, 3281, 2824, 6447, 17788, Mario Franić, Antun Jambrović, Tatjana Ledenčan, Luka Andrić, Maja Mazur, Vera Cesar, Josip B rkić, Lidija Begović, Zvonimir Zdunić, Andrija Brkić, Jasenka Antunović, Ivan Brkić, Vlatko Galić, drought, diabrotica, plant density, cadmium excess, genomic selectionPlant responses to different stresses are highly complex and involve changes at the genetic and physiological levels. Maize as a major crop worldwide is essential for industry and is cultivated mostly in rain-fed cropping systems where changes in climate or diminishing water supply take place. Grain yield, the most important trait in maize as a composite trait is influenced by many stress-related traits. The main goal of this project is to elucidate and integrate common genetic and physiological mechanisms underlying the multiple-stress tolerance in maize. The specific aims are to detect genetic and physiological factors responsible for plant response to high plant density, drought, Diabrotica and Fusarium attacks as well as cadmium excess in soil in testcrosses of two maize populations (reference IBM population and a doubled haploid population) and their respective parents. By investigating root and leaf characteristics including chlorophyll fluorescence and other stress parameters as reliable indicators of stress in four-year field and pot experiments conducted in Croatia and Turkey, DNA marker-assisted selection and genomic selection could accelerate maize breeding for yield, abiotic and biotic stress tolerance. A multidisciplinary approach, which ties together breeding, physiology and molecular genetics, can bring a synergistic understanding to the response of maize to multiple stresses.
1513Povijesne perspektive transnacionalne prakse i međukulturnog dijaloga u Austro-Ugarskoj monarhijiHistorical Perspectives on Transnationalism and Intercultural Dialogue in the Austro-Hungarian Empire1018Anita Sujoldžić IP2013-11IP-2013-11-3914TIDA01.09.2014 - 31.08.2018Završio554.600,00 KnHumanističke znanosti, Društvene znanosti, Humanities, Social sciences, Etnologija i antropologija, Ethnology and anthropology, Institut za antropologijuInstitute for Antropological Research in Zagreb2965, 3447, 1284, 4784, 1524, 3749, 1300, 2753, 20152, 3395, Zrinjka Glovacki-Bernardi, Gottsmann Andreas, Olga Orlić, Stefan Wedrac, Mirna Jernej Pulić, Anja Ivekovic Martinis, Josip Lah, Marina Rončević, Duga Mavrinac, Krešimir Sučević-Međeral, multilingualism, transnational, intercultural, communication, hybridity, legacyThis interdisciplinary project aims to provide a new way of learning from the past about strategies used in the South-Eastern part of the Austro-Hungarian Empire to overcome social tensions as a potential legacy of intercultural dialogue in the present European context. It will explore how in the multilingual imperial space of intensive cultural exchange and economic mobility the interethnic and social tensions were shaped by (trans)-intercultural communication and practices, both from above and from below. It focuses on accounts of plural belongings and hybrid identities that are geographically grounded, socio-economically situated and embedded in cultural and linguistic practices manifested by multilingualism and intercultural competence of social scripts and behaviour.The project will cover spatially and regionally confined patterns of interaction in the Croatian part of Istria, and the cities of Pula and Zadar under direct Habsburg influence and in the cities of Rijeka and Zagreb, politically bound to the Hungarian part of the Empire during the period 1870-1918. The main strains of research will focus on uncovering discourses produced through three social spaces, those of institutions (administration and education), associations (cultural, sport), and those visible in everyday life, through consumption practices and tourism. The analyses will encompass social practices in different domains of life, symbolic system (focusing on language) and the use of artifacts, or material life. The specific objective is to provide a contrastive reading of Austro-German, Italian and Slavic sources illuminating both the established discourses of knowledge production, emanating from imperial centres of Vienna and Budapest, and the counter-discourses, and their reception by common people in the periphery.
1516Pravni status i stvarni položaj osoba s duševnim smentnjama - interdisciplinarni pristup i europske perspektiveLegal Status and Real Position of People with Mental Difficulties – Interdisciplinary Approach and European Perspectives597Velinka Grozdanić IP2013-11IP-2013-11-2287LSRPPMDIAEP01.03.2015 - 28.02.2018Završio146.092,23 KnDruštvene znanosti, Biomedicina i zdravstvo, Social sciences, Biomedicine and health sciences, Pravo, Law, Sveučilište u Rijeci, Pravni fakultetUniversity of Rijeka, Faculty of Law3337, 2985, 7306, 2901, 4639, 2875, 3315, 4403, 19033, Miroslav Goreta, Vesna Šendula Jengić, Zoran Kanduč, Kristijan Grđan, Marissabell Škorić, Dalida Rittossa, Igor Martinović, Sandra Debeljak, Dražen Tripalo, people with mental disorders, legal status, actual position, interdisciplinary perspective, European standards In last two years the European Court for Human Rights assessed three major cases involving rights of persons with mental disorders in the Republic of Croatia (Đorđević v. Croatia, M.S. v. Croatia and A.K. and L. v. Croatia). The Court concluded that current legal regulations and practice governing the prevention of violence against mentally disabled persons, their power to instigate criminal proceedings without explicit guardian's consent and divestment of parental rights have violated the Article 3 and 8 of the Convention of Human Rights and Fundamental Freedoms. Court decisions present a clear warning that rights of people with mental difficulties have not been adequately protected in Croatia and that there is a need for substantial reform of the laws regulating their legal status. Bearing this in mind, the Project is designed to critically analyse current legal regulations in the light of already accepted high international standards and to conduct empirical research at four county courts with the widest jurisdiction in order to evaluate whether the regulations are adequately applied in practice. Analytical and empirical results will be used as a valid basis to create a new Bill on Protection of Persons with Mental Difficulties as the main legal instrument to regulating the legal status of this especially vulnerable group. In order to facilitate application of the new Law in practice and to make a concrete impact on real position of people with mental health issues, the project will seek to organise seminars, round table discussions and workshops for mental health lawyers and psychiatrists. By its in-depth research approach in interdisciplinary settings, the ultimate Project goal is to improve and promote rights of people with mental disability and increase their empowerment, enabling them to enjoy full citizenship on an equal basis with other members of Croatian society.
1518Standardizacija i primjenjena istraživanja kvartarnih sedimenata HrvatskeSTANDARDISATION AND APPLYED INVESTIGATION OF QUATERNARY SEDIMENTS IN CROATIA3320Lidija Galović UIP2013-11UIP-2013-11-4425SAPIQ01.09.2014 - 31.12.2017Završio978.062,04 KnPrirodne znanostiNatural sciencesGeologija, Geology, Hrvatski geološki institutCroatian Geological Survey3963, 4030, 4262, 3950, 3511, 3956, 165, 4536, 7107, 20279, 20272, 20205, Lara Wacha, Adriano Banak, Anita Grizelj, Hrvoje Posilović, Koraljka Bakrač, Danijel Ivanišević, Jadranka Mauch Lenardić, Manfred Frechen, Petar Stejic, Rodoljub Gajić, Mihajlo Pandurov, MARSCHE INGEBORG Soulie-Marsche , Quaternary, litostratigraphical unites, Croatia, spatial distribution, climate proxiesQuaternary sediments in Croatia cover about 40% of the surface and have hence an important role in the economy of the country. Achieved models and tools for investigation enable wider application of results in economy. Furthermore, Quaternary deposits are direct results of ancient climatic conditions and hence understanding them can help interpreting and predicting actual events. The goal of this Installation Research Project is to establish a group of researchers in the Croatian Geological Survey (CGS), Department of Geology, to additionally equip and train them, so they could standardise and carry out their research of Quaternary sediments of Croatia applying new analytical techniques and new scientific findings. Those new compositional data will enable correlating our results with the EU, especially for the middle and south Europe. In this project we would like to deal with Quaternary sediments on the both regions: Pannonian and Dinaric. During the first year we plan to get know new equipment, methodology and to investigate all the different types of Quaternary sediments in Croatia. In the second and third year plan is to scrutinize the sediments in selected area in the each region (Pannonian and Dinaric).The strategic importance of Quaternary sediments for Croatia is based partly on the agricultural utilization of the Holocene soils developed on these deposits and partly as a collector of drinking water, reflecting to the whole biosphere. Furthermore, the hydrogeological properties of separate horizons of Quaternary sediments are different, so, insight in the structures of sediment layers could lead to finding new water resources.
1526Razvoj višenamjenskog sustava upravljanja zemljištemDevelopment of Multipurpose Land Administration System426Miodrag Roić IP2013-11IP-2013-11-7714DEMLAS01.09.2014 - 31.08.2018Završio922.750,00 KnTehničke znanostiTechnological sciencesGeodezija, Geodesy, Sveučilište u Zagrebu, Geodetski fakultetUniversity of Zagreb, Faculty of Geodesy5698, 6561, 6133, 3172, 3563, 3628, 3704, 3304, 3205, 837, 3180, 3060, 4353, 3245, 3065, 3889, 4200, 4197, 3758, 3356, 3629, 3725, 4349, 4189, 5610, 6782, 21294, 21295, Siniša Mastelić Ivić, Zdravko Kapović, Mira Ivković, Vlado Cetl, Rinaldo Paar, Dražen Tutić, Hrvoje Matijević, Ante Marendić, Loris Redovniković, Hrvoje Tomić, Mario Mađer, Baldo Stančić, Iva Ališić, Goran Jurakić, Saša Vranić, Boris Blagonić, Irena Benasić, Veljko Flego, Blaženka Mičević, Nikola Vučić, Darko Šiško, Jelena Jurišić, Tiana Pribanić, Marijan Ratkajec, Frančesko Duboković, Miroslav Kuburić, Dragan Divjak, Igor Grgac, Land Administration System, Land Registers, Land Management, Sustainable Development, GeoinformationThe primary purpose of a land administration system (LAS) is the registration of legal or other formal relations of persons to land. Besides its primary purpose, land administration system can and should also serve as a basis for land management. Different to the land administration, land management is a set of processes ensuring that the land is used in an efficient and sustainable manner. Unfortunately, land administration systems are rarely able to fulfill such additional requirements, even in the developed countries.This project aims at finding what needs to be done in order to transform a traditional land administration system into a modern multipurpose land administration system (MLAS), which can efficiently support land management. Our hypothesis says that such a transformation can be done by improving two aspects of a LAS, its efficiency and its usability.Under efficiency we consider the ability of a LAS to update its data quickly whilst ensuring the consistency and correctness thereof. Within the project we will investigate options for outsourcing the preparation of transactions to private sector and the possibilities to more efficiently collect field data within the improved process of updating LAS data.Even more important that its efficiency, is the usability of a LAS. This is the second aspect that we try to improve within the project. Besides the mere registration of the land, MLAS must be able to efficiently support processes of land valuation, urban planning and various rearrangements aiming to increase agricultural productivity of the land. Within the project we will investigate which additional data needs to be collected, processed and stored within the LAS in order to enable efficient support to land management processes.As a starting point for the research we use our previous research closely related to the topics of land administration and land management, and the Land Administration Domain Model (LADM), which recently became the ISO standard.
1528Repozitorij metafora hrvatskoga jezikaCroatian Metaphor Repository3388Kristina Štrkalj Despot UIP2013-11UIP-2013-11-3624Meta4Cro01.09.2014 - 31.08.2017Završio560.000,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Institut za hrvatski jezik i jezikoslovljeInstitute of Croatian Language and Linguistics4388, 4516, 2897, 2966, 4665, 5556, Benedikt Perak, Mirjana Tonković, Ana Ostroški Anić, Bruno Nahod, Mario Essert, Mario Brdar, conceptual metaphor, image schemas, frames, metonymy, metaphor in natural language processing and artificial intelligenceThe Croatian Metaphor Repository project will involve: theoretical research of conceptual metaphor, metonymy, image schemas and frames in the Croatian language from a synchronic and diachronic perspective; computational linguistic research on metaphor in natural language processing and artificial intelligence involving developing tools for semi-automatic metaphor detection and semi-automatic extraction of linguistic metaphors; psychological experiments to further explain the nature of the links between concept meaning and perception as manifested through primary metaphors. The applied goal of the project is to create a metaphorical language database ? the Croatian Metaphor Repository. The database will be available on the Internet. It will include the following levels: conceptual metaphors, linguistic metaphors, image schemas, cogs and frames. Metaphors will be divided by type (primary, complex and entailed metaphors), by level (general, specific), and by family (Event Structure Metaphors, Mind Metaphors, Morality Metaphors, Scalar Metaphors, Time Metaphors, Emotion Metaphors, Economics Metaphors, Governance Metaphors, Cascade Metaphors, Well-being Metaphors etc.). The theoretical background for the linguistic analysis of conceptual metaphors is the Neural Theory of Language and Thought and the Neural Theory of Metaphor. Formal annotation tools are taken from embodied construction grammar. Both theoretical research and the creation of the repository will significantly advance Croatian cognitive and computational linguistics, artificial intelligence studies and the research of language and learning processes. The database will allow for generalizations and will become a very useful tool for cross-linguistic and cross-cultural research of metaphor and thought leading to further development of the theory and the field and to understanding how people learn, understand, and use language. The project has significant potential for further international development.
1531Kodovi i s njima povezane kombinatoričke struktureCodes and Related Combinatorial Structures885Dean Crnković IP2013-11IP-2013-11-1637CoCoS01.07.2014 - 30.06.2018Završio866.256,82 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Rijeci, Odjel za matematikuUniversity of Rijeka, Department of Mathematics919, 907, 5381, 5935, 4515, 4484, 4992, 841, 1089, 3161, 3906, 3468, 3226, 5384, 17780, 20561, Sanja Rukavina, Vedrana Mikulić Crnković, Mario Osvin Pavčević, Vedran Krčadinac, Andrea Švob, Anamari Nakić, Kristijan Tabak, Loredana Simčić, Doris Dumičić, Marija Maksimović, Ana Grbac, Nina Mostarac, Marina Šimac, Sanja Vranić, Renata Vlahović, Ronan Egan, code, network coding, t-design, q-ary design, graph, strongly regular graph, finite groupThe project will deal with construction of codes and combinatorial structures, such as combinatorial designs, designs over finite fields (q-ary designs), difference sets and various types of graphs, for example strongly regular graphs and divisible design graphs. Beside linear codes over finite fields and finite rings, we will also investigate quantum codes and network codes. In fact, the links and connections between codes and combinatorial structures are the main focus and emphasis of the proposed project. For constructions of the combinatorial structures and codes we will mainly use algebraic, geometric and enumerative techniques, as well as computational methods. When dealing with combinatorial structures, these include in particular constructions from finite groups and constructions using orbit matrices. The very general Kramer-Mesner method will be implemented and combined with other methods like that of tactical decompositions. Codes will be constructed directly from the obtained combinatorial structures, and vice versa. Our research in scope of this project will also include constructions of Hadamard matrices and related designs and codes. All gotten structures will be analyzed in terms of their automorphism groups and other structural (geometric, algebraic) properties. Obtained codes, designs and graphs will be compared with the previously known structures. As a result of the proposed research, we expect constructions of codes with good properties, possibly better than the presently known codes, and constructions and classifications of various combinatorial structures.
1535Upravljanje vodom i toplinom i trajnost membranskih gorivnih članakaWater and Heat Management and Durability of PEM Fuel Cells1118Frano Barbir IP2013-11IP-2013-11-8700PEMFUELCELL01.01.2015 - 30.06.2018Završio801.880,00 KnTehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnjeUniversity of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture3668, 4330, 3698, 4347, 4058, 97, 4479, 17740, 18920, Ivan Tolj, Dario Bezmalinović, Gojmir Radica, Gojko Magazinović, Jagoda Radošević, Ante Bilušić, Paško Županović, Ivan Pivac, Željko Penga, PEM fuel cell, temperature control, humidity of reactant gases, durability stressors, decay mechanismsThe subject of the proposed research and development are the fuel cells – devices for direct electrochemical conversion of fuel (usually hydrogen) into electricity, with many potential applications, from propulsion of vehicles to mobile and stationary power generation at different scales (from mW to MW). This project will investigate a possibility to design and operate a Polymer Electrolyte Membrane (PEM) fuel cell with ambient air without external humidification using water and heat produced inside the fuel cell. This may be accomplished with adequate temperature distribution along the cathode channel, which would require a specific design of the fuel cell in terms of spatially variable heat transfer rates, and corresponding control of the cooling subsystem. In order to determine whether the proposed concept would result in longer life of fuel cell, some basic understanding of causes of fuel cell degradation is needed, particularly related to water and heat management. Particularly, it is proposed to investigate heat transfer in nano-structured catalyst layer because inadequate heat removal from the electrochemical reaction sites may be one of the causes for fuel cell degradation. Other stressors will be studied as well, and procedures for accelerated durability testing will be established, in order to confirm that the proposed concept of water and heat management is beneficial to fuel cell durability.The proposed research is expected to improve understanding of water and heat transfer in PEM fuel cell, including the effects that dry conditions and inadequate heat removal from the catalyst sites may have on fuel cell durability. This novel concept of variable temperature along the cathode channel would result in simplification of the fuel cell support system by eliminating the devices needed for external humidification, without affecting fuel cell performance and durability in various applications.
1540Hrvatska i Srednja Europa: umjetnost i politika u razdoblju moderne (1780. - 1945.)Croatia and Central Europe: Art and Politics in the Late Modern Period (1780-1945)3499Dragan Damjanović UIP2013-11UIP-2013-11-4153CroCE-ArtPolitics15.06.2014 - 14.06.2017Završio562.000,00 KnHumanističke znanostiHumanitiesPovijest umjetnosti, Art history, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences4143, 4151, 4195, 4206, 4237, 4446, 4475, 4459, 4416, 4794, 4554, Željka Miklošević, Nadežda Čačinovič, Zvonko Maković, Sandi Bulimbašić, Daniel Zec, Lovorka Magaš Bilandžić, Sanja Zadro, Iskra Iveljić, Silvija Lučevnjak, Frano Dulibić, Jasminka Najcer Sabljak, Croatia, Central Europe, 19th Century Art, 20th Century Art, Modernism, Sociopolitical Context, Art Discourses, Visual Communication, Popular CultureThe main aim of the project Croatia and Central Europe: Art and Politics in the Late Modern Period (1780-1945), is to get a comprehensive insight on the basis of fundamental research into relationships between art and political regimes seen from various perspectives and based on different discourses (governmental, social, economic, religious, gender, ethnic and the like) in the given area which has a common political and sociocultural background. The project spans the period from the 1780s, which was marked by great changes in the Hapsburg Monarchy during the reign of Joseph II, to the end of the Second World War when political circumstances brought an end to the integrity of Central Europe. The project has been conceived as a broad-based research of fine and applied arts (painting, sculpture, architecture, graphic arts, photography, comics, cartoons, etc.) through multidisciplinary and interdisciplinary approaches using methods pertaining to humanities and social sciences. Research will comprise topics relating to (mis)use of art for or against political regimes, artistic heritage of marginalized groups, the concept of unwanted heritage and institutional construction of art discourses and their reception. Understanding sociopolitical background can contribute to greater understanding of heritage-based conflicts, while indications of the transnational nature of Central European art can encourage its protection and ensure its sustainability. The research team, headed by an assistant professor from the Faculty of Humanities and Social Sciences, University of Zagreb, consists of academic researchers, doctoral candidates, and professionals from museums and monument protection institutes. Expected results and outcomes of the project include publications on the given topics, a more profound scientific knowledge about art developments within sociopolitical contexts and future collaboration with foreign researchers.
1543Utjecaj okolišnog stresa na pojavnost i međudjelovanje biološki važnih organskih molekula i mikronutrijenata u morskom ekosustavuAppearance and interaction of biologically important organic molecules and micronutrient metals in marine ecosystem under environmental stress81Blaženka Gašparović IP2013-11IP-2013-11-8607AMBIOMERES01.10.2014 - 31.01.2019Završio831.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb101, 75, 120, 84, 362, 106, 691, 85, 17849, Marina Mlakar, Marta Plavšić, Vlado Cuculić, Sanja Frka Milosavljević, Snježana Kazazić, Slađana Strmečki Kos, Petra Vukosav, Abra Penezić, Tihana Sesar, organic matter, lipids, acidic polysaccharides, micronutrient metals, oligotrophy, eutrophy, monocultures, field workRecently documented oligotrophication of the Adriatic Sea caused by global changes opened questions how this reflects on the quality and quantity of organic matter (OM) produced by the phytoplankton and on the consequent influence on the micronutrient metals availability and cycling. Within the project, a progressive (model and in-situ) approach will be accomplished to reveal crucial alterations in the marine ecosystem. Initial investigations will imply model experiments on the interaction of selected OM (polysaccharides, lipids, polymeric organic matter containing N catalytic atoms) with micronutrient metals (Fe, Co, Cu, Zn and Cd). Additionally, phytoplankton monoculture incubation under various growth conditions (nutrient concentrations and temperature variations) will be included in order to comprehend multiple impacts on the phytoplankton OM production and micronutrients metals distribution. Model experiments will be followed by in-situ investigations at the selected oligotrophic and eutrophic areas of the Adriatic Sea. This will give holistic informations on the natural marine biochemical cycles and linkage between OM and micronutrient metals. In-situ investigations will be focused on the seasonal variations of the OM and micronutrient appearance and concentrations in combination with physico-chemical parameters (temperature, salinity, pH, O2), and dissolved and particulate organic carbon content, surface-active organic substances and macronutrients (PO4, NO3, NO2, NH4). These investigations will be assessed by intercomparable and multimethodological approaches using various chromatographic to electrochemical techniques. Finally, taking into account all obtained results an important part of the natural marine ecosystem processes will be characterized in the prospective of climate changes.
1551Što se zbiva u sjevernom Jadranu? - Klimatske promjene, acidifikacija, bioraznolokost, eutrofikacija. - Nove tehnologijeWhat Works Within northern Adriatic? – Climatic changes, Acidification, Biodiversity, Eutrophication. - New Enhanced Technology3596Robert Precali IP2013-11IP-2013-11-8541www.NA-CABE.net01.10.2014 - 30.09.2018Prekinut0,00 KnPrirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb429, 318, 465, 467, 468, 451, 473, 4424, 3992, Romina Kraus, Tina Šilović, Ingrid Ivančić, Tamara Đakovac, Nastenjka Supić, Jelena Godrijan, Paolo Paliaga, Daniela Maric Pfannkuchen, Jakica Njire, northern Adriatic, climatic changes, acidification, biodiversity, eutrophicationThe northern Adriatic (NA) seems to be strongly influenced by the anthropogenic drivers - climatic changes, acidification and eutrophication. Its semi-enclosed nature, characterised by smaller inertia - due to the relative short residence time of its water masses, makes it highly reactive to the external forcing, in particular to the variations of the water, energy and matter fluxes at the interfaces. The NA, identified as a Mediterranean's climatic change „hotspot“, is expected to withstand environmental impacts that are considerably greater than in many other places worldwide. Such a uniquely dynamic system allows as to investigate the biological capacity and ecosystem elasticity in relation to these forcings. This project, at this state of knowledge, will be the first one that tries addressing the impact of the aforementioned anthropogenic drivers on the ecosystem behaviour (changes in water chemistry, metabolic activity and biodiversity). It will also advance the international state of the art in the following aspects: temporal resolution of the in situ acidification and phytoplankton physiology analysis, taxonomic resolution, combined taxonomic and metabolic analyses and molecular biodiversity.A buoy positioned at a point that integrates the most of the NA dynamics will serve as a hub for the continuous acquisition of the oceanographic and biological parameters. Together with the largest historical data set in the wider area and the most advanced approaches (in situ pH and phytoplankton physiology, taxonomy and analyses of metabolic activities), it will allow us an exhaustive insight in these interactions. At the end, this research will enable us to build scenarios of possible ecosystem reactions to predicted environmental changes in the NA and, in a wider sense, to all marine systems.
1557Cjelogenomska analiza povezanosti Hashimotovog tiroiditisaGenome-wide association analysis of Hashimoto thyroiditis63Vesna Boraska UIP2013-11UIP-2013-11-4950HashimotoGWAS15.09.2014 - 14.01.2018Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine118, 137, 3571, 388, 260, 611, 4749, 1067, 17744, 19036, 1113, Tatijana Zemunik, Maja Barbalić, Ante Punda, Sanda Gračan, ANA BARIĆ, Vesela Torlak, Stana Tokić, Eleftheria Zeggini, Luka Brčić, Ivana Gunjača, Veselin Škrabić, Hashimoto thyroiditis, thyroid gland, genome-wide association analysis (GWAS), statistical genetics, single nucleotide polymorphism (SNP), biobankAutoimmune thyroid diseases (AITD) are very common and affect 2-5% of the general population. The most frequent form of AITD is Hashimoto thyroiditis (HT) that is characterised by progressive destruction of thyroid tissue. Many studies tried to unravel genetic contribution to HT development in the past few decades but with low success. The breakthrough of the genome-wide association studies (GWAS) tremendously increased the rate of detecting novel associations. However, HT has been unrepresented in the GWAS mostly because of the lack of large cohorts of HT patients and the performance of such study is a matter of urgency. We plan to recruit 500 HT patients and to create a DNA/serum/plasma biobank of deeply phenotyped HT patients that will serve as a powerful resource for current and future investigations. The aim of this study is to identify genetic variants underlying HT by performing the first GWAS focusing on HT exclusively. We will use newly recruited HT patients and 500 existing controls (from the “10,000 Dalmatians” study) in case-control GWAS and validate observed associations in an independent replication cohort. To further help in elucidating genetic contribution to HT we will perform pathway analysis and gene-interaction analysis using variety of environmental factors and medical records that will be collected from HT patients. We will also perform deep phenotype characterisation of HT patients that may provide additional clues about HT aetiology. This is timely planned study that aims to generate new knowledge that will advance our understanding of the genetic basis and underlying biological mechanisms of HT. This knowledge will be crucial in guiding the development of new prevention, diagnostic and therapeutic methods. Other benefits of this project include promotion of collaboration, transfer of knowledge, building of infrastructure and it will help in establishment of independent research carrier of principal investigator.
1559Ultrazvučni sustav za određivanje parametara kompleksnih materijala u nelinearnim uvjetima radaUltrasound system for complex material parameters determination in the nonlinear working conditions146Antonio Petošić UIP2013-11UIP-2013-11-4996ULTRASNON01.09.2014 - 31.12.2017Završio980.200,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing962, 1392, 1379, 3153, 284, 682, 3101, 4829, 19019, Ivan Đurek, Nazenin Bassiri Gharb, Marko Budimir, Dražan Skelin, Dragan Damjanovic, Marijan Klarica, Petar Mateljak, Bojan Ivančević, Marko Horvat, material parameters, ultrasound, modular measurement system, nonlinear effects, effciency factorThe main objective of this project is to develop a new measurement procedure and to construct a modular measurement system for determination of complex material parameters that are used in ultrasound (US) systems which are working in the nonlinear conditions. The materials' parameters in existing US systems used in biomedicine and industry are determined at low excitation levels assuming linear physical principles and consistent thermodynamical conditions. This is different from real operating conditions where range of applied powers and types of excitation signals is various and very often far away from linear. The neglect of these nonlinearities in active and passive materials, used in the complete US system construction process, leads to the problem of the US systems’ efficiency factor in the nonlinear driving conditions. The construction of modular measurement system with included and modified interferometry and time of flight principle with added new measurement procedure is crucial for developing novel US systems with higher electroacoustic efficiency factors. The new method is based on tracking the resonant frequency changes of the nonlinear electro-mechanical-acoustical system for determination complex material parameters. The new modular measurement system will enable exposure of materials to the US fields with various driving conditions. Tracking the resonant frequency changes of excitated loading medium sample (active piezoceramic or passive construction elements or different types of loading mediums) is novel method for determination of material parameters when nonlinear effects appear in the loading mediums. As a result of more precise constructive material parameters determination, three prototypes of US systems with probes and electronic excitation circuits for applications in biomedicine and industry, with obtained higher electroacoustic efficiency factors will be developed, constructed and tested during this project.
1560Održivost ekonomske politike i razvoja u HrvatskojSustainability of Croatian Economic Policy and Development503Jurica Šimurina IP2013-11IP-2013-11-7031SCrEPoDe01.10.2014 - 30.09.2018Završio383.606,03 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Zagrebu, Ekonomski fakultet u ZagrebuUniversity of Zagreb, Faculty of Economics and Business3966, 3909, 3635, 3957, 4150, 3729, 3747, 4093, 3801, 4626, 3914, 3874, 6934, Alka Obadić, Irena Raguž Krištić, Tomislav Globan, Tomislav Sekur, Josip Tica, Ozana Nadoveza, Vladimir Arčabić, Šime Smolić, Tamara Boras, Tomislav Gelo, Marija Penava, Ana Andabaka Badurina, Vinko Barić, sustainability, economic structure, resources, public sector economics, spatial economicsRESEARCH QUESTION: Do Croatian economic policies lead to sustainability with respect to scarce resources, demographic changes, spatial effects and economic structure?Long term Croatian economic policy and development stem from both short term policies and long term sustainability. By combining macroeconomic and development policies, the long term objectives of sustainability of natural resources, public sector economics, demographic changes, spatial economics and overall economic structure may be achieved. Thus, the goals of this research stem from the above stand point, and include:• Establish development policies for Croatia based on sustainable use of natural resources• Show how change of age structure in Croatia affects fiscal sustainability and short and long run economic development• Explore how three way interaction among increasing returns, transportation costs, and movement of factors of production affect international, regional and urban development• Analyze structure of Croatian economy suitable for sustainable and deeper integration into the EU• Define integrative policies which lead to sustainable development of Croatian economyFor achieving above mentioned goals, the project team is separated into four equally contributing groups and is structured as follows:1. Sustainability of economic development within the context of scarce natural resources.2. Sustainability of public sector economics and the labor market in the context of demographic changes in Croatia.3. Sustainability of the degree of centralization in the context of spatial (international, urban and regional) economics.4. Sustainability of current economic structure within the context of the EU integrationOutcomes of the research will be innovative approach to controversy of long vs. short term development and stability, as well as integrative approach to different, and thus far, insufficiently interconnected fields of economic research.
1563Primjena frazeološke teorije u frazeografiji Application of phraseological theory in phraseography 3653Željka Fink-Arsovski IP2013-11IP-2013-11-4054FRAZLOGGRAF01.07.2014 - 30.06.2018Završio139.100,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences3577, 1477, 1516, Branka Barčot, Anita Hrnjak, Antica Menac, phraseme, phraseology, phraseography, dictionaries, contrastive linguistics, Croatian, Slavic languages, non-Slavic languagesThe active development of phraseology as an independent linguistic discipline began in the former USSR in the 1950s. Phraseology is primarily a linguistic and culturally multi-layered discipline. The basic unit of phraseology is a phraseme (idiom). It consists of at least two components. Its characteristic is that it is not created in the process of speaking, but is included in discourse as an already known whole. Its main features are continuity of use, integrity and a solid structure, higher or lower degree of desemanticization, a colourful nature, expressiveness and connotative meaning. The project will primarily include theoretical work on analyzing Croatian phrasemes from various aspects. Furthermore, with the application of the method of contrastive analysis, structural, semantic, etymological, motivational and cultural similarities and differences between Croatian idioms and idioms of other Slavic and non-Slavic languages will be examined. We consider the latter to be extremely important because in this way Croatian idioms would be placed in the context of European idioms. The second part of the project proposal relates to phraseographical work. Phraseography is an area that deals with the issue of compiling phraseological dictionaries. The publication of several phraseological dictionaries is planned. Particularly important will be the two phraseological dictionaries which will be completely new in a conceptual sense (a trilingual dictionary of associations and a dictionary of gender-marked phrasemes). All dictionaries will be compiled according to the latest phraseographical methodology. In addition, we should mention the work on the updated edition of the Bibliography of Croatian phraseology. We believe both of these aspects to be very important for the recognition of Croatian phraseology and phraseography within European phraseology, phraseography, Slavic studies and philology.
1578Multidisciplinarni klaster za istraživanje tranzicijskog kriminaliteta - trgovanje ljudima, korupcija i gospodarski kriminalitetMultidisciplinary Research Cluster on Crime in Transition - Trafficking in Human Beings, Corruption and Economic Crime125Davor Derenčinović IP2013-11IP-2013-11-1949Trans.Crim.01.01.2015 - 31.12.2018Završio451.270,96 KnDruštvene znanostiSocial sciencesPravo, Law, Sveučilište u Zagrebu, Pravni fakultet u ZagrebuUniversity of Zagreb, Faculty of Law3828, 4083, 4111, 4174, 4199, 4292, 4357, 4492, 4457, 229, 3052, 3149, 4535, 580, 4165, 4158, 4222, 2814, 2928, 4522, 4297, 4187, 4274, 4763, 4774, 4955, 4467, 5073, 5549, Maja Munivrana Vajda, Anna-Maria Getoš, Aleksandar Maršavelski, Željka Burić, Marta Dragičević Prtenjača, Vanja-Ivan Savić, Davorin Lapaš, Peter Henning, Vanda Božić, Jasenko Marin, Iva Savić, Nikolina Brnjac, Dražen Dragičević, Hrvoje Lisičar, Nina Gumzej, Tihomir Katulić, Marko Jurić, Nikoleta Radionov, Mišo Mudrić, Richard Farkas, Marko Šikić, Lana Ofak, Frane Staničić, Marko Turudić, Mateja Crnković, Ivana Jaramaz Reskušić, Sanja Milivojevic, Suncana Roksandic Vidlicka, Leo Cvitanović, crime, transition,research cluster, trafficking in human beings, corruption, economic crimeThe first project research focus is human trafficking, modern age slavery that has been condemned by the ECHR as a gross human rights violation. The number of those identified as victims in Croatia remains low. However, there is no dispute that the dark number in this field is significant. This could be explained by the structural deficiencies of national anti-trafficking policies and disregard of research and multidisciplinary approach in addressing three key priority areas – that of prevention, protection of victims, and prosecution of perpetrators. The need for the research based policies is indispensible for Croatia as a new EU member state that has been under the risk of turning into a country of destination for victims from the Western Balkan countries as well as from the countries either affected from internal instabilities and conflicts (e.g. Syria) or from the African countries (e.g. Nigeria). Therefore, the aim of this project is to contribute, through establishment of fully operational informal network of experts from different disciplines, in promoting research based policies and to provide support for establishment of National Rapporteur on THB (this is an obligation under the Directive 2011/36/EU that still has not been fully implemented by Croatia). The second research focus is corruption and economic crime, major obstacles for further development of society stretched between systemic dysfunctions characteristic for transition period and the rule of law standards formally accepted through the process of European integration. Informal network of experts will address the issues of liability of legal persons for corruption and economic criminal offences, shortcomings in legislation and case law, legislation that regulate access to information etc.
1579Diofantove m-torke, eliptičke krivulje, Thueove i indeksne jednadžbeDiophantine m-tuples, elliptic curves, Thue and index form equations95Andrej Dujella IP2013-11IP-2013-11-6422DIOPHANTINE01.07.2014 - 30.06.2018Završio768.234,76 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science1267, 1262, 1282, 2600, 3264, 1264, 2990, 1348, 1251, 1312, 4086, 17746, 23281, Ivica Gusić, Alan Filipin, Borka Jadrijević, Zrinka Franušić, Mirela Jukić Bokun, Ana Jurasić, Tomislav Pejković, Ivan Soldo, Petra Tadic, Sanda Bujačić, Nikola Adžaga, Marija Bliznac, Vinko Petričević, Diophantine equations, elliptic curves, Diophantine approximations, polynomials, cryptographyThe proposed project will coordinate and support research activities of Croatian number theory group. One of the main topics of research in this project will be Diophantine m-tuples (sets with the property that the product of its any two distinct elements increased by 1 is a perfect square) and their generalizations. The first Diophantine quadruple {1,3,8,120} was found by Fermat. Baker and Davenport proved that Fermat's set cannot be extended to a quintuple. This result motivated the famous conjecture that there does not exist a Diophantine quintuple. Dujella proved that there does not exist a Diophantine sextuple and that there are only finitely many Diophantine quintuples. Recently, Filipin, Fujita and Elsholtz significantly improved previously known upper bounds for the number of Diophantine quintuples, but the main conjecture still remains open. Various generalizations of Diophantine m-tuples will be studied, in particular, considering the problem in the rings of integers of number fields of small degree. Diophantine triples were used by Dujella in construction of high-rank elliptic curves over Q and Q(T) and new results in that direction are expected. In determining exactly the Mordell-Weil group of several elliptic curves over Q(T), an important tool is recent algorithm by Gusić and Tadić for finding rationals at which the specialization map is injective. We plan to improve and extend this algorithm for elliptic curves over K(T) for general number fields K. Members of the group will also work on Thue, Thue-Mahler and index forms equations, problems related to sums of divisors, polynomial root separation and applications of Diophantine approximations to cryptanalysis. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number-theorists and qualify young researchers for scientific research in number theory.
1585Primjena metode scenarija u planiranju i razvoju ruralnih područja HrvatskeCroatian Rural Areas: Scenario-based Approach to Discuss Planning and Development3724Aleksandar Lukić UIP2013-11UIP-2013-11-4513Croruris01.10.2014 - 30.09.2017Završio507.602,89 KnDruštvene znanosti, Biotehničke znanosti, Prirodne znanosti, Social sciences, Biotechnical sciences, Natural sciences, Ekonomija, Economy, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science6156, 6662, 4934, 4600, 4881, 6407, 5671, 5139, 4846, 6137, Dane Pejnović, Maja Štambuk, Anica Čuka, Ornella Mikuš, Ivan Zupanc, Ivana Lučev, Ivan Čanjevac, Petra Radeljak, Luka Valožić, Marin Cvitanović, scenario, rural areas, typology, planning, modelling, Delphi, CroatiaThe main anticipated result of the interdisciplinary CRORURIS study is the production of a set of alternative future scenarios for Croatian rural areas in 2030 with the goal of encouraging informed and evidence-based public debate on rural futures. Rural areas account for almost 90% of the land and are home to almost half of the population, both in Croatia and the EU. They are still the most important food production zones in Europe, although this primary function has been challenged by numerous modernization and globalization processes and complemented by other economic, social, cultural, and environmental functions. As a result, we have witnessed the (re)emergence of heterogeneous and diversified rural areas, juxtaposing depopulation and land abandonment in some regions, and tourist development or agricultural intensification in others. Given their size, population number, functions and variety of challenges they face, the question of future of rural areas is one of the most pressing issues in Europe today. This is evident from recent scenario-based approaches to study future trends and driving forces for rural Europe, both in academic and political discourse, on national and EU level (e.g. SCENAR 2020, EURURALIS etc.). On the other hand, although the majority of rural areas in Croatia face tremendous demographic and economic challenges, to our knowledge no scenario-based research has been done and only a few partial impact analyses have been conducted in recent Croatian agricultural policy. Therefore, the main objectives of the CRORURIS study are as follows: 1. to develop a conceptual framework for understanding recent change in rural Croatia; 2. to develop methodological framework for identifying predominant trends and key uncertainties, differentiating them geographically and projecting them forward using statistical modelling and Delphi method; 3. to construct alternative future scenarios and relate them to the context of rural Europe.
1588Istraživaje prirodnih spojeva i aroma: kemijsko profiliranje i otkrivanje potecijalaResearch of natural products and flavours: chemical fingerprinting and unlocking the potential367Igor Jerković IP2013-11IP-2013-11-8547NaPro-Flav01.06.2014 - 31.05.2018Završio659.744,52 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Splitu, Kemijsko-tehnološki fakultetUniversity of Split, Faculty of chemistry and technology664, 666, 3752, 1139, 1133, 507, 1520, 4186, 4185, 771, Ani Radonić, Marina Zekić, Marina Kranjac, Maja Kliškić, Senka Gudić, Carlo Ignazio Giovanni Tuberoso, Zvonimir Marijanović, Dragan Bubalo, Lidija Svečnjak, Goran Baranović, natural products, flavours, preparative techniques, chromatography, spectroscopy, antioxidant assays, corrosion inhibition assaysThe proposed project develops up-to date topic in the subject area, offers high-quality research of natural products (NPs) and flavours (FLs) and tends to impact the biodiversity, traceability and authentication issues of targeted samples (major EU concerns), as well as to unlock the potential (useful activities of the samples/NPs). Targeted samples are unexplored or insufficiently investigated honeys, honeydews, bee-products, wines, cheese, others. While characteristic NPs (secondary metabolites) already possess flavours, other flavour compounds can derive from precursors during processing, fermentation, dry-curing, heating, others (e.g. Maillard reactions, Strecker degradations, retro-aldol reactions, Amadori rearrangements, heterocyclizations, lipid oxidations and others). NPs/FLs isolation involves application of selective preparative procedures followed by the organic analysis applying modern chromatographic and spectroscopic techniques. Specific project goal is to determine reliable chemical fingerprints of targeted samples depending on biodiversity of natural sources in different regions. Varieties of acetate, shikimate, mevalonate and/or deoxyxylulose biosynthetic pathway derivatives are expected to be found. Among them, it can be possible to find specific or nonspecific chemical biomarkers characterizing certain sources. In addition, the obtained NPs or selected samples will be evaluated in order to unlock their potential, particularly antioxidant activity by different assays and corrosion inhibition potential with in-situ and ex-situ electrochemical/non-electrochemical techniques. Project work plan includes: 1) the samples selection and preliminary characterisation; 2) set-up of preparative/chromatographic/spectroscopic methods followed by elaboration of the obtained chemical fingerprints); 3) set-up of antioxidant/corrosion inhibition assays followed by unlocking the samples/NPs potential; 4) training of young researchers/cooperation.
1590Taksonomija, Ekologija i Uporaba rogača (Ceratonia siliqua L.) i lovora (Laurus nobilis L.) u HrvatskojTaxonomy, Ecology and Utilization of Carob Tree (Ceratonia siliqua L.) and Bay Laurel (Laurus nobilis L.) in Croatia372Siniša Srečec IP2013-11IP-2013-11-3304TEUCLIC07.07.2014 - 06.10.2018Završio719.945,59 KnBiotehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, Biotechnical sciences, Natural sciences, Biomedicine and health sciences, Biotehnologija, Biotechnology, Visoko gospodarsko učilište u KriževcimaCollege of Agriculture in Križevci4381, 4864, 5669, 5474, 6201, 313, 6170, 6304, 6326, 5692, 4916, 5084, 6046, 5510, 5662, 5690, 5630, 6097, 6236, 5853, 5364, 6184, 1317, Dario Kremer, Snježana Bolarić, Nada Bezić, Dubravka Dujmović Purgar, Irena Vedrina-Dragojević, Maja Popović, Ingrid Bauman, Marija Vukobratović, ŽELIMIR VUKOBRATOVIĆ, Ivka Kvaternjak, Ksenija Karlović, Renata Jurišić Grubešić, Nives Marušić, Gordan Mršić, Daniel Špoljarić, Zvjezdana Augustinović, Dejan Marenčić, Ivna Dragojević Müller, Maja Benković, Tomislava Peremin Volf, Renata Erhatić, Marinko Petrović, Valerija Dunkić, carob tree, Ceratonia siliqua L., bay laurel, Laurus nobilis L., biodiversity, utilizationCarob tree (Ceratonia siliqua L.) is nutritionally and protectively very valuable plant, especially seeds which are widely used in the food industry. Carob pods and juice has a very important role in diet of Mediterranean countries. Bay laurel (Laurus nobilis L.) is also nutritionally and protectively very valuable plant overspread on the Mediterranean basin. The most important parts of the bay laurel plant are leaves which are used in traditional medicine, and in the food, pharmaceutical and cosmetic industries. Both species are also an important component of the Mediterranean vegetation and grows in marginal and prevailing calcareous soils. Since there is limited knowledge about Croatian populations of carob tree and bay laurel this studies will be conducted to determine morphological, genetic, phytochemical and ecological traits of Croatian populations of these species. Morphometric investigations will be made on leaves and fruits (carob tree) samples gathered in situ, while the genetic variability will be determined using AFLP analysis of genomic DNA isolated from the leaves. The content of polyphenolic compounds, antioxidant activity in vitro with the use of UV-Vis spectrophotometer, and the share of macro and microelements using emission spectrometry (AES) will be determined in the leaves and fruits samples. Carob based soft drinks and pastry fillings will be developed as new products on Croatian market. Additionally, possible positive effects of addition supplement of carob tree in standard food for animals on health and production parameters in weaned pigs as the natural replacement of antibiotic growth promoters will be investigated.
1596Pouzdanost konstrukcije oštećenog naftnog tankera u Jadranskom moruStructural reliability of damaged oil tanker in the Adriatic Sea810Joško Parunov IP2013-11IP-2013-11-8658DATAS01.09.2014 - 31.08.2018Završio956.681,00 KnTehničke znanostiTechnological sciencesBrodogradnja, Naval architecture, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture6629, 6823, 6385, 6793, 6254, 6626, 6227, 5584, 6309, 6166, 6437, 6414, 6209, 6640, 5212, 6271, 6483, 17869, 17868, 17787, Vedran Žanić, Većeslav Čorić, Andreja Werner, Nastia Degiuli, Smiljko Rudan, Vedran Slapničar, Jerolim Andrić, Ivan Ćatipović, Stanislav Kitarović, Pero Prebeg, marko tomić, Karlo Pirić, Maro Ćorak, Jadranka Radanović, Branka Bužančić Primorac, Luka Mudronja, Ivan Munić, Marko Katalinic, Ivana Martić, Ivana Gledić, oil tanker, Adriatic sea, damaged ship, structural reliability, risk assessmentThe aim of the project is to propose methodology of structural safety assessment of the damaged oil tanker in the Adriatic Sea and to set-up procedure for rational decision making of ship in the situations requiring emergency response actions. This can also be used to develop more rational rules and regulations related to the traffic of large ships operating in the Adriatic and to investigate possibilities of a ship structural design improvement with respect to the most dangerous incident types. Despite advancements in navigation systems, ship accidents continue to occur, the most recent one being the grounding of a cruise ship Costa Concordia. These accidents have resulted in the loss of cargo, pollution of environment, and most unfavorable the loss of life. Accidental damages of ships can occur in any number of ways. The two cases which exhibit most concerns are the collision between ships and hard grounding on seabed. When a ship is damaged, the operators need to decide on immediate repair actions by evaluating the effects of the damage on safety of the ship by considering simultaneously effects of the damage in the hull girder ultimate bending moment and in the applied loads (wave and still-water induced bending moments). In general, as the consequence of an accident still water loads on ship will considerably increase, while the ship strength will decrease. Disaster of the tanker Prestige in 2002 clearly showed that the ship in damaged condition can be broken due to the above mentioned phenomenon and sink as the most unfavorable outcome of such an accident with likely spillage of a large amount of pollutant oil on board.Since the Adriatic is an enclosed sea basin, with the low level of the activity of the sea waves and current, an accident of the oil tanker with significant oil spill would make irreversible ecological disaster with enormous economic losses. Therefore, safety of oil transportation in the Adriatic is a major concern of the whole society.
1598Elektrokemijski superkondenzator visoke snage i velikog sadržaja energije za primjenu u električnim vozilimaHigh power-high energy electrochemical supercapacitor for hybrid electric vehicles961Zoran Mandić IP2013-11IP-2013-11-8825ESUP-CAP03.11.2014 - 02.11.2018Završio955.800,00 KnTehničke znanosti, Prirodne znanosti, Technological sciences, Natural sciences, Kemijsko inženjerstvo, Chemical engineering, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology3029, 3035, 3651, 4131, 5278, 6109, 17810, 19020, 21370, Višnja Horvat-Radošević, Katja Magdić, Marijana Kraljić Roković, Suzana Sopčić, Gabrijela Slavić, Željko Ban, Denis Sačer, Davor Antonić, Antonio Ivanković , Supercapacitors, electrochemical energy sources, electric vehicles, renewable energy, carbon electrodes, conducting polymersIn the context of renewable and “clean” energy sources, the main aim of the present project is to provide a technology output for the novel, high power-high energy electrochemical supercapacitor device that could be implemented in hybrid electric vehicles. The project addresses an interdisciplinary research and combines fundamental and applied research activities in chemical, electrical and environmental engineering fields. The highest possible scientific and technological impact of the project is supposed to be ensured by joining of the human and experimental resources of several different Croatian’s groups. The novel, high power-high energy electrochemical supercapacitor device will be based on hybridization of two different types of electrodes (double-layer and pseudo-capacitive) in a respective electrolyte. Various forms of carbon and carbon based binary and ternary composites with transition metal oxides and/or conducting polymers will be tested as negative and positive electrodes, respectively. For being competitive in the area of energy storage, the tested electrodes should fulfil the requirements of high specific capacitance, long cycle-life, good charge/discharge efficiency, low self discharge and adequate operating voltage. The project is planned to be realized mostly on the basis of fundamental experimental research directed towards increasing of the basic knowledge comprising choice of material, proper design of electrodes and careful elucidation of all underlying physical and chemical processes at active electrode/electrolyte interfaces. The results of fundamental experimental research will be utilized for selection of proper electrodes, their arrangement into electrochemical supercapacitor device, optimization of device to the energy content and power ability, testing of device in practical environment and implementation of device into hybrid electrical vehicle.
1603Karakterizacija niskotemperaturne molekulske dinamike sustava s neuređenom rešetkom metodom ESRLow-temperature molecular dynamics of systems exhibiting lattice disorder probed by ESR510Marina Ilakovac Kveder IP2013-11IP-2013-11-1108DESiRe01.09.2014 - 31.08.2018Završio791.853,07 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb3280, 3546, 3545, 1213, 4209, 2647, 17790, Boris Rakvin, Mladen Andreis, Srećko Valić, Dalibor Merunka, Nadica Maltar Strmečki, Dijana Žilić, Jurica Jurec, ESR, disorder, boson peak, spin relaxation, spin frustrationSystems exhibiting geometrical frustration challenge contemporary condensed-matter physics due to the fact that they exhibit strange dynamical properties such as boson peak excitations, which strongly deviate from the standard Debye model. Therefore, the quest for a self-consistent theory applicable for description of systems with lattice disorder is a fundamental issue. Despite the efforts put into investigation of vibrational excitations in disordered systems at low temperatures, the consensus about their physical origin is still lacking. This project aims to address the subject by fully exploiting the advantage of embedded paramagnetic centres through focusing on their relaxation behaviour, which bears the information about the local frustration of the environment. The energy exchange within the spin system and between the spin system and the lattice will be detected by electron spin resonance spectroscopy (ESR) as a function of disorder in the vicinity of the paramagnetic centre. This we can control by preparing the host matrix in the glassy, supercooled or crystalline state. We propose to investigate the specific molecular dynamics due to the presence of disorder in the system while switching the very same compound doped with paramagnetic centres from disordered to more ordered state, such as from glassy to crystalline state. Additionally, the microscopic picture of local disordered sites will be examined in other systems doped with paramagnetic centres such as various polymer matrices or hydrogen-bonded crystals. The origin of local disorder will be correlated with the influence of different numbers of hydrogen bonds in the vicinity of paramagnetic site as well as with the degree of local spin frustration. We expect that this comparative study will enlighten the peculiarities of vibrational density of states of amorphous materials and contribute towards development of the unique model of low-temperature molecular dynamics of disordered systems in general.
1617Modeliranje ekonomskog rasta - napredno sekvenciranje i algoritam predviđanjaModelling Economic Growth - Advanced Sequencing and Forecasting Algorithm3894Marinko Škare IP2013-11IP-2013-11-9481MEGASFORA16.06.2014 - 15.06.2018Završio554.324,28 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište Jurja Dobrile u PuliJuraj Dobrila University of Pula1166, 2963, 1268, 1331, 4628, 1094, 1055, 5795, 6579, 6549, 5351, 5675, 5391, 5396, 5635, 5036, 4659, 4863, 5062, 6832, 19122, Steve Keen, Guglielmo Maria Caporale, Roman Semko, Daniel Tomić, Saša Stjepanović, Hazbo Skoko, Sanja Blažević, Đani Burić, Tea Hasić, Sabina Lacmanović, Katarina Kostelić, Nawazish Mirza, Danijela Rabar, Soumitra Sharma, TOMASZ WOLOWIEC, Manuel Benazić, ROMINA PRŽIKLAS DRUŽETA, Tea Golja, Dean Sinković, Valter Boljunčić, Mieta Bobanović, Growth, forecasting, algorithm, dynamic models, golden triangle modelThe main objective of the project is to give a final and scientifically based answer to the question whether economic growth can be forecasted and business cycles predicted? A practical objective of the proposed research project is to build an optimal economic growth/cycle model for Croatia using Advanced Growth Sequencing and Forecasting Algorithm (AGSIFAL) that we plan to build. In order to do so, an algorithm (selected from the best of artificial neural network model, structural econometric model, dynamic general equilibrium model, nonlinear econometric model, golden triangle model) for cycle/growth sequencing and forecasting will be developed. Sequencing of the economic growth on a international scale (119 countries) will be performed using business cycle tracer methods and novel golden triangle model developed by Škare (2010). For this purpose, advanced cycle/growth algorithm will be created. Using individual country data as primer, we plan to isolate growth determinants using three dimensional golden triangle model and spectral analysis techniques. Output, inflation and employment form the three dimension of the cycle/growth triangle that will be used for sequencing growth. After a growth sequencing is finished, a best forecasting algorithm is built from the derived growth sequencing bases. Pairing isolated growth determinants help us to rebuild a growth sequence. Using different algorithm models, reconstructed economic growth series is compared to the actual growth series (observed data). Algorithm resulting in the smallest forecast error (RMSE) is selected as optimal to explain economic growth and predict business cycles. EThis conclusion will have important theoretical and policy implications both for the science of economics and economic agents on the market.
1619Razvoj i upotreba modela za procjenu potencijala za rast za mala i srednja poduzeća u HrvatskojDevelopment and application of growth potential prediction models for small and medium enterprises in Croatia2825Nataša Šarlija IP2013-11IP-2013-11-3933CROSMEGROWTH01.07.2014 - 30.06.2018Završio458.230,00 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište Josipa Jurja Strossmayera, Ekonomski fakultet u OsijekuJosip Juraj Strossmayer University of Osijek, Faculty of Economics4247, 6530, 5265, 305, 5065, 4797, 17875, Sanja Pfeifer, Slavica (Vjekoslava) Singer, Marina Jeger, Danijel Grahovac, Anamarija Delić, Sunčica Oberman Peterka, Ana Bilandžić, prediction of growth potential, high-growth SMEs, creative industry, policy recommendation for high growth SMEs, access to finance for high-growth SMEThe importance of high-growth enterprises for job creation has been widely substantiated by economic research in recent years. The number and share of high-growth enterprises is relatively small, but the number and share of jobs they create is disproportionally large. The small and medium enterprises with the potential of growth are in the focus of this project. Two overarching goals of this project are:1. Development of growth potential prediction models for SMEs in CroatiaThe main activities leading up to this goal are: (i) to analyse previous studies relevant for the topic of SMEs' growth potential; (ii) to develop growth potential prediction models for SMEs in Croatia; (iii) to make the models for assessing growth potential available to SMEs to use for purposes of assessing and improving their businesses; (iv) to compare differences in growth potential among SMEs from main industries; (v) to analyse growth potential of SMEs within creative industries and within manufacturing industries. 2. Providing recommendations to policy makers, recommendation for development of educational programs for SME owners and managers, and recommendations related to sources of finance available to SMEsBased on the research results and models created as part of this project, the main recommendations related to growth potential of SMEs will cover areas of: (i) policy making; (ii) education; and (iii) sources of finance. In recent years policy makers have shown increased interest in fostering fast growing enterprises as they are seen as a key driver of economic growth and employment. Studies conducted in listed companies have showed that two key aspects in supporting high-growth companies are education and access to finance. To allow for comparison of other countries with Croatia, results of this project will be published in relevant scientific journals. To help boost Croatian economy, the results will be presented to all stakeholders interested in this topic.
1630Molekularna epidemiologija nekih invazijskih oboljenja divljih životinjaMolecular epidemiology of selected parasitic diseases of wildlife3919Dean Konjević UIP2013-11UIP-2013-11-3421EpiMol01.09.2014 - 31.08.2017Završio967.000,00 KnBiomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, Biomedicine and health sciences, Natural sciences, Biotechnical sciences, Veterinarska medicina, Veterinary medicine, Sveučilište u Zagrebu, Veterinarski fakultetUniversity of Zagreb, Faculty of Veterinary Medicine6172, 6141, 5928, 6315, 5763, 6460, 6444, 6598, 4742, 17766, Ana Galov, Haidi Arbanasić, Krešimir Krapinec, Julian Drewe, Marina Pavlak, Magda Sindičić, Franjo Martinković, Živičnjak Tatjana, Krešimir Severin, Miljenko Bujanić, molecular epidemiology, wildlife, parasitology, MHC genes, GIS modellingWildlife diseases are increasingly important field of veterinary medicine, conservation medicine, and protection of human health. Of all wildlife diseases parasitic diseases participate with 75%. In this project, selection of diseases encompasses potentially fatal diseases with high economic impact, frequently present disease with mainly subclinical course, and potential zoonotic diseases. Main objectives of the project are to: 1) determine the occurrence of selected parasitic diseases of gastrointestinal and respiratory system in red deer, roe deer, wild boar and jackal, 2) determine environmental factors that contribute disease occurrence, 3) determine the epidemiology of selected parasitic disease of wildlife, 4) analyse MHC genes expression in animals with different health status, and 5) analyse obtained results with molecular epidemiology tools. This will be achieved by interdisciplinary research team (composed of veterinarians, biologists and forester) divided in four main topics: parasitology, environmental conditions and GIS modelling, MHC genes polymorphism in wildlife and epidemiology and molecular epidemiology. Other objectives of the project are to facilitate establishment of internationally competent multidisciplinary research team through research, cooperation and continuing professional development and to enhance development of molecular epidemiology in Croatia. With such comprehensive approach proposed project offers for the first time in Croatia creation of multidisciplinary team that will analyse all aspects of wildlife diseases and important environmental factors. Furthermore, molecular epidemiology will provide insights into susceptibility to disease and potential survival rate that is dependent on major histocompatibility complex variations.
1641Liječenje neuropatske boli stimulacijom spinalnog ganglijaTreating neuropathic pain with dorsal root ganglion stimulation4000Damir Sapunar IP2013-11IP-2013-11-4126NeuroMod15.12.2014 - 14.12.2019U tijeku1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine768, 4233, 4348, 4338, 4409, 4510, 4384, 4379, 4439, 4511, 4417, 4561, 4420, 3385, 6089, 6077, 17768, 21335, Adriana Banozic, Antonia Jeličić Kadić, Natalija Filipović, Sandra Kostić, Marija Heffer, Livia Puljak, Marta Balog, Senka Blažetić, Barbara Viljetić, Vedrana Ivić, Robert Blažeković, Ozana Katarina Tot, Irena Labak, Ivica Grković, Danijel Nejašmić, Damir Kovačić, Tihana Repić, Ivana Vuka, neuropathic pain, nerve injury, neuromodulation, dorsal root ganglion, ganglionic field stimulation, T-junction, microelectrode arraysNeuropathic pain is a debilitating disease of the somatosensory system that has a huge socio-economic impact. Numerous studies, including those from our laboratory have established that the injured dorsal root ganglion (DRG) is the important site for pathophysiologic changes that lead to development of neuropathic pain. Although DRG neurons are critical for the onset of neuropathic pain, there are no relevant clinical treatments for neuropathic pain that target this organ. With this proposal we aim to prove that neurostimulation techniques can be successfully used to manipulate neuronal function at the level of experimentally injured DRGs. In order to test this hypothesis we will construct a fully implantable neuronal stimulator for freely moving rats, devise an implantation technique and define stimulation protocols. This stimulator will be tested in rats with two types of experimentally induced nerve injury; spinal nerve ligation and carrageenan-induced inflammation model. Since this invasive procedure bears substantial risk of inflammation and other adverse neural tissue response, which can induce pain per se, we will also investigate connective tissue fibrosis and neuroinflammatory response in neural tissue of DRG and dorsal horn. The effect of the stimulation on excitability of injured DRG neurons will also be tested in vitro. Our last aim builds on our previous study in which we showed that neuronal injury may disable T-junction filtering and thereby increase the net conduction of afferent traffic. With this proposal we will test whether stimulation can modulate filtering properties of DRG T-junction. This will be addressed using recordings from injured sensory neurons of dorsal root ganglia excised from adult rats, and recently developed methodology that will allow us to electrically visualize action potential propagation in DRG neurons grown over custom microelectrode arrays.
1643Uokvireno ziđe - kompozitni nosivi sustav kod armirano-betonskih zgradaFrame - masonry composites for modelling and standardization3000IVICA GULJAŠ IP2013-11IP-2013-11-3013FRAmed-MAsonry01.09.2014 - 31.08.2017Završio723.830,00 KnTehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet OsijekJosip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek3693, 2730, 3637, 3000, 4956, 3178, 3560, 3043, 3049, 3699, 2971, 1408, 7253, 3063, 765, 6190, 6177, 4046, 7284, 4805, 5368, 7288, 7309, 7489, 7389, Damir Markulak, Damir Varevac, Petar Brana, IVICA GULJAŠ, MIRJANA BOŠNJAK-KLEČINA, JURKO ZOVKIĆ, Đurđica Matošević, Tanja Kalman Šipoš, Marin Grubišić, Goran Gazić, Mario Galić, Ivan Kraus, Damir Džakić, Davorin Penava, Mehmed Čaušević, Tatjana Isaković, Matej Fischinger, Veronika Shendova, Golubka Nechevska-Cvetanovska, Đorđe Lađinović, Mustafa Hrasnica, Santiago Pujol, Schwarz Jochen Bernhard Rudolf, Christoph Butenweg, Mete Sozen, r/c frames, masonry infill, behavior, safety, modelling, standardization, framed-masonryIn r-c frames infilled with masonry (framed-masonry) the infill walls stiffen the frame and reduce the first-mode period leading to a reduction in drift response to strong ground motion. At the same time, the addition of the masonry wall to the frame tends to increase the base-shear response and reduce the drift capacity of the structure. The increase of lateral force and reduction of drift capacity leads to serious vulnerabilities unless proper proportioning is exercised. For frames with competent walls, the challenge for safe and economical design is to be able to take advantage of the stiffening but to make certain that the increase in lateral forces and reduction in drift capacity do not handicap performance. Available evidence has pointed out that shear strength of the confining column is the ''Achiless's heel'' of the system. Solution of the problem requires understanding the behavior of masonry and concrete subjected to dynamic and random loading reversals, a challenge that demands testing under reasonably realistic conditions for confident analysis of the problem and its generalization.This is a proposal to investigate the safety and behavior of buildings with masonry-infilled r-c frames through near full-scale dynamic earthquake-simulation tests accompanied by supporting pseudo-dynamic tests of structural assemblies and components and by calibrated analytical solutions. The overall goal is to develop pragmatic methods, by cooperative efforts of team members and co-working international body, for design, safety evaluation and standardization. Because framed-masonry serve both architectural and structural demands efficiently, people in seismic regions live and will continue to live in buildings of this type. An organized solution of the safety of such construction is essential. This proposal intends to put the ''framed-masonry'' composite up as a full-fledged building type, it is ''transformative'' and will change design practice.
1650Stvaranje pšenice za budućnost-potraga za novim genima iz postojećih izvoraCreating wheat for the future–quest for the new genes in the old gene pool 3812Sonja Petrović UIP2013-11UIP-2013-11-2000PHENOWHEAT16.06.2014 - 15.07.2017Završio833.000,00 KnBiotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti OsijekJosip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek381, 5094, 4574, 4054, 5925, Sonja Marić, Tihomir Čupić, Andrijana Rebekić, Ivana Rukavina , Luka Drenjančević, wheat, adaptability, phenotyping, SSR, DArT, association mapping, candidate genesAround 20% of human food productions relays on wheat. Climate change evokes new demands for successful wheat breeding such as adaptability to various abiotic stress factors. The most important traits that are affected with climate changes such as drought are yield and quality. Drought tolerance in wheat is quantitative trait with very complex phenotype and genetic control. Significant number of wheat traits has different influence level on drought tolerance. Current global research trend is directed toward development of functional markers linked with wheat adaptability traits. Functional markers are derived from polymorphic sites within the gene that are directly associated with phenotypic variation. Proposed project includes total of 364 wheat accessions originated from five continents. Aims of the project are: assessment of phenotypic and molecular genetic diversity of wheat breeding germplasm; identification of existing functional markers for agronomical important traits in tested germplasm; identification of marker-trait associations; outlining the most suitable parents for future crossing and breeding programs. Project will include phenotyping of traits that are linked with wheat adaptability to drought. This project will contribute to improvement of knowledge of wheat genome research and detection of candidate genes for major marker-traits associations. Knowledge gained through this project will be helpful to better understand genetic control of wheat traits important for adaptation to climate change and drought tolerance. Project will bring out new skills to research group and to research institutions in Croatia by utilisation of DArT markers on wheat for the first time in Croatia. Project will also contribute to wheat selection – research will point out best parents for crossing and it will enable development of new wheat breeding population for further selection and research.
1651Mjerenje svojstava Higgsovog bozona i potraga za novom fizikom detektorom CMSThe Higgs boson properties measurements and search for new physics with the CMS detector4052Ivica Puljak IP2013-11IP-2013-11-7118HIGGSPRO01.10.2014 - 30.09.2018Završio927.721,72 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnjeUniversity of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture6750, 6374, 6738, 6471, 7133, 7481, 7488, 7495, 7484, 7563, 19069, 19070, Damir Lelas, Nikola Godinović, Ilja Doršner, Željko Antunović, Charlot Claude, Marko Kovač, Roberto Salerno, Ochando Christophe, Baffioni Stephanie, Sirois Yves, Pedro Miguel Ribeiro Cipriano, Toni Šćulac, CMS detector, LHC, Higgs boson, leptoquarks, electron reconstructionThe discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC has opened a new era for particle physics, namely precision consistency tests of the SM Higgs boson. The proposed project has two main goals: measurement of the SM Higgs boson properties, as the window for the search for new physics beyond the Standard model, and a direct search for new physical phenomena looking for hypothetical particles called leptoquarks. In the first year of project we will explore the data collected by the CMS experiment during 2011 and 2012, while preparing for the LHC Run II, which is expected to start in 2015. Preparation consists of developing and implementing new electron reconstruction, identification and isolation algorithms, which will be used by the whole collaboration when the new data taking starts. During the second year of the project we will commission and maintain electron reconstruction algorithms, start collecting the data and make first analysis at new energy. During third and fourth year we will explore the data and concentrate to the two main goals of the project: SM Higgs boson properties measurements and search for new physics.
1667Poluvodičke kvantne strukture za napredne sklopoveQuantum semiconductor structures for the next generation devices627Branko Pivac IP2013-11IP-2013-11-6135QD STRUCTURES01.06.2014 - 31.05.2018Završio665.067,42 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb2639, 1240, 1241, 2934, Pavo Dubček, Goran Kovačević, Robert Slunjski, Jasna Dasović, nanoscience, quantum dots, percolation conductivity, tunneling, photoluminescence, scanning probe microscopy, small angle x-ray scattering, modeling,The fundamental properties of matter are drastically changed due to quantum effects in nanoscopically confined particles. It presents the essence of nanoscience and hence is a cornerstone for the production of advanced materials and devices. The scope of this project is to explore semiconductor nanoparticles in 0-dim, so called quantum dots (QDs), which are the building blocks for advanced materials. We shall study QDs made of different semiconductors embedded in various dielectric materials. The main intention is to explore many of basic physical properties of such systems which are not clear yet and hence prevent their successful development and application. The several key issues that we shall explore are: a) the process of nucleation and growth of QDs, their self-assembly and self-organization. We shall study experimentally and theoretically nucleation growth and crystallinity of different QDs in various dielectrics, and possibility of superstructures formation. Once formed QDs present several serious challenges. The interface QD/dielectric and/or the structure of dielectric layers close to QDs as well as its impact on optical and electrical properties is still completely obscured. In this respect we shall study radiative and nonradiative recombinations of carriers in this region by PL and TRPL. A special effort will be given to theoretical modelling of interfaces, defect formation on such interfaces modeled with molecular dynamics and attempts to describe the transport properties with such modelling. Finally, electronic properties of such composite material will be explored by transport measurements and compared to several simulation models. Several models of unbiased and biased percolation will be explored and applied to this problem. Finally, formation of metal nanoparticles and their plasmonic effect will be explored and analyzed as a special approach to the light management.
1669Matematičko modeliranje i numeričke simulacije procesa u tankim i poroznim sredinamaMathematical modeling and numerical simulations of processes in thin or porous domains1462Eduard Marušić-Paloka IP2013-11IP-2013-11-3955MaSiMo01.07.2014 - 30.06.2018Završio519.853,72 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science3164, 3683, 3254, 3179, 817, 3663, 3424, 5900, Mladen Jurak, Josipa Pina Milišić, Ana Žgaljić Keko, Anja Vrbaški, Igor Pažanin, Maja Starčević, Andrijana Ćurković, Marija Prša, Mathematical modelling,Asymptotic analysis,Numerical simulations,Fluid flow,Homogenization, Boundary layer,Lubrication,Complex fluids,Porous mediumWe frequently deal with systems described by the differential equations coming from conservation laws that are too complicated to be solved and are of limited use in practice. In many such situations the original physical laws can be replaced by empirical laws or other approximations derived on engineering level of rigor. Mathematical point of view requires justification of those models to see their validity, applicability and accuracy. That can be achieved theoretically by investigating the deviation from the original model, or numerically by comparing simulations with experimental data. Each approach, has its advantages and disadvantages and are, frequently, complementary. In the frame of MaSiMo project we will consider fluid flow through thin domains like pipes and fractures, as well as low permeability domains as porous media.The fluids are either Newtonian or micropolar, monophase or multiphase. Physical processes in those fluids are convective, diffusive, dispersive or conductive, isothermal or nonisothermal. Theoretical analysis is based on a priori estimates for governing differential equations, different notions of convergence and compactness. In particular asymptotic analysis and homogenization will be used. For derivation of a priori estimates a powerful tool is the entropy dissipation method that is considered in this project in the context of nonlinear diffusion and population dynamics problems with a perspective of extension to other considered models. Proposed research is connected to many engineering disciplines, such as mechanical and petroleum engineering, hydrogeology etc. Expected results could improve engineering practice. In Croatian mathematical community there is a significant research in this field with several trained scientists. However, they are dispersed in smaller groups. One of the aims of this project is formation of larger research group with focused scientific interests more competitive in a search for European grants.
1672Općeslavenski lingvistički atlas (OLA) i Europski lingvistički atlas (ALE)General Slavic Linguistic Atlas (OLA) and European Linguistic Atlas (ALE)18899Ranko Matasović IP2013-11IP-2013-11-8706OLAALE01.09.2014 - 31.10.2018Završio549.000,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences751, 3723, 818, 787, 3726, 2596, 886, 869, 933, 3624, 2984, 3755, 2997, 3415, 3473, 3583, 3659, 5981, 5988, 6131, 5593, 17864, Mira Menac-Mihalić, Dunja Brozović Rončević, Anđela Frančić, Anita Celinić, Tijmen Pronk, Silvana Vranić, Boris Kuzmić, Mijo Lončarić, Vesna Zečević, Sonja Wölke, Martina Ireinová, Jadwiga Waniakowa, Walentina Rusak, Pavlo Hrytsenko, Gabriela Núcsková, Petra Pradkova, Jana Villnow Komárková, Goran Filipi, Carmen Kenda-Jež, Dubravka Ivšić, Jožica Škofic, Ivana Štokov, dialectology, linguistic atlas, linguistic maps, slavic languages, european languagesThe “General Slavic Linguistic Atlas” (OLA) and the “European Linguistic Atlas” (ALE) are long-term international linguistic projects. The OLA project involved research material derived from a special survey carried out in 853 settlements, the result of which was an extremely rich dialectological registry. The material collected does not confirm the traditional view of the disintegration of the Proto-Slavic language, instead showing that the disintegration process of the Slavic whole was much more complex. This is seen in isoglosses that cut Slavic territory into the most highly differing directions. This is proof that particular Slavic groups in various historical periods found themselves in complex relationships amongst themselves and that were constantly changing for economic, political, or cultural reasons. Linguistic material for ALE was collected using a special survey carried out in a majority of European countries, including 15 Croatian survey points. The project also involves the etymological and onomasiological interpretation of linguistic material from all European survey points.This project of linguistic atlases provides world dialectology with organised data on the phonetic, phonological, morphological and lexical systems of a large number of languages and dialects, and enables the well-founded study of the linguistic development of European languages. Croatian material is presented and interpreted, and the linguistic relationships between data from the dialects researched is confirmed. Conclusions are drawn on the history and development of languages, on the relationships between them, and thus on the relationships of the Croatian language towards neighbouring and distant dialects. This will provide material for comparative genetic and typological research of linguistic systems in the Slavic and non-Slavic world. These synchronic and diachronic relationships will be presented in the OLA and ALE books and atlases in the form of maps and commentary.
1673Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 DalmatinacPleitropy, gene networks and gene pathways in isolated human populations: the 10,001 Dalmatians biobank4228Ozren Polašek IP2013-11IP-2013-11-887510,001 Dalmatians01.07.2014 - 30.06.2018Završio961.400,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesJavno zdravstvo i zdravstvena zaštita, Public health and health services, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine5317, 5251, 5405, 5407, 5323, 1358, 19117, 17833, Inga Patarčić, Ana Miljković, Mirna Kirin, Igor Rudan, Mirela Stipetić, Ivana Kolčić, Ajka Relja, Andrea Gelemanović, Genomics, anthropometrics, 3 dimensional, exome, analysisThis project will investigate how pleitropy (the effect of one gene on multiple phenotypic traits), gene networks and gene pathways are determining a number of clinically relevant quantitative traits. Primary research focus is on the genetic basis of body shape and facial features, based on an innovative approach to produce large number of measurements from the 3-dimensional body and face scanning. In order to achieve this aim, we will perform 3D scanning of 2,000 healthy subjects from the island of Korcula, within one of the largest biomedical research resources in Croatia – the 10,001 Dalmatians biobank. Besides excellent genotyping and sequencing opportunities, the inclusion of subjects from the isolated island populations facilitates gene discovery and enables the search for the rare genetic variants. After completion of genome-wide association and exome analysis, we will also use gene networking and pathway analysis tools, as well as the advanced analytic tools, such as random forest, lasso regression and partial least squares regression in order to produce results that can be translated to clinical medicine, fitness and beauty, as well as legal medicine and forensics. Progress over the existing research designs will also be achieved by inclusion of extensive confounding information and family structure into analysis. All these findings will also be investigated in follow-up measurements and linked with the morbidity and mortality information in the future, thus further developing a coherent resource capable of producing highly competitive research results. With the excellent track record of the principal investigator, outstanding institutional support and well-established research team experienced in computational genomics and field work, this project will provide a substantial step forward over the existing state-of-the-art studies that rely on simple genomic associations, yet manage to publish their results in the top-end journals.
1674Starosno-ovisna ekspresija membranskih prijenosnika u štakoraAging-related expression of membrane transporters in rat179Davorka Breljak IP2013-11IP-2013-11-1481AGEMETAR01.10.2014 - 31.03.2019Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut za medicinska istraživanja i medicinu radaInstitute for Medical Research and Occupational Health179, 200, 228, 226, 951, 221, 128, 216, 201, 343, 1099, 87, 171, 1396, 19039, 126, Davorka Breljak, Marija Ljubojević, Carol Mirna Herak-Kramberger, Ivana Vrhovac, Dean Karaica, Vedran Micek, Jasna Jurasović, Tatjana Orct, Maja Peraica, Dubravka Rašić, Ivana Novak Jovanović, Goran Gajski, Marko Gerić, Ivica Rubelj, Lucia Nanić, Ivan Sabolić, aging, antioxidants, drug transporters, hepatotoxicity, liver, kidney, Klotho, membrane transporters, nephrotoxicity, oxidative stress, telomeres Aging is a physiological process characterized by a gradual decline in physical fitness and other functional capabilities. The mechanisms of aging and possible actions of slowing down or ameliorating aging-related processes are poorly understood. In humans, one of the characteristics of old age is polypharmacy, which elevates risks of drug-drug interactions and drug-induced adverse reactions and organ toxicity, such as hepatotoxicity and nephrotoxicity. These reactions may partially result from diminished drug metabolism and/or mainly from impaired activity/expression of various membrane transporters that are responsible for drug excretion in liver and kidneys. These both mechanisms have been poorly studied in senescent organs. Here we promote a hypothesis that the aging-induced oxidative stress, known to downregulate the activity/expression of the aging suppressor gene (Klotho) and to shorten the length of telomeres, also diminishes the activity/expression of various membrane transporters in liver and kidneys, and that these changes can be ameliorated by treating animals with antioxidants resveratrol and melatonin. The extent and the intensity of aging-related changes, and the beneficial effects of antioxidants may be sex-related. To test this hypothesis, we propose various biochemical and cell- and molecular-biological studies of aging parameters and aging-dependent expression of various membrane transporters in the mammalian liver and kidneys using a rat model of experimental aging. Possible aging-related decline in the expression of these transporters may explain a higher incidence (women > man) of drug interactions and toxicity in old people. The studies will define the underlying cellular mechanisms that contribute to generation of the aging-related pathophysiological conditions in the liver and kidneys, and will indicate possible ways of their amelioration. Positive results may point to remedies to be used for improving the health of elderly people.
1680Ekološki pristup projektiranju broda i optimalnom planiranju ruteGreener Approach to Ship Design and Optimal Route Planning4256Jasna Prpić-Oršić IP2013-11IP-2013-11-8722GASDORP20.07.2014 - 19.07.2018Završio994.000,00 KnTehničke znanostiTechnological sciencesBrodogradnja, Naval architecture, Sveučilište u Rijeci, Tehnički fakultetUniversity of Rijeka, Faculty of Engineering4179, 3868, 2951, 4580, 4658, 4890, 5599, 5931, 5403, 6911, 19041, Duško Pavletić, Tomislav Mrakovčić, Marko Valčić, Roko Dejhalla, Dunja Matulja, Odd Magnus Faltinsen, Ozren Bukovac, Nikola Račić, Igor Rudan, Vladimir Medica, Natalija Vitali, seakeeping, ship speed, ship resistance, ship propulsion, fuel consumption, GHG emission, weather routingThe accurate calculation of attainable ship speed at actual sea is essential from economical and also environmental aspects. Reliable ship speed loss estimation under real environmental conditions allows a more accurate prediction of the power increase and fuel consumption as well as gas emissions from ships. Nowadays this second issue becomes very important because of the problem of global warming. Following the increasing awareness of the environmental and human health concerns of shipping, legislative actions have been taken on global and national levels making mandatory (from January 1st 2013) that new ships over 400 gross tonnage, to comply with the regulations, should have emissions of CO2 under limiting value. Technological enhancement to ships like improved hull designs as well as improvement in power and propulsion systems could potentially reduce CO2 emission up to 35 %. These measures could effectively be combined with several other operational measures, such as weather routing and voyage planning, in order to ensure that fuel consumption and CO2 emissions from ships are minimized on every voyage.The proposed research will be conducted in three main areas: 1. Improvement of the methodology of ship speed, fuel consumption and greenhouse gases (GHG) emissions (especially CO2) calculation on actual weather conditions, 2. Optimization of the ship hull (bow and stern) and ship propulsion system operating in actual weather condition, 3. Optimization of ship route by taking into account all relevant parameters: weather prediction, attainable ship speed on waves, main engine performance and navigation constrains. The objective is to improve ship design and performance taking into accounts the environmental issue, creating a so called eco-efficient or “green” ship design. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering and marine engineering field which allow solving this problem multidisciplinary.
1682Genetska osnova količne bioaktivnih hranivih tvari hrvatskih populacija grahaGenetic basis of bioactive nutrient content in Croatian common bean landraces1294Klaudija Carović-Stanko UIP2013-11UIP-2013-11-3290BeanQual16.06.2014 - 15.06.2017Završio916.756,04 KnBiotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture770, 6287, 3338, 4953, 5513, 5829, 4927, 4954, 3037, 17838, 12601, Zlatko Liber, Jerko Gunjača, Mirjana Herak Ćustić, Marko Petek, Martina Grdiša, Ivan Radosavljević, Tomislav Karažija, Boris Lazarević, Igor Palčić, Monika Vidak, Ana Barešić, Phaseolus vulgaris L., nutrients, bioactive substances, molecular markers, genetic diversity, association mappingCommon bean is a valuable legume for human consumption worldwide, being an important source of proteins, vitamins and minerals with considerable potential as a functional food. However, the increased mineral content in the diet does not guarantee increased mineral status for consumers and consequently mineral malnutrition is one of the global health concerns. Phytic acid (PA) acts as antinutritive compound by binding mineral cations and forming mixed salts. PA is also the main storage molecule for phosphorus and it is essential for normal seed development and germination. Seed mineral and PA content varies widely among bean genotypes. In Croatia bean is traditionally grown in low input production systems. The production is based on landraces which are adapted to local environments and display high levels of morphological diversity. A broad variability is also expected in seed bioactive nutrient content as well as on genetic level. Through international collaboration on Phaseolus genomics, a lot of information has become available including genetic linkage maps, microsatellite databases and a massive number of single nucleotide polymorphisms (SNP) sequences. In proposed project an integrated approach will be used to characterize bioactive nutrient variability and the inherent genetic diversity. In conjunction with a detailed data on bioactive nutrient content, a whole genome association mapping analysis will be carried out in order to identify quantitative trait loci (QTLs) related to bioactive nutrient content. Success in bean breeding for higher quality relies on the availability of information on bioactive nutrient content and the knowledge of genetic bases of quality trait variability. The integration of fundamental (molecular genetics) and applied (plant nutrition, plant breeding) sciences will facilitate the management of traditional landraces as sources of bioactive nutrients in future breeding programs based on marker-assisted selection (MAS).
1683Rekonstrukcija okoliša u Hrvatskoj tijekom kvartara primjenom izotopnih metodaReconstruction of the Quaternary environment in Croatia using isotope methods1168Ines KRAJCAR BRONIĆ IP2013-11IP-2013-11-1623REQUENCRIM01.09.2014 - 30.11.2018Završio999.647,77 KnPrirodne znanostiNatural sciencesGeologija, Geology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb353, 3702, 3367, 1159, 1343, 1413, 3789, 1324, 3115, 3097, 4142, Nada Horvatinčić, Tatjana Bakran-Petricioli, Sanja Faivre, Jadranka Barešić, Maša Surić, Neven Bočić, Andreja Sironić, Robert Lončarić, Nenad Buzjak, Nina Lončar, Iva Babić, paleoclimate, paleoenvironment, Quaternary, speleothem, algal rim, tufa, lake sediment, stable isotopes, 14C dating, U-Th series datingInterdisciplinary scientific study of paleoclimate and paleoenvironment is of the great importance for prediction of future climate and environmental changes. Croatia occupies a key position between eastern and western Mediterranean basins and delimits central European and the Mediterranean regions influenced by different climates. Dinaric karst, covering half of the Croatian territory, offers exquisite potential for such a research, having the wide range of karstic forms already proven as good (paleo)environmental archives, such as terrestrial and submerged speleothems, tufa deposits and lake sediments in karstic lakes and marine algal rims in the coastal area. Within this research various carbonate sediments from different climate zones will be studied: speleothems from 3 locations in littoral Croatia, mountainous Gorski Kotar region and central Croatia, lake sediments from Plitvice Lakes, tufa deposits from Zrmanja River, and marine algal rims from ~8 locations along the eastern Adriatic coast. Research will be based on isotopic methods that include analyses of stable isotope ratios 13C/12C and 18O/16O in carbonate deposits, 2H/1H and 18O/16O in water, and radioactive isotopes 14C and U-Th series for dating. Stable isotopes in carbonates will provide information about past environmental conditions, temperature variations, lake evaporation, bioactivity and productivity, and indicate the origin of carbon and mechanisms of calcite precipitation. Algal rims serve as good and precise sea-level indicators and additionally their morphology, age and stable isotope composition could be directly linked to climate changes.The expected outcome is the estimation of regional response of the environment in Croatia to global changes during the Quaternary, and of differences in response of various carbonates to paleoenvironmental changes and their correlations.The project combines groups from Ruđer Bošković Institute, Faculty of Science (Univ. of Zagreb), and University of Zadar.
1687Zaštita privatnosti deidentifikacijom u nadzornim sustavima De-identification for Privacy Protection in Surveillance Systems 4290Slobodan Ribarić IP2013-11IP-2013-11-6733DePPSS01.10.2014 - 30.09.2018Završio615.069,00 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing4684, 4689, 4593, 4595, 20381, 20383, 4584, Ivan Fratric, Branko Samaržija, Marijo Maračić, Markan Lopar, Vitomir Štruc, Darko Mihalić, Darijan Marčetić, privacy protection, biometric identification, de-identification, surveillance systems, video Owing to advances of video surveillance systems it is possible, besides detection of people's behavioural anomalies, by using of reliable recognition software to perform identification and simultaneously trace people in the real time. Whilst it is recognized that there are justified reasons for acquisition and sharing videos in manners such as security, bio-terrorism surveillance applications, low enforcement and forensics, there is also a strong need for protecting the privacy of the guiltless individuals who are inevitably captured in the recordings. Video surveillance is privacy intrusive because it allows the observation of certain information that is considered privacy intrusive. Face has central role in the process of human recognition and identification in videos, thus the special attention has to be devoted to the face de-identification methods for privacy protection. De-identification addresses, in context of our project, the automated methods of concealing or/and removing face identifiers of individuals captured in videos. The importance of privacy protection is mirrored in documents such as UN Universal Declaration of Human Rights, and EU’s Data Protection Directive (95/46/EC) as well as commissioned review of the Data Protection Directive (95/46/EC) by the EU Information Commissioner’s Office from July 2008. The general public has become increasingly aware of the potential danger for their personal data to be abused.Beside scientific objectives and goals (robust face localization, novel methods for face de-identification in videos, preserving data utility and naturalness in de-identification videos, privacy protection), the main objectives of the proposed project are human resources (early stage researchers and PhD students) development by transfer of knowledge in the fields of advanced technologies to carry out problem-oriented research, and increasing a competitiveness level of the research team for Horizon 2020 project applications.
1690Klasifikacija i objašnjenja antisocijalnog poremećaja osobnosti i moralna i kaznena odgovornost u kontekstu Hrvatskog zakona o mentalnom zdravlju i skrbiClassification and explanations of antisocial personality disorders and moral and criminal liability within the context of Croatian mental health law and care4121Luca Malatesti IP2013-11IP-2013-11-8071CEASCRO01.09.2014 - 31.08.2018Završio318.200,00 KnHumanističke znanostiHumanitiesFilozofija, Philosophy, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences2985, 4704, 4172, 3788, 4815, 6425, 7394, 7077, 4401, 2875, 22814, Vesna Šendula Jengić, Predrag Šustar, Marko Jurjako, Zdenka Brzović, John McMillan, Filip Čeč, Mariastella Pulvirenti, Vanni D'Alessio, Jelena Hodak, Dalida Rittossa, Karge Heike, antisocial personality disorders, psychiatric classification, psychiatric explanation, moral responsibility, Croatian mental health law and careThis interdisciplinary project investigates the problem of the social response in Croatia to a class of offenders classified as having antisocial personality disorders. The core methodology consists in conducting philosophical investigations that are aimed at offering practical recommendations and that are constrained by knowledge of the practical setting of Croatian mental health law and care. Two central philosophical issues appear to be relevant to the philosophical investigation and, thus, addressing them is the aim of the project. First, a significant part of the contemporary debate on the social response to antisocial personality disorder centers on this notion. Some have argued that this notion involves normative preconceptions against the liberties of certain individuals. Others have questioned the accuracy and scientific robustness of the diagnosis of antisocial personality disorders and its precision of related risk predictions. Second, the justification for choosing the appropriate treatment for people with antisocial personality disorder must also be a moral one. In particular, a relevant type of moral justification has to be grounded in principles that correlate psychological descriptions and explanations of a person’s behavior with his or her degree of responsibility. Similarly, compulsory treatment appears to be conditional upon a person’s diminished responsibility or capacity to act accordingly to a treatment decision, together with the existence of a risk to themselves or to others.The philosophical investigation of the project will be integrated with the contributions of a leading forensic psychiatrist in Croatia, a sociological qualitative analysis of the practices and challenges that are encountered by institutional representatives in the forensic department of the Rab psychiatric hospital and an historical investigation of the institutional response to antisocial personality disorder in the region in the period 1918-1980.
1697Održiva proizvodnja bioetanola i biokemikalija iz otpadnih poljoprivrednih lignoceluloznih sirovinaSustainable production of bioethanol and biochemicals from agricultural waste lignocellulosic raw materials 4332Božidar Šantek IP2013-11IP-2013-11-9158SPECH-LRM01.09.2014 - 31.08.2018Završio960.000,00 KnBiotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology5761, 5778, 5039, 4314, 3709, 4912, 6032, 450, 4102, 4098, 4100, 4321, 4324, 5414, 4450, 4544, 4437, 4438, 4430, 17840, 23620, Predrag Horvat, Srđan Novak, Vesna Zechner-Krpan, Anita Slavica, Vlatka Petravić Tominac, Sunčica Beluhan, Mirela Ivančić Šantek, Tonči Rezić, Mladen Pavlečić, Antonija Trontel, Mario Novak, Ivan-Krešimir Svetec, Anamarija Štafa, Marina Miklenić, Bojan Žunar, Draženka Komes, Ana Belščak-Cvitanović, Aleksandra Vojvodić, Arijana Bušić, Martina Andlar, Nenad Marđetko, bioetahnol, lactic acid, physiological active oligosaccharides, lignocellulosic raw materials, integrated bioprocess, mathematical modeling, LCAThe aim of this project proposal is the development of sustainable bioprocesses for the production of bioethanol and biochemicals [lactic acid (LA) and physiologically active oligosaccharides (PAO)] from agricultural waste lignocellulosic raw materials (e.g. wheat straw, corn stover and cob, onion peels, cocoa husks, pea pods, walnut shells and sugar beet pulp). All these agricultural byproducts are abundant, cheap, non-food competing and renewable polysaccharide-based feedstocks. In this project, agricultural waste lignocellulosic raw materials will be hydrolyzed by thermal, chemical or enzymatic methods or their combinations in order to obtain adequate disintegration of raw materials. Studies of bioethanol and LA production will be performed by the semi-solid or solid state fermentation in the new constructed horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for bioetahnol and LA production will be identified and improved by genetic methods. Studies regarding suitable purification methods for all three bio-products will be performed in order to obtain pure compounds for theirs further practical use. Integration between production and separation bioprocess stages will be also examined in order to improve ecological and economical aspects of these bioprocesses. The sustainability of bioethanol and LA production will be evaluated through the realization of Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be determined and consequently scale-up procedure will be proposed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for the transformation of agricultural waste lignocellulosic raw materials into high added value products.
1699Klima jadranske regije u njenom globalnom kontekstuClimate of the Adriatic REgion in its global context3375Mirko Orlić IP2013-11IP-2013-11-2831CARE01.07.2014 - 30.06.2018Završio876.200,00 KnPrirodne znanostiNatural sciencesGeofizika, Geophysics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science4069, 2552, 2840, 1265, 2650, 1315, 2898, 1417, 2655, 2635, 1121, 3146, 2839, Čedomir Branković, Ksenija Cindrić, Marjana Gajić-Čapka, Ivan Güttler, Ivana Herceg Bulić, Iva Međugorac, Miroslava Pasarić, Zoran Pasarić, Mirta Patarčić, Melita Perčec Tadić, Renata Sokol Jurković, Lidija Srnec, Ksenija Zaninović, Adriatic, climate change, extremes, climate models, downscaling, spatial interpolation, sea-level trend, coastal flooding, sea-level projectionsTemporal and spatial statistical analysis of climatological variables will be performed, with the emphasis on the multidecadal changes in temperature and precipitation indices of extremes in the Adriatic region. Particular attention will be paid to the analysis of drought, floods and heat waves. Possible change in climate suitability for tourism will be investigated. The obtained gridded fields will become a reference data for the validation of climate models and an input into the flash-flood warning systems. Current and future climate of the Mediterranean area will be examined by analyzing the results of global-model simulations and by using the statistical and dynamical downscaling approach. Simulations by RegCM4.2 regional climate model will be performed at the horizontal resolution of 12.5 km. Also planned is to utilize results from experiments based on coupled atmosphere-ocean models from the currently running Med-CORDEX project with a purpose of analyzing the contribution of oceanic component in the simulations over the Adriatic Sea and the surrounding land area. Trends and interdecadal variability of sea level in the Mediterranean sub-basins will be identified and contributions of the governing processes will be assessed. Coastal flooding in the Northern Adriatic and time evolution in occurrence of extreme sea levels in the context of mean-sea-level rise will be considered. Finally, older variants of semi-empirical method of projecting global sea level will be compared with the more general method recently developed. It is expected that the project thus considered will meet the three important criteria (relevance, reliability, feasibility), by addressing one of the few priorities put forward by the European Union in its growth strategy Europe 2020, by relying on the state-of-the-art methods of data analysis and modeling, and by involving a majority of researchers engaged in the study of climate-related physical processes in Croatia.
1703Jako korelirani elektroni u slojnim organskim materijalima i manganitima: niskofrekventna pobuđenja i nelinearna dinamikaStrongly Correlated Electrons in Layered Organics and Manganites: Low Frequency Excitations and Non-linear Dynamics2680Silvia Tomić IP2013-11IP-2013-11-1011SCEinLOM01.06.2014 - 31.07.2018Završio966.804,25 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut za fizikuInstitute of Physics in Zagreb1433, 2708, 2752, 3073, 3184, 2842, 3352, 17776, 21185, Amir Hamzić, Mario Basletić, Emil Tafra, Bojana Hamzić, Tomislav Ivek, Matija Čulo, Marko Pinterić, Branimir Mihaljević, David Rivas Góngra, correlated electrons, unconventional superconductivity, colossal magnetoresistance, charge and spin orderings, quantum spin liquids, nonlinear effectsStrongly correlated electrons in solids generate broken symmetry phases and collective excitations that are fundamental to our understanding of the most intriguing properties of quantum matter. Phase diagrams of layered cuprate, organic superconductors and manganites, as well as some other transition-metal systems, famous for the phenomena of unconventional superconductivity (SC) and colossal magnetoresistance (CMR), respectively feature an extraordinary complexity of electronic phases, which can be tuned by chemical composition, magnetic field and pressure. A prominent place among these phases is held by stripes, patterns of charge order (CO), which are thought to be linked to SC and CMR, as well as by CO phases with ferroelectric signatures due to a rich variety of nonlinear properties and complex dynamics. Despite intense research efforts, these basic issues in condensed matter physics bear many open questions. We propose to investigate the nature of charge/spin-ordered phases and their motion developed in series of organic and transition metal solids applying modern experimental tools available at the Institute of Physics, Zagreb and at the Department of Physics, Faculty of Science, University of Zagreb (dielectric spectroscopy, pulsed nonlinear conductivity, ac/dc resistance, magnetoresistance and Hall effect). Our overall contributions to the field and our expertise in condensed matter physics have been internationally recognized. Together with the available experimental means, this positions us as researchers fully suitable and competent for the proposed task. Our international partners will give an added value with samples, experiments and expertise in the terahertz and infrared spectroscopy. Integrated students and postdocs are going to acquire advanced skills in the materials science and learn to solve complex problems in a collaborative environment. Results will be published in international scientific journals and presented at international conferences.
1706Kruženje sumpora i ugljika u morskom i slatkovodnom okolišuThe Sulphur and Carbon Dynamics in the Sea- and Fresh-Water Environment287Irena Ciglenečki-Jušić IP2013-11IP-2013-11-1205SPHERE01.09.2014 - 31.08.2018Završio971.354,41 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb561, 989, 454, 290, 278, 1155, 84, 17873, Elvira Bura-Nakić, Nevenka Mikac, Palma Orlović-Leko, Marija Marguš, Milan Čanković, Jelena Dautović, sanja frka milosavljević, Ana Cvitešić, sulphur speciation, organic matter properties, nanoparticles in water environment, aerosols, global climate changes, extreme events, euxinia The SPHERE aims to study sulphur (S) and carbon (C) dynamics between different environmental compartments (atmosphere, water, sediment, biota) of the sea- and fresh-water environment including distribution between organic, inorganic, dissolved, colloidal and nanoparticulate fractions. S and C cycles in the aqueous environment are recognized as important factors for regulating global climate. Nowadays, human activities have vastly affected the S and C cycles. The aquatic ecosystem responses to likely changes in physical, chemical and socio-economic forcing induced by global climate changes, including warming, acidification, biodiversity modifications as well changes in frequency of extreme events (flooding, dust input, hypoxia-anoxia appearance) and by growing anthropogenic pressures will be considered under SPHERE. Effects of the main natural and anthropogenic forcing (extreme events, eutrophication, global changes) related with S and C dynamics will be studied.The SPHERE objectives are: 1) testing and improving existing methods and development of new methods essential for S and organic matter (OM) characterization in water and atmospheric environment; 2) to estimate exchanges and interactions of S and C with other natural and potentially toxic trace elements within and between the major environmental compartments; 3) to monitor and couple S and C dynamics under extreme events (stratification-destratification, hypoxia-anoxia, extreme atmospheric inputs); 4) to synthesize all obtained data for assessment of ecosystem vulnerability and ecological status, in line with water framework directive and national strategy. The SPHERE will be implemented in the period of 4 years through 5 workpackages: 1) OM properties and dynamics; 2) S speciation and dynamic; 3) S, C interaction with trace metals and importance of chalcogenide nanoparticles; 4) thermodynamic predictions for S and C distribution and dynamics; 5) project management.
1715Primjena matematičkog modeliranja i inteligentnih algoritama pri konstrukciji odjećeApplication of mathematical modelling and intelligent algorithms in clothing construction42Tomislav Rolich IP2013-11IP-2013-11-3011AMMIACC01.10.2014 - 30.09.2018Završio412.900,00 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Tekstilno-tehnološki fakultetUniversity of Zagreb, Faculty of Textile Technology4302, 1095, 296, 5086, 7420, 4325, Slavica Bogović, Daniel Domović, Darko Grundler, Jacqueline Domjanic, Zoran Stjepanovič, Slavenka Petrak, intelligent algorithms, mathematical modelling, packaging, optimization, automatic marker-making, clothing construction, geometric morphometryIn the project it is intended to develop new computer programs based on mathematical modelling and intelligent algorithms. Scope of computer programs is an area of clothing construction, and therefore data from measurements and scanning using 3D body scanners will be collected. For the analysis of digitized data of human body, data acquisition of static and dynamic anthropometry will be collected and then processed with geometric morphometry and PCA methods. In that way data of shapes and sizes that cannot be acquired with the usual methods of measurement and data processing will be obtained. Based on these data new methods of construction will be developed, for which the most applicable methods of mathematical modelling will be defined. Intelligent algorithms will be used for solving problems related to the automatic marker making, where solutions to specific problems and conditions that must be met for that purpose will be found.Using distinctive interdisciplinary approach computer programs will be developed for the purpose of construction of specific garment that is not common in our market such as overalls for professional sports, diving suits or clothes that is used for medical purposes (compression garments, etc.), and protective clothing. The development of software applications will be based on scientific knowledge, and it also can have its practical application in the manufacture of clothing. In cooperation with industry, garments could be developed that are not in everyday use and for which there is a need in the domestic and foreign markets.
1716Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekulaNon-covalent interactions in design of novel photosensitive molecules 243Davor Margetić IP2013-11IP-2013-11-9310NoncoPhoto01.09.2014 - 31.08.2018Završio925.713,41 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb3939, 368, 3569, 4851, 566, 5193, 963, 17759, Vjekoslav Štrukil, Zoran Glasovac, Pavle Trošelj, Anamarija Briš, Ivana Antol, Iva Jušinski, Tomislav Portada, Mateja Đud, physical-organic chemistry, green chemistry, synthesis, computational chemistry, organic materialsProject addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and physico-chemical characterisation of molecules.The aim of project is to study fundamental physico-chemical properties of supramolecular systems built by non-covalent interactions (NC) - hydrogen bonding and metal-ligand coordination. The objectives are: a) Synthesis and structural characterization of functionalized bis-chromophoric molecular systems possessing guanidine, (thio)urea and carboxylate functionalities by employment of novel environmentally friendly synthetic methods; b) Detailed insight into the fundamental mechanisms how NC bonds mediate excited energy-transfer processes from one chromophore to another within assemblies; c) Analysis of influence of guanidine and (thio)urea functionalities and their anion complexation on the spectroscopic properties; d) Study of novel assemblies based on NC interactions and influence of different media; e) Development of model heterogeneous photo-responsive catalysis materials; f) Construction of complex multichromophoric supramolecular assemblies.Results of fundamental studies carried out within this project will enrich the understanding of physico-chemical factors in electron transfer processes in supramolecular systems constructed of chromophoric pairs employing the non-covalent bonding. Expected results will enable design of novel photoactive systems which could be applied in the technological development including sensors, fluorescent probes in biomedicine, organic photovoltaics, molecular electronics and heterogeneous catalysis.
1718Nuklearna struktura i reakcije: eksperimentima prema neutronskoj liniji kapanjaNuclear structure and reactions – experiments towards the neutron drip line 166Suzana Szilner IP2013-11IP-2013-11-7194SR-ETNo01.09.2014 - 31.10.2018Završio954.252,76 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb193, 257, 4019, 188, 414, 186, 185, 255, 155, 163, 24613, Deša Jelavić Malenica, Tea Mijatović, Matko Milin, Lovro Prepolec, Neven Soić, Vedrana Tokić, Milivoj Uroić, Mile Zadro, Zoran Basrak, Igor Gašparić, Romana Popočovski, nuclear structure, nuclear reactions, neutron-rich nuclei, nucleon-nucleon correlations, nuclear pairing, nuclear clusteringUnderstanding of atomic nuclei relies on knowledge about interaction between their components and details of their relationship. Recent advent of detector arrays allows systematic studies of nuclei away from the region of nuclear stability. With the proper selection of colliding systems and reaction energies, the exchange of nucleons can lead to the population of neutron-rich nuclei, peculiar systems having challenging aspects in their nuclear structure behaviour. The main objective of this research project is to advance understanding of the nuclear reactions and structure in the vicinity of the neutron drip line. By the use of the new generation instrumentation, we will experimentally study three different neutron-rich groups of nuclei: very heavy nuclei (difficult to access experimentally with other methods), medium-mass nuclei (where well known magic numbers disappear), and finally, lower mass nuclei (were the neutron drip line has already been experimentally reached). The major part of the proposed experimental work will be performed at the top international accelerator facilities, but in the well suited cases, the measurements will be performed at the RBI accelerator. The new experimental data will significantly improve our understanding of nuclei far from the stability line and will have a considerable impact on the reaction measurements at next generation of the radioactive beam facilities. Scientists involved in this project are active members of a number of leading international collaborations in the field, with large experience in experimental research and considerable international reputation. Project PI has remarkable research track record and has led a successful project before. Senior scientists on the project have led a number of competitive projects (funded by MSES, FP7, ESF and Croatian SF). Finally, this project is well integrated with the strategic community document Long Range Plan of the Nuclear Physics European Collaboration Committee.
1721Poslovna i osobna insolventnost - putevi izlaska iz prezaduženostiBusiness and Personal Insolvency - the Ways to Overcome Excessive Indebtedness4238Mira Dimitrić IP2013-11IP-2013-11-6558BPII01.07.2014 - 30.06.2018Završio298.190,00 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Rijeci, Ekonomski fakultetUniversity of Rijeka, Faculty of Economics4370, 6745, 5495, 5884, 2915, 5117, 5618, 5867, 6706, 5536, 17867, Ivana Tomas Žiković, Dunja Škalamera-Alilović, Andrea Arbula Blecich, Tomislav Ćorić, Saša Žiković, Dejan Bodul, Branka Crnković-Stumpf, Predrag Bejaković, Jana Katunar, Nikolina Dukić, Sonja Brlečić Valčić, Business Insolvency, Personal Insolvency, Indebtedness, Bankruptcy Law, RestructuringProject proposal targets the vital problem of contemporary economic reality and science: insolvency and excessive indebtedness. The goal is to shed light and to interconnect different views of the problem, therefore deepening the understanding of the subject area, and offer preventive and curative solutions. This is necessary because insolvency, on business level, disables development and adequate business and financial restructuring, on personal level it destroys an individual and a family, whereas at social level it creates poverty and enhances negative economic trends. Goals are aimed at: different levels of the principal groups of insolvency and over-indebtedness actors, which are: business, personal and public level, and at business environment as a platform for finding better indebtedness management possibilities. The results of the business level research should significantly improve the prediction possibilities of financial distress and enable larger time-opportunity-window to exploit different restructuring options. Also, the results should provide the scientific knowledge of such financial management that would encourage business development by financial leverage and not threaten the survival of business entities because of the inadequate capital structure. The results of the personal level research should make way to the widespread alteration of approach to new debt. New personal finance culture pattern is expected to be backed by these results and should emerge both among individuals (as demand force of debt), and financial institutions (as supply force of debt). Project proposal is directed toward the research of four distinctive segments of business environment, predominantly of political – legal or economic origin: personal insolvency regulation, business insolvency regulation, monetary and fiscal possibilities in overcoming excessive indebtedness, and banks and financial industry in generating anticipative consumption causing excessive indebtedness.
1722Modeli i metode upravljanja inovacijama u razvoju kompleksnih inženjerskih sustavaModels and Methods of Innovation Management in Complex Engineering Systems Development4471Mario Štorga IP2013-11IP-2013-11-6430MInMED01.10.2014 - 30.09.2018Završio1.000.000,00 KnTehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture6389, 6397, 6428, 6393, 19022, 17795, 6840, 20038, 19667, Krešimir Osman, Stanko Škec, Ida Midžić, Dorian Marjanović, Tomislav Martinec, Marija Majda Perišić, Maroje Marohnić, Vladimir Smojver, Jasmin Juranić, innovation dynamics, knowledge management , socio-technical systems, complex networks, engineering systems developmentThe goal of the proposed research project is to develop a set of fundamental models and methods for innovation management within and across hierarchical social networks exiting in contemporary private and public R&D organisations, and to explore and develop analyse and simulation tools for quantifying knowledge and information dynamics as a mean for prediction of the future trends in organisational innovation. The context of the socio-technological framework that transcends the organisational innovation dynamics within contemporary engineering systems and services life-cycle requires the research overriding commitment to methodological pluralism. The integrated analyse – evaluate - create – refine - validate approach will be used as research methodology.The research will build on state of the art developments in the exploration of principles of knowledge management for R&D organisations and will go further; in that it will seek to incorporate the insights from modelling, simulation and visualisation of the complex social, natural and technical systems to the knowledge and information dynamics that encompass the generation, storage, dissemination, filtering, and reprocessing of innovation across hierarchical socio-technological networks. The research effort will entail the development of concepts, theories, metrics and case studies related to the R&D organisational innovation management. The controlled experiments in real-world private and public R&D organisations will be used in research to gain valuable insights across different sectors (automotive, aerospace, energy, transportation, healthcare, public administration, etc.).It is expected that the results of the proposed research will provide valuable interdisciplinary contributions and improve overall understanding respective to the organisational innovation.
1738Promjene u kristaliničnim materijalima izazvane ionskim snopovima MeV-skih energijaMeV Ion Beam Induced Changes in Crystaline Materials4589Stjepko Fazinić IP2013-11IP-2013-11-8127MIOBICC15.06.2014 - 14.11.2018Završio810.623,75 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb4629, 5437, 4893, 4670, 3498, 5686, 5793, 4976, 5947, 21267, 19583, 24631, Milko Jakšić, Ettore Vittone, Tonči Tadić, Zdravko Siketić, Marko Karlušić, Natko Skukan, Veljko Grilj, Iva Božičević Mihalić, Donny Domagoj Cosic, Kristina Tomić, Ivana Zamboni, Marin Vukšić, MeV Ion Beams, Stopping Power, Ion Beam Modification of Materials, Ion Beam Analysis, Ion Beam Channeling, IBIC, RBS, PIXE, PIGEIn the recent years MeV ions have been extensively utilized as indispensable powerful tool in a wide range of materials science research. Ions are very efficient in creating numerous ionizations on their path through the material by ejecting/exciting electrons (electron stopping) and in creating vacancies by recoiling the whole atoms (nuclei) from their lattice sites (nuclear stopping). Therefore, irradiation of materials with energetic ion beams is considered as a) an efficient tool to alter materials physical, chemical, electrical and optical properties and b) a sensitive probe that can be used to characterise materials using some of the Ion Beam Analysis (IBA) methods. Understanding of complicated dynamical processes that lead to structural modifications of materials requires the knowledge of experimental data related to kinematics of defects during and after irradiation. Therefore the goal of the present proposal is experimental study of the time evolution of radiation induced changes induced by energetic (MeV) ion beams and their characterization using the RBI Tandem Accelerator Facility. The focus will be on studying: (i) influence of electronic stopping and related nanostructuring of materials by ion track methodology; (ii) influence of nuclear stopping to radiation damage and amorphization in crystals, including crystalline and functional materials of interest for future fusion reactors; (iii) charge transport properties in crystalline materials, focusing on novel semiconductor materials for radiation detection. Experimental methodology relies mostly on the unique RBI dual-beam end station that will be used for ion beam irradiations and simultaneous characterization of induced changes using IBA methods like RBS and PIXE in channelling mode, ERDA, NRA and PIGE, as well as IBIC (Ion Beam Induced Charge).
1741Razvoj suvremenog pravnog i osigurateljnog režima za hrvatske marine - unapređenje konkurentnosti, sigurnosti, sigurnosne zaštite i zaštite morskog okolišaDeveloping a Modern Legal and Insurance Regime for Croatian Marinas - Enhancing Competitiveness, Safety, Security and Marine Environmental Standards 4076Adriana Vincenca Padovan UIP2013-11UIP-2013-11-3061DELICROMAR01.03.2016 - 28.02.2019Završio395.128,20 KnDruštvene znanostiSocial sciencesPravo, Law, Hrvatska akademija znanosti i umjetnostiCroatian Academy of Sciences and Arts4077, 2814, 4464, 4201, 2928, 4194, 4607, 4620, 3984, 18987, 4386, 4187, Vesna Skorupan Wolff, Nikoleta Radionov, Dorotea Ćorić, Ranka Petrinović, Mišo Mudrić, Nikola Mandić, Ivana Oršulić, Marija Pospišil Miler, Božena Bulum, Iva Tuhtan Grgić, Marija Pijaca, Lana Ofak, marina, nautical tourism, transport law , marine insurance, liability, safety, security, marine environmentThe proposed research project shall consist of an examination of the existing legal regime governing the establishment, management and the activities of the nautical tourism ports in Croatia, with a special focus on marina operator’s liabilities, insurance arrangements, standards of maritime safety and security and marine environmental protection; comparative analysis of the respective legislation, insurance arrangements and court practice in the European countries; analysis of the European marina operators’ common practices, general terms and conditions, their experiences in the combat against and dealing with the adverse events such as vessel thefts, fire, unauthorised entry, marine accidents within the port, marine pollution, etc; proposing improvements in the legal framework relating to the regime of liability and insurance of the Croatian marina operators, with a view of enhancing their competitiveness, safety, security and environmental protection standards; in particular, a recommended model of general terms and conditions would be created as an innovative business solution for marina operators and a possible reform of the respective positive legislation would be proposed, paying due respect to the necessary compliance with the relevant EU legislation. The proposed project is aimed at consolidating the relevant national legislation and clarifying the related legal concepts through the currently lacking doctrine, with a view of unifying the domestic court practice and contributing to legal certainty in the interest of all parties involved. This should lead to a progress and further sustainable development of the nautical tourism sector in Croatia subject to the requirements of the marine environmental protection, maritime safety and security, particularly considering the country’s strategic orientation to that sector of economy and the planned substantial increase of the nautical tourism ports’ berthing capacities in the following years.
1742Sloboda volje, uzročnost i slučajFree Will, Causality and Luck242Filip Grgić IP2013-11IP-2013-11-5343FreeWilL01.07.2014 - 30.06.2018Završio320.000,00 KnHumanističke znanostiHumanitiesFilozofija, Philosophy, Institut za filozofijuInstitute for Philosophy in Zagreb1441, 3206, 2690, 3485, 3345, 2634, 4359, 4870, 1381, 17854, Pavel Gregorić, Boris Kožnjak, Tvrtko Jolić, Ljudevit Hanžek, Dario Škarica, Ivana Skuhala Karasman, Marijan Palmovic, Tomislav Janović, Davor Pećnjak, Anna Kocsis, free will, causality, luck, determinism, compatibilism, moral responsibility, consciousnessThe overall goal of our research is to contribute to our deeper understanding of what is involved in having and experiencing free will by offering some new insights and arguments in the pertaining areas. The more specific goal of our project is to produce original contributions in some central areas of research into free will, in the following disciplines: metaphysics, philosophy of mind, ethics, history of philosophy, philosophy of physics, as well in philosophical interpretations of relevant results of psychology and neuroscience. The most specific goals of the research are the following. First, we plan to show that deterministic threats to free will are surmountable. Second, we plan to show that indeterministic threats (i.e. those based on randomness and luck) are also surmountable. Third, we will argue that some problems with compatibilistic accounts are more serious than has hitherto been recognized. This is due, first, to the fact that, in our opinion, compatibilism is also susceptible to a specific luck objection, and second, to the fact that it is sometimes based on insufficiently clear notions of causality, determinism and natural laws. Fourth, we will argue that Aristotelian version of compatibilism can bring some fresh light to contemporary discussions, but that it is also susceptible to a specific luck objection.Research activities can be grouped under five main headings: 1. Causality, laws of nature and luck (1.1. Causality, laws of nature and action; 1.2. Indeterminism and luck; 1.3. The varieties of determinism), 2. Brain, mind and agency (2.1. Freedom and consciousness, 2.2. Mental causation and ascriptions of intentionality, 2.3. Some perspectives from neuroscience), 3. Moral responsibility (3.1. Principle of Alternative Possibilities, 3.2. Bioenhancement and responsibility), 4. Aristotelian perspective (4.1. Aristotle’s compatibilism, 4.2. Aristotle on moral responsibility and luck), 5. Free will, determinism and the quantum rescue.
1743Nejednakosti i primjeneInequalities and Applications3427Josip Pečarić IP2013-11IP-2013-11-5435INEQUALITIES01.06.2014 - 30.05.2018U tijeku547.130,36 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Tekstilno-tehnološki fakultetUniversity of Zagreb, Faculty of Textile Technology1499, 3770, 4166, 3837, 3777, 4003, 3774, 630, 524, 3034, 3820, 4020, 3074, 3745, 3852, 3541, 3503, 3423, 857, 3762, 3736, 592, 3861, 3040, 3744, 4178, 3869, 3818, 795, 3484, 1149, 3389, 584, 3707, 2673, Andrea Aglić Aljinović, Maja Andrić, Senka Banić, Ana Barbir, Josipa Barić, ILKO BRNETIĆ, Tomislav Burić, Vera Čuljak, Neven Elezović, Iva Franjić, Božidar Ivanković, Slavica Ivelić Bradanović, Julije Jakšetić, Rozarija Jakšić, Dragana Jankov Maširević, Milica Klaričić Bakula, Sanja Kovač, Mario Krnić, Kristina Krulić Himmelreich, Neda Lovričević, Anita Matković, Jadranka Mićić Hot, Zlatko Pavić, Ivan Perić, Jurica Peric, Tibor Poganj, Dora Pokaz, Marjan Praljak, Mihaela Ribičić Penava, Mirna Rodić Lipanović, Ksenija Smoljak, Sanja Varošanec, Ana Vukelić, Predrag Vuković, Lenka Vukšić, inequalities, convexity, operators, asymptotic expansions, series of special functionsThe proposed research project belongs to the category of theoretical research in fundamental sciences, with the main purpose to stimulate gaining new knowledge. The general purpose of this project is to contribute to the systematic development of the theory of inequalities and to its integration in the current trends in mathematics, especially in the fields of real, functional and numerical analysis. Our aim is also to create and maintain a competent team of researchers whose relevant results and cooperation with other field experts from all over the world will contribute to the promotion of Croatian mathematics worldwide.Specific objectives are:-to improve, refine, interpolate, generalize Jensen’s type inequalities and related inequalities such as Jensen-Steffensen, Hermite-Hadamard, Jensen-Mercer etc.-to prove some generalizations, improvements and refinements of some classical inequalities (Holder, Minkowski, Hilbert, Hardy, Ostrowski, Gruss, Opial, Chebyshev etc.) in various settings-better understanding of different kinds of convexities (higher convexities, s-convexity and h-convexity, exponential convexity, local convexities, Schur-convexity, superquadracity etc.) with applications in inequalities;-to give further extensions and applications of the Mond-Pečarić method in operator theory, especially in obtaining reverse type operator inequalities;-to develop methods and applications of asymptotic expansions and series of special functions (asymptotic expansion and comparison of bivariate and multivariate means; research in series of Bessel and Bessel-like functions, integral expressions and summation formulae for Neumann and Kapteyn series, establishing sharp truncation error estimates occuring in sampling series approximations etc.).We expect to publish more than one hundred papers in this project period. One of our aims is to give overviews of the obtained research results. We plan to publish at least five monographs on these topics.
1747Supramolekulska sinteza samo-organizirajućih funkcionalnih nanomaterijala i kompleksnih kemijskih sustavaSupramolecular Synthesis of Self-Assembled Functional Nanomaterials and Complex Chemical Systems348Leo Frkanec IP2013-11IP-2013-11-7387SInFONIA01.09.2014 - 30.09.2018Završio639.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb689, 4307, 963, 3856, 959, 1104, 4852, JANJA MAKAREVIĆ, Milan Jokić, Tomislav Portada, Nataša Šijaković Vujičić, Tihomir Pospišil, Ruža Frkanec, Adela Štimac, Supramolecular Chemistry, Self-Assembly, Gels, Hydrogels, Functional Materials, Nanomaterials, Molecular Surface Recognition, Complex Chemical SystemsThe aim of this project proposal is supramolecular synthesis of self-assembled functional materials and study thus created complex chemical systems. Such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in areas ranging from materials science to medicine. The bottom–up synthesis of highly complex functional materials from simple modular blocks is an intriguing area of research. These hierarchically assembled systems extend beyond the individual molecule and rely on non-covalent interactions in a directed self-assembly process. Intrinsic properties of the materials can be modified by exploiting dynamic and specific uni-directional interactions among building blocks, thus allowing construction of novel supramolecular structures. These supramolecular networks belong to a novel category of soft biomaterials exhibiting attractive properties. Research in this project will include the formation of dynamic polymeric networks through molecular recognition and complex assembly formation. Self-assembly of small organic molecules is a suitable method for synthesis of organic nano-structured materials. LWM organo- and hydro-gels with oxalamide units represent construction units with high H-bonding potential; they are self-complementary, capable of unidirectional H-bonding suited for construction of self-assembled with fibrous morphology. In continuation of our previous research the attention will be focused on two main areas of research 1. nanofabrication; preparation of new materials by polymerization through cross linking the gel network or transcript to the TEOS and development of new organic materials that incorporate photoactive functional groups, and 2. bioinspired supramolecular systems for detection and degradation of fibrous supramolecular aggregates, such as Aß-protein and amyloid plaques (that are a major cause of Alzheimer’s disease) and vesicles functionalization for surface molecular recognition studies.
1751Translacijsko istraživanje neuroplastičnosti disanja i učinka intermitentne hipoksije u anesteziji i spavanjuTranslational research on neuroplasticity of breathing and effect of intermittent hypoxia in anesthesia and sleep4553Zoran Đogaš IP2013-11IP-2013-11-5935TIHO2_SLEEP_BREATH01.09.2014 - 31.08.2020U tijeku990.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesKliničke medicinske znanosti, Clinical sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine4542, 83, 4547, 4549, 4543, 3359, 4635, 182, 65, 6675, 6725, 6329, 7034, 6899, 7175, 19211, Ivana Pavlinac Dodig, Maja Rogić, Renata Pecotić, Maja Valić, Linda Lušić, Sunčana Kukolja Taradi, Mladen Carev, Tina Tičinović Kurir, Joško Božić, Mario Mihalj, Goran Račić, Nenad Karanović, Toni Brešković, Marin Šimunić, Dušan Šuput, Tea Galić, intermittent hypoxia, phrenic long term facilitation, respiratory neuroplasticity, sleep apnea, neurophysiology, polysomnographyOur understanding of the brain control of breathing and awareness of the widespread prevalence of obstructive sleep apnea syndrome (OSAS) have both increased in the last decade or two. The link between the two is poorly understood. There is growing evidence that OSAS contributes to the initiation and progression of hypertension, heart failure, cardiac ischemia, stroke and cognitive decline. Chronic sympathetic activation resulting in elevated sympathetic nerve activity and cardio-respiratory sensitivity to hypoxia appears to be important. Still, the exact mechanisms underlying the link between OSA and cardiovascular and neurophysiologic disturbances are not completely known. Intermittent hypoxia (IH) in experimental animals can mimic periods of repeated apneas seen in OSAS patients. Exposure to repeated bouts of hypoxia in human leads to increased sympathetic activity, whilst intermittent hypoxia in experimental animals evokes increases in phrenic and sympathetic nerve activities. The proposed study will examine the role of neurotransmitters/neuromodulators (e.g. serotonin and opioids) in evoking sympathetic long-term facilitation using anesthetized animal model of IH.The only way to understand complex pathophysiological interactions in OSAS patients is to use translational and multidisciplinary approach, as proposed in this project. Our focus in the human studies is to study neurophysiologic (brain motor control, control of breathing, neurographic features of peripheral nerves, and muscle sympathetic activity) function in OSAS patients and the links to metabolic, stress, and cognitive parameters. Preliminary data from pilot studies suggest it is possible to achieve the new findings using this novel approach. We will also study longitudinal therapeutic effects of the gold standard therapy in OSAS such as the overnight use of continuous positive airway pressure (CPAP) devices in Split Sleep Cohort of patients, which we plan to form during the work on this project.
1755Uloga inozitolskih fosfata i inozitolskih pirofosfata u regulaciji staničnog ciklusaThe role of inositol phosphates and inositol pyrophosphates in the regulation of cell cycle4650Hrvoje Banfic IP2013-11IP-2013-11-4597Inopyrocycle01.07.2014 - 30.06.2018Prekinut985.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine4936, 4921, 6302, 4677, 4676, 4837, Vesna Lukinović-Škudar, Vladiana Crljen, John York, Dora Višnjić, Hrvoje Lalić, Vilma Dembitz, inositol phosphates, inositol pyrophosphates, cell cycle, matabolism, protein pyrophosphorylationInositol phosphates and pyrophosphates are second messengers generated by the sequential phosphorylation of inositol 1,4,5,-trisphosphate (InsP3). Several recent studies pointed to their role in the regulation of different cellular processes in eukaryotes, yet in many instances direct mechanistic roles remain elusive. Our recent study provided genetic, metabolic and biochemical evidence that synthesis of inositol pyrophosphates through activation of Plc1 and Kcs1 play an important role in the signalling response required for cell cycle progression after mating pheromone arrest in Saccharomyces cerevisiae (Banfic et al. J. Biol. Chem. 288: 1717-1725, 2013). However, it is still uncertain which of the pyrophosphates increased is/are responsible for Kcs1-mediated effects, and it is unclear what might be the possible link between the Kcs1-mediated increase in the level of pyrophosphates and the progression of yeast cells through the S phase of the cell cycle. This is a proposal that aims to define the mechanism of pyrophosphates-mediated regulation of cell cycle progression. We will use a set of yeasts deletion mutants to define a) the particular pyrophosphate responsible for S phase-associated effects, b) to test for the possibility that inositol pyrophosphates generated during S phase progression regulate telomere length, c) to test the possibility that the increase in the level of pyrophosphates in alpha-factor synchronized cells is associated with an increase in pyrophosphorylation of the proteins and/or protein expression or modification, and d) to determine the changes in metabolism in alpha-factor synchronized cells and to correlate them with the changes in the level of inositol pyrophosphates. Overall, this proposal seeks to elucidate lipid-derived inositol phosphate signal transduction pathways in the regulation of cell cycle and metabolism.
1762Prirodni zeoliti kao reaktivne barijere za obradu procjednih otpadnih voda odlagališta otpadaNatural zeolites as a reactive barrier for landfill leachate treatment639Marina Trgo IP2013-11IP-2013-11-4981NAZELLT20.07.2014 - 19.07.2018Završio672.600,00 KnTehničke znanostiTechnological sciencesKemijsko inženjerstvo, Chemical engineering, Sveučilište u Splitu, Kemijsko-tehnološki fakultetUniversity of Split, Faculty of chemistry and technology4361, 3947, 917, 3380, 4454, 4501, Nediljka Vukojević Medvidović, Jelena Perić, Ivona Nuić, Marin Ugrina, G. Diego Gatta, Sanja Slavica Matešić, natural zeolites, landfill leachate, column method, heavy metals, reactive barrierLimited reserves of fresh water are a serious global problem. For that reason the main objective is to preserve the quality of all available sources of drinking water. Among all the threats to water in nature, leachate landfills are most dangerous because of their complex chemical composition and continuous uncontrolled pollution of groundwater. Processes and methods of preventing the spread of pollution into groundwater and leachate treatment are a challenge for many researchers. This proposal should be a contribution to the landfill leachate treatment using natural zeolite as a reactive barrier. This material is available in nature, environmentally compatible, thermally and chemically stable, and possesses adsorption and ion exchange properties. Depending of the surface charge, zeolites can uptake organic and inorganic positive and negative species. The desired surface charge can be achieved by chemical modification using different methods at a controlled pH value. Modified zeolites should have significantly higher removal capacities and selectivity towards pollutants contained in the landfill leachate. These wastewaters are highly concentrated, have the most complex possible composition, contain low biodegradable organic matter (halogenated hydrocarbons, aromatic hydrocarbons and phenols), inorganic ions (Cl-, NH4+, SO42-,NO3-, NO2-,PO43-), and heavy metals (Cd, Cr, Cu, Ni, Pb, Zn, Mn). Many of these components have shown excellent removal from modal solutions onto zeolite; therefore investigations will start with batch studies, continue in lab-scale fixed bed columns, and finally in scale-up and multi stage columns filled with different modified zeolites. The multi stage column performance should be carried out with real leachate collected from the regulated landfills in the Dalmatian region. The exhausted zeolite, saturated with organic and inorganic pollutants, can be thermally treated and disposed of in nature, or solidified into the cement matrix.
1793Evocirani potencijali moždanog debla i testiranje autonomnog živčanog sustava kao metode procijene progresije bolesti u bolesnika s klinički izoliranim sindromomBrainstem Evoked Potentials Score and Composite Autonomic Scoring Scale as a Predictors of Disease Progression in Clinically Isolated Syndrome1081Mario Habek UIP2013-11UIP-2013-11-2622BACIS01.09.2014 - 31.08.2017Završio742.700,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesKliničke medicinske znanosti, Clinical sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine5732, 4744, 4530, 3050, 5730, 4606, 5787, 4721, 4564, 4746, 5637, 5051, 17860, Barbara Barun, Tereza Gabelic, Ivan Adamec, Magdalena Krbot Skoric, Damir Petravić, Darija Mahović Lakušić, Branko Malojčić, Mila Lovrić, ivana zadro, Ivo Lušić, Silva Butković-Soldo, Marijana Lisak, Luka Crnošija, clinically isolated syndrome, multiple sclerosis, evoked potentials, autonomic nervous system testing, brainstemAbout 85% of patients have onset of MS with a relapse, which is known as a clinically isolated syndrome (CIS). Several studies have shown that infratentorial lesions are related to conversion rate and long-term prognosis for patients with CIS and thus may help to identify patients at high risk for earlier occurrence of clinically relevant disability. Bearing in mind the poor correlation between clinical symptoms and MRI findings there is a need for ancillary tools in the evaluation of brainstem pathology in MS. The aim of the current study is to evaluate the role of the brainstem evoked potentials score (bilateral AEP, bilateral ocular and cervical VEMP and bilateral tongue SSEP), the modified evoked potentials score (combination of brainstem evoked potentials score and VEP and SSEP of the median and tibial nerve) and standardized autonomic nervous system testing (Composite Autonomic Severity Score (CASS)) in the prediction of conversion from CIS to MS and accumulation of future disability. After 24 months of follow-up, this study could reveal the prognostic value of the brainstem EP score, modified EP score and CASS in patients with CIS on a number of parameters including: time until second relapse, accumulation of disability, accumulation of MRI lesions in the first 6 months, time to conversion from CIS to MS according to the 2010 revision of the McDonald criteria, number of relapses in the first 2 years of follow up. It can be presumed that the brainstem EP score and CASS score as direct and indirect measures of brainstem dysfunction, respectively will prove as reliable markers of future disability of CIS and MS patients. As a consequence, this would allow us to start more appropriate treatment in a subset of patients with higher probability of worse outcome.
1806Rimska ekonomija u Dalmaciji: proizvodnja, distribucija i potražnja u svijetlu keramičarskih radionicaRoman Economy in Dalmatia: production, distribution and demand in the light of pottery workshops3064Goranka Lipovac Vrkljan IP2013-11IP-2013-11-3973RED01.07.2014 - 30.06.2018Završio400.000,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Institut za arheologijuInstitute of Archaeology in Zagreb2786, 3216, 5824, 7392, 7577, 21192, 5318, 21199, 22964, Ivana Ožanić Roguljić, Ana Konestra, Maja Miše, Hrvoje Kalafatić, Bartul Šiljeg, Marina Ugarković, Mato Ilkić, Nera Šegvić, Fabian Welc, Roman economy, Dalmatia, pottery, landscape archaeology, archaeometryMain goal of the RED project is to found out as much as possible about production, distribution and demand of goods in Roman Dalmatia through most common material found in arhaeological excavations – ceramics. From Late Hellenistic period when Central Dalmatia was enrolled in vivid Mediterranean trade, not only as a receiver of everything that comes from the larger centre, but also as a driving force of social and economic changes establishing pottery manufactures. This social transformation was enhanced by Romans. Trade of ceramic objects is one of the main starting points for understanding the history of the Roman economy and society. For such scientific research it is necessary to establish a project using archaeometric analysis and archaeological research and a database of ceramics. Landscape archaeology methods such as field surveys, GIS, sampling patterns and statistical analysis will be used to analyse and interpret the wealth of data. RED project will include the development of an online database of documentary, archaeological material and archaeometric samples. Aim of this project will also be to establish relations between local production to the imports and to what extent was production in province Dalmatia driven by consumer demand and involvement of provincial communities within the Late Hellenistic/Republican and Imperial Roman economy.
1807Primjena inovativnih tehnologija u proizvodnji biljnih ekstrakata kao sastojaka funkcionalne hraneApplication of innovative technologies for production of plant extracts as ingredients for functional food1243Verica Dragović-Uzelac IP2013-11IP-2013-11-3035IT-PE-FF01.09.2014 - 31.08.2018Završio968.000,00 KnBiotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology2657, 2702, 2644, 223, 2509, 2593, 2615, 2512, 2830, 1062, 1002, 1330, 1056, 2663, 2558, 3057, 3314, 5708, 17829, 24300, 25335, Damir Jezek, Mladen Brnčić, Branka Levaj, IRENA LANDEKA JURČEVIĆ, Senka Djaković, Marijana Jukić, Danijela Bursać Kovačević, Jasmina Lapić, Ivana Kmetič, Sandra Pedisić, Ivona Elez Garofulić, Maja Repajić, Zoran Zorić, Sven Karlović, Marina Tranfić Bakić, Teuta Murati, Domagoj Đikić, Ivanka Žutić, Vanja Plazibat, Predrag Putnik, Domagoj Gabrić, medicinal and aromatic plants, innovative technologies, plant extracts, bioactive compounds, bioavailability, antioxidant properties Medicinal and aromatic plants (MAPs) contain numerous bioactive compounds (BACs) (e.g. polyphenols, carotenoids, organosulphur compounds) that can affect the nutritive, chemical, microbiological, and sensory quality of food products. Additionally, they may provide numerous positive effects to the human health (such as risk reduction for: cardiovascular disease, diabetes, obesity, hypertension etc.). Due to large structural diversity among different groups of BACs and their physical/chemical properties it is important to identify/optimize the most effective extraction methods required to isolate and/or separate them from other plant components. Hence, various innovative extraction techniques (e.g. microwave-, ultrasound- and high-pressure- assisted extraction) will be tested for plant extracts production with high BACs content from selected MAPs grown in Croatia. Each applied extraction technique will be optimized with regards to particular MAP, increasing extraction yield, enhancing quality of extract, shortening extraction time, and decreasing solvent consumption. MAPs extracts and/or BACs will be analyzed for antioxidant properties with application of various assays (e.g. total antioxidant, hydrogen peroxide scavenging, and free radical scavenging, metal chelating activities). Antiproliferative effects against tumor cells and possible protective role from lipid oxidation (including antioxidant activity) will be tested in appropriate cell line model system. The MAP extracts (dried/liquid) and BACs (extracted and/or purified separately or in mixtures) will be studied in animal models for bioavailability; absorption; antioxidant activity; as ingredient for functional food products (fortified beverages and snack bars based on Mediterranean fruits), and for possible use in diabetic/hypercholesteremic management. The obtained results may provide novel opportunities for functional product categories that are likely to have positive benefits on human health.
1808Promjenjivost Sunca i zvijezdaSolar and Stellar Variability4850Bojan Vršnak IP2013-11IP-2013-11-6212SOLSTEL01.09.2014 - 31.08.2018Završio992.412,89 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Geodetski fakultetUniversity of Zagreb, Faculty of Geodesy6306, 6078, 6028, 4326, 5550, 5899, 6152, 6121, 6181, 19711, Hrvoje Božić , Roman Brajša, Davor Sudar, Domagoj Ruždjak, Tomislav Žic, Jaša Čalogović, Mateja Dumbović, Rajka Jurdana-Šepić, Ivana Poljančić Beljan, Ivica Skokić, solar activity, space weather, climate, heliosphere, sun-like stars, variable stars, binary stars, accretion discs, exoplanets, substellar companionsThe proposed four-year project connects solar physics, solar-terrestrial physics, heliospheric physics, space weather & climate, geophysics, and stellar physics. It is based on empirical/interpretative, theoretical/analytical, and theoretical/numerical approach, and concerns all astrophysical problems currently in focus of the research at the Hvar Observatory (HO) of the Faculty of Geodesy of the University of Zagreb. Thus, the proposed program is in a great deal determined by, and directed towards, effective exploitation of the observational capacities and manpower of HO. The project is divided into five thematic topics: 1) solar activity and eruptive phenomena in the solar atmosphere; 2) solar-activity impact on the Earth; 3) stellar eruptive activity; 4) radiation processes in solar and stellar atmospheres; 5) exoplanets and substellar companions. In the first topic special attention is devoted to the research of the physics of coronal mass ejections and solar flares, since they drive the most intense geomagnetic storms, as well as changes of radiation belts and ionosphere. The central issue of the second topic is the influence of the solar variability on the Earth climate. The third topic is devoted to stellar eruptive magnetic-field activity, aiming to provide a better understanding of the long-term evolutionary aspect of the solar activity. The fourth topic is an important subject not only for astrophysics, but also for plasma physics in general, since it provides an alternative view on plasma instabilities and emission processes. The fifth topic is a timely astrophysical theme, since it provides new insights into physics of planetary systems, and is very important subject for understanding of the solar-system formation and evolution.
1837Urbanizam naslijeđa - Urbanistički i prostorni modeli za oživljavanje i unaprjeđenje kulturnoga naslijeđaHeritage Urbanism - Urban and Spatial Planning Models for Revival and Enhancement of Cultural Heritage1458Mladen Obad Šćitaroci IP2013-11IP-2013-11-2032HERU01.09.2014 - 31.08.2018Završio834.500,00 KnTehničke znanostiTechnological sciencesArhitektura i urbanizam, Architecture and Urban Environment, Sveučilište u Zagrebu, Arhitektonski fakultetUniversity of Zagreb, Faculty of Architecture1459, 3550, 3010, 3625, 3024, 4796, 2560, 3157, 3056, 3015, 3190, 4392, 3174, 1319, 1194, 3469, 1196, 3084, 3098, 3917, 2936, 3480, 3407, 4778, 3208, 3237, 3027, 3862, 3220, 3213, Bojana Bojanic Obad Šćitaroci, Alenka Delić, Sanja Gašparović, Jesenko Horvat, Vedran Ivanković, Tihomir Jukić, Damir Krajnik, Nenad Lipovac, Ivan Mlinar, Lea Petrović Krajnik, Biserka Dumbović Bilušić, Jasenka Kranjčević, Tamara Marić, Ana Mrđa, Tin Oberman, Boško Opalić, Marko Rukavina, Igor Gojnik, Irma Huić, Marina Pavković, Ksenija Petrić, Dario Sironić, MARIJANA SIRONIĆ, Nikša Božić, Boris Dundović, Nikola Matuhina, Mirna Meštrović, Vesna Poljančić, Ksenija Radić, Ana Sopina, Cultural Heritage, Urban Planning, Spatial Planning, Heritage Enhancement, Heritage RevivalCroatia’s urban heritage is at least 25 centuries old. Examples of cultural/architectural and landscape heritage in Croatia are numerous, valuable and diverse. Part of this heritage is recognised worldwide and is protected by UNESCO. Croatia’s most valuable heritage is protected at a national level, although a part of it has, as yet, not been recognised. For various reasons the numerous examples of Croatian heritage are in a poor condition and decaying because they don’t have a permanent use and are not included in the life of cities and towns, despite being formally protected.In former research project, Urban and Landscape Heritage of Croatia as Part of European Culture, cultural heritage was researched in an attempt to present its values and traits as part of Croatia’s national identity and culture. The new project proposal partly supplements previous project thematically and uses results of this research, but the focus of research is on the creative, sustainable and responsible usage of urban, architectural and landscape heritage, which is a non-renewable resource. Contemporary attitudes of conservationists on the holistic protection based on international conservation documents connect protection with urban and regional planning through the concept of sustainable development. The aim of proposed research is to affirm heritage as an active space and spatial resource, to include it in future life and to allow it to be the initiator and active participant in sustainable spatial, social and cultural, economic and touristic development.The research will be based on the selected case studies for each type of cultural heritage. The aim is to define spatial criteria, methods and models for revitalisation and for the implementation of new projects within cultural heritage which may contribute to their enhancement. The project results (criteria, methods, models) will be applied in spatial and urban planning and conservation practices, and will be of far-reaching impact.
1839Procjena prihvatnog kapaciteta za turiste u zaštićenim područjima prirodeAssessment of Carrying Capacity for Tourists in Nature Protected Areas2551Jadranka Pečar Ilić IP2013-11IP-2013-11-2202ACCTA01.07.2014 - 30.06.2017Završio698.667,69 KnPrirodne znanosti, Tehničke znanosti, Društvene znanosti, Natural sciences, Technological sciences, Social sciences, Biologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb2551, 5520, 5519, 5710, 4006, 3321, 5922, 17593, 13114, 4898, Jadranka Pečar-Ilić, Tin Klanjšček, Sunčana Geček, Zdenko Tkalčec, Hrvoje Carić, Jasminka Klanjšček, Drago Marguš, Nina Marn, Ivana Kušan, Tarzan Legović, carrying capacity, nature protected area management methods, conservation, environmental modeling, calculation, GIS, tourism, NP Krka, PP TelašćicaNatural protected areas (NPAs) are a crucial part of nature conservation; many of them are tourist hotspots. Managers of NPAs have to balance environmental protection and tourism to maximize socio-economic benefits while avoiding irreparable environmental consequences. Since 1978, carrying capacity for tourists (CCT) has been recognized and legislated as a crucial tool in finding the balance. CCT is traditionally defined as the maximum number of people concurrently visiting an area without irreversibly damaging physical, economic, and/or socio-cultural environment. In practice, managers determine acceptable level of environmental damage, and then use adaptive management to achieve and maintain that damage level. We propose a more conservation-oriented approach of estimating CCT that maximizes nature protection. Although every tourist damages the environment, he/she also contributes to protection by providing financial assets. Without revenues from tourism, protection is significantly underfunded because meeting protection and educational goals of NPAs requires costly activities such as research, oversight, mitigation, and management. We propose to estimate CCT as the maximum number of visitors for which the marginal contribution to nature protection is positive, with the requirement that visitor satisfaction not be compromised. We will first formalize the estimation procedure, then identify tourist activities with their consequences on the environment and socio-economic parameters, develop general models for common factors affecting environmental quality of the NPAs, and integrate the models into a GIS-based framework. Finally, we will demonstrate the approach by estimating CCT for two very different protected areas crucial for Croatian tourism and the local economy: NP Krka and PP Telašćica. While the new way of estimating CCT will initiate a paradigm shift in NPA management, the two applications will contribute to Croatia's nature conservation and economy.
1844Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli Purine salvage pathway enzymes from Helicobacter pylori and Escherichia coli 302Marija Luić IP2013-11IP-2013-11-7423PSPE01.09.2014 - 30.11.2018Završio918.327,58 KnPrirodne znanosti, Biomedicina i zdravstvo, Natural sciences, Biomedicine and health sciences, Biologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb3400, 690, 424, 3310, 3300, 3781, 3687, 2999, 23182, 4270, 23168, Goran Mikleušević, Ivana Leščić Ašler, Zoran Štefanić, Saša Kazazić, Biserka Kojić-Prodić, Biserka Žinić, Vanda Plečko, Agnieszka Bzowska, Ante Bubić, Branimir Bertoša, Petar Knezevic, Purine metabolism, enzyme inhibiton, drug design, H. pylori, E. coli, crystal structure, analytical biochemistry, H/D exchange, susceptibility testingThe main goal of the proposed project is to identify new drug targets and accordingly design, prepare and characterise new drugs for Helicobacter pylori eradication. Helicobacter pylori is a bacterium that colonizes one half of the world population and it is regarded as one of the most invasive human pathogens responsible for development of many diseases. There are two possible pathways that organisms can use to synthesize purines as indispensable building blocks for DNA and RNA synthesis. However, bacterium H. pylori uses the salvage pathway, only. Therefore, we plan to disable H. pylori growth and replication by inhibiting the key enzymes, purine nucleoside phosphorylase and adenylosuccinate synthetase, on this pathway.The proposed project includes the interdisciplinary team with expertise in the research areas of molecular biology and genetics, biochemistry and biophysics, macromolecular crystallography, biological mass spectrometry, molecular modelling, organic synthesis, analytical ultracentrifugation methods, susceptibility testing, and managing ‘big data’ through data integration (extracted from various databases). All equipment necessary to accomplish the proposed research is available in the host institution (Rudjer Bošković Institute) except for analytical ultracentrifuge available by foreign co-worker A. Bzowska (Warsaw, Poland).
1845INTEGRATIVNI PRISTUP PROUČAVANJU TRANFORMACIJSKE ULOGE TURIZMA U 21. STOLJEĆUAN INTEGRATED APPROACH FOR THE STUDY OF TRANSFORMATIVE ROLE OF TOURISM IN 21ST CENTURY5000RENATA TOMLJENOVIĆ IP2013-11IP-2013-11-6164TRANS-TOURISM 01.09.2014 - 31.03.2019U tijeku582.112,71 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Institut za turizamInstitute for Tourism in Zagreb5782, 7029, 1004, 3669, 5707, 5245, 5228, 5218, 7502, Sanda Čorak, Daniela Angelina Jelinčić, Snježana Boranić Živoder, ZRINKA MARUŠIĆ, Neda Telišman-Košuta, NEVEN IVANDIĆ, Nikola Ćelić, Ivan Sever, IRENA ATELJEVIC, culture, tourism, transformation, values, behaviour, changeThe overall objective of TRANS-TOURISM is to critically investigate the role of tourism in attaining the vision for sustainable world of peace and harmony, and to develop tools and options in order to provide practical models to harness the transformative power of tourism. The main proposition is that tourism, as an enormous economic and social force, can be a significant contributor to the vision for sustainable world. The vision for personal is an urgency today and already the new group of culture creatives is identified spearheading this movement. This vision is also embedded in the overall vision of Europe 2020 for creation of more just and inclusive societies and provision of greater quality of lives for all citizens. This proposition will be analysed from three aspects: by capturing the transformative power of past and present travel experience of the culture creatives, motivations and practises of pioneering change-makers who create transformational travel products and tourism stakeholders’ receptiveness to integrate transformational view of tourism into design of their products. The research will employ mixed-method approach, involving quantitative (surveys) and qualitative (in-depth interviews, focus groups, workshops, diary) methods. The research on the theme is in infancy and the project builds the existing research in three ways. In contrast to the existing studies, the research will focus on those whose values are transformed and will seek to capture the role of travel experience in that process, on the long term behavioural change following the travel in contrast to the existing focus on immediate post-trip attitude change. The research will also overcome the existing host – industry – guest divide, as it will include entrepreneurial perspective of transformative travel providers, mainstream industry players and host communities in the process of fostering activities which can facilitate societal transformation through tourism.
1846Neuralna osnova viših spoznajnih funkcijaMicrocircuitry of higher cognitive functions2567Zdravko Petanjek IP2013-11IP-2013-11-5943COGNITIVECIRCUIT01.07.2014 - 30.11.2018Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine3907, 4699, 5085, 3483, 4770, 2549, 2646, 2632, 5063, 4972, 18991, 12673, Dubravko Jalšovec, Davor Mayer, Mislav Stjepan Žebec, Sanja Darmopil, Marija Baković, Ana Hladnik, Domagoj Džaja, Ivana Bičanić, Ivana Miler, Fadi Almahariq, Branka Hrvoj Mihic, Dora Mandić, pyramidal neurons, interneurons, glutamate, GABA, synaptic transmission, cortical connectivity, evolution, cognition, schizophrenia, autism, layer IIIMost of our knowledge about organization of cortical circuitry comes from studies in rodents, but those results have not lead to major breakthrough for the treatment of human brain disorders. Despite common principles in connectivity, human cerebral cortex contains specific neuron types like associative layer III pyramidal neurons and subtypes of calretinin expressing GABA-interneurons. They are key elements of human microcircuitry which molecular specificity and neuronal interaction between and inside columns needs to be determined in order to assess how human cerebral cortex processes information. The aim of this project is to study organization and molecular properties of microcircuitry in the human frontal cortex that is believed to have unique features being the biological substrate for the most complex cognitive functions. The emphasis is to use histo-molecular techniques to dissect connectivity at cellular level and to establish a experimental monkey model to study microcircuitry in collaboration with Brain Dynamic Institute Marseille (http://ins.medecine.univmed.fr/) and Max Planck Institute for Evolutionary Anthropology Leipzig (http://www.eva.mpg.de/). This will enable formation of unique database providing structural, physiological, molecular and genetic fingerprint of identified neurons as well as their connectivity within the entire cortical network in primates. Such database will be extremely valuable to create a simulation model of the human brain and to understand neuronal network alterations in various brain disorders. Studying cortical circuitry in the human is in the focus of current neuroscience research. Proposed project has potential to overcome gap in knowledge at cellular level, providing information gainful for more comprehensive interpretation of data obtained by imaging studies. Through the project Croatian researchers will be trained in experimental techniques that will be implemented into Croatian research and medical institutions.
1848Kulturna povijest kapitalizma: Britanija, Amerika, HrvatskaA Cultural History of Capitalism: Britain, America, Croatia4485Tatjana Jukić Gregurić IP2013-11IP-2013-11-1543CHCBAC01.07.2014 - 30.06.2018Završio594.480,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences3808, 4823, 5020, 4315, 4929, 5089, 5189, 5401, 5527, 5906, 6602, 23126, Jelena Šesnić, Borislav Knežević, Martina Domines Veliki, Sven Cvek, Stipe Grgas Mufa, Tihana Klepač, Vladimir Brljak, Iva Polak, Vanja Polić Jurković, Grant Farred, Kimberly Engber, Hrvoje Tutek, cultural history, economy, capitalism, Britain, America, CroatiaOur claim is that a detailed analysis of what constitutes a cultural history of capitalism is indispensable for a grasp of recent Croatian cultural and political history, and of the current positioning of Croatia in Europe and the world. We start from the observation that the scholarly discourses in Croatia have so far not sufficiently acknowledged the cultural complexity of the economic sphere, especially the seminal significance of histories of Britain and America in that regard. Our methodological point of departure is therefore the assertion that the economic sphere can be understood only in reference to the entirety of culture. We intend to explore the complexity of this totality as refracted through cultural histories of Britain and America, as a horizon necessary for understanding Croatian cultural history. Our intent is to investigate complex interrelations of the sophisticated Victorian variant of capitalism and its American mutations, in the 19th and the 20th centuries. This applies primarily to Cold-War America, when capitalism contrasted to socialism becomes a totalizing formula to regulate various economic and political structures, but also the sphere of culture where public vs private is defined. Thus caught in relation to socialism, capitalism is definitive to life in the former Yugoslavia as well; this then sediments into a difficult genealogy which burdens capitalism when, after the fall of the Berlin Wall, it enters formerly socialist countries, now as a platform for understanding and regulating postsocialism. Our approach is anchored in the assumption that research based only in economy or political theory fails to shed light on the logic of capitalism. This defines our methodology: we maintain that a truly functional analysis of the impact of capitalism demands a confluence of literary history, film studies, psychoanalysis, philosophy, cultural theory and, especially, the knowledge specific to English and American Studies.
1850Transporna, magnetska i termodinamička svojstva odabranih anorganskih i organskih materijalaTransport, magnetic and thermodynamic properties of selected inorganic and organic materials5009Ivan Kokanović IP2013-11IP-2013-11-6216TRANMAGTHERPROMAT01.09.2014 - 31.08.2018Završio744.724,11 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science1173, 5781, 5722, 3227, 6713, 17743, Mario Novak, Boran Leontić, Sanda Pleslić, Mirko Baćani, Cooper John Robert, Filip Orbanić, Superconductivity, topological insulators, metallic glasses, nanocrystalline alloys, conducting polymers, This Project is centred on the physics of selected YBCO single crystals, HTSC, topological insulators, TI, metallic glasses, MG, nanocrystalline alloys, NCA, and conducting polymers, CP, and investigation of their transport, thermodynamic, thermoelectric, magnetic, superconducting and structural properties. The primary issue addressed in the field of HTSC is the existence of electron pockets in low magnetic fields caused by charge density waves, CDW, in pure YBa2Cu3O6+x single crystals. We propose to measure the magnetisation and specific heat in the whole doping range to extract the total density of states at the Fermi level and thereby determine the number of pockets. At the same time we will look for thermodynamic signatures of the CDW phase transitions. Other unresolved controversies which will be investigated include the doping evolution of the mean-field upper critical field and whether Gaussian superconducting fluctuations can account for the magnetisation and specific heat of both underdoped and overdoped YBa2Cu3O6+x single crystals at T>Tc. In the field of TI, we will investigate the thermoelectric properties of bismuth based chalcogenide (BiSbTeSe2) and 3D Dirac semimetals and to find the evidence of the linear dispersion and nontrivial topology of these materials. Our next aim is to achieve ferromagnetism in selected TIs; TlBi(S0.5Se0.5)2, PbSnTe and PbSnSe by doping with Mn or Fe and gain understanding of the mechanism responsible for the ferromagnetic ordering. In the field of MG and NCA the goal is to gain some insight into the glassy structure and mechanism involved in its crystallisation. In the field of organic conductors we intend to investigate PANI-DBSA (DBSA-dodecylbenzenesulfonic acid) thin film samples. A particular emphasis of the research will be the further development of novel apparatus to measure the magnetisation and specific heat of small single crystals which are often of the highest quality.
1853Transport i kemodinamika elemenata u tragovima u slatkovodnim i priobalnim sedimentacijskim sustavimaTransport and Chemodynamics of Trace Elements in Freshwater and Coastal Sedimentary Systems60Goran Kniewald IP2013-11IP-2013-11-7555TRACESS01.09.2014 - 31.08.2017Završio706.688,30 KnPrirodne znanostiNatural sciencesGeologija, Geology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb989, 624, 4900, 2726, 3584, 544, 399, 614, 5147, 5151, Nevenka Mikac, Neda Vdović, Goran Mihelčić, Željka Fiket, Martina Furdek, Julijan Dobrinić, Tadej Dolenec, Irena Jurina Tokić, Niko Bačić, Mavro Lučić, trace elements, chemodynamics, sediments, freshwater systems, coastal systemsThe aim of the proposed project entitled ''Transport and Chemodynamics of Trace Elements in Freshwater and Coastal Sedimentary Systems'' (TRACESS) is to increase our understanding of the biogeochemical cycles that are important forfreshwater and coastal sedimentary systems in karstic areas, using specific groups of elements i.e. anthropogenic and bioactive (Cd, Co, Cr, Cu, Mn, Ni, V, Zn), rare earth elements (REE), toxic elements and compounds (organotin compounds) which were chosen to represent different biogeochemical environments where a suite of geochemical processes can be traced.
1855Organska zagađivala u okolišu - markeri i biomarkeri toksičnostiOrganic Pollutants in Environment - Markers and Biomarkers of Toxicity5026Davor Želježić IP2013-11IP-2013-11-8366OPENTOX01.09.2014 - 31.08.2018Završio994.892,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesJavno zdravstvo i zdravstvena zaštita, Public health and health services, Institut za medicinska istraživanja i medicinu radaInstitute for Medical Research and Occupational Health4035, 4034, 2516, 3033, 1235, 221, 555, 549, 1390, 3076, 5303, 331, 2513, 1490, 323, 1224, 1212, 1384, 1376, 198, 4161, 4156, 2633, 341, 1223, 12850, 2649, Vilena Kašuba, Ružica Rozgaj, Nevenka Kopjar, Suzana Žunec, Marin Mladinić, Vedran Micek, Ivančica Trošić, Ivan Pavičić, Ana Marija Marjanović, Ana Lucić Vrdoljak, Radovan Fuchs, Vlasta Drevenkar, Sanja Fingler Nuskern, Marija Dvoršćak, Želimira Vasilić, Gordana Mendaš Starčević, Sanja Stipičević, Snježana Herceg Romanić, Darija Klinčić, Zorana Kljaković-Gašpić, Irena Brčić Karačonji, Nataša Brajenović, Tanja Živković, Alica Pizent, Mirta Milic, Anja Mikolić, Blanka Tariba Lovaković, pesticides, organochlorine pollutants, genotoxicity, endocrine disruption, oxidative stress, cytoskeleton, environmental distribution, risk assessmentThe proposed project is based on Directive 2009/128/EC, the EU Thematic Strategy for Pesticides, and the Collegium Ramazzini Statement concerning control over pesticides and their impact on human health and the environment. The project will focus on studying two major pesticide classes with three subgroups per each: (A) insecticides (organophosphates, neonicotinoids, and pyrethroids), (B) herbicides (triazines, organophosphates, allelopathic), and persistent organochlorine pollutants under the Stockholm convention. Low concentrations corresponding to real-life exposures will be evaluated based on residential exposure levels, occupational exposure limits, acceptable daily intakes, and reference doses in appropriate cell lines and animal models. The malsegregation of chromosomes (X, Y, 9), integrity of gatekeeping genes (TP53, c-Myc), and protein structures (cytoskeleton components) will be studied within the transplacental genotoxic evaluation of selected pesticide groups. Among these, some are suspected to be endocrine disruptors. Potential effects on sex hormone levels will be assessed in neonatal rats and transfer via mother’s milk in pubertal rats. Oxidative stress will be estimated by measuring lipid peroxidation and activity of antioxidative enzymes in vitro and in vivo. We will study the processes affecting the distribution of pesticides in water/soil systems as well as the genotoxicity of their residues in soil and water. Results for low levels of pollutant exposure will serve to significantly extend the knowledge on their genotoxicity, cytotoxicity, sex endocrine disruption, mechanisms of oxidative stress, and distribution in the environment. Also, they will be used as a base for amending and adopting the Croatian National Action Plan for sustainable use of pesticides in accordance with demands postulated in Directive 2009/128/EC and the EU Thematic Strategy for Pesticides.
1857Dijagnostika autizma s robotskim evaluatoromAutism Diagnostic Observation with Robot Evaluator5054Zdenko Kovačić IP2013-11IP-2013-11-1024ADORE01.09.2014 - 31.01.2019U tijeku1.000.000,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing5295, 5272, 5167, 5058, 3759, 5090, 5244, Jasmina Stošić, Damjan Miklic, Domagoj Tolić, Frano Petric, Sanja Šimleša, Maja Cepanec, Stjepan Bogdan, social robotics, humanoid robots, autism, small children, diagnostics, rehabilitationAutism spectrum disorder (ASD) is a developmental disorder characterized by impairment in social interaction, verbal and nonverbal communication and by repetitive behaviors and interests. The diagnosis, which is usually given during the preschool period, depends on the education and experience of human evaluators, which can be susceptible to personal bias. The ongoing collaboration between the researchers from the Faculty of Electrical Engineering and Computing (FER) and Faculty of Education and Rehabilitation Sciences (ERF) initiated the use of humanoid robots in the process of ASD diagnostic procedures in preschool children. The goal of the project is the development of a robot-based diagnostic protocol and testing of its verification in clinical settings. The robots will be used as ASD co-evaluators to help a human evaluator to assess the child behavior objectively. To the best of our knowledge, such a robot-based ASD diagnostics system will be the first of its kind. Technically, this means developing specific robot skills and behaviors to be deployed within the standard clinical diagnostic procedure of ASD. The robots will have two functions: observation and quantitative measurement of child’s social responses; and performance of standardized social presses designed to provoke child response. This involves actions such as analyses of the audio signal and differentiation of vocalizations and speech, detection of eye-gaze direction, performance of different actions and gestures and utilization of human-robot and robot-robot interaction to attract child attention. Our interdisciplinary approach includes ERF's development of diagnostic protocol and its testing on children with and without ASD and FER's realization of needed robot behaviors using methods and algorithms from social signal processing, computer vision, machine learning and cognitive reasoning. This involves work on cooperation, cognition and human-robot interaction, focusing on multimodal communication.
1858Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorimaMultifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors480Ivo Piantanida IP2013-11IP-2013-11-1477DNA/RNA-MolSense01.09.2014 - 31.10.2018Završio987.922,61 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb1214, 2953, 1232, 3781, 3684, 1476, 2522, 444, 2648, 5802, 17784, Marijana Radić Stojković, Lidija-Marija Tumir, Ivo Crnolatac, Biserka Žinić, Dijana Saftić, Željka Ban, Renata Kobetić, Vilko Smrečki, Aleksandar Višnjevac, Carsten Schmuck, Prof. Dr., Tamara Šmidlehner, Molecular sensing, DNA/RNA, fluorescence, oligopeptide, nucleobaseMolecular recognition of DNA/RNA is of fundamental importance e.g. for gene transcription and regulation, protein synthesis or cell-division. Small molecules selectively targeting specific DNAs or RNAs are therefore highly interesting not only to understand such processes in more detail but also for potential medicinal applications, as sensors or probes for fluorescence based bioimaging as well as for analytical purposes in isolated biosamples. Proposal is based on the collaboration between I. Piantanida and Prof. Dr. C. Schmuck (Germany), joined results in leading chemistry journals (Chemistry, Eur. J; 2010 and 2012, J. Am. Chem. Soc. 2012; Org. Biomol. Chem. 2011, Bioorg. Med. Chem. Lett. 2008). We want to design, synthesize and study highly selective probes for the sensing of DNA/RNA with emphasis on the multi-purpose probes: single molecules able to simultaneously differentiate by several highly sensitive spectrometric methods between the most common secondary structures of ds- DNA/RNA. For increased affinity and selectivity, we plan to test new, more efficient fluorophores (cyanine, phenanthridine, fluorescent nucleobases-Piantanida group) combined with pyrrole-guanidinium cations (Schmuck group) and explore structural diversity of the compounds, by combinatorial approach (solid phase synthesis) based on peptide backbone carrying recognition units/fluorophores. The interaction with DNA/RNA will be studied by Piantanida group (UV/Vis, fluorescence, CD/LD spectroscopy, DSC/ITC microcalorimetry), screening of oligopeptide libraries by IRORI method and atomic force microscopy by Schmuck group. Proposal addresses CSF goals: a) support the collaboration with well-established international leaders, b) foster training of young researchers by work on the INTERNATIONAL research; c) expected results with commercializing potential (novel biochemical probes and/or drugs). The latter feature (c) will be studied within FP7-REGPOT “Innomol” Project at Ruđer Bošković Institute.
1862Između Dunava i Mediterana. Uloga rimske vojske u mobilnosti ljudi i roba na tlu Hrvatske u antici. Between the Danube and the Mediterranean. Exploring the role of Roman military in the mobility of people and goods in Croatia during the Roman Era4028Mirjana Sanader IP2013-11IP-2013-11-6505RoMiCRO15.06.2014 - 14.06.2018Završio593.960,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences7522, 7512, 7515, 7519, 7513, 7516, 7534, 7526, 7532, 7537, 7545, 7547, 7536, 7551, 7548, 17731, Marina Milićević Bradač, Domagoj Tončinić, Dino Demicheli, Ina Miloglav, Iva Kaić, Vinka Matijević, Domagoj Perkić, Igor Vukmanić, Sanja Ivčević, Ana Pavlović, Saša Denegri, Tatjana Lolić, Zrinka Buljević, Zrinka Šimić-Kanaet, Tomislav Šeparović, Mirna Vukov, Roman Empire, Danube, Mediterranean, mobility, economy, Roman military, local elite.The objective of the project is to investigate and extend scientific information to aid in solving as yet unanswered questions about the significance of the Roman military in changes that occurred on the territory of Republic of Croatia in the period from the first contacts with Rome (229 BC) to the end of the Marcomannic Wars (180 AD). The geopolitical strategy of Rome in conquered regions was to encourage the integration process, where the Roman army gave its contribution. Archaeological data testify that the indigenous communities of Illyricum reacted differently to this process. Some were willing to accept the Roman heritage (e.g. Liburnians), while the others (e.g. Delmatae) were providing resistance. Given previous research today we have a number of valuable studies about certain aspects of Roman domination. However, they are primarily focused either on the ancient written sources or the archaeological material from Dalmatia and Pannonia. This research of the integration would cover for the first time the Roman military presence on the area of Croatia. The main focus is on the Roman military sites along the Dalmataean and the the Danube limes. New data will be derived using the methodology purposely created for this project and includes archaeological survey, classification, comparison and evaluation of all available data both archaeological and ancient sources with the application of the variable of geographic origin. Such research has never been undertaken in Croatia. The results would fill the informational gaps that exist for this part of the Empire through the analysis of the largest possible amount of information about the Roman army activities and the integration of indigenous people. The project leader’s research has focused so far on the problems of Roman provincial archaeology. Many years of her successful research of and of all the collaborators guarantee the sustainability of the approach and the successful implementation of the project objectives.
1865Hrvatska filozofija i znanost u europskom kontekstu od 12.-20. stoljećaCroatian philosophy and science in the European context between the 12th and 20th century1321Pavo Barišić IP2013-11IP-2013-11-3524HRFIZ01.06.2014 - 31.05.2018Završio405.000,00 KnHumanističke znanosti, Prirodne znanosti, Humanities, Natural sciences, Filozofija, Philosophy, Institut za filozofijuInstitute for Philosophy in Zagreb1321, 1442, 748, 307, 505, 808, 811, Pavo Barišić, Bruno Ćurko, Mihaela Girardi-Karšulin, Željka Metesi Deronjić, Snježana Paušek-Baždar, Nenad Trinajstić, Vanja Flegar, Croatian philosophy, history of philosophy, history of science, natural sciences,aesthetics, Neo-Platonism, Aristotelianism, alchemy, postmodernWe hereby submit to the HRZZ the project “Croatian philosophy and science in the European context between the 12th and 20th century” for financial support. Due to the integrative nature of the modern world, the primary issue for each member of the European and global community is the preservation of its identity, which implies cherishing national culture and the inherent philosophical and scientific tradition. Croatia’s accession to the EU has imposed an even stronger need for preservation. Research into Croatian philosophy and science started at the turn of the 20th century, but to re-examine national identity each generation inevitably has to revert to tradition, which is why studies of the works of Croatian philosophers and scientists should be our permanent mission. Continuing the work of previous researchers, our desire is to analyse the still unexplored aspects of Croatian philosophy and science in order to gain better insight into their contribution to European philosophy and science. That is why this project plans to tackle the following topics: “Reception of Plato’s philosophy in the works of Croatian philosophers between the 12th and 16th century”; “The development and shifts in Aristotelianism during the 16th and 17th century”; “The philosophy of Juraj Dragišić”; “Croatian aesthetics and poetics in the European context between the 16th and 18th century”; “The relationship between natural philosophy and alchemy in the works of Croatian authors Andrija Dudić, Pavle Skalić, and Frane Petrić”; “The alchemy in Croatia from 14th to 18th”century; “The history of Croatian chemistry during the development of natural sciences in the 19th and 20th century”; “A review of the history of Croatian philosophy in the 19th and 20th century”. The aim of this project is an anthology that would present the results of four years of research and serve as the basis for creating a comprehensive overview of the entire history of Croatian philosophy and science.
1875Kromatografsko pročišćavanje biomolekula i njihova karakterizacijaChromatographic purification of biomolecules and their characterization111Marija Brgles UIP2013-11UIP-2013-11-8193CHROBIO15.09.2014 - 14.09.2017Završio676.340,51 KnPrirodne znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, Natural sciences, Biomedicine and health sciences, Biotechnical sciences, Kemija, Chemistry, Sveučilište u ZagrebuUniversity of Zagreb3085, 1144, 3357, 102, 936, 17755, Jelena Ivančić Jelečki, Tihana Kurtović, Maja Markušić, Beata Halassy, DUBRAVKO FORČIĆ, Dora Sviben, chromatography, viruses, plasma proteins, snake venom, monoliths, bioanalytics, aggregationAim of the proposed research is the design of non-invasive chromatographic methods suitable for purification and concentration of biomolecules (viruses and proteins) and their characterization. Purification and analysis methods will be focused on measles virus, snake venom and antivenom proteins, and human plasma proteins. Measles virus is used as a vaccine and is found very suitable as a gene vector and as an oncolytic virotherapeutic, with the last two applications requiring large amounts of the virus. Venom is an antigen for antivenom production and both require careful analysis in order to obtain the final product of high quality. Proteins from plasma, namely albumin and immunoglobulin, are of great medical importance and their purification and stability are of utmost significance. All these biomolecules are important as biotechnological products and are subjected to rigorous quality requirements to ensure their safe usage. Therefore, non-invasive purification methods upgrading their quality and sustainable production and ensuring stability of these fragile biomolecules are essential. This project will base purification on chromatography using monolith stationary phases which are featured by their suitability for biomolecules due to high porosity, high binding capacity and convective based transport. Ion-exchange and affinity chromatography will be employed and various conditions tested for obtaining target material with high purity and yield. Also, various formulation conditions enabling preservation of virus viability and protein functionality and stability throughout the process will be tested. The analysis of the virus infectivity and protein functionality, removal of contaminants and the overall procedure effectiveness will be done by classical biochemical and virological methods as well as by some novel methods such as nanoparticle analysis that enables detection of virus and protein aggregates (NanoSight).
1879Povezanost fleksibilnosti, aktivnosti i strukture u porodici dipeptidil-peptidaza IIIFlexibility, activity and structure correlations in the dipeptidyl peptidase III family2974Sanja Tomić IP2013-11IP-2013-11-7235FlAcS01.07.2014 - 31.10.2017Završio653.551,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb5071, 2975, 56, 3310, 2700, 4281, 2638, 1522, 1429, 4619, 3091, 17832, Marija Abramić, Antonija Tomić, Borislav Kovačević, Saša Kazazić, Dejan Agić, Bojana Vukelić, Igor Sabljić, Zrinka Karačić, Nina Jajčanin Jozić, Mihaela Matovina, Aleksandra Maršavelski, Marko Tomin, dipeptidyl peptidase III, metallopeptidase, catalytic activity, protein flexibility, MD simulations, QM/MM, H/D exchange, protein interactionsWithin the project frame we intend to investigate diversity in evolutionary conserved metallopeptidase family M49 (DPP III family) through characterization of catalytic, structural and dynamical properties of its members. The project would encompass five dipeptidyl peptidases III (DPP III): human, yeast, two bacterial orthologs, from thermophile Caldithrix abyssi and oral pathogen Porphyromonas gingivalis, and a DPP III from plant Physcomitrella patens. The DPP III cleaves dipeptides from the N-terminus of many oligopeptides and contributes to the intracellular protein metabolism as well as to endogenous defense against oxidative stress. Human DPP III (h.DPP III) is also related to pathological processes of cataractogenesis, tumor growth and influenza virus infection. The project research should elucidate whether the large flexibility determined for h.DPP III is conserved within DPP IIIs, and how it correlates with the protein function. It would reveal submolecular details important for substrate stabilization and, in the case of h.DPP III, the enzymatic mechanism. Elucidation of the key interactions between h.DPP III and Keap1 protein (Nrf2-Keap1 signalling pathway is major regulator of cytoprotective responses to oxidative and electrophilic stress), and possible correlation of DPP III flexibility with the complex stability, should aid in clarification of its cellular roles. Plant DPP III, differently from DPP IIIs in other organisms possesses a NUDIX box. The project should elucidate its potential dual activity (peptidase and NUDIX). Study of DPP III from thermophile should improve our knowledge on thermophile proteins, potentially useful in biotechnology. In order to fulfill the outlined goals a finely tuned multidisciplinary approach would be used in which molecular biology, biochemistry and mass spectrometry methods would be complemented with bioinformatics, multiscale molecular modeling (coarse grained/all atom MD, QM/MM) and macromolecular crystallography.
1880Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasaProteomic approach in the discovery of early-stage biomarkers in kidney and cardiac disease of dog801Vladimir Mrljak IP2013-11IP-2013-11-4135BioDog01.07.2014 - 30.06.2018Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesVeterinarska medicina, Veterinary medicine, Sveučilište u Zagrebu, Veterinarski fakultetUniversity of Zagreb, Faculty of Veterinary Medicine3369, 6678, 4117, 6240, 4115, 6598, 6734, 2720, 6965, 6338, 5882, 2601, 6943, 6501, 17792, 19055, 2779, 19049, 19047, Vesna Matijatko, Martina Crnogaj, Mirna Brkljačić, Jelena Selanec, Marin Torti, Živičnjak Tatjana, Josipa Kuleš, Blanka Beer Ljubić, Renata Barić Rafaj, Jose Ceron, Alan Kovacevic, Srđan Vučinić, Carlos de Torre, Mazzucchelli Gabriel, Petra Nižić, Mangesh Bhide, Anita Horvatić, Asier Galan, Guillemin Nicolas, biomarkers, dog, proteomics, kidney, heart, babesiosis, idiopathic dilated cardiomyopathy, chronic valvular diseaseProteins play essential roles in every cellular process. Biomarkers have the potential to identify key disease indicators at the individualised level, as well as to detect a disease at the early-stages before the development/advance of a serious illness. The emergence of innovative, post-genomic technology, like proteomics, led to the development of strategies aimed at identifying altered, sensitive biomarkers specific to the disease among thousands of molecules present in biological samples. Blood and urine contains multitude, unstudied, and unknown biomarkers, particularly in low-molecular region of blood and urine proteome. Babesiosis, idiopathic dilated cardiomyopathy (iDCM), and chronic valvular disease (CVD-MV) in dogs are common and serious disease. The aims of the project is: to discover novel, early-stage biomarkers of kidney and cardiac disease in dogs which could lead toward more precise and adequate diagnose, prognosis, and monitoring of these diseases; to perform a proteomic analysis on the sera and urine of dogs with uncomplicated and complicated form of babesiosis, as well as dogs with diagnosed iDCM and CVD-MV in order to identify novel, early-stage diagnostic and prognostic biomarkers; to expand the pathway signalling research in order to improve the understanding of pathogenesis for studied disease; to validate new biomarkers for studied diseases. Tthese expected scientific outcomes will contribute in practice: (a) in a short term view, to detect individualised molecular fingerprints; to improve the diagnosis and prognosis of iDCM, CVD-MV, and babesiosis, as well as potential targets for novel approaches to monitor the therapies of these diseases; to enable the ability to personalise the treatment of individual patients resulting in enhanced patient care; and (b) in a long-term view, to allow entry of proteomics in clinical veterinary medicine in Croatia and transfer of knowledge in –omics- technologies in other parts of veterinary medicine.
1884Jadranske geopolitike u modernosti, 1493.-1914.The Modern Geopolitics of the Adriatic Sea, 1493-19145171Josip Vrandečić IP2013-11IP-2013-11-8469Megas01.07.2014 - 30.06.2018Završio130.900,00 KnHumanističke znanostiHumanitiesPovijest, History, Sveučilište u Splitu, Filozofski fakultetUniversity of Split, Faculty of Philosophy5524, 6986, 2763, 5570, Nikša Varezić, Edi Miloš, Marko Trogrlić, Marko Rimac, Imperio Maris Adriatici, Heartland, Venice, Austria, Ottoman Empire, Napoleon, IrredentismThe project aims to draw attention to the foreign politics and the military build-up of the great and middle powers at the Adriatic during the both early modern period and the 19th century. The starting point of the study is the Ottoman occupation of Bosnia in 1463 confirmed by defeat of Croatian army in the Battle of Krbava in 1493. The main allies of anti-Ottoman resistance Habsburgs, Venice and the popes sought to prevent the Ottoman penetration to the Adriatic and in the West. In their long term efforts they used tools of military revolution that has prevailed on their side. However, the early modern alliance is marked by a profound Habsburg-Venetian rivalry on the Adriatic which was ended by the fall of Venice in 1797 year. A new contender at the Adriatic, the revolutionary France, sought to repel Russians and Britons, and to provide a springboard to the East. After the fall of Napoleon, Austria secured supremacy on the sea, but the newly proclaimed Kingdom of Italy continued the centuries-long conflict over the Adriatic. In addressing the historical prospective, the project focuses on publishing five books which will present each phase of the competition and the main protagonists in this conflict. 1. Josip Vrandečić, The Adriatic Mission Zadar of Minuccio Minucci, the Archbishop of Zadar, 1596-1604. 2. Nikša Varezić, Republic of Dubrovnik and the Holy See, 1645-1699. 3. Marko Rimac, The Cetina region between Ottoman and Venetian rule (1683-1730). 4. Marko Trogrlić-Josip Vrandečić, Reports of Dalmatian Governor Vincenzo Dandolo to Emperor Napoleon, 1806-1809. 5. Marko Trogrlić, Memoirs of the Dalmatian Governor General Gabriel Rodić, 1812-1890.
1895Raznolikost i interakcije kestena, patogene gljive koja izaziva rak kestena i virusa koji inficira gljivu: učinak na oporavak kestenaDiversity and interactions of chestnut, chestnut blight fungus and biocontrol agent – virus: implications on chestnut recovery761Mirna Ćurković Perica IP2013-11IP-2013-11-5381Chestnut30.06.2014 - 29.06.2017Završio745.500,00 KnBiotehničke znanosti, Prirodne znanosti, Biotechnical sciences, Natural sciences, Šumarstvo, Forestry, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science975, 770, 4710, 1532, 1336, 2565, 757, 2506, 1456, 17770, 19883, Marilena Idžojtić, Zlatko Liber, Mirta Tkalec, Ljiljana Krstin, Daniel Rigling, Rosemary Vuković, Igor Poljak, Marin Ježić, Zorana Katanić, Lucija Nuskern, Jelena Mlinarec Novosel, biological control, chestnut disease, epigenetics, hypovirulence, molecular ecologyEuropean sweet chestnut is an important multipurpose tree species. For decades, chestnut blight, a disease caused by one of the world´s most aggressive invasive pathogens Cryphonectria parasitica has been causing high mortality in chestnut forest populations and orchards. However, the fungus can be controlled by the naturally-occurring virus Cryphonectria hypovirus 1 (CHV1) which causes a reduction in fungal virulence and sporulation (a phenomenon called hypovirulence), which in turn enables infected trees to recover. Hypovirulence is the most efficient way to successfully control chestnut blight in Europe, but unfortunately the spread of CHV-1 is limited by the fungal diversity and its sexual reproduction. This project aims at revealing individual and joint aspects of the dynamic three-lateral interaction between chestnut, its fungal pathogen and the pathogen-biocontrol agent-virus. The proposed study will: (1) reveal the diversity of natural chestnut populations in south-eastern Europe, (2) connect the sequences and 3-D structures of CHV1 subtype I proteins with the level of fungal hypovirulence, (3) reveal the role of epigenetic changes of fungal genome in respect to hypovirus infection and geographical spread of the fungus (4) assess the efficiency of naturally-occurring virus isolates to induce chestnut recovery in natural conditions. The results will also contribute to the combat efforts against chestnut blight in the field conditions, by enabling production of therapeutic paste for induction of recovery in a valuable chestnut cultivar.
1901Očuvanje genofonda šumskog drveća u svjetlu klimatskih promjenaConservation of genetic resources of forest trees in light of climate changes5275Mladen Ivanković IP2013-11IP-2013-11-8131ConForClim01.09.2014 - 31.08.2018Završio840.000,00 KnBiotehničke znanostiBiotechnical sciencesŠumarstvo, Forestry, Hrvatski šumarski institutCroatian Forest Research Institute5744, 5235, 5716, 5607, 17850, 12638, 44, 20996, 21001, 13263, Sanja Novak Agbaba, Nevenka Ćelepirović, Marija Gradečki-Poštenjak, Maja Popović, Sanja Mrmić, Ivica Čehulić, Saša Bogdan, Netzer Florian, Anđelina Gavranović, Aikaterini Dounavi, Genetic conservation, Climate changes, Forest , provenance trials, variability, Quercus robur, Fagus sylvatica The preserving of the genetic diversity of the forest types is the basis for sustainable management and conservation of the natural composition of the forests. Natural forests make up 95% of the total forests in Croatia and in its wealth geographic region contains different ecological types and a large number of the forest tree species. Global climate changes, rising temperatures, falling rainfall, occurrence of the extreme weather events directly affect on genetic diversity. The main objective of the proposed project is to make recommendations for the conservation of the genetic diversity of the forest trees. Precondition for achieving the goal is the identification and understanding of the genetic variability of the individual tree species. The research to be carried out by the project would be based on the common oak and beech. On existing genetic tests that were established at different sites, data on the survival and growth of plants, phenology, silvicultural properties, plant resistance to pests, etc should be collect. The stem forest stands from which the seed was taken will be used for collecting the data of health condition, fruiting and climatic parameters. The genetic diversity of the provenance will be analyzed by DNA markers. This project should be continued and expanded research on the identification of proven European beech resistant to drought, which are conducted in the framework of a bilateral cooperation with Germany (MSES-DAAD 2013/14) and the preservation of the gene pool and study of the variability of our most important tree species which are conducted as part of the project “Breeding and forest seed” supported by MSES of Croatia. From the economic point of view, the project aims is to raise the category of the forest reproductive material (FRM) in a higher category according to the Law of FRM (Official Gazette 75/2009, 61 /2011 - EU directive EC/105/99). Higher category guarantees a higher quality, and thus a higher price in the market.
1911Rekombinacija, popravak DNA i očuvanje integriteta genoma: novi puteviDNA recombination, repair and maintenance of genome integrity: new pathways5202Davor Zahradka IP2013-11IP-2013-11-2978RECNEWPATH01.09.2014 - 31.12.2018Završio987.966,13 KnPrirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb5240, 5308, 5923, 5816, 5274, 5340, 5343, 5910, 17821, Ksenija Zahradka, Damir Đermić, Dušica Vujaklija, Miroslav Radman, Maja Buljubašić, Jelena Repar, Svjetlana Cvjetan, Tina Paradžik, Ana Hlevnjak, hommologous recombination, DNA repair, genome stability, Escherichia coli, Deinococcus radiodurans, RecA protein, gross chromosomal rearrangementsHomologous recombination is an essential biological process that is involved in DNA repair and in the maintenance of genome integrity. The RecA protein is a key component of recombinational systems in bacteria. Its homologs are also present in higher organisms including humans. RecA functions in the form of nucleoprotein filaments that are assembled on single-stranded DNA, and which catalyze pairing and strand exchange between two homologous DNA duplexes. In Escherichia coli, the RecBCD and RecFOR protein complexes mediate RecA filament assembly, and consequently, play an important role in recombination. We have recently discovered that some E. coli mutants recombine quite efficiently in the absence of both RecBCD and RecFOR complexes. This recombination is RecA-dependent suggesting the existence of an alternative RecA loading activity. The aim of the project is to genetically characterize this RecBCD- RecFOR-independent (RecBFI) recombination pathway, and gain insight into this novel mechanism of RecA filament assembly. Although RecA is crucial for efficient recombination in bacteria, the recA mutants of radiation-resistant bacterium Deinococcus radiodurans display a significant residual ability to repair double-strand DNA breaks. Recent results from our group have shown that this RecA-independent repair is quite inaccurate leading to gross chromosome rearrangements. Our project is to identify the key genes/proteins involved in this RecA-independent repair, and to characterize, at the sequence level, gross genome rearrangements in D. radiodurans. Given that recombination is a fundamental process largely conserved during evolution, our research on bacteria may reveal molecular mechanisms that are applicable to eukaryotic recombination systems. Thus, the results of our project could be instructive for research on cancer and other human hereditary diseases related to defects in DNA recombination functions.
1912Detekcija objekata više razreda za pametna vozila i sigurnije cesteMulti-class object detection for smart vehicles and safer roads361Siniša Šegvić IP2013-11IP-2013-11-1395MULTICLOD01.10.2014 - 30.09.2017Završio704.766,91 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing6558, 6564, 6565, 6563, 6914, 6351, 6700, 6984, 7053, 7393, 6814, Josip Krapac, Zoran Kalafatić, Ivan Krešo, Ivan Filković, Axel Pinz, Marko Ševrović, Valentina Zadrija, Domagoj Jakobović, Ivan Sikirić, Albert Diosi, Karla Brkić, Computer vision, structure from motion, object detection, image categorization, multi-body structure from motionThroughout the last decades we witness persistent improvement in understanding ways to make machines see. Consequently, opportunities for computer vision applications are becoming more and more abundant. Understanding dynamic traffic scenes is especially interesting due to exciting applications in the fields of smart vehicles (driver assistance, autonomous cars) and intelligent transportation systems (road safety inspection, adaptive traffic control). Nevertheless, many of these applications are out of reach since the computers are still unable to match human perception. We believe that this gap would be reduced by improving our understanding of scalable detection of multiple object classes in dynamic scenes.The task of object detection is to localize objects of interest in input images. We address detection in the most general case where the objects of interest exhibit large appearance variation. In this case the problem is often referred to as multi-class object detection. Our proposal focuses on dynamic traffic scenes acquired by a calibrated stereo rig from the driver's perspective. We propose to develop detection approaches which would combine estimated camera motion and scene structure with learned appearance features, and to experimentally compare them with the state of the art. We shall employ advanced methodologies such as SfM, dense stereo, variational optimization, scene flow, spatio-temporal descriptors, latent SVM and Fisher vectors. These methodologies shall enable us to achieve improvements upon the state of the art in terms of scalability and detection performance. This will open way to exciting applications capable of reducing traffic accidents, improving efficiency and decreasing traffic congestion. Some of these applications shall be demonstrated by experiments on a real autonomous car. The proposed research would also contribute to a future unified theory of computer vision which would encompass detection, reconstruction and categorization.
1915Biološki učinci vina: utjecaj vinifikacijske tehnologije, dealkoholizacije i starenja vinaBiological effects of wine: the influence of vinification technology, dealcoholization and aging of wine2679Mladen Boban IP2013-11IP-2013-11-8652BioWine01.09.2014 - 31.08.2019Završio998.070,76 KnBiomedicina i zdravstvo, Biotehničke znanosti, Biomedicine and health sciences, Biotechnical sciences, Temeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine3385, 3249, 4348, 2713, 3112, 5297, 3823, 3690, 2542, 809, 3346, 3068, 3048, 21325, 12573, 24315, Ivica Grković, Grgo Gunjača, Natalija Filipović, Ana Jerončić, Jungbauer Alois, Višnja Katalinić, Danijela Skroza, Vlado Krauthaker, Ivana Mudnić, Nikolina Režić Mužinić, Ana Šešelja Perišin, Nataša Boban, Josip Volarević, Ana Marija Milat, Benjamin Benzon, Danica Ivanković, wine, wine technology, cardiovascular, antimicrobial, anti-inflammatory, antioxidantGrape production technology and procedures in wine making and processing significantly affect biochemical composition and organoleptic properties of wine. However, the effects of different enological procedures on biological activity of wine are poorly investigated.The overall aim of this project, which represents an interdisciplinary research effort of experts from fields of biotechnology and biomedicine, is to investigate how different enological procedures in wine making (changes of maceration time, partial/complete dealcoholization, aging of wine) may affect its biological activity. This also includes investigation of potential differences in distinctive biological effects between wines obtained by the technology of white and red wine production.In contrast to the process of red wine production, in the white wine production there is no maceration in contact with grape seeds and skins, and only fermentation of immediately separated grape juice occurs. So, biological potentials of white wines may considerably differ from that of red wines. Conversely, if even short maceration is allowed in the process of white wine making, polyphenolic content and antioxidant potential of such wines is significantly enhanced. There are several studies demonstrating superior effects of red versus white wine on certain cardiovascular parameters. However, epidemiological evidence demonstrating specific benefits of red over white wine is poor and conclusive studies comparing the two are missing.Detailed biochemical analyses of all test wines will be performed and their biochemical properties will be correlated with their biological activity.Among numerous biological effects of wine and its constituents, this project focuses on cardiovascular, antioxidative, anti-inflammatory and antibacterial effects of wine that will be examined on a spectrum of in vitro and in vivo biological systems including small laboratory animals and human volunteers.
1924Numeričko modeliranje složenih elektromagnetskih pojava u transformatorimaNumerical Modelling of Complex Electromagnetic Phenomena in Transformers312Željko Štih IP2013-11IP-2013-11-1118NM_TRAF01.08.2014 - 31.07.2018Završio921.267,43 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing314, 2877, 328, 319, 1117, 1373, 324, 2797, 2823, 2777, 2712, 2792, 3271, 4947, 4355, Sead Berberović, Livio Šušnjić, Martin Dadić, Bojan Trkulja, Žarko Janić, Dalibor Filipović-Grčić, Tomislav Župan, Robert Sitar, Mladen Marković, Kosjenka Capuder, Franjo Kelemen, Igor Žiger, Lucija Babić, Goran Plišić, Ivan Šulc, numerical methods, transformers, insulation systems, lossess, high frequency modellingTransformers are crucial devices in efficient and reliable transmission and distribution of electricity. Croatian transformer manufacturers are among a top few in the world, and their annual production is worth about €300 million, what is about 2% of the world production. It is possible to keep this position on the world market only if there is a close collaboration between the academic community and transformer manufacturers. Notable progress in technology of transformers is based on utilization of new materials and application of advanced design methodologies, which incorporate sophisticated numerical methods for modelling of processes in transformers. This project is focused on research and development of advanced numerical techniques for solving various electromagnetic phenomena in transformers and their application in design. Crucial subjects in transformer design are: insulation system, electromagnetic losses and windings. Consequently, researches within this project are organized in three subprojects:1. New methods for design of insulating systems. The aim of this subproject is to develop new comprehensive numerical method for computation of electric fields within the insulating system.2. Computation of electromagnetic losses with the aim to develop a new method of estimation of stray losses level of power transformer, as well as the methodology of simultaneous modelling of electromagnetic field, thermal field and fluid dynamics field in transformers.3. High frequency modelling of windings. The objective of this subproject is to develop fast and accurate procedures for the determination of capacitances, inductances and resistances in high-frequency range. These elements will be used for creating an equivalent lumped-element circuit for determination of voltage stresses along a winding.The overall goal is to reduce dimensions of transformers and to increase their reliability by application of new methods and procedures.
1942Matematičko modeliranje, analiza i računanje s primjenama na kompleksne mehaničke sustaveMathematical modelling, analysis and computing with applications to complex mechanical systems2945Zlatko Drmač IP2013-11IP-2013-11-9345MMACACMS01.09.2014 - 31.08.2018Završio584.727,85 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science4557, 5056, 4816, 5431, 4757, 17823, Luka Grubišić, Zvonimir Bujanović, Josip Tambača, Ivica Nakić, Nela Bosner, Ivana Šain, scientific computing, complex mechanical systems, eigenvalue problems, model reduction, distributed control, high perfomance scientif computingThis proposal is focused on functional and numerical analysis of mathematical models of selected complex mechanical systems from mathematical physics and engineering, with particular emphasis on the development of numerical methods and robust algorithms for computing. Such operator theoretic models are particularly amenable to be treated algebraically in the context of efficient and robust computational procedures of modern numerical linear algebra. The themes include adaptive (interior penalty) discontinuous Galerkin method in the penalty based formulation of the model for the complex mechanical system (e.g. stent), and vibration analysis for powertrains (car industry). In a related topic of vibration control, we study distributed control using dynamic multipliers from the dissipativity theory. In the frequency domain, we consider the problems of system identification and model order reduction posed as problems of rational approximation in the Hardy space H2. For all considered problems, we devise numerical algorithms and identify core numerical linear algebra computational tasks for which we plan to develop robust algorithms. These include Arnoldi-type eigensolver for both linear and quadratic large scale eigenvalue problems, and high accuracy algorithms for structured matrices of paired Cauchy structure. All developed algorithms will be delivered also as high performance mathematical software.
1945Epigenetička regulacija glikozilacije immunoglobulina GEpigenetic regulation of IgG glycosylation5416Vlatka Zoldoš IP2013-11IP-2013-11-3361EpiGlycoIgG01.10.2014 - 30.09.2018Završio994.815,24 KnPrirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science5420, 5620, 5359, 5449, 5468, 5425, 5596, 5428, 5952, 17847, 1497, Gordan Lauc, Aleksandar Vojta, Ivana Samarzija, Paula Dobrinić, Marija Klasić, Dora Markulin, Vedrana Vičić Bočkor, Genadij Razdorov, Toma Keser, Vanja Tadić, Petra Korać, DNA methylation, Epigenetics, Histone modifications, IgG, Protein glycosylation, TALENSIgG is one of the main effectors of the immune system. Contrary to antigen binding properties which are defined by nucleotide sequence for its Fab part, effector functions of IgG are mostly regulated by Fc glycosylation, which is regulated by complex interplay of dozens of genes in the IgG glycosylation pathway and different environmental factors. Different clones of B lymphocytes have defined patterns of glycosylation, indicating temporal stability in the glycosylation pathway. DNA CpG methylation is the most stable epigenetic modification and is thus the most prominent candidate for “fixation” of the IgG glycosylation profile in different clones. Our past and current genome wide association studies (GWAS) are identifying complex genetic network which regulates IgG glycosylation. In this project we will use several complementary experimental approaches to identify genes and epigenetic regulatory mechanisms which regulate IgG glycosylation. IgG glycosylation is relevant in numerous diseases, including autoimmune diseases, inflammatory diseases and cancer. Several epigenetic drugs are already used to treat cancer, and many others are developing. Understanding of the role of the epigenetic regulation in IgG glycosylation will provide new targets for the development of new epigenetic drugs and new biomarkers for patient stratification.
1950Pogrebni običaji i društvo kasnog brončanog doba na jugu Karpatske kotlineLate Bronze Age mortuary practices and society in southern Carpathian Basin3646Daria Ložnjak Dizdar UIP2013-11UIP-2013-11-5327BAMPICa01.07.2014 - 30.06.2017Završio587.000,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Institut za arheologijuInstitute of Archaeology in Zagreb5790, 7071, 7061, 1371, 7110, 7022, 7601, Petra Rajić Šikanjić, Marko Dizdar, Stašo Forenbaher, Zrinka Premužić, Boris Kavur, Carola Metzner-Nebelsick, Marie Louise Stig Sorensen, Late Bronze Age, mortuary practices, society, archaeology, anthropology, southern Carpathian BasinThis project proposes to combine archaeology and physical anthropology in order to expand the current knowledge of Late Bronze Age (LBA) mortuary practices and society in Carpathian Basin. It will integrate analyses of burial features and associated artifacts with analyses of cremated human remains from at least seven urnfield cemeteries in northern Croatia, dated between 13th and 9th century BC. We shall seek correlations between skeletal and artifactual evidence, which should allow us to recognize regularities and possible discrepancies linked to a specific gender or age group. Our primary aim is to investigate the variability of mortuary practices as reflected in modes of corpse treatment and disposal. At a more general level, we shall combine our data in order to investigate LBA social identities in southern Carpathian Basin. Our second aim is to investigate whether the traditionally perceived difference between 'Urnfield culture' and 'Belegiš II group' can be detected in mortuary evidence other than urns. Our sample of 120 burials covers a time span of six centuries, which will allow us to monitor the diversity of mortuary practices during the entire LBA and also contribute to the resolution of regional chronology. In order to archive the data, as well as to distribute and promote our findings, we shall design a public-access data base, organize a round table with experts from region and publish our results in a monograph.
1955Formacija i destrukcija domena u vodenim otopinamaMulti-scale description of meso-scale domain formation and destruction5374Larisa Zoranić UIP2013-11UIP-2013-11-4514MS-FORMDES15.09.2014 - 14.12.2017Završio567.919,91 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Splitu, Prirodoslovno-matematički fakultetUniversity of Split, Faculty of Science5591, 5569, 3581, 6896, 1469, 3589, 6868, 19038, 19062, Bernarda Lovrinčević, Martina Požar, Juraj Simunić, Marijana Mijaković, Franjo Sokolić, Nada Ilić, Aurelien Perera, Yogesh Sonavane, Tomislav Primorac, associated liquids, micro-heterogeneity, molecular dynamics, integral equation theory, antimicrobial peptidesThe physics of associated liquids, amphiphilic solutions and lipids in water is determined by competing hydrophobic and hydrophilic interactions between various molecular groups. By exploring assemblies ranging from molecular to cellular sizes we are aiming at building a unified view of the principal mechanisms responsible for domain formation and destruction. This new approach hasn't been explored as such in similar research projects. In the project's first year, by molecular dynamic simulations, we will quantify micro-heterogeneity in liquids as a structural order that exists on the local scale and doesn't propagate on the global scale. As a continuation of the first-year results, we will study how the structure of the above mentioned liquids changes when dissolving molecules that promote or destroy domains defined by the local ordering. The used methods will be simulations and integral equation theory. In parallel with the molecular scale studies, the cellular membranes will be probed by means of experimental measurements and simulations. The aim will be to describe the mechanism of destruction of lipid bilayers induced by antimicrobial peptides. Principal investigator Larisa Zoranić has competencies to establish a new research group with an interdisciplinary subject and members of diverse fields because of her scientific background in physics, biology and biophysics. She has experience working in both international and Croatian groups, thus obtaining the required managing skills. The group's acquired knowledge and expertize will ensure a good quality start towards more demanding issues that stem from the project. The aims and methods of this research are competitive internationally in the area of molecular physics and biophysics. This kind of innovative project, built around an interdisciplinary group and having strong connections with the diploma and doctorate studies, will strengthen the Croatian scientific network.
1982Napredni tekstilni materijali dobiveni ciljanom modifikacijom površineAdvanced textile materials by targeted surface modifications747Sandra Bischof IP2013-11IP-2013-11-9967ADVANCETEX01.09.2014 - 31.01.2019U tijeku989.200,00 KnTehničke znanostiTechnological sciencesTekstilna tehnologija, Textile technology, Sveučilište u Zagrebu, Tekstilno-tehnološki fakultetUniversity of Zagreb, Faculty of Textile Technology3887, 3088, 1464, 4810, 5211, 5841, 1504, 1494, 1466, 1481, 7190, 7291, 17700, 15905, 17701, 17882, 17882, Edita Vujasinović, Anita Tarbuk, Ružica Brunšek (Šurina), Tihana Dekanić, Sandra Flinčec Grgac, Tanja Pušić, Marijana Pavunc, Zorana Kovačević, Ana Budimir, Branka Vojnović, Branka Marinovic, Andrea Katović, Iva Matijević, Eva Magovac, Ana Sutlović, Suzana Kutnjak-Mravlinčić, Suzana Kutnjak-Mravlinčić, advanced materials, textiles, surface modification, fibre reinforced composites, nano-metal particles, LCA, The demand for advanced textile materials has dramatically increased during the last few decades, in particular for engineering, medical and technical applications. A new sight proposed by this project is in the merging of so far separate research teams involved in the development of advanced textile materials, through targeted eco-driven surface modifications. Surface pre-treatments and modification will be carried out on selected sustainable textile materials, using environmentally friendly substances and processes, in order to attain antimicrobial, flame retardant, oil/hydrophobic, wellness or medical properties obtaining high added value textiles. Different environmentally friendly methods of microwave, ultrasound or plasma modification processes will be used to enhance targeted functionalities as well as to increase interfacial adhesion between fibres and polymer matrix in fibre reinforced composites. The other approach of the production of highly active surfaces which will have capability to block UV and microwave radiation, enhance oil and water repellence, antimicrobial, self-cleaning, and flame retardant properties is in the application of micro/nano-particles such as TiO2, ZnO, Cu, Ag and Au. These particles can be applied on the surface of fibers, textiles, clothing or inlayers for footwear. Detailed characterization of each treatment effectiveness, so as their effect on humans and the environment will be investigated. Laundering durability and maintenance properties are equally important as the effectiveness of developed advanced material. Introduction of novel eco-driven surface modification processes in textile production will be complemented by the risk analysis and sustainability issues, focusing onto production and product safety, usage and recyclability of newly developed product without significant environmental burden. Innovative textile products will be directed towards the needs of the textile, chemical, pharmaceutical or medical industries.
1984Diracovi operatori i teorija reprezentacijaDirac operators and representation theory5573Pavle Pandzic IP2013-11IP-2013-11-4176representations01.06.2014 - 31.05.2018Završio621.317,37 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science5930, 5518, 6295, 5512, 5479, 5954, 17808, Mladen Božičević, Hrvoje Kraljevic, Matija Bašić, Ksenija Kitanov, Rafael Mrđen, Ana Prlić, Karmen Grizelj, Harish-Chandra modules, Dirac operators, cohomology, Dirac induction, branching problemsDirac operators were introduced into representation theory by Parthasarathy in the 1970s. In the 1990s, Vogan conjectured a strengthening of Parthasarathy's Dirac inequality, which relates the cohomology of the Dirac operator to the infinitesimal character of the representation. This conjecture was proved in a joint paper with Huang . In further research, in part joint with various collaborators (Barbasch, Huang, Kang, Mehdi, Protsak, Renard, Somberg, Zhu) , we related Dirac cohomology to other kinds of cohomology, calculated it explicitly for many interesting representations, and studied algebraic Dirac induction, a construction of representations with given Dirac cohomology. The proposed project will continue this research in several directions: 1) the study of representations obtained by Dirac induction, in particular the discrete series representations (doctoral research of Ana Prlić). 2) applying Dirac cohomology to problems of restricting representations. Some instances of this have been studied with Huang-Zhu and with Somberg. 3) trying to strengthen the Dirac inequality, which should have implications for the study of unitary representations. Some preliminary work on the convex hull conjecture of Salamanca-Vogan has been done with Renard. 4) calculating the Dirac cohomology of unipotent representations. Some cases of this have been obtained jointly with Barbasch. This could lead to better understanding of characters of unipotent representations, which is related to the Assem conjecture. It would also be interesting to calculate the Dirac cohomology of unitary highest weight modules. Other topics we plan to cover include studying translation principle for Dirac index (joint with Mehdi and Vogan); studying n-cohomology and BGG resolutions using Penrose transforms (joint with Soucek); studying some abstract homotopy and homology theory, with applications to tensor categories of representations (doctoral research of Matija Bašić).
1987Nastava i škola za net-generacije: unutarnja reforma nastave u osnovnim i srednjim školamaSchool for Net-generation: Internal Reform of Primary and Secondary School Education814Milan Matijević IP2013-11IP-2013-11-3814SCHOOL 4 NET-GEN01.09.2014 - 31.08.2017Završio395.266,50 KnDruštvene znanostiSocial sciencesPedagogija, Pedagogy, Sveučilište u Zagrebu, Učiteljski fakultetUniversity of Zagreb, Faculty of teacher education4771, 4809, 4729, 4127, 4126, 4874, 834, 3753, 3382, 18932, 18933, 18938, 18934, Dubravka Miljković, Višnja Rajić, Mario Dumančić, Damir Velički, Vladimira Velički, Goran Lapat, Tomislav Topolovčan, Siniša Opić, Nevenka Maras, Lidija Eret, Željka Dijanić, Ivana Medica Ružić, Davorka Bačeković-Mitrović, digital media, internal reform, net-generation, parents, primary school, principals, secondary school, student centred education, teachersIn the last few years, research has shown that the teachers and methodologies in schools today are far from the expectations and needs of students belonging to the Net- Generation. The advantages offered by new digital and communication media are not sufficiently exploited to enhance communication in the classroom, and the course books available to students of elementary and secondary schools are not appropriate to the students' needs and expectations. The main aim of the planned research is to explore the attitudes and (self-)evaluation of teachers, school principals (managers), parents and students about the specific traits of the existing didactical paradigm (teacher-centred education) that still dominates in Croatian schools, and to explore the possible didactical solutions for internal reform that focuses on student-centred education based on contemporary theories of teaching and learning and the possibility to enrich education with ICT.Empirical non-experimental, quasi-experimental, and action research is planned. The following methods of data collection will be used during the research: questionnaires, interviews, focus groups, systematic observation, case studies, and content analysis. A number of stratified student samples (N=3000), teacher samples (N=600) and school principals (N=300) from different counties in the Republic Croatia will be used for data collection. According to the general aim of the research and research problems, a number of research instruments (either constructed by the researchers or already verified) will be employed. In order to apply a holistic approach to the research area, qualitative and quantitative methodology will be used and triangulation will be applied for the purpose of ensuring quality in the data analysis.
1991Implicitna ličnost i radno ponašanjeImplicit personality and work behavior3974Zvonimir Galic UIP2013-11UIP-2013-11-6719IPAWB01.10.2014 - 30.09.2017Završio362.785,71 KnDruštvene znanostiSocial sciencesPsihologija, Psychology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences4943, 4502, 5480, 5745, 6601, 6848, 4979, Minja Birimiša Komazec, James LeBreton, Andreja Bubić, Maša Tonković Grabovac, Maja Parmač Kovačić, Željko Jerneić, Nataša Trojak, implicit personality, work behavior, conditional reasoning, aggressiveness, power motive.Recent developments in implicit personality conceptualization and measurement could shed a new light on the relationship between personality and work behavior and help us explain, predict, and even control important aspects of work behavior. In the focus of this project are conditional reasoning measures of implicit personality that represent “a model for psychometric, conceptual, and theory based implicit association measurement” (Landy, 2008, p. 390). This measurement system is called conditional reasoning because it is based on the assumption that an individual’s reasoning is conditional on his/her personality and that these differences in reasoning can be measured with inductive reasoning tasks capturing unconscious cognitive biases that stem from individuals’ personality motives.The project aims to further advance the knowledge about the conditional reasoning method of personality measurement, and the relationship between (implicit) personality and work behavior by exploring implicit aggression and power motive. We plan to (1) test the implicit nature of conditional reasoning tests and the strength of their relationship with other implicit personality measures intended to assess similar constructs; (2) further explore the relationship between the conditional reasoning tests and work behavior by testing mediators and moderators of that relationship; (3) study how different measures of implicit and explicit personality assessing the same construct (i.e., aggressiveness and power motive) interact in explaining work behaviors. We plan to focus on aggressiveness and power motive because they have the pivotal role in explaining very important aspects of work behavior such as counterproductive work behavior and leadership.
1993Razvoj fotokatalitičkih polimernih nanokompozita za obradu otpadnih vodaDevelopment of Photocatalytic Polymer Nanocomposites for Wastewater Treatment913Zlata Hrnjak-Murgić IP2013-11IP-2013-11-5092DePoNPhoto01.09.2014 - 31.08.2018Završio915.300,00 KnTehničke znanostiTechnological sciencesKemijsko inženjerstvo, Chemical engineering, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology973, 4291, 1437, 1407, 1273, 3470, 5174, 17771, Zvonimir Katančić, Jasenka Jelenčić, Ljerka Kratofil Krehula, Igor Peternel, Anita Ptiček Siročić, Jadranka Travas-Sejdic, Mark Žic, Vanja Gilja, conducting polymers, metal oxide nanoparticles, polymer nanocomposites, structure-properties relations, wastewater treatmentEnvironmental problems associated with water pollution are an important issue correlated negatively with the health and ecosystem. The main goal of this proposal is to develop novel polymer nanocomposites of extending photoactivity toward visible region under UV/VIS light irradiation and to introduce an innovative technology for water purification. The conducting polymers (CPs) are known as good hole conducting materials1 and are combined with semiconductor nanoparticles to produce a synergistic effect and complementary properties. Due to that Polyaniline (PANI), polypyrrole (PPy) and poly(3,4-ethylene-dioxythiophene) (PEDOT) conducting polymers will be studied with metal oxides (TiO2, ZnO) nanoparticles to develop polymer nanocomposite photocatalysts (CPNPs) with enhanced photocatalytic properties. The optimal structure-properties relationships are crucial for efficient degradation of organic contaminants in water to convert them into harmless chemicals. Novel CPNPs will be applied in photocatalytic degradation of organic azo dyes (reactive red 45 and methyl orange) chosen as targeted wastewater pollutants. The utilization of waste material, fly ash, as a catalyst support will be explored to provide the additional environmental benefit. The proposed integral approach that will be used in the evaluation of the process efficiency will scrutinize any negative implications of CPNPs application. The project will contribute to the development and modernization of science and technology in Croatia, advancing toward the knowledge-based society within the European research area.Project includes a multidisciplinary effort, ranging from polymer science and technology, chemistry and environmental chemistry to electrochemical engineering, in order to meet challenging project tasks and propose an efficient photocatalytic polymer nanocomposite for sustainable water treatment technology. 1. M.R. Karim, C.J. Lee, Y.T. Park, M.S. Lee, J. Polym. Chem. 14 (2006) 5283–5290.
2002Perspektive održivosti socijalne države: prema transformaciji sustava socijalne sigurnosti za pojedince u personaliziranoj mediciniPerspectives of maintaining the social state: towards the transformation of social security systems for individuals in personalized medicine5231Nada Bodiroga-Vukobrat IP2013-11IP-2013-11-5709POMTS29.12.2014 - 28.12.2018Završio572.744,44 KnDruštvene znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, Social sciences, Biomedicine and health sciences, Biotechnical sciences, Pravo, Law, Sveučilište u Rijeci, Pravni fakultetUniversity of Rijeka, Faculty of Law5119, 5585, 5367, 413, 5762, 5821, 6526, 6344, 5784, 6701, 6584, 6921, 6165, 2767, 3540, 7358, 7422, 6583, Matija Miloš, Ana Pošćić, Sanja Barić, Vanja Smokvina, Adrijana Martinović, Ivo Eškinja, Dario Đerđa, Jelena Jardas Antonić, Sandra Laleta, Nenad Vretenar, Marija Kaštelan Mrak, Marko Boban, Viktor Peršić, Krešimir Pavelić, Sandra Kraljević Pavelić, Jasmina Mutabžija, Martina Bajcic, Danijela Sokolić, transition, social security system, biotechnologies, personalized medicine, reform of the social stateKnowledge economy and high-end services have a distinct role in the economic system and in transformation of the social state in the context of globalisation. This project will submit the current situation to an interdisciplinary analysis and provide a suggestion of a future scaffolding that will be possible both in legal and in economic terms, at the same time grant the end-user benefits of personalized medicine, biotechnology and cutting-edge research. New biotechnologies are the source of challenges on different levels. In the widest perspective, they promise to bring about the clash of globalization, Europeanization and transition. Focusing on the EU in particular, they may bring about changes in the open methods of coordination and shake up the European social model. The national social state is also likely to be affected.The project will therefore gather biotech, legal and economic experts to deliver a platform for identification of challenges posed by development of new technologies in the field of medicine to the society in general; the way the new technological advances may affect the development of a constitutional democracy and the way the mechanisms of this democracy may affect the new technologies.Important social, regulatory, legal, ethical and moral issues will be analysed within this Project. A central issue to be covered is therefore finding adequate ways for a proper communication between scientists, health care providers, patients and health insurance providers, who all need to understand what they are dealing with in order to define their roles and responsibilities. The objectives of the project address scientific, policy, infrastructure and education issues. Specific recommendations include: road mapping (defining research agendas); funding (define future Joint programming projects); education; synergies (creation of inter-disciplinary networks); knowledge transfer and communication; impact (through wide dissemination in journals, books, etc.).
2003Epigenetičke promjene karcinoma pločastih stanica glave i vrataEpigenetic changes in head and neck squamous cell carcinoma572Magdalena Grce IP2013-11IP-2013-11-4758EpiC-HNSCC18.06.2014 - 17.10.2018Završio750.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb3294, 898, 2896, 4023, 5477, 2696, 2507, 2728, 3949, 17822, Nina Milutin Gašperov, Ivan Sabol, Robert Belužić, Marinka Mravak-Stipetić, Drago Prgomet, Zoran Rakušić, Antonia Jakovčević, Spomenka Manojlović, Emil Dediol, Ksenija Božinović, methylation, microRNA, HPV, head and neck cancer, biomarkerHead and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Despite aggressive treatment of HNSCC patients, which entails surgery, chemo- and radio-therapy, the five-year survival is only 40-50%. Tobacco, alcohol, microbial factors (high-risk human papillomaviruses, hrHPVs), systemic factors (immunosuppression, micronutrient deficiency) and UV-radiation are common risk factors for development of HNSCC. HNSCC patients with HPV infection were found to have better prognosis and treatment response. Besides the HPV status, no adequate biomarkers have been found so far to predict the poor/good clinical outcome nor is the mechanism of how HPV modulates therapy response fully understood. Epigenetic changes such as DNA methylation of specific gene promoters and posttranscriptional modification of gene expression by specific microRNA (miRNA) seems to be promising biomarkers of disease occurrence and progression. Therefore, the primary objective of this project is to identify novel specific epigenetic biomarkers to predict early-stage of HNSCC, notably oral and oropharyngeal cancer, patients at greater risk for developing invasive cancer, and finally understand treatment response in patient with HPV-associated cancers. State-of-the-art technologies, wide-genome microarray assay and types-specific validation of DNA methylation and miRNA profiles (methylome and mirome, respectively) will be used on subsets of healthy tissue, HPV-related and HPV-unrelated precancerous oral lesions, oral and oropharyngeal cancer, and metastasis. The integration of all findings should yield ideal epigenetic biomarkers. This project is a comprehensive interdisciplinary research, which includes basic and clinical research, and will enable the improvement of existing knowledge, development of new technological approaches in diagnostics and prognostics, and possible new treatment approach for oral and oropharyngeal cancer.
2017Identifikacija i funkcionalna karakterizacija (eko)toksikološki važnih polispecifičnih membranskih transportnih proteina u zebrici (Danio rerio)Identification and functional characterization of (eco)toxicologically relevant polyspecific membrane transport proteins in zebrafish (Danio rerio) 986Tvrtko Smital IP2013-11IP-2013-11-4806TRANS-ZEBRATOX01.10.2014 - 30.04.2018Završio821.107,33 KnPrirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb4504, 4272, 1050, 1063, 3923, 17738, Roko Zaja, Marta Popović, Ivan Mihaljević, Petra Marić, Jovica Lončar, Jelena Dragojević, polyspecific uptake and efflux transporters, zebrafish, identification, functional characterization, knockout studies, (eco)toxicological relevance A coordinated system of transport proteins, channels, receptors and enzymes act as cellular gatekeepers to foreign molecules, critically determining the so-called ADME-Tox (absorption, distribution, metabolism, excretion – toxicity) properties of a molecule. The polyspecific uptake and efflux transmembrane proteins are essential components of this complex cellular defense and detoxification/xenobiotic processing machinery in mammals, highly important and widely recognized in the context of pharmacology and human toxicology. However, they are scarcely investigated in non-mammalian species, and not adequately addressed in the field of environmental toxicology. Consequently, the major goal of the proposed project is identification and detailed functional characterization of new, potentially (eco)toxicologically relevant uptake and efflux transport proteins not addressed so far in the context of environmental toxicology, or in non-mammalian species in general. Our research will be focused on selected polyspecific uptake transport proteins from the SLC21 and SLC22 (Solute Carriers) proteins families, the efflux transporters from the MATE (multidrug and toxic compound extrusion proteins) family, and finally the RLIP76 as the most recently discovered stress-responsive, multi-functional membrane protein. We will use zebrafish (Danio rerio) as a highly relevant vertebrate research model, and our methodological approach will be based on several subsequent research phases: phylogenetic and gene expression analyses; transfection studies in appropriate heterologous expression system(s); transport-activity assays; analyses of the transport mechanism and structural properties; high-throughput-screening identification of chemical interactors of selected transporters among environmental contaminants; and finally in vivo evaluation of the (eco)toxicological relevance of selected transporters using the zebrafish functional genomics tools.
2026Mreže javnog komuniciranja u Hrvatskoj: medijatizacija javne sfere i izazovi novih medijaNetworks of public communication in Croatia: mediatisation of the public sphere and the challenges of new media3039Nada Švob-Đokić IP2013-11IP-2013-11-4014NETCOMM01.09.2014 - 31.03.2016Prekinut108.684,85 KnDruštvene znanostiSocial sciencesSociologija, Sociology, Institut za razvoj i međunarodne odnoseInstitute for Development and International Relations1329, 190, 4507, Paško Bilić, Ivan Balabanić, Nina Obuljen Koržinek, Networks, public communication, public sphere, mediatisation, new media, CroatiaThe media and society are tightly intertwined in a close and dynamic relationship. Shaped by societies, the media also shape societies. This relationship engenders social change that is at the core of the current mediatisation process and theory debates (Schulz, 2004; Krotz, 2007; Hjarvard, 2008; Hepp, 2011). Networked communication technologies reshape the equilibrium of the media/society relationship and extend the mediatisation process to new directions. The process is not a straightforward technological impact, but a complex accommodation process. In this research we study how the public sphere (Habermas, 1991) has been reshaped through networked communication (Cardoso 2008). We focus on four aspects of mediatisation: extension, substitution, amalgamation and accommodation (Schulz, 2004) to study organizational changes in the process of media production; and media use and practices among internet users. The main objective is to understand processes of media production, consumption and their interrelations, with regard to public communication through new, online and networked media. Specific goals include contributions to development of the mediatisation theory; establishment of a classification of online media in Croatia; development of mixed methods research designs and providing impetus to related public policies. We employ a sequential, explorative research strategy (Creswell, 2009). In the first stage, we conduct multiple, qualitative case studies of the processes of organizational change in different online media. In the second, intermediary stage we construct survey questionnaires based on previous qualitative work. In the third stage, we use a survey on a national representative sample and provide further analytical conclusions derived from the research. The potential users of our research results include: scientific research communities, media industry, media organizations, policy decision-makers, regulatory institutions, and various NGOs.
2027Upravljanje povjerenjem i koordinacija interakcija u pametnim mrežama ljudi, strojeva i organizacijaManaging Trust and Coordinating Interactions in Smart Networks of People, Machines and Organizations2602Vedran Podobnik UIP2013-11UIP-2013-11-8813SmartPMONetworks01.07.2014 - 30.06.2017Prekinut823.235,00 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing2989, 2612, 5883, 2717, 6404, 6415, 4894, 17798, 6453, 20486, 20516, Iva Bojić, Gordan Ježić, Darko Štriga, Ignac Lovrek, Luka Vrdoljak, Jurica Babić, Marina Bagić Babac, Marina Ptiček, Vanja Smailovic, Goran Jelen, Ivana Rašan, social networks, machine-to-machine communication, networked organizations, networked society, trust, coordination, context-awareness, big dataWe live in a networked society where everything is connected. By 2020 there will be 8 billion people and 50 billion machines in the world and almost all of them will be connected through some kind of network. Furthermore, people and machines that share a certain collective goal will be grouped into some kind of organization, which again will be connected with other organizations and/or people/machines. In order to maintain sustainability of the networked society we need a framework and algorithms which will enable us to i) manage trust; and ii) coordinate interactions in such a complex eco-system consisting of thousands, millions or even billions of interconnected entities. Both the framework and algorithms should be scalable and robust (from the perspective of a network size and heterogeneity), support real-time dynamics (from the perspective of network interactions) as well as be applicable and analyzable at different levels of granularity (at a micro, mezzo and macro network levels). A possible solution for the framework is the “Smart Network”, where people/machines/organizations are represented as nodes which are described by profiles and build a network of connections. The “smartness” of “Smart Networks” stems from profiling nodes and realizing connections using automated computational methods, what is enabled by latest enhancements in information systems and state-of-the-art solutions in communication technologies. The “Smart Network” framework enables design of scalable, robust and real-time algorithms for managing trust and coordinating interactions because it can be i) formally operationalized as a graph where edges represent nodes and vertices represent connections; ii) functionally modeled as a multi-agent system where agents embody edges and relationships embody vertices; and iii) analyzed through complexity theory where sustainable solutions emerge as a result of a bottom-up modeling principle.
2031Primjena nanomaterijala u izradi potenciometrijskih tenzidnih senzora za primjenu u industriji i zaštiti okolišaThe use of nanomaterials in the construction of potentiometric surfactant sensors for industrial and environmental applications4824Milan Sak-Bosnar IP2013-11IP-2013-11-9060NANOSENS01.07.2014 - 30.06.2017Završio545.751,88 KnPrirodne znanosti, Tehničke znanosti, Natural sciences, Technological sciences, Kemija, Chemistry, Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemijuJosip Juraj Strossmayer University of Osijek, Department of Chemistry3613, 4188, 3597, 4397, 4128, 3616, 4919, 3531, 6981, 6620, 7300, 17818, Mirela Samardžić, Nikola Sakač, Olivera Galović, Marija Jozanović, Sanja Petrušić, Martina Medvidović-Kosanović, Martina Šrajer Gajdošik, Tomislav Balić, Sanja Martinez, Lidija Valek Žulj, Dubravka Madunić-Čačić, MATEJA HAJDUKOVIĆ, surfactant, analysis, sensor, potentiometry, nanomaterial, environment, industryThe project comprises development and construction of a nanomaterials-based potentiometric surfactant sensor, that will be used for measurement of ionic surfactants concentration in surfactant raw materials, consumer products, pharmaceutical and cosmetic products, environmental materials etc. The new sensor should eliminate the drawbacks of the standard time-consuming extraction-spectrophotometric procedures and classical polymer liquid membrane based sensors. It can be used as an end-point detector by potentiometric titration of ionic surfactants or by their direct potentiometric determination.The new sensor can be also used as a specific detector in microfluidic techniques such as Flow Injection Analysis (FIA), Sequential Injection Analysis (SIA), as well as in the separation techniques (HPLC), substituting in this way more expensive, larger nonspecific detectors such as optical and conductivity detectors etc.
2032Tvar i međudjelovanja na ubrzivačima i u svemiruMatter and Interactions at Accelerators and in Universe335Krešimir Kumerički IP2013-11IP-2013-11-8799MIAU01.06.2014 - 30.09.2018Završio792.907,00 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science5932, 5292, 3358, 3140, 3059, 3183, 5958, 3243, 3129, 3602, 17794, Sanjin Benić, Ivan Dadić, Davor Horvatić, Amon Ilakovac, Dalibor Kekez, Dubravko Klabučar, Dieter Mueller, Ivica Picek, Luka Popov, Branimir Radovčić, Petar Čuljak, quantum chromodynamics, hadrons, quarks and gluons, quark matter, leptons, neutrino mass, new particles at LHC, dark matter Hadrons, such as proton or pion, are particles composed ofquarks and gluons which interact through fundamental strongforce. Objective of MIAU project is to contribute to ourunderstanding of this strong force as described by thetheory of quantum chromodynamics (QCD). Additionally, we aimto study physical processes happening at hadronaccelerators, including electroweak production ofas-yet-unseen particles at the large hadron collider (LHC).Thereby, we will investigate models of new physics in whichsuch new particles are introduced in attempts to explainneutrino masses and abundance of dark matter in theuniverse. To achieve these objectives we will study specific hadronicprocesses, both in the high-energy regime where strong forceis weak enough for perturbative approach, as well as inregimes where non-perturbative features of QCD, such asconfinement and chiral symmetry breaking come to the fore.Our focus will be on processes measured by the range ofexperimental collaborations which will facilitate closecontact with reality and immediate testing of our resultsand ideas. As outcome, we expect to be able to significantly improvethe knowledge of the quark-gluon structure of the proton, asencoded by the so-called generalized parton distributions,to improve the description of various meson properties invacuum and at finite densities and temperatures, toelucidate QCD phase diagram in model frameworks, and to setbounds to the parameter space of several models of newphysics.
2050Utvrđivanje sastava crijevne mikrobiote, upalnih markera, prehrambenog i endokrinog statusa u pacijenata s upalnom bolesti crijevaAssessment of Microbiota, Inflammatory Markers, Nutritional and Endocrinological Status in IBD Patients5552Donatella Verbanac IP2013-11IP-2013-11-5467MINUTE for IBD01.09.2014 - 31.08.2018Završio998.400,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine4214, 5577, 4152, 967, 965, 1278, 6237, 1398, 6406, 5897, 5241, 4012, 1369, 4183, 6297, 4249, 5562, 6316, 13628, 3288, 12582, 13684, Željko Krznarić, Silvija Čuković-Čavka, Marko Brinar, Mihaela Perić, Hana Čipčić Paljetak, Mario Matijašić, Vera Kufner, Darija Vranešić Bender, Nikša Turk, Marija Crnčević Urek, Mirjana Kalauz, Karmen Brajša, Gabrijela Ergović, Anja Barešić, Ivana Kraljević, Dina Ljubas Kelečić, Dora Grgić, Ana Kunovic, Marina Panek, Dunja Rogić, Tomislav Meštrović, Marko Banic, IBD, microbiota, blood biomarker, tissue, translational research, clinical researchInflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with increase in incidence that severely deteriorates patients’ quality of life. The onset of the disease is mainly associated with the immune status, gut microbiota and food intake. The current scientific knowledge of specific triggers and diagnostic markers is limited; therefore, new data on gut microbiota, inflammatory, endocrine and nutritional status are required to better understand the IBD pathophysiology.It this study we will thoroughly explore host-gut microbiota interactions in order to define novel strategies for management of IBD.We will collect intestine biopsies, stool and blood samples from 40 newly diagnosed IBD patients and 20 non-IBD control individuals, as well as record their nutritional status. Since majority of the gut microorganisms are not culturable, we will use the in house available next-generation sequencing to characterize the composition of the microbiota in collected samples. Moreover, specific blood biomarkers, including cytokines, growth factors and hormones, will be determined using novel and highly sensitive proximity extension assays, recently developed in our laboratories. Collectively, these results will support better stratification of patients and initiate an appropriate therapy.
2054Epistemološki modeli hrvatske književne historiografije (1913-1980)Epistemological Models of Croatian Literary Historiography (1913-1980)5895Leo Rafolt UIP2013-11UIP-2013-11-2242EPISTEMLITHIST02.06.2014 - 01.06.2017Prekinut381.700,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences5066, 2947, 6647, Dolores Grmača, Milovan Tatarin, Julijana Matanović, epistemology, literary history, theory of literary historiography, Marxist literary history, philological approach, textology, stylistic criticismThe project covers one of the most interesting periods of development of the Croatian literary studies. It analyzes it regarding the systems of knowledge or epistemological matrixes and predominant hermeneutic paradigms in the context of European and Anglo-American literary historiography. Research period is delimited by the year 1913, when one of the first overall synthesis of the Croatian literature was published (B. Vodnik, Povijest hrvatske književnosti), and the year 1980, when the first anthropologically implemented theories of literature occur in our academic context. These two extremes, in the periodical sense, are thus interconnected, primarily because of the hermeneutic concepts announced by the early Croatian literary historians, s.a. Vodnik, Prohaska, Hergešić. The goals of this continuous research activity is to analyze: (1) dominant systems of knowledge significant for the development of Croatian literary historiography, s.a. positivism, folk-psychology, psychoanalysis in its Freudian sense, aestheticism, first phase of the responsive theories, applied sociology of literature, early Marxism, formalist, structuralist, stylistic criticism, early poststructuralism, anthropological tendencies; (2) dominant figures of Croatian literary historiography and their methods, derived from their published works, starting from B. Vodnik, D. Prohaska, T. Matić etc., all the way to I. Slamnig, Ž. Jeličić, M. Vaupotić, I. Frangeš, S. Lasić; (3) dominant figures of our literary historiography and their unpublished oeuvres (s.a. Vodnik, Kombol, Prohaska, Matković), which will be published in a critical form; (4) comparative context of this literary historiography, regarding dominant circles in the 20th century (s.a. Czech and Polish circle, Ljubljana school of literary history, German and Italian academic milieu and its influence on the Zagreb stylistics, French structuralism in Croatian milieu).
2058RIMSKODOBNA PREOBRAZBA I UPORABA PRAPOVIJESNIH GRADINA U ISTRI - ANALIZA I STUDIJA SLUČAJAROMAN AGE TRANSFORMATION AND REUSE OF PREHISTORIC HILLFORTS IN ISTRIA – ANALYSIS AND CASE STUDY3231Klara Buršić-Matijašić IP2013-11IP-2013-11-2370RAT-ROPH01.07.2014 - 30.06.2018Završio467.750,00 KnHumanističke znanosti, Prirodne znanosti, Humanities, Natural sciences, Arheologija, Archeology, Sveučilište Jurja Dobrile u PuliJuraj Dobrila University of Pula5386, 4408, 5306, 5525, 5481, 3440, 823, Giovanni Boschian, Davor Bulić, Maša Sakara Sučević, Jana Škrgulja, Sandra Šoštarić, Katarina Gerometta, Robert Matijašić, Istria, prehistoric hillfort, ancient landscape, roman villa, geoarchaeology, GIS, spatial analysisPrehistoric hillforts are characterised by their position on heights with excellent strategic and defensive traits. An impressive number of settlements of this type can be found in Istria, representing an interesting scientific and important cultural phenomenon. Most of the hillforts were established during the Bronze Age, and due to population increase and social stratification they were transformed from simple settlements into pre- and proto-urban centres. While the ethnic identity of the Bronze Age population is still unknown, the ethnically uniform population of the Histri inhabited these settlements during the Iron Age. After the Roman conquest of Istria most hillforts were abandoned; some of them remained in use, but under different circumstances and conditions which led to their substantial modification. Despite the large number of these sites (240 confirmed, 200 hypothetical), few of them were systematically excavated. Previous research was limited to intra-site interpretation and to targeted field survey. The main goals of this project are to identify anthropogenic landscape change at the time of the conversion of site function, and to obtain new insights on the spatial organisation of settlements and their relationships with the surrounding environment. Landscape studies, geoarchaeology, topography and archaeology will be integrated under interdisciplinary GIS environment, providing a new holistic interpretation of past landscape dynamics. This research will fill the gap in the understanding of human-landscape interaction and of anthropic transformation of land from Late Prehistory to Roman times. A case study on human impact on landscape will be conducted in the micro-region of Poreč, and will be explained within its broader regional context. The project will also provide training for young researchers involved in PhD programmes, giving them the chance to develop interdisciplinary skills and encouraging them to become successful independent scientists.
2059GRAĐANSKOPRAVNA ZAŠTITA GRAĐANA U FINANCIJSKOJ KRIZICIVIL LAW PROTECTION OF CITIZENS IN THE FINANCIAL CRISIS5005Tatjana Josipović IP2013-11IP-2013-11-5269CitProtect01.02.2015 - 31.01.2018Završio319.627,32 KnDruštvene znanostiSocial sciencesPravo, Law, Sveučilište u Zagrebu, Pravni fakultet u ZagrebuUniversity of Zagreb, Faculty of Law6925, 6935, 5532, 7065, 1042, 1434, 4150, 3842, 235, 3982, 5924, 21146, Ksenija Grubišić, Siniša Petrović, Igor Gliha, Hano Ernst, Ivana Kanceljak, Ana Keglević, Josip Tica, Saša Nikšić, Iva Kuštrak Managić, Romana Matanovac Vučković, Marko Baretić, Jan Torjanac, civil law, protection of citizens, financial crisis, responsible lending, information duty, debt management, debt collectionThe main, overall aim of this research is twofold. First, the team will analyse the question of the influence of the existing civil law system to the aggravation of the financial difficulties of citizens. Second, the team will analyse the question of potentials of the civil law system for remedying these difficulties and for preventing them in the future. The team shall focus on five objectives: 1. researching the legal model of pre-contractual obligations of traders to inform citizens of their contractual rights and obligations, 2. researching the legal model of responsible lending, 3. researching the model for the protection of citizens in case of a deterioration of the financial situation after agreeing to and/or defaulting on a monetary obligation, 4.researching alternative models of voluntary performance of monetary obligations, and 5. researching the models of civil law protection of citizens in debt collection.The aim of the project is to find optimum measures, both of regulatory and non-regulatory nature, which are necessary to be implemented in order to improve unfortunate financial position of citizens.The research is projected to be undertaken in four consecutive stages or “work packages” (WP’s) in total duration of three years. WP 1 consists of the analysis of the legislation, theory and case law in the field of civil law which has an impact of the current financial crisis of citizens. WP 2 consists of empirical survey. WP 3 consists of the development of recommendations of measures of regulatory and non-regulatory nature which should be implemented in order to improve the existing legal, economic and social environment to the benefit of citizens. WP 4 consists of dissemination of the results of the research.
2063Nestali jezerski krajobrazi istočnog dijela Jadranskog moraLost Lake Landscapes of the Eastern Adriatic Shelf162Slobodan Miko IP2013-11IP-2013-11-9419 LoLADRIA01.07.2014 - 30.06.2018Završio787.971,38 KnPrirodne znanostiNatural sciencesGeologija, Geology, Hrvatski geološki institutCroatian Geological Survey4970, 3521, 5598, 5844, 5052, 6839, 5740, 5741, 6095, 6065, 3511, 7598, 7588, 7597, 7552, 17774, Ivan Razum, Valentina Hajek-Tadesse, Dragan Bukovec, Tamara Marković, Nikolina Ilijanić, Ozren Hasan, Vlasta Premec Fućek, Morana Hernitz Kučenjak, Saša Mesić, Martina Šparica Miko, Koraljka Bakrač, George Papatheodorou, Maria Geraga, George Ferentinos, DIMITRIOS CHRISTODOULOU, Dea Brunović, Paleolimnology, Paleoclimate, Last Glacial Maximum, Holocene, Pleistocene, Mesolithic, Sea Level Rise, Proxies, Human Migration, Adriatic Shelf, KarstThe LoLADRIA project represents a multidisciplinary, effort to recover, for the first time, long paleoenvironmental, and paleoclimate records from existing coastal karst lakes and submerged karstic lakes of the eastern Adriatic shelf in Croatia. The project will attempt to reconstruct the specific karst lake landscapes and their surroundings in view of environmental and climate change and human migration from the Last Glacial Maximum (LGM) through the Holocene. LoLADRIA will provide long, high resolution, paleohydrological reconstructions from a region extremely sensitive to changes in effective moisture and atmospheric dynamics. The multiproxy-based reconstructed curves will provide new data to identify and date the main climate events, and to characterize the climate variability at century and millennium scale since the LGM. Pollen and ostracods offer the possibility to develop transfer functions in order to reconstruct quantitative changes in regional climate and hydrological conditions of the lakes. LoLADRIA will offer an environmental context which enabled the human entrance to Europe along the eastern Adriatic shelf since this pathway is still widely unknown and the detailed framework of climatic and environmental conditions still requires extensive research. In combination with landscape reconstruction based on high resolution geophysical methods will allow the insight to the preserved changes in the landscapes at selected sites along the Eastern Adriatic and their habitability related to the Mesolithic cultures that were present there. Submarine prehistoric sites in the Mediterranean show that the continental shelf was occupied by humans to a depth of at least -40m, and the lost (submarine) lakes and surrounding submerged landscapes of the eastern Adriatic have a potential for site discovery.
2065Hrvatska srednjovjekovna baština u europskom kontekstu: mobilnost umjetnika i transfer oblika, funkcija i idejaCroatian medieval heritage in European context: mobility of artists and transfer of forms, functions and ideas5939Miljenko Jurković IP2013-11IP-2013-11-6095CROMART15.06.2014 - 14.06.2018Završio600.000,00 KnHumanističke znanostiHumanitiesPovijest umjetnosti, Art history, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences839, 1244, 6253, 4714, 5985, 6944, 5797, 2561, 6375, 6039, 6260, 6090, 6382, 6390, 5523, 6041, 7112, 7157, 6071, 6354, 6026, 6360, 7191, 7320, 7192, 6694, 7362, 6098, Marijan Bradanović, Ivan Matejčić, Krešimir Karlo, Maurizio Levak, Sunčica Mustač, Ranko Starac, Predrag Marković, Josipa Lulić, Xavier Barral i Altet, Gian Pietro Brogiolo, Jean-Pierre Caillet, Chevalier Pascale, Morana Čaušević-Bully, Sebastien Bully, Vincenza Lucherini, Jana Maříková-Kubková, Mihailo Milinković, Alejandra Chavarria, stefano riccioni, Angela Borzacconi, Milagros Guardia , Carles Mancho, Géraldine Mallet, Terrier Jean, Maja Zeman, Sapin Christian, Joan Molina Figueras, Enrico Cirelli, Late antiquity, middle ages, architecture, sculpture, painting, forms, functions, artistic transfers, historical landscapeThe project puts Croatia in the focus of European research of the middle ages. The international team will implement already elaborated methodologies combined with new technologies (geo-radar, remote sensing) on the medieval artistic heritage of Croatia as to track and map the changes that occurred in monumental landscape in the time span from late antiquity to the late middle ages. Croatia was a border zone between super-powers: eastern and western Roman Empire; Byzantium and respectively Lombard, Carolingian, Ottonian rule; from the 11th c. on, the powers of the West change: the Papacy and Venice, then Hungary. The ecclesiastical and social elites as protagonists of political and diplomatic activities have always strengthened their power by investing and sponsoring architecture and works of art. Those investors often commissioned works of art in their respective countries or summoned architects, sculptors and painters.The main goal of this project is to track down those artists who came from abroad as well as those going out from Croatia and to analyse the origins of the forms and functions of architecture built from late antiquity to the late middle ages. The understanding of the transformation of the Roman world in late antiquity and the early middle Ages, the need to track those changes in a longer time span, even within the growth of the medieval feudal society and to explain the role of the elites becomes fundamental. To answer those questions large field surveys will be carried on as well as the research of elites as investors and carriers of ideas, forms and functions of ecclesiastical architecture. The team is divided in working groups covering different historical regions of Croatia, submitted to very different influences during the middle ages, as well as covering different chronological sequences. By means of thorough field survey, creating catalogue data of architecture, sculpture and painting, through comparative analysis the goal will be achieved.
2066Razvoj naprednih energetski učinkovitih struktura upravljanja generatorom sa stalnim magnetima bez mjernog člana Development of Advanced Sensorless Control of Permanent Magnet Generator for Improving Energy Efficiency5949Damir Sumina UIP2013-11UIP-2013-11-7601PMGEFC01.09.2014 - 30.04.2018Završio604.000,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing6380, 6695, 2674, 3279, 17782, 19026, 6481, 22554, Igor Erceg, Martina Kutija, Ivan Mrčela, Tanja Poljugan, Tin Bariša, Igor Sirotić, Šandor Ileš, Luka Pravica, permanent magnet generator, wind power generation, back-to-back converter, energy efficiency, sensorless control,Renewable energy sources have been attracting great attention due to the cost increase, limited reserves and advanced environmental impact on fossil fuels. In the meantime, technology advancements, cost reduction and governmental incentives have made some renewable energy sources more competitive in the market. Among them, wind energy is the one of the fastest growing renewable energy sources. The conversion of the wind energy into electric energy is of a multidisciplinary nature, involving aerodynamics, mechanical systems, electric machines, power electronics, control theory, and power systems.The main goal of this project is to establish new research group which will improve the quality, performance and competitiveness of industrial sector in the field of wind power generation. The research group has already participated in the project for the development of advanced control structures for induction generator connected via back-to-back-converter to the grid in wind turbine application. As a step forward in innovation, research and development the research focus is set on permanent magnet synchronous generator (PMG) parameter identification, estimation of PMG rotor position using high frequency signal injection and speed estimation. Also, focus is on energy efficient based control method such as model predictive control of PMG. Advanced sensorless control algorithms for PMG will be developed and experimentally verified on the industrial laboratory model. Basic infrastructure for implementation and verification of developed algorithms exists in the Laboratory and for testing of advanced control structures on PMG laboratory model needs to be further upgraded. The final result will be the capability of research group for future cooperation with industrial partners for development of wind power generator systems and other generation systems.
2068Nespecifična imunost na hantaviruseInnate immunity to hantaviruses5967Alemka Markotić IP2013-11IP-2013-11-4393HANTA-INNATE01.07.2014 - 30.11.2018Završio995.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Ništa od navedenogNothing from this list6924, 5654, 5653, 5650, 4412, 7152, 4999, 7127, 5641, Ofer Mandelboim, Lidija Cvetko Krajinović, Ivan-Christian Kurolt, Ante Tadin, OKTAVIJA ĐAKOVIĆ RODE, Dragan Ledina, ĐURĐICA CEKINOVIĆ, Ljiljana Žmak, Petra Svoboda, hantavirses, Puumala, Dobrava, reoinfection, acute infection, monovytes, macrophages, NK cells, innate immunity, hemorrhagic fever with renal syndromeHantaviruses (HTV), family Bunyaviridae, are emerging, enveloped RNA viruses, which cause hemorrhagic fever with renal syndrome (HFRS) in Croatia and in the rest of Europe, where two main HTV cause HFRS: Puumala (PUUV) and Dobrava (DOBV). A broad spectrum of HFRS clinical conditions has been recognized, ranging from inapparent or mild to a fulminant hemorrhagic process with severe renal failure and death. The strong proinflammatory response during acute infection in humans is probably responsible for viral clearance but also for potentially fatal proinflammatory-mediated disease. Innate immunity is the first line of defense to various pathogens which may substantially determine the further development and outcome of disease. There is strong lack of knowledge on innate immune response to HTV in acute phase of disease and no evidence on immune response to reinfection with HTV at all. Overall objective of this project is to identify some key elements of innate immune response in acute HFRS infection and in experimentally simulated HTV reinfection at the level of monocytes/macrophages, NK cells, their crosstalk, “memory” and potential mediation by microRNAs (miRNAs). For that purpose, ex vivo experiments on peripheral blood mononuclear cells, monocytes/macrophages and NK cells will be performed in patients with acute HFRS and patients previously encountered HFRS. Primary monocytes/macrophages and NK cells will be additionally infected with HTV and co-cultivated. In order to asses potential miRNAs role, some inhibition experiments will be performed. Computational analysis will follow all experimental process in order to generate new data, pursue study in right direction and indicate important signaling pathways for the future research. Such concept may represent the next step in the design of future vaccines for HTV.
2070Stvaranje grada: prostor, kultura i identitetCIty-making: space, culture and identity1045Jasna Čapo Žmegač IP2013-11IP-2013-11-2350CITID01.10.2014 - 30.09.2018Završio585.000,00 KnHumanističke znanostiHumanitiesEtnologija i antropologija, Ethnology and anthropology, Institut za etnologiju i folkloristikuInstitute of Ethnology and Folklore Research in Zagreb311, 4785, 5400, 4789, 4712, 5288, Valentina Gulin Zrnić, Nevena Škrbić Alempijević, Laura Šakaja, Tihana Rubić, Petra Kelemen, Sanja Đurin, urban anthropology, city, everyday life and culture, politics of space, politics of difference, urban identities, anthropology of migration The project has emerged from theoretical insights in urban anthropology, anthropology of space and place, urban migration studies, cultural geography, post-socialist studies and post-colonial theory. It proposes a complex research outline based dominantly on qualitative methodology, aiming at untangling and comprehending multiple, multilayered and interdependent (f)actors and processes that influence contemporary transformations in the Croatian capital, Zagreb. The concept of city-making in this research refers to a comprehensive construction and articulation of urban life along two axes—space and diversity. Both constitute nodes at which global political, economic and cultural flows meet and collide with local histories, way of life, imaginaries, interests and developments, bringing about the restructuring of the city and its identity as well as identities of city inhabitants. This ethnological and cultural anthropological project emphasises agency of city dwellers in these transformations and investigates how they negotiate and re-create the given social, cultural, and spatial landscape (cityscape) investing it with meaning and humanising it. The project will have an important bearing on the city's politics and policies, with the goal of achieving more sustainable and inclusive functioning of the city while, at the same time, it will advance the state of the art of urban studies. In addition, it will ensure the transfer of knowledge via university courses and public presentations aimed at raising the awareness about various urban issues (planning, environment, representation, cultural production, diversity, marginality etc.).
2072Istraživanje patoloških procesa u ljudskom ishemičnom miokardu; bazični znanstveni pristup za razumijevanje najčešće bolesti današnjiceInvestigating Pathological Processes in Ischemic Human Myocardium; Basic Science Tools for Major Health Problem187Darija Baković Kramarić UIP2013-11UIP-2013-11-3718ISTHMUS01.10.2014 - 30.09.2017Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine3757, 1026, 168, 1395, 194, 599, 4635, 4715, 4581, Ana Barać , Tonći Batinić, Marko Ljubković, Damir Fabijanić, Jasna Marinović Ljubković, Cristijan Bulat, Mladen Carev, Mihajlo Lojpur, Lemaire Christophe, myocardial ischemia, chronic heart failure, cardiac bioenergetics, cardiomyocyte pathophysiology, cardiac imagingCoronary artery disease (CAD), with its clinical representations (angina, acute myocardial infarction and chronic heart failure), is the most common cause of morbidity and mortality in developed world. The pathological remodelling occurring in ischemic myocardium gradually leads to chronic contractile dysfunction and affects many intracellular mechanisms participating in energy production, calcium homeostasis and apoptosis. In the current project, we propose to investigate these pathological processes in patients suffering from the CAD. Patients who are candidates for coronary artery bypass graft surgery will be included and will undergo a detailed cardiac evaluation, which, in addition to standard diagnostic tools, will be enriched by the advanced diagnostic techniques still non-existing in Croatia (stress cardiac magnetic resonance imaging). This will provide accurate identification and quantification of regional myocardial ischemia. Following clinical evaluation and during revascularization surgery, left ventricular biopsies will be taken from characterized ischemic regions, as well as from non-ischemic regions, and a detailed analysis of intracellular energy metabolism, calcium-contractility and endoplasmic reticulum stress will be performed. The Specific Aims of the project are:Aim #1 is to assess regional myocardial perfusion and function in patients with CAD who are considered for revascularization therapy. Aim #2 will investigate pathological processes affecting mitochondria, calcium homeostasis and endoplasmic reticulum stress that take place in the ischemic parts of myocardium.Aim #3 is to evaluate the effects of the heart rate-lowering pharmacological therapy on ischemic myocardium.Thus, the overreaching aim of this proposal is to investigate intracellular mechanisms underlying myocardial adaptation and remodelling in chronic ischemia and to identify predictors of outcomes in patients with coronary artery disease undergoing revascularization therapy.
2082Definiranje uloge cirkadijurnih gena kod bihevioralne senzitizacije na psihostimulanse kod Drosophile melanogasterDefining the role of circadian genes in behavioral sensitization to psychostimulants in Drosophila melanogaster69Rozi Andretić Waldowski IP2013-11IP-2013-11-4920FLYHIGH01.09.2014 - 31.12.2017Završio600.117,36 KnPrirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u RijeciUniversity of Rijeka5439, 4624, 5961, Ralph Greenspan, Ana Filošević, Helija Dokić, addiction, psychostimulants, Drosophila, circadian, genes, screenAddiction to drugs is a brain disease characterized by changes in the brain functioning caused by repeated drug taking. Repeated drug taking leads to neuroadaptations which over time affect neural networks and change behavior. One such change induced by drugs and commonly studied in lab animals is behavioral sensitization. Regulation of gene expression is one important mechanism by which drugs change the plasticity of the networks which regulate behavior. A group of transcriptional regulators of the molecular circadian clock have been identified to function as regulators of behavioral sensitization to cocaine in Drosophila. Subsequent studies in rodents proved the universality of those genes in mediating drug responses. The genetic pathways and molecular interactions through which circadian genes regulate drug responses has remained undefined.We hypothesize that new genes which interact with circadian genes in the regulation of behavioral sensitization to psychostimulants can be identified in a genetic screen in Drosophila. This is a goal for which Drosophila is perfectly suited, because genetic screens aimed at defining new genes can be performed relatively easy, fast and cheap. Our first aim is to devise a high-throughput method for measuring behavioral sensitization in flies by modifying the existing method for measuring activity. Second, we will undertake a directed behavioral screen by pre-selecting candidates with reported molecular interaction with circadian genes. In the third aim we will use transgenic flies and other genetic tools to investigate neural mechanisms involved in behavioral sensitization. The proposed research is innovative and relevant for human health. New gene candidates isolated in this screen could easily be translated into mammalian research where they will help in further understanding of neuroplastic changes induced by psychostimulants. Given our expertise and available resources the project has great potential to advance the field.
2094Stvaranje socijalističkoga čovjeka. Hrvatsko društvo i ideologija jugoslavenskoga socijalizmaMaking of the Socialist Man. Croatian Society and the ideology of Yugoslav Socialism2955Igor Duda UIP2013-11UIP-2013-11-1718Socialist Man15.06.2014 - 14.06.2017Završio491.025,00 KnHumanističke znanostiHumanitiesPovijest, History, Sveučilište Jurja Dobrile u PuliJuraj Dobrila University of Pula3187, 4024, 4494, 3833, 5558, 4286, 4625, 4631, 3429, 4311, Lada Duraković, Andrea Matošević, Hrvoje Klasić, Snježana Koren, Magdalena Najbar-Agičić, Boris Koroman, Vanessa Vitković Marčeta, Teodora Fonović Cvijanović, Igor Stanić, Anita Buhin, socialist society, self-management, ideology in practice, communist indoctrination, Croatia, YugoslaviaMaking of a “new man” – and woman in the present-day terms – is a concept that has constantly been re-examined and discussed in many political and geographical contexts throughout the twentieth century. The focus of this research project highlights a specific historical situation: the endeavours of Yugoslav authorities in making of a new socialist citizen after the World War II, especially in Croatia as one of the republics forming the Yugoslav Federation. The socialist citizen was first placed in a strongly Soviet-oriented society, but the situation very soon shifted towards a specific kind of Yugoslav self-management and market socialism. The long period of four and a half decades (1945-1990) calls for special attention due to changes in the political system over time: from the formative period of the socialist man to the partial deconstruction of the concept. In many ways Croatia represents an excellent case-study for the research of the Yugoslav society, but in this project it will always be included in the Yugoslav framework and – whenever necessary – in a wider historical context and related comparatively to other socialist societies ruled by communist parties. The academic profile of researchers included in the project guarantees that the new socialist citizen will be closely analyzed in a variety of his or her appearances: from childhood to retirement, in work and leisure or sport, as a creator and a recipient of culture, from the theoretical ideals of high politics to the successful or problematic practices. A wide selection of written, visual and oral sources will be interpreted with a complex multi-disciplinary methodology that includes political, economic, social and cultural history, social and cultural anthropology, cultural studies and linguistics. The aim is to set a new light to the period and topic that are still under-researched by the Croatian and other post-Yugoslav humanities.
2103Od protomodernizacije do modernizacije školstva u Hrvatskoj (18. i 19. stoljeće)From Proto-Modernisation to Modernisation of Croatia's School System (18th and 19th Century)232Ivana Horbec UIP2013-11UIP-2013-11-4919FPTMOCSS01.09.2014 - 28.02.2018Završio488.800,00 KnHumanističke znanostiHumanitiesPovijest, History, Hrvatski institut za povijestCroatian Institute of History1526, 4458, 1164, 1311, 990, 1501, 948, 4836, Vlasta Švoger, Dinko Župan, Milan Vrbanus, Robert Skenderović, Maja Matasović, Arijana Kolak Bosnjak, Mislav Gregl, Branko Ostajmer, History of Education, Intellectual Transfer, Secularisation, Modernisation, State Education Policy, Habsburg MonarchySchool system as an educational subsystem of society touches upon and intertwines with political, economic, scientific, cultural, religious and family subsystems of society. In order to be able to understand societal development it is therefore necessary to understand school legislation and educational institutions which, through secondary socialisation, reproduced the desirable normative frameworks for the society within which they operated. Proto-modernisation and modernisation processes implemented during the 18th and 19th centuries were of key importance for forming the school system as an educational system that became an important factor in the emergence of modern civil societies. A research into the problem area of the school system requires a multidisciplinary and interdisciplinary approach that differs essentially from the researches undertaken thus far and closed within the boundaries of the discipline. The objectives of this project proposal are to determine, using modern methodological approaches and critically analyzing archival material, factors that were of crucial importance in the process of creation and functioning of Croatia’s school system and for the influence this system exerted, to evaluate correlation of Croatia’s school system with the school system in the Habsburg Monarchy and its reflection on the network of power in the society in the period of (proto)modernisation. The project will result in three volumes of documents that were of crucial importance for the development of Croatia's school system, internet database on students studying at higher schools in the Monarchy, interactive map of educational institutions, a workshop for doctoral students, international scientific conference and an exhibition in the Croatian School Museum. One of the objectives of the project is to create prerequisites for expanding international cooperation and including various topics of history of Croatia's education in internationally funded projects.
2118Uloga ekonomskog sentimenta u tumačenju makroekonomskih trendova: metodološka unapređenja i nova područja primjeneThe role of economic sentiment in explaining macroeconomic trends: methodological improvements and new areas of application4299Mirjana Čižmešija IP2013-11IP-2013-11-3858MCPSIL2484BI01.09.2014 - 30.09.2018Završio510.678,00 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Zagrebu, Ekonomski fakultet u ZagrebuUniversity of Zagreb, Faculty of Economics and Business4385, 6252, 5144, 5721, 6268, 21201, Petar Sorić, Ivana Lolić, Nataša Erjavec, Nataša Kurnoga Živadinović, Vlasta Bahovec, Marina Matošec, Business and Consumer Surveys, economic sentiment, leading indicators, behavioral economics, nonlinear econometricsThe aim of this project is to incorporate psychological sentiment (obtained by Business and Consumer Surveys; BCS) in macroeconomic modeling. Namely, BCS offer direct assessment of the otherwise intangible factors such as economic agents’ perceptions and expectations. They measure the agents’ willingness to consume/invest/save, as opposed to their ability to do the same. Hence these psychological factors are crucial to understand the underlying market forces and agents’ behavior. The project goals are to:- Discern whether the non-rationality of consumers’ inflation expectations stems from the true inability of consumers to anticipate price changes, or did the researchers induce it themselves by falsely assuming that the distribution of BCS responses is normal. - Question whether the poor forecasting accuracy of BCS leading indicators can be improved through obtaining the optimal weights by (non)linear optimization.- Compose an optimism indicator based on BCS responses and determine the nature of its relationship with the stock market returns. Nonlinear time series analysis will be employed to test if the stock market reacts asymmetrically to positive/negative shocks in the economic sentiment.- Estimate the consumers’ willingness to buy realty and econometrically model its relationship with actual real estate prices.- Assess the value of BCS responses on households’ financial distress by correlating them to the common measures of poverty.- Employ the BCS data on managers’ perceptions to construct a liquidity indicator for the Croatian economy.The first 5 goals will be fulfilled by analyzing the proposed issues in EU countries, which will improve the general understanding of the role of sentiment in economic decision-making. Each of the stated research fields is expected to result in the publication of a paper in a reputable international journal. The results empirically obtained for Croatia will be synthesized in a scientific book at the end of the project.
2119Genska tipizacija patogena prenosivih krpeljima analizom sekvenici više gena: popunjavanje praznina između životinjskih rezervoara, krpelja i ljudiMultilocus sequence genotyping of tick borne pathogens: covering the gap between animals, ticks and humans939Relja Beck UIP2013-11UIP-2013-11-1957GENOTICKTRECK01.09.2014 - 31.08.2017Završio962.800,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesVeterinarska medicina, Veterinary medicine, Hrvatski veterinarski institutCroatian Veterinary Institute2546, 2597, 2599, 4419, 4117, 3369, 4115, 3991, 1341, 3360, 129, 4239, 2528, 2676, 4412, 2743, 2794, 2608, 4328, 529, 538, 1147, 2582, 3510, 2954, 2570, 21273, 1181, Lorena Jemeršić, Dragan Brnić, Jelena Prpić, Ana Beck, Mirna Brkljačić, Vesna Matijatko, Marin Torti, Sanja Bosnić, Renata Brezak, Irena Reil, Stjepan Krčmar, Alan Medić, Boris Dželalija, Nenad Pandak, OKTAVIJA ĐAKOVIĆ RODE, Željko Mihaljević, Miroslav Benić, Gordan Kompes, Željko Cvetnić, Silvio Špičić, Ivana Račić, Sanja Duvnjak, Boris Habrun, Krunoslav Pintur, Nikica Šprem, DANKO DEŽĐEK, Maja Stepanić, Doroteja Huber, tick-borne pathogens, multilocus sequnce genotyping, pathogen distribution, animals, humansGlobalization and climate change have an unprecedented worldwide impact on emergence and re-emergence of animal diseases, especially vector borne zoonoses.. Diseases that used to be limited only to tropical areas are now increasingly spreading to other previously unaffected regions. A wide variety of pathogens that can be propagated and transmitted by ticks infect humans, wildlife or domestic animals. Over the past decades, the scientific landscape of tick-borne diseases has changed significantly due to advances in molecular biology. Several new rickettsial and ehrlichial diseases, as well as new Borrelia and Babesia genotypes have been confirmed, and consequently, improved diagnostics of emerging diseases in veterinary and human medicine. A number of cases of tick-borne encephalitis (TBE) and Lyme disease have increased. To better understand the importance of tick-borne diseases, a proposed project follows an interdisciplinary approach involving physicians, veterinarians and biologists, also known as One Health approach. Since the cultivation of pathogens is difficult and slow, and for number of pathogens this cultivation is impossible, multylocus sequence typing MLST approach will be used for their genetic characterization of Babesia spp., Borrelia burgdorferi s. l., B. miyamotoi, Rickettsia spp., Anaplasma spp, Ehrlichia spp. Bartonella spp., Neoehrlichia mikurensis, Tick-borne encephalitis virus, Coxiella burnetii and Francisella tularensis from animal reservoirs, ticks and humans. Another objective will be to map tick species, since they were investigated 40 years ago, and to confirm species with PCR and sequencing. Application of genetic typing of multiple genes allows a detailed differentiation of genotypes and their heterogeneity. In this way, the genetic variability of the isolates, their geographical distribution and population genetic structure, as well as transmission routes of various isolates within ticks and their natural reservoirs, will be defined.
2127Hrvatska pravosudna suradnja u kaznenim stvarima u Europskoj uniji i regiji: nasljeđe prošlosti i izazovi budućnostiCroatian Judicial Cooperation in Criminal Matters in the EU and the Region: Heritage of the Past and Challenges of the Future6266Zlata Đurđević IP2013-11IP-2013-11-8282CoCoCrim01.03.2015 - 30.09.2019U tijeku582.711,50 KnDruštvene znanostiSocial sciencesPravo, Law, Sveučilište u Zagrebu, Pravni fakultet u ZagrebuUniversity of Zagreb, Faculty of Law6296, 6657, 3828, 7404, 7173, 7202, 6110, 816, 6285, 7456, 6275, 7529, 18963, Davor Krapac, Elizabeta Ivičević Karas, Maja Munivrana Vajda, Stjepan Gluščić, Marin Bonačić, Petar Novoselec, Marija Pleić, Matko Pajčić, Zoran Burić, Ante Novokmet, Marina Gutschy, Željko Karas, Ivo Josipović, judicial cooperation in criminal matters, european criminal law, criminal prosecution of war crimes, regional cooperation, european arrest warrantGeneral objectives of the project are the improvement of Croatian criminal justice system and the advancement in Croatian legal scientific research in the field of judicial cooperation in criminal matters. The improvement of prosecution will occur as regards: a) cooperation with the EU member states, b) regional cooperation. The advancement of Croatian legal scientific research will be realized through scientific activities of research group composed of senior and young researchers from three Croatian universities specialised in the field of EU, international and regional cooperation in criminal matters. Cooperation in the prosecution of war crimes has been a crucial political and legal issue in Croatia in the past two decades. Presently the focus is moved to cooperation with the EU member states. As judicial proceedings before the ICTY were unsustainable without criminal law cooperation of the States, the effective national criminal prosecution today is as well possible only through realization of full and intensive judicial cooperation with the EU member states. Effective cooperation in the prosecution of serious crimes has multiple political and legal values for Croatia, such as credible membership in the EU, stability in the region, and the protection of human rights. It is crucial for the identification of Croatia as a democratic European state that respects the rule of law and does not tolerate any kind of serious crimes. The outcome of the research will be publication of collection of scientific papers on issues related to forms, institutions and problems of the EU and regional judicial cooperation and the level of compliance of Croatian law, judiciary and case law. The research results will be presented at the public round tables and final conference, and implemented in course curriculum at the Croatian Universities. The project will contribute to the training of six young researches and will strengthen mentoring capacities of Croatian law schools.
2129PONOVNA UPORABA MULJA S UREĐAJA ZA PROČIŠĆAVANJE OTPADNIH VODA U BETONSKOJ INDUSTRIJI - od mikrostrukture do inovativnih proizvodaREUSE OF SEWAGE SLUDGE IN CONCRETE INDUSTRY - from microstructure to innovative products5991Dražen Vouk UIP2013-11UIP-2013-11-7927RESCUE01.09.2014 - 31.08.2017Završio479.500,00 KnTehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište u Zagrebu, Građevinski fakultetUniversity of Zagreb, Faculty of Civil Engineering4065, 3406, 3398, 6938, 6521, 5060, 6620, 7020, 17785, Mario Šiljeg, Nina Štirmer, Marijana Serdar, Davor Malus, Stanislav Tedeschi, Ana Baričević, Lidija Valek Žulj, Christopher Cheeseman, Domagoj Nakić, Wastewater treatment, Sewage sludge, ISSA, Concrete, Microstructure, Sustainable materialsIn the wastewater treatment process, a by-product is generated, as additional waste called sewage sludge (0.5 kg of sludge per 1 m3 of wastewater). Adequate wastewater management implies collection and treatment of wastewater, but also adequate management of waste substances generated in the treatment process. Joining the European Union Croatia has made the commitment to construct all treatment plants of capacities over 10.000 PE by 2018. This will result in putting into operation of treatment plants with the total load of about 4.000.000 PE (250.000.000 m3 of wastewater), which will generate about 215.000 tons per year of raw sewage sludge and after incineration around 49.000 tons per year of incinerated sewer sludge ash (ISSA). Taking into account that EU Directives are limiting the amount of sewage sludge waste to be landfilled, and Waste Framework Directive (2008/98/EC) puts reuse and recycling of waste into the most favorable position, it is evident that enormous amount of ISSA will become available for appropriate management.The composition of the generated sewage sludge and ISSA is dependent on the technology of wastewater and sludge treatment. Reviewing the available knowledge in this field leads to the conclusion that the influence of the method of incineration on physical properties of ISSA and the technology of preparing and processing of concrete and concrete elements has not been fully analysed. The main objective of the project is to investigate the possibilities of recycling the sludge from WWTPs in preparing of new innovative products in concrete industry. Based on comprehensive experimental research and multidisciplinary knowledge of the partners (hydrotecnical, materials and chemical engineering), a strategy will be proposed for the comprehensive and sustainable management of ISSA and its transformation from unwanted waste material into valuable resource for production of construction products with ecological, economical and technological benefits.
2131Genetski mehanizmi lizosomalne disfunkcije u Parkinsonovoj bolestiGenetic mechanisms of lysosomal dysfunction in Parkinson's disease 2684Fran Borovečki IP2013-11IP-2013-11-9386LYSOGENE PD15.07.2014 - 14.12.2018Završio997.709,32 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine6044, 5625, 5619, 5330, 5749, 5959, 4119, 6442, 6446, 4828, 4818, 19045, 19042, Nada Čikeš, Zdravka Poljaković, Sanja Hajnšek, Kristina Gotovac, Filip Josip Bingula, Tiago Fleming Outeiro, Maja Relja, Martina Rinčić, Lukrecija Brečević, Silva Katušić Hećimović, Marko Košiček, SRĐANA TELAROVIĆ, Antonela Blažeković, Parkinson's Disease, alpha synuclein, next-generation sequencing, lysosomal dysfunction, iPSCAccumulation of misfolded proteins in the brain represents a pathological hallmark of neurodegenerative diseases, suggesting that inadequate clearance of aggregation-prone proteins plays an important role in the disease pathogenesis. The synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (LBD), are a group of neurodegenerative disorders characterized by the accumulation and aggregation of a-synuclein (aSyn). Studies on the rare inherited forms of PD caused by mutations in the aSyn gene have highlighted disturbed aSyn clearance through the autophagy-lysosomal pathway (ALP) as a key mechanism leading to PD/LBD. Furthermore, several rare inherited disorders caused by mutations in the lysosomal genes show parkinsonian-like phenotype and accumulation of aSyn, providing additional evidence for the role of lysosomal dysfunction in the pathogenesis of synucleinopathies. The goal of the project is to elucidate the involvement of lysosomal gene mutations and lysosomal dysfunction in the ethiology of PD/LBD. Using the next-generation sequencing and Haloplex-based protocol we will design LYSOGENE platform to anayze genetic mutations/variations in the ALP genes that may lead to and predispose to PD/LBD. The identified ALP mutations will be further characterized in vitro in human neuronal cell lines using the knockdown and overexpression approaches. In particular, we will monitor how the identified mutations affect ALP function, accumulation and aggregation of aSyn, as well as neurotoxicity. Finally, we will validate our mechanistic findings in a biologically relevant model of human dopaminergic neurons derived from the PD/LBD patient’s fibroblasts using the induced pluripotent stem cell technology. Through these studies we will identify genetic variations/mutations in the ALP genes that cause or contribute to PD/LBD. The results of the project may help to identify potential new therapeutic targets for development of neuroprotective treatments.
2144Algoritmi za analizu slijeda genomaAlgorithms for Genome Sequence Analysis1480Mile Šikić UIP2013-11UIP-2013-11-7353AGESA01.11.2014 - 31.10.2017Završio772.750,00 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing7098, 6982, 7051, 6592, 7322, 18951, 18950, Niranjan Nagarajan, Damir Seršić, Martin Šošić, Ana Sović, Branko Jeren, Krešimir Križanović, Robert Vaser, genome sequence, DNA sequence alignment, RNA-seq mapping, database search, algorithms, GPUTwenty years ago, sequencing the human genome was one of the most ambitious science projects ever attempted. Today, DNA and RNA sequencing are now key components of research carried out in many laboratories. The total amount of available genomic data is increasing approximately tenfold every year, a rate much faster than Moore’s Law for computational processing power. The exponential growth of genomic datasets leads to a situation, where computing power becomes a critical issue.The overarching goal of the project is to develop accurate, fast algorithms and tools for analyzing the whole genome-sequencing data. The emphasis of the project is on the output data from the third-generation of sequencing machines that produce longer, more error-prone sequence reads. The basis of the project are sequence alignment algorithms, graph algorithms and signal processing methods. They will be implemented for DNA sequence assembly, sequenced RNA data and sequence similarity database search. The algorithms should feasibly handle data obtained from mammalian and plant genomes (sizes greater than one billion base pairs). Special emphasis will be put on multi-core, many-core and intra-core parallelism. Additionally, the algorithms should provide good scalability over the available underlying computational architecture. All implementations of algorithms will be performed in C/C++. The research will result in the development of novel algorithms tailored to specifications of current and future long-read sequencing data. The implemented methods will further the state-of-the-art of sequence similarity database search, RNA-seq mapping and DNA assembly, ideally providing researchers with methods that return results in feasible time with limited computational resources. This, in turn could affect the current practices of genomic research; help designing new medical strategies and enable faster and more accurate analyses and diagnoses.
2145Anisakis spp: genomska epidemiologijaAnisakis spp: genomic epidemiology132Ivona Mladineo IP2013-11IP-2013-11-5576AnGEL30.06.2014 - 29.06.2018U tijeku854.500,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesVeterinarska medicina, Veterinary medicine, Institut za oceanografiju i ribarstvoInstitute of Oceanography and Fisheries1217, 1192, 1305, 996, 4832, 978, 1111, 1029, 1238, 4601, 1127, 2850, 2621, 3610, 3130, 15951, 13683, Kristina Blažeković, Ivana Bočina, Ivana Bošnjak, Ivana Bušelić, ESMA ČEČUK-JELIČIĆ, Martina Đuras, Andrea Gudan Kurilj, Ivana Lepen Pleić, Diana Nonković, Mirela Petrić, Vedran Poljak, Ivana Radonić, Ingrid Tripković, Željka Trumbić, Ivana Ujević, Romana Roje Busatto, Jerko Hrabar, Anisakis spp., zoonosis, seroprevalence, patohistology, transcriptomic, risk analysisGlobal migration and trade of the foodstuff, climate change, novel trends in human eating habits characterised by an elevated demand for raw food, are today considered as major reasons why reports of food borne infections, especially zoonotic parasitosis, have increased in the last decade. Thus the prevention and protection against zoonotic parasites in fishery products designated for human consumption has recently become a priority. Consequently, health authorities and fishing industry have increasingly become aware of the significance of nematode genus Anisakis, which affects human health and the commercial value of fish products. Adriatic fish, marketed fresh, frozen, salted or marinated and exported to EC, are frequently rejected on the border because of Anisakis infection. Although considered one of the most significant emerging food-borne zoonosis, anisakiasis in many Mediterranean countries is still misdiagnosed or underestimated. AnGEL will deepen the knowledge on Anisakis with a multidisciplinary approach, studying the fish as paratenic, cetaceans as the final and men as accidental host. It will start by identifying anisakids species by molecular tools in picarel and damselfish, that are particular dish in culinary tradition of SE Adriatic islands where a significant level of anti-Anisakis IgE in local population was found. It will evaluate histopathological effect of the nematode in the digestive tract of the final host in order to evaluate Anisakis carcinogenic potential, as well as its transciptomic signature during migration through hosts. It will assess larval multixenobiotic resistance mechanisms helping to design more effective therapy, and measure anti-Anisakis seroprevalence in population employed in the fish processing industry by indirect ELISA. Lastly, AnGEL will encompass resulting data in a risk analysis frame, aiming to the design of measures for the safe alimentary seafood production and strengthening of risk communication to stakeholders.
2155Istraživanje uloge optineurina u neuroprotekcijiElucidating the Role of Optineurin in Neuroprotection4630Ivana Munitić UIP2013-11UIP-2013-11-7459OptineurinNeuroimm01.09.2014 - 31.12.2017Završio990.722,50 KnPrirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Rijeci, Odjel za biotehnologijuUniversity of Rijeka, Department of Biotechnology5775, 6187, 6264, 12500, Hrvoje Jakovac, Kristina Grabušić, Jonathan Ashwell, Andrea Markovinović, cell signalling, autophagy, microglia, neurodegeneration, animal modelsMutations in a widely expressed ubiquitin-binding protein optineurin were recently found in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of unresolved pathogenesis. Unlike most of the other mutated proteins known to cause ALS by their toxic prion-like properties, optineurin is largely thought to cause disease by loss-of-function, arguing for its protective role. In vitro studies proposed that it regulates a variety of cellular processes including cell signaling, autophagy and vesicle trafficking, but their link to neurodegeneration is unknown. ALS is not an autonomous disease of selected neurons. Glial cells including microglia, are essential for neuroinflammation, which greatly shapes disease progression. The major aim of this study is to elucidate the exact role(s) whereby optineurin exerts neuroprotection, pinpoint the cell types in which it acts, and determine its putative effect(s) on the interactions between the cell types relevant for neurodegeneration. We aim to dissect these questions in a stepwise fashion by (1) assessing cell-intrinsic functions in neurons, microglia and macrophages, (2) addressing crosstalk in mix-and-match co-cultures and organotypic spinal cord slices, and (3) verifying these findings in mice. To this end, we have generated a novel disease-mimicking genetic mouse model of optineurin insufficiency. Analyzing the function of optineurin in primary cells and mice models is crucial to the success of this study, given that ubiquitin-binding proteins are prone to in vitro artifacts. Incomplete understanding of ALS pathogenesis is directly mirrored in almost complete inability to treat ALS patients: a single approved drug exerts only a small prolongation in survival. Here, we propose to study a unique ALS model, set apart from the currently available models of direct toxicity by its ability to provide insight into basic neuroprotective mechanisms, thus expectedly paving the way for more successful therapies.
2161Neomitologizam u kulturi 20. i 21. stoljećaNeomythologism in the Culture of the 20th and 21st Century 5143Jasmina Vojvodić IP2013-11IP-2013-11-6077Neomyth01.09.2014 - 31.08.2018Završio553.000,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences3595, 6512, 6551, 6853, 18976, Danijela Lugarić Vukas, Ivana Peruško, Živa Benčić-Primc, Josip Užarević, Zoran Tihomirović, neomythologism, contemporary science, Russian literature/culture, Croatian literature/culture, myth, everydayness, Slavic Studies, humanitiesNeomythologism in the culture of the 20th and 21st century is a project proposal designed to study one of the basic phenomena in the contemporary culture and science. The relevance of the topic of neomythologism stems precisely from the crisis in fundamental scientific research and reliance on the phenomenon of irrationality which is happening in the contemporary world. Since there is a crisis in the field of major scientific concepts, man tries to look for answers in a new mythology, which is visible in all forms of cultural research (literary text, visual arts, film, discourse of advertising). This is why this project proposal offers launching of a new type of research into neomythologism. The focus of the proposed research is based on the corpus of Russian and other Slavic literatures, including Croatian, in theatre, visual arts, film culture and contemporary media in order to study and define the elements of neomythologizing, especially those of the myths of everyday life (the myth of youth, the myth of the end of the world, the myth of the family, the myth of a healthy diet). Collection of materials, preparation works, workshops and conferences about the myths of everyday life shall take into account all aspects of this challenging topic in order to research this phenomenon, as well as the concept of the mythical in different aspects of Slavic cultures which are historically interconnected with a common mythology. The aim of the project is, hence, to obtain new scientific knowledge about the phenomenon of neomythologism which, though observable, has not scientifically been considered.
2163Ekonomski, statistički i politički aspekti tržišta državnih obveznicaEconomic, statistical and political aspects of sovereign bond markets603Maruška Vizek UIP2013-11UIP-2013-11-1356SOBOM01.09.2014 - 31.08.2017Završio420.462,77 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Ekonomski institut ZagrebInstitute of Economics in Zagreb790, 1066, 733, 606, 983, 5442, 17742, Bojan Basrak, Josip Glaurdić, Petra Posedel, Marina Tkalec, Goran Vukšić, Petra Žugec, Petra Palić, Sovereign bond market, sovereign spreads, volatility spillovers, sovereign bond market integration stochastic volatility models, extreme value theory,Recent developments related to the Eurozone debt crisis clearly demonstrated the inability of the literature to provide a theory and associated empirical models that can explain the past and predict the future sovereign bond yield changes. Therefore in this research we investigate the features of the sovereign bond markets that are either underexplored or the literature offers conflicting findings. We focus specifically on bond markets in all EU member states and the US, and differentiate seven research segments that are mutually interrelated. First segment applies GARCH-type models and estimates sovereign bond spread volatility and the volatility risk premium. The output of this segment is used in subsequent segments; in the model of spread determinants, volatility spillovers, and capital flight. Second segment is dedicated to the analysis of the statistical properties of sovereign spreads volatility by an application of extreme value theory, self-exciting and Markov switching models. We quantify extremal dependence between spreads and the distribution of clusters of their extreme movements using the extremogram. Two segments are devoted to the analysis of volatility spillovers across bond markets and time-varying degree of sovereign bond market integration in developed and emerging EU countries. We also analyze political factors that may influence the sovereign bond market and cross-border capital movement. In this segment we code political variables employed as explanatory variables in the remaining two segments. Hence segment six estimates the model of spread determinants that includes a more balanced and detailed representation of market sentiment and volatility, fiscal features, and political factors. Due to the fact that in recent times extreme changes in sovereign bond markets induced cross-border reallocation of the capital, in the seventh segment we estimate a capital flight model that includes political factors and sovereign spread volatility premium.
2165Kulturološke, ekonomske, monetarne i društvene promjene u svjetlu arheološke baštine srednjeg Podunavlja između 279. g. pr. Kr. i 582. g.Cultural, economic, monetary and social transformations in view of the archaeological heritage of the Middle Danubian region 279 B.C. – A.D. 5822800Tomislav Bilić IP2013-11IP-2013-11-1549ECMS15.06.2014 - 14.06.2018Završio571.000,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Ništa od navedenogNothing from this list2868, 2804, 4660, 2860, 6690, 7464, Ivan Mirnik, Miroslav Nađ, Ivan Radman-Livaja, Anja Bertol, Ivan Drnić, Zoran Gregl, Middle Danube region, Pannonia, Roman archaeology, numismatics, La Tene period, Archaeological museum in ZagrebThe main goal of the CEMS project would be to focus on the numismatic and archaeological heritage of a geographical area in a given time-frame, i.e. the Middle Danube region from the La Tene B period till the Great Migrations period (between two symbolic dates, 279 B.C., the arrival of the Celts in the Danube basin, and A.D. 582, the fall of Syrmium). Four of the Zagreb Archaeological Museum’s departments have an extremely large number of artefacts from this period found in this particular region, most of which remain unpublished and require a thorough scientific assessment. Therefore, the main emphasis of the project would be on the study and publication of the material kept in the holdings of the Museum.The principal results of the CEMS project would be to publish up to ten monographs on the archaeological and numismatic heritage of the Middle Danube region within a given time frame. These publications would not merely be catalogues of material but would aim to present, following modern methodological approaches in archaeology, ancient history and numismatics, all the cultural, social, economical, monetary and technological transformations that occurred over that fascinating period in a defined geographical area.
2176Strateško korištenje prostoraStrategic use of landscape6496Zorko Marković IP2013-11IP-2013-11-3700Stratuselandscape01.07.2014 - 30.09.2016Završio240.000,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Institut za arheologijuInstitute of Archaeology in Zagreb6516, 6838, 7440, 7392, Katarina Botić, Danimirka Podunavac, Kornelija Minichreiter, Hrvoje Kalafatić, field survey, trial excavation, landscape archaeology, natural resources, Drava regionLandscape archaeology is developing slowly in Croatia. It is of great importance to speed up this process and to connect the available data to other regions in central-eastern Europe. It is especially important to connect central Balkan regions with Carpathian basin for better understanding of emergence and development of societies in various prehistoric periods. So far, the ways of communication between these regions were not of primary interest of archaeological scientific work. The complete work in defined area, combining field survey, trial excavations and data concerning natural resources, hasn’t been done. The goal of this project is the recognition of strategic points of settlement in prehistory and later periods and reconstruction of ways of communication. The project will concern itself with the area of municipalities Našice, Podgorač, Drenje and Koška (Drava region). This area is recognized as a potential crossroad of ways of communication of our interest. The work will be divided into 4 stages including field survey, trial excavations, data collection from geological maps and satellite images, combining data, web site construction and presenting the results in form of exhibitions, conferences, lectures etc. The final publication will be made presenting goals, collected data, the final results and list of museum activities. The results will also be available on-line in the form of a web site. The project is planned in collaboration with Našice Local History Museum.
2178Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusaVirus-specific Activating NK Cell Receptors and Their Viral Immunoevasion4958Astrid Krmpotić IP2013-11IP-2013-11-7132ViSpeNKRec01.07.2014 - 31.10.2018Završio853.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine4980, 5273, 4682, 5131, 4723, 4834, 5357, 4652, 17754, 23184, Marina Babić Čač, Irena Slavuljica, Vanda Juranić Lisnić, Johanna Reichel, Branka Popovic, Ilija Brizić, Daria Kveštak, Berislav Lisnić, Jelena Železnjak, Mia Cesarec, NK cells, cytomegalovirus, immunoevasion, Ly49 receptors, KIR receptors, transcriptomicsThe infection of mice with mouse cytomegalovirus (MCMV) as a model of human CMV (HCMV) infection has been particularly informative in elucidating the role of antiviral immune response. NK cells are essential in early control of CMV infection. An evolutionary struggle between NK cells and CMVs can be inferred from a numerous viral mechanisms designed to compromise NK cell function. A deeper insight was gained by studying MCMV evasion of ‘missing-self’ mechanisms and host response to this immunoevasion, illustrated by several MCMV-specific NK cell activating receptors. The work on Ly49H receptor emphasized the selective pressure imposed on the virus to generate variants no longer recognized by this receptor. Another example can be seen from the function of viral m04 protein, which binds to newly synthesized MHC-I molecules and escorts them to the cell surface to engage inhibitory Ly49 receptors. However, while m04 prevents NK cell activation by escaping ‘missing-self’ recognition, several activating Ly49 receptors also depend on its presence for their own recognition of infected cells. Beside m04, another so far unidentified viral factor is required for turning on the activating Ly49 receptors. In addition to characterization of this new viral gene, the aim of this study is to elucidate the functional significance of MCMV-specific activating Ly49 receptors and their interaction with inhibitory counterparts during primary and latent infection.Ly49 receptors in mice are functional homologues of KIR receptors in humans. Recent studies also indicate a strong impact of HCMV on the repertoire and frequency of activating KIR-expressing NK cells, suggesting their specific response to this virus. Therefore, in addition to the MCMV genes involved in ligation of activating Ly49 receptors, here we also propose study aimed to characterize HCMV gene(s) involved in ligation of activating KIRs. We expect these studies to provide new data of groundbreaking potential in the field.
21793D sustav za mjerenje oblika trupa tijelaA low-cost automated system to measure the three-dimensional shape of trunk surface6456Tomislav Pribanić IP2013-11IP-2013-11-37173DHumanTorso03.11.2014 - 02.11.2017Završio728.000,00 KnTehničke znanosti, Biomedicina i zdravstvo, Technological sciences, Biomedicine and health sciences, Računarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing6749, 17809, 6641, Stanislav Peharec, Matea Đonlić, Tomislav Petković, 3D reconstruction, structured light, passive stereo, scoliosis, degenerative disease, 3D spine shapeThe aim of this work is to develop a low-cost automated system to measure the three- dimensional shape of the back and front of the human torso. It will enable numerous physicians to acquire the trunk surface (TS). TS symmetry is one of the key elements in diagnostic and evaluation of various treatments in patients with trunk deformities. Common radiographic evaluation methods are known to expose patients to a radiation and, besides, radiography is actually 2D representation of 3D problem which has been shown not to be directly related to the shape of the back. Thus, there has been a constant motivation among researchers at (inter)national level to develop an optimal methodology for 3D reconstruction of the back. Still, most of those developed systems are mainly directed to 3D reconstruction of the spine and calculation of the Cobb angle which is still regarded by many as the gold standard method to measure scoliotic deformity. Still, the Cobb angle alone cannot explain the whole of the surface deformity. Evidently, there is high need to investigate development of a 3D reconstruction system which will capture both back and front of the patient, i.e. the entire trunk surface. In turn it would enable a more thorough analysis of the patient’s deformity pattern, i.e. a second major goal during this project is to derive other parameters (not only Cobb angle) in order to quantify trunk deformities. In designing 3D system we underline that we plan to research the implementation of both passive and active stereovision strategies. Researching the implementation of combined best features from passive and active stereo for one concrete of 3D system aimed at TS reconstruction (scoliosis), would be a great contribution for potential other 3D applications. Degenerative diseases of spine represent a serious social problem in Croatia. More than 10% of population has frequent problems with it. Clearly, every research contribution for this matter would be an extremely valuable asset.
2182Jezična obrada u odraslih govornikaAdult language processing400Jelena Kuvač Kraljević UIP2013-11UIP-2013-11-2421ALP15.09.2014 - 14.09.2017Završio394.151,67 KnDruštvene znanostiSocial sciencesLogopedija, Logopedics, Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultetUniversity of Zagreb, Faculty of Education and Rehabilitation Sciences4359, 6147, 6436, 3759, 3050, 5429, 17791, 20388, Marijan Palmovic, Gordana Hržica, Melita Kovačević, Sanja Šimleša, Magdalena Krbot Skoric, KAROLINA LICE, Marina Olujić, Ana Matić, language processing, adult and elderly population, language disorders, executive functions, linguistic aphasiologyAdult Language Processing project is intended to address psycholinguistic and neurolinguistic aspects of the aging population in Croatia. As an installation research project it will help set up an interdisciplinary and multidisciplinary research group that would tackle all aspects of the language processing in adults and in the aging population. Clinical groups (patients with aphasias, dementias and dyslexia) will be included into the project; language breakdown in these clinical groups helps in the study of language processing in healthy adults and vice versa. It is generally assumed that the subtle changes in language processing in the aging population arise from the cognitive decay related to executive functions, not language per se. The decrease in the processing speed influences language processes that require fast execution or simultaneity. This results in a typical pattern of changes, different from the ones in clinical populations. Therefore, executive functions in these groups will be studied in order to build a comprehensive model of adult language processing. Theories of language processing (namely, Role and Reference Grammar - RRG) will be considered to define specific traces of language processing that assume fast execution or simultaneity and therefore should be the most vulnerable in aging population. These traces will be defined and described which will put Croatian into a cross-linguistic perspective in contemporary studies of linguistic aphasiology and provide coherent picture of age related changes in adult language system.
2184Problemi temeljnoga suvremenog glazbenog nazivlja u HrvatskojProblems of Basic Contemporary Musical Terminology in Croatia1454Nikša Gligo IP2013-11IP-2013-11-5355conmusterm08.09.2014 - 07.09.2018Završio280.000,00 KnHumanističke znanosti, Humanities, Filologija, Philology, Sveučilište u Zagrebu, Muzička akademijaUniversity of Zagreb, Music Academy3664, 3395, 5984, 2897, Tomislava Bošnjak Botica, Krešimir Sučević-Međeral, Sanja Kiš Žuvela, Ana Ostroški Anić, musical terminology, Croatian standard language, music education, language standardization, corpus analysis, comparative terminologyThe project will be dealing with the basic problems of contemporary musical terminology in Croatia. Aware of the high cultural value of the state-funded music education system in Croatia, as well as an indispensable role of musical metalanguage in teaching music at all levels, the PI Nikša Gligo has noticed an array of doubtful basic musical terms appearing within the above mentioned system. The discrepancies among teaching professionals are so present that it often comes to misunderstandings and other difficulties in communication. The objectives of the project will be to locate problems through analysis of recent corpus of professional literature in the field, to analyse the variants in the use of musical metalanguage among teaching professionals, to compare the Croatian musical terminology with other languages, as well as to propose alternative solutions for inappropriate basic musical terms in daily use. The main aim of the project is to make available to public a set of 2000 standardized and harmonized basic musical terms in form of a free internet database and a published handbook. Further dissemination will follow in form of terminology workshops and seminars throughout Croatia. This interdisciplinary project will be achieved through intensive cooperation of musicologists and linguists, which will ensure a high level of linguistic normativity along with musicological aptness. The PI Gligo is a frequent speaker and the leading author on musical terminology in Croatia.
2185STRUKTURNA OBILJEŽJA KOJA ODREĐUJU NUKLEOFUGALNOST IZLAZNIH SKUPINA TE TEORIJSKI MODEL ZA PROCJENU SOLVOLITIČKE REAKTIVNOSTISTRUCTURAL FEATURES THAT DETERMINE THE NUCLEOFUGALITY OF LEAVING GROUPS AND THE THEORETICAL MODEL FOR ESTIMATING THE SOLVOLYTIC REACTIVITY2610Olga Kronja IP2013-11IP-2013-11-1021NUCLEOFUGALITY01.07.2014 - 30.09.2018Završio559.702,93 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultetUniversity of Zagreb, Faculty of Pharmacy and Biochemistry3221, 3453, 3505, 3946, Bernard Denegri, Mirela Matić, Sandra Jurić, Marijan Marijan, nucleofugality, electrofugality, kinetics, solvolysis, reactivityThe impact of electronic effects in the leaving group (nucleofuge) on the overall reactivity will be investigated thoroughly. Importance of negative hyperconjugation, contribution of the leaving group to the height of the reaction intrinsic barrier, importance of the inductivity and resonance as well as solvation will be analyzed. Series of substituted phenyl and alkyl carbonates, phosphates, phenolates, sulfates, phosphorous ylides, quaternary ammonium salts, etc. will be subjected to solvolysis in aqueous solvents and the rate constants will be correlated with the electrofugalities of the generated carbocations by applying a special LFER equation: log k = sf (Nf + Ef). To detect changes of the C—H bond strength in the TS, secondary deuterium KIEs will be determined. The rates of the backward combination reactions in some cases will be measured, which will provide a complete free energy profile of some reactions. The Marcus intrinsic barriers will be calculated and analyzed. The existing electrofugality scale will be extended with other aromatic (e.g. ferocenyl) as well as non-aromatic electrofuges by introducing the correction factors for the solvolysis rates. Such extended electrofugality scale, not limited to aromatic derivatives only, will allowed estimation of the heterolysis rates for wide range of compounds. The quantum-chemical model will be developed which mimics heterolysis reactions and whose barriers for variety of leaving groups correlate well with experimental barriers obtained with benzhydryl derivatives (?G‡calc vs ?G‡exp). By applying this correlation, the nucleofugality scale will be extended considerably and estimation of the rate constants for SN1 solvolysis of numerous leaving groups will be enabled. Such interplay of the theoretical calculations and experiment will allow prediction of the reactivity of a huge number of new nucleofuges, which have not been used earlier, as well as design of the substrates with required reactivity.
2187Dubrovnik: Civitas et Acta Consiliorum, Vizualizacija razvoja kasnosrednjovjekovnog urbanog tkivaDubrovnik: Civitas et Acta Consiliorum, Visualizing Development of Late Medieval Urban Fabric431ANA PLOSNIĆ ŠKARIĆ UIP2013-11UIP-2013-11-9492DUCAC01.10.2014 - 30.09.2017Završio398.900,00 KnHumanističke znanostiHumanitiesPovijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb6995, 5352, 5998, 5497, 7130, 5555, Nada Grujić, Donatella Calabi, Danko Zelić, Ana Marinković, Alessandra Ferrighi, Matko Matija Marušić, new archival data, urban development, changes of tissue, dissemination, comparative perspective, general public, new digital technologiesThe aim of the DUCAC project is to establish an international, Croatian-Italian group of urban history researchers that would participate in the work, research and discussions within the international community of humanities and social sciences. The project's main goal is to systematically investigate the unpublished 15th century archival records of Dubrovnik's three governing bodies (Great Council, Minor council and the Senate) in order to select, gather, interpret and publish data concerning urban spaces and buildings and to examine the relationships between Councils’ deliberations and the urban development. The results would be discussed within the comparative perspective regarding the similar topics of other European towns as well as disseminated within scientific community and general public. These objectives would be established using new digital technologies for the humanities - HGIS interactive database and 3D visual presentations of the related processes.
2189Organske molekule u kondenziranoj fazi: međudjelovanja i modeliranjeOrganic molecules in condensed phase: interactions and modeling4668Hrvoj Vančik IP2013-11IP-2013-11-7444ORGMOL01.09.2014 - 30.11.2018Završio751.424,47 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science4679, 4656, 4669, 5069, 4687, 19061, Zlatko Mihalić, Ivana Biljan, Ivan Kodrin, Igor Rončević, Katarina Varga, Petar Bibulić, reaction mechanisms, solvent effects, solid-state reactions, molecular self-assembly, nitroso compounds, ferrocenesThis research will consist of two parallel research pathways. The first will include study of mechanisms of organic reactions in the solid state, and the second will mainly deal with the theoretical study of mechanisms in the solution.Mechanisms of the solid-state processes cannot be interpreted using the established concepts of reaction mechanisms because the phase change plays the crucial role in determining reaction kinetics and the structure of the products. Until now, papers published in this field represent mostly kinetics of phase transformations and descriptions of kinetic data by various mathematical models. As a result, the relationship between such a macroscopic approach and structural changes on the molecular level is still poorly understood. Knowledge about the principles of solid-state reactions is of broad interest, and especially useful to chemists who use solvent-free synthetic methods. In this research, we propose investigations of solid-state reactions based on our recent discoveries and explanations of mechanisms of dimerizations and polymerization of nitroso compounds. Using this established approach and corresponding molecular models, we plan to develop a mechanistic concept of the solid-state reactions, and use it to design novel supramolecular structures.As a starting point of our investigations of organic reaction mechanisms in the solution, we will finish development of our new cluster-continuum solvation model. It will provide us with the most important solute-solvent molecules clusters, allowing the realistic estimates of standard Gibbs energies of involved species and thus prediction of kinetic and thermodynamic data for the examined reactions. The approach will be tested on several model problems, and then used for the analysis of several representative organic mechanisms, including the ones occurring in solids.
2193Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitkaHistological, MRI and gene expression analysis of the reorganizational processes in the medial (limbic) wall of developing human cerebrum3523Mario Vukšić IP2013-11IP-2013-11-7379MEDCEREB01.09.2014 - 31.08.2018Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine6256, 4298, 5534, 4125, 17812, 23386, 22600, Nataša Jovanov Milošević, Milan Radoš, Zeljka Krsnik, Goran Sedmak, Vinka Kovačević, Damir Mulc, Mihaela Bobić, subplate, marginal zone, human brain development, immunohistochemistry, gene expression, in situ hybridization, MRI analysis, hippocampus, cingulumThe salient feature of the human fetal cortex is the presence of the subplate zone (SP), a prominent, synapse rich compartment composed of „waiting“ afferents, loosely arranged axons, synapses, growth cones, migratory neurons, glial cells and extraordinary amount of extracellular matric molecules (ECM). The medial (limbic) cortical regions (areas involved in emotion and memory functions) develop a different laminar structure in comparison with lateral cortical regions. Unlike the lateral cortex, where the SP is a major site of neurogenetic events, in the medial archicortex marginal zone (MZ) seems to be a key zone for early molecular neuronal interactions, synaptogenesis and patterning of growing pathways. The goal of this project is to correlate developmental reorganization of major cellular (cell bodies, growing axons) components of the SP and the MZ in developing medial wall of the human cerebrum (cingulum, hippocampus, amygdala) by combining immunochistochemistry, in situ hybridization, transcriptome analysis with in vivo/in vitro MRI. Histological analysis wiil be performed on postmortem human brains, ranging from 10 postconceptional weeks (POW) to 6.5 years, to analyze the expression patterns of different developmentally regulated proteins in relation to synaptic, laminar, neuronal, glial and ECM development. These results will be correlated with in vivo/in vitro MRI findings obtained in age-matched fetuses, infants and children. In addition, we will also analyze publicly available gene expression database (Kang et al., 2011) to investigate the relationship between structural changes and spatio-temporal expression of specific candidate genes. For the selected candidate genes we will perform in situ hybridization and immunocytochemistry in order to elucidate in which cells are these genes expressed. The obtained data will be used for setting the baseline for studying developmental abnormalities characteristic for diverse neurological disorders
2194Precizna mjerenja svojstava hadronskih sustava i niskoenergijska QCDHigh precision measurements of hadronic system properties and low energy QCD3809Damir Bosnar IP2013-11IP-2013-11-1680PExpQCD01.07.2014 - 30.06.2018Završio823.000,00 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science4395, 4413, 5059, 4909, 4993, Ivica Friščić, Petar Žugec, Gorjana Jerbić-Zorc, Ulrich Müller, Catalina Oana Curceanu, electron scattering, nucleon structure, NN correlations, kaonic atoms, low energy QCDIn the focus of the project are high precision measurements of specific hadronic system properties relevant for the low energy QCD: electron scattering investigations of nucleons and nuclei at Mainz Microtron (MAMI) and X-ray transitions in kaonic atoms at DAPHE at Laboratori Nazionali di Frascati (LNF). The ultimate goal of the proposed experiments, together with other experimental and theoretical investigations, is to provide crucial pieces of information for the understanding how hadrons emerge from their fundamental constituents - the quarks and gluons, why the colour is confined, the symmetry is spontaneously broken and the nucleon is much heavier than its constituents. The main objectives in electron scattering experiments at MAMI are: cross section determination of the p(e,e’ ?+)n reaction at Q2=0.078 (GeV/c)2, the lowest measured value till now, of crucial relevance for axial nucleon form factor determination, measurements of virtual Compton scattering in the momentum transfer range of relevance for nucleon structure determination, investigations of 12C(e,epp)10Be and simultaneous measurement of 12C(e,epp)10Be and 12C(e,e’pn)10B reactions of relevance for determination of the role of quark degrees of freedom in nuclei and also for understanding of cold dense nuclear systems such as neutron stars. The main objectives in the kaonic atoms experiments at LNF are: upgrade of SIDDHARTA setup in order to reach desired resolution and subsequently high precision measurements of transitions in kaonic deuterium, 3He and 4He, that should yield isospin dependent kaon-nucleon scattering lengths. Their precise determination will put strong constraints on the low-energy kaon-nucleon dynamics and eventually constrain the SU(3) description of chiral symmetry breaking. Important component of the project proposal is also development of new detector systems, in particular silicon detector system and diamond detector system with data acquisition based on fast digitizers.
2195Razvoj naprednih visokonaponskih sustava primjenom novih informacijskih i komunikacijskih tehnologijaDevelopment of advanced high voltage systems by application of new information and communication technologies5632IVO UGLEŠIĆ IP2013-11IP-2013-11-9299DAHVAT01.09.2014 - 31.08.2018Završio478.478,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing3614, 5633, 3670, 1373, 6159, 6804, 6797, 5760, Viktor Milardić, Božidar Filipović-Grčić, Boško Milešević, Dalibor Filipović-Grčić, Bojan Franc, Ivica Pavić, Bruno Jurišić, Milivoj Mandić, high voltage, electric raliway, power quality, EMC, modelling, ICTThe Research Project will develop the following implementation of new ICT technologies in High Voltage systems: 1. Application of new information and communication technologies such as lightning location system data for analysis of lightning overvoltages and overvoltage protection optimization:- Develop an original algorithm for lightning location data analyze in order to determinate the lightning flashes from the lightning strokes. - Analyze of collected lightning location date and develop an original algorithm for correlation with protection relay tripping in transmission and distribution lines. 2. Modeling the consumers with a big influence on the power quality in high voltage system- Influence of electric railway system on power quality in 110 kV transmission system.- Model of 25 kV 50 Hz electric railway system for power quality studies (electric locomotive, traction network, traction substation):- Compare the developed model with measurement results obtained on locomotives, electric trains and in electric traction substations. 3. New methods for the assessment of Electromagnetic Compatibility - Methodology for more precise electromagnetic influence calculation of contact line and electric traction system to the metal structure in the vicinity:- Identification and assessing the effect of changing values of model parameters based on the theory of electrical circuits to calculate the induced voltage.4. New models of components in studies of electromagnetic transients in high voltage systems- Development of wideband models for power system components (power and instrument transformers, circuit breakers, surge arresters, shunt reactors).- Summarize and analyze the detailed bibliography on the high frequency electromagnetic behavior of transformers (calculations and measurements). - High frequency transformer modeling.
2203Upotreba cijelog genoma mitohondrijske DNA u oplemenjivanju i konzervacijskoj genetici govedaUtilisation of the whole mitogenome in cattle breeding and conservation genetics6650Ino Čurik IP2013-11IP-2013-11-9070MitoTAUROmics01.07.2014 - 30.10.2018Završio912.378,00 KnBiotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture4140, 6553, 7105, 539, 6279, 7067, 7343, 7372, 7206, 7401, 17837, 19007, 1339, 6771, 7242, Strahil Ristov, Anamarija Smetko, Johann Sölkner, Nikola Raguž, Maja Ferenčaković, Ivana Kovač, Vlatka Čubrić Čurik, Mato Čačić, Gregor Gorjanc, Antun Kostelić, Martin Reljanović, Vladimir Brajković, Dinko Novosel, Marija Špehar, Dragica Šalamon, Whole mitogenome, Cattle, Detrimental effects, Phenotypic variability, Quantitative geneticsThe main goal of this proposal is to sequence mitochondrial whole genome (mtWGS) in a 500 to 600 bulls or cows (440 to 540 belonging to Istrian cattle, Busha cattle, Slavonian-Syrmian Podolian cattle and Holstein population in Croatia) in order to: 1). identify polymorphic sites within mtWGS in genetically small populations and to analyse (confirm) the presence of selection for the whole mitochondrial genome as well as for each single gene (comparison of non-synonymous versus synonymous mutations); 2). Identify potentially detrimental mutations and to estimate detrimental load in all analysed populations; 3.) develop computerised approach (set of algorithms) that will, in terms of probability or likelihood, enable imputation of sequenced mtWGS haplotypes for other pedigree members as well as to point to animals that are wrongly assigned to the pedigree, 4.) Identify mutations that are associated with phenotypic variability of milk production and fertility traits and to estimate the magnitude of the mtWGS effects (haplotypes) in terms of variance components and 5.) Identify private (specific) mutations that can be used in traceability or genetic bar-coding of species and breeds (this is of particular interest for endangered populations). In performing these comprehensive analyses we will use newly developed methodologies of high-throughput sequencing and complex computing analyses. We believe that this research will stimulate other researchers involved in animal genetics and breeding of other species (dog, horse, swine, rabbit, etc…) for similar researches. Furthermore, results of the project will be economically utilised in cattle breeding as well as conservation management of endangered Croatian breeds. At the same time, we hope that innovative and technologically advanced component of this research will result in good publication record for all scientists involved which will further increase our competitiveness to approach to EU funded projects.
2209Antički vodni sustavi grada Salone i Dioklecijanove palače i njihov utjecaj na održivost urbane sredineRoman Water Systems of City of Salona and Diocletian's Palace and Their Impact on Urban Sustainability6669Jure Margeta IP2013-11IP-2013-11-9852RWSCSDP01.09.2014 - 31.12.2018U tijeku581.500,00 KnTehničke znanostiTechnological sciencesArhitektura i urbanizam, Architecture and Urban Environment, Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezijeUniversity of Split, Faculty of Civil Engineering, Archtecture and Geodesy6671, 6575, 6674, 6871, Katja Marasovic, Snježana Perojević, Miroslav Katić, Davor Bojanić, Urban water system, Salona, Diocletian's palace, Aqueduct, SewageThe aim of the project is to study two Roman Water Systems which are using the same water source - Jadro spring. First one is Water System of Salona, capital of Roman province Dalmatia, from the 1st century, and the second one is of Diocletian's Palace in Split from 4th century. The study will consist of analysis and reconstruction of two, by its purpose, different Water System, one of typical urban character and another very specific of Emperor Palace. Unlike the Water System of the Palace, which is partly preserved (aqueduct is in function) and therefore more studied, the Water System of Salona is mostly unknown. They will be studied separately using the same methodology.All parts of Water Supply system will be studied: water intake on Jadro spring, route and elements of the aqueduct (channel, bridges and tunnels), water distribution tanks, lead pipe network and water appliances together with water quantity and quality issues. The study of sewage will consider wastewater and storm water drainage, as well as the protection from external surface water and groundwater. Besides those, methods, materials and techniques used by Roman engineers to establish efficient urban Water System indispensable for the life and health of the citizens will be analyzed and compared with modern system. The study will be based on collecting all data regarding explored elements of the Water System and on new archaeological excavations financed by this project. Existing topographic and architectonic surveys will be summarized and supplemented by new ones which will enable reconstruction of the whole system and elements. The project team is multidisciplinary and gathers civil engineers, architects and archaeologist. Apart from new knowledge about the planning, building and maintaining Roman Water Systems this project will give necessary data to protect elements of the system form devastation, to make a proper presentation and even to put some elements is use.
2210Održivi optički komunikacijski i senzorski sustavi zasnovani na rezonatoru s produženom rezonantnom šupljinomSustainable Optical Communication and Sensor Systems based on Extended-Cavity Resonators6686Zvonimir Šipuš IP2013-11IP-2013-11-3425EXCAR01.09.2014 - 31.08.2018Završio894.400,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing7148, 7044, 6893, 6929, 6886, 6949, 19032, 20069, Dubravko Babic, Borivoj Modlic, Marko Bosiljevac, Tin Komljenović, Dario Bojanjac, Damir Muha, Marko Šprem, Josip Lončar, optical access networks, WDM-PON, optical sensors, colorless optical transmitter, extended cavity, optical noise, noise reduction, wavelength re-useThe objective of this project is to advance the state-of-the-art in optical access networks and also apply the same ideas to sensor networks. Proposed project addresses the EU targets as defined by European Commission’s “Europe 2020” strategy for smart growth by focusing on research and development of highly-integrated and energy efficient optical transceivers and wavelength-division-multiplexing (WDM) components for next-generation of access and mobile backhaul networks using passive optical network (PON) infrastructure. The primary challenge, in wider adoption of WDM-PON, lies in the development of sufficiently low cost technology to be used at the users’ premises. Self-seeded WDM-PON has been actively investigated in recent years as potentially the lowest cost solution for next-generation access networks. The primary attraction of this architecture is its simplicity, lower power consumption, and cost advantage. Similar principles can be applied to multiplexing and interrogation systems for optical sensors and our aim is to develop, analyze and demonstrate sustainable all-optical infrastructure based on extended cavity resonators able to provide physical layer for both, access communication and sensor networks.At University of Zagreb we invented an optical component, the modulation-averaging reflector, which reduces the penalty due to modulation of the seeding light and depolarizes the light oscillating in the cavity thereby stabilizing the extended resonator. This was the first step towards a future-proof optical access technology. Within this project we will fully develop and characterize systems based on extended cavity resonators with modulation averaging reflectors. We will also explore the use of modulation averaging concept in a novel communication optical source architecture based on wavelength re-use. Finally, the concept of extended cavity resonators will also be implemented in non-communication applications such as new optical sensor schemes.
2213Gravitacija i narušenje paritetaGravity and parity violation3313Maro Cvitan UIP2013-11UIP-2013-11-8946GRAPARION01.09.2014 - 22.02.2018Završio682.928,15 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science3371, 3433, 3399, 3418, 6887, 17858, 20367, 21426, Ivica Smolić, Predrag Dominis Prester, Silvio Pallua, Loriano Bonora, Bruno Lima de Souza, Tamara Štemberga, Stefano Gregorio Giaccari, Mateo Paulišić, gravity, black holes, parity violation, quantum anomalies, holography, string theory, conformal symmetry, entanglement entropyThe effect of parity or charge-parity (CP) violation in gravitational theories has not been extensively studied so far in the literature. Nevertheless this phenomenon might be very important and help explaining the baryon asymmetry of the Universe: our Universe consists of matter, with the negligible amount of antimatter. Despite many attempts a satisfactory explanation for this asymmetry is not yet at hand, although it is generally accepted that the processes responsible for it must violate CP. The qualifying aim of this project is to explore the idea that CP violation may be traced back to gravity. However we believe it is more effective to cope with this problem in the framework of a more general research on parity violating effects in gravity, which we will study by means of modern methods of exploring the gravitational interaction: holography, Kerr black hole horizon-conformal field theory (Kerr-CFT) correspondence, trace anomalies, entanglement entropy, fluid-gravity correspondence. The focus will be in particular on the natural candidates for parity violating gravity processes - the Chern-Simons terms, both pure gravitational and mixed gauge-gravitational ones - using extra-dimension models inspired by the string theory. The expected outcome is a significant increase in understanding the consequences of parity violating gravitational interactions, not only in relation with possible CP violations, but also for other effects, e.g. for corrections to black hole entropy.
2215Panorama hrvatske književnosti u Dubrovniku 17. stoljećaA Panorama of Croatian Literature in 17th Century Dubrovnik2947Milovan Tatarin IP2013-11IP-2013-11-8110Panorama01.08.2014 - 31.07.2018Prekinut114.514,57 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultetJosip Juraj Strossmayer University of Osijek, Faculty of PhylosophyCroatian Literature, Dubrovnik, 17th Century, Critical edition, TekstologyAssuming that only the availability of all the works written in the 17th century will allow for a valid interpretation, both of individual oeuvres and of the period as a whole, I decided to use the manuscripts (not the existing printed editions) to prepare for publication the works of all the writers that were active from the end of 16th century until 1637 (death of Injacije Đurđević). We are talking about 42 poets. This project is thus a survey of everything that was written in the 17th century, in all three literary forms (Lyric, Narrative and Drama), excluding the writers that already have their own critical editions (Palmotić, Gleđević, Gundulić, Đurđević, Bunić). The project is substantial since it encompasses: a) collecting and comparison of manuscripts; b) transcribing the manuscripts; c) an accompanying study. This project is neither an anthology nor a chrestomathy, but it strives to collect in one place everything that a certain writer wrote, regardless of the literary value.
2216Preobrazba građanskog pravosuđa pod utjecajem globalnih i regionalnih integracijskih procesa. Jedinstvo i različitostTransformation of Civil Justice under the Influence of Global and Regional Integration Processes. Unity and Diversity3028Alan Uzelac IP2013-11IP-2013-11-6988TCJust-UD01.01.2015 - 31.12.2018Završio559.934,69 KnDruštvene znanostiSocial sciencesPravo, Law, Sveučilište u Zagrebu, Pravni fakultet u ZagrebuUniversity of Zagreb, Faculty of Law4219, 3969, 4405, 3341, 5320, 5043, 5032, 3428, 5783, 3062, 5042, 17777, Cornelis Hendrik van Rhee, Elisabetta Silvestri, Aleš Galič, Aleksandra Maganić, Marko Petrak, Ivan Milotić, Tomislav Karlović, Slađana Aras, Barbara Preložnjak, Marko Bratković, Henrik-Riko Held, Juraj Brozović, civil justice, civil procedure, harmonisation, unification, globalization, integration, ius commune, effective legal protection, legal historyNational civil justice systems are deeply rooted in national legal culture and traditions. However, in the past few decades they are increasingly under the influence of integration processes at the supra-national, regional and international level. The emergence of economic and political unions and globalisation processes exert as a by-product pressure to harmonise or even unify the way in which national civil justice systems operate. In an attempt to create a ‘genuine area of justice’, new unified procedures are being developed. They operate in parallel with national civil procedures, and sometimes even strive to replace them. As a reaction to the forces that endeavour to harmonise and unify procedural laws and practices, an opposite trend is gaining momentum: a trend that insists on diversity and pluralism of national civil procedures. The basis of this trend is the claim for national procedural autonomy/sovereignty. The research within this project will focus on the evolution of procedural reforms in various jurisdictions, with a particular emphasis on Croatia, its broader region (successor states of the former Yugoslavia) and Europe. The purpose is to identify to what extent the tensions between the centrifugal and centripetal forces contribute to development of judicial structures that provide a higher level of proper and effective legal protection, and to which extent these tensions create confusion and produce legal transplants and irritants that are equally or less effective than traditional procedures.
2224Fleksibilna energetska čvorišta u nisko ugljičnim naprednim elektroenergetskim mrežamaFlexible energy nodes in low carbon smart grid6497Igor Kuzle IP2013-11IP-2013-11-7766FENISG01.10.2014 - 30.09.2018Završio968.400,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing6990, 6996, 7001, 7087, 7162, 7186, 7211, 7278, 7348, 7160, 7194, 19028, 4484, 22939, Zeljko Tomsic, Marko Delimar, Tomislav Capuder, Davor Škrlec, Hrvoje Pandžić, Ninoslav Holjevac, Miljenko Brezovec, Tomislav Plavšić, Juraj Havelka, Sejid Tešnjak, Matija Zidar, Kristina Jurković, Anamari Nakić, Stjepan Tusun, energy/power nodes, smart grids, reneawable energy sources, distributed generation, energy storage, plug in electrical vehiclesThe share of renewable energy sources (RES) in electric power systems (EPS) has increased during the recent years and this trend is expected to continue. The stochastic nature of electricity production from RES imposes new challenges for the EPS operation and control. A large share of undispatchable RES can lead to significant disturbances of EPS components. These disturbances need to be balanced out and the security of the system has to be preserved. If the resources for providing balancing energy and flexibility are limited, secure operation of the EPS will become highly expensive. Conventional generation units provide the necessary flexibility to maintain a continuous balance between supply and demand. The question is: are these conventional resources the most feasible way of providing system flexibility in the future low carbon systems? During the recent years, plug-in hybrid electric vehicles (PHEV) have become an attractive way of transportation. While passive approach to their integration might cause problems to the system, active utilization of their flexibility might enable higher penetration of RES. A similar reasoning can be applied to the distributed generation, especially technologies with the potential of multi energy vector interaction (efficient electric heating, combined heat and power, battery storage etc.).Current grids need to be capable of dealing with mentioned requirements. The concept of Smart Grid (SG) is based on using of novel information and communication technology (ICT) and includes application of a spectrum of innovative and flexible technologies.The purpose of this project is to establish a methodological and comprehensive framework providing the costs and benefits evaluation of SG projects and technologies. Given the sizeable investments needed, there is a need for a fair, consistent and methodological approach for estimation of the best investment option, taking into account economic and environmental aspects of a specific project.
2225Teoretsko i primjenjeno jezikoslovno istraživanje korpusa hrvatskih crkvenoslavenskih tekstova s izradom Rječnika crkvenoslavenskoga jezika hrvatske redakcijeTheoretical and applied linguistic research of the corpus of the Croatian Church Slavonic texts with the Dictionary of the Croatian Redaction of Church Slavonic compiling 1047Vida Vukoja UIP2013-11UIP-2013-11-2462TALRCCCSTDCRCSC01.07.2014 - 30.06.2018Završio361.968,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Staroslavenski institutOld Church Slavonic Institute in Zagreb1119, 2569, 4724, 6597, 6756, 5965, 7397, Jozo Vela, Lucija Turkalj, Zdenka Ribarova, Anica Nazor, Ana Kovačević, Saskia Elisabeth Pronk-Tiethoff, Marija Klenovar, Croatian Church Slavonic, (paleo)slavistic studies, (historical) lexicography, Medieval studies, linguistics Croatian Church Slavonic (CCS) is a bookish language system written in Glagolitic script, with the preserved documents originated from the XI/XII to the XVII c., developed on the basis of the Old Church Slavonic (OCS; created by Sst. Cyrill and Methodius), and under heavy influence of the medieval Croatian vernacular. Being referential and representative, the corpus of the CCS texts provides the most effective basis available for the relevant research of the CCS.The project includes theoretical and applied linguistic research. Among the applied linguistic disciplines, two lexicographic tasks play focal roles: compiling of Rječnik crkvenoslavenskoga jezika hrvatske redakcije (Eng. Dictionary of the Croatian Redaction of Church Slavonic; DCRCS) and conversion of the CCS corpus into digitally readable text(s). Theoretical and other, non-lexicographical, applied linguistic research include those within the fields of: semantics (esp. of the lexis expressing feelings/passions), theory and practice of (medieval) translation (direct translation from Latin into CCS, and inherited OCS translations of the Greek texts within the CCS tradition), grammar (primarily syntax of negation, agreement, infinitive, CCS psalter), textology (selected CCS texts, CCS psalter). Substantial contribution of the project research cover (inter)national fields of: (paleo)slavistic and medieval studies, historical lexicography, diachronic study of the Croatian language diasystem, interdisciplinary investigation of the history of emotions. Finally, through the CCS corpus management (i.e. conversion of the CCS corpus into digitally readable format) and the DCRCS compiling, the project offers irreplaceable and permanent assistance to any scholarly or scientific field interested in the CCS texts contents. Due to the range of texts incorporated into the corpus, this contribution is virtually unforseeable.
2230MAtematička analiza multifizikalnih problema koji uključuju tanke i kompozitne strukture i fluideMathematical Analysis of Multiphysics problems Involving Thin and Composite Structures and Fluids6764Igor Velčić UIP2013-11UIP-2013-11-9477MAMPITCoStruFl01.09.2014 - 31.08.2017Završio783.100,38 KnPrirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing7180, 5074, 5872, 6840, 4816, 17761, 20370, Suncica Canic, Boris Muha, Mario Bukal, Maroje Marohnić, Josip Tambača, Marija Galić, Marin Bužančić, thin structures, composite structures, dimensional reduction, homogenization, Gamma convergence, fluid-structure interaction, existence of solution Composite materials are materials made from two or more constituent materials with different physical properties that, when combined, produce a material with characteristics different from those of its individual components. Thin and composite structures are of extreme importance for applications in engineering (e.g. building blocks, boats, ships, aircraft design) and biology (bones, biological tissues, blood vessels) where they are often subjected to fluid load. The analysis of these kind of complex multi-physics systems is very challenging from the mathematical point of view. Namely, the analysis of thin and composite structures and fluids includes the analysis of nonlinear partial differential equations (nonlinear PDEs), which leads to interesting mathematical questions (Gamma limits of a certain system of nonlinear equations with highly oscillating coefficients, existence for a certain system of nonlinear PDEs). This project plans the following: derivation of lower dimensional models in elasticity for highly oscillating materials, optimal design problems, derivation and analysis of fluid-structure interaction problems (derivation of coupling conditions, well-posedness and asymptotic stability analysis). We will use both Calculus of Variation and PDEs techniques to approach different topics, using the benefits from both. We strongly believe that this diversity will bring additional value to Croatian applied mathematics and will provide young people to develop and get acquainted with different approaches of the modern applied mathematics.
2232Razvoj konkurentnosti hrvatskog prerađivačkog sektoraBuilding competitiveness of Croatian manufacturing653Jasna Prester IP2013-11IP-2013-11-3535EMS_GMRG01.07.2014 - 30.06.2018Završio338.459,10 KnDruštvene znanosti, Tehničke znanosti, Social sciences, Technological sciences, Ekonomija, Economy, Sveučilište u Zagrebu, Ekonomski fakultet u ZagrebuUniversity of Zagreb, Faculty of Economics and Business293, 2584, 4422, 4455, 2519, 5210, Božidar Matijević, Najla Podrug, IVANA RAŠIĆ BAKARIĆ, Davor Filipović, Maja Daraboš, Ivan Kumić, Manufacturing, manufacturing practices, technology, organizational innovations, EMS, GMRG, CroatiaThere are several trends in global manufacturing. Higher automatization reduces the need for human labour and China manufacturing is posing a considerable threat. Manufacturing companies in developed countries are seeking ways to stay competitive on the global market since a considerable part of their GDP is acquired by manufacturing, but unfortunately, shrinking. At the moment there are two large scale projects exploring manufacturing sector: EMS and GMRG Survey. Both surveys look at different aspects of manufacturing and engage different countries. EMS covers 18, while GMRG survey includes 24 countries including China, Taiwan and others. The main objective for application is to enable Croatian scientist to be equal partners in such large scale projects and access data from other countries and carry out comparative analyses that will benefit the researchers and manufacturing industry in Croatia. It must be emphasized that Faculty of Business and Economics is the partner for both EMS and GMRG project for number of years but never had the chance to exploit the privileges. Both surveys explore in detail manufacturing so willingness of the industry to participate is essential. In order to do that, Faculty of Business and Economics will have to provide several workshops on which participants will see the comparative results between countries and be motivated to participate in the next round. All the acquired knowledge will be shared with industry experts and all the results will be available on the internet page of the host Institution. The project is interdisciplinary because it investigates the manufacturing technology and processes, as well as the usage of novel materials. Therefore colleagues from Engineering Sciences are participating in the project since the latest results in manufacturing research shows that advanced technology and advanced materials are the only source left for sustaining the competitive advantage in comparison to China.
2246Nanominerali u sedimentima i tlima: formiranje, značajke i uloga u biogeokemijskim procesimaNanominerals in sediments and soils: formation, properties and the role in biogeochemical processes.6786Ivan Sondi IP2013-11IP-2013-11-2504NanoMin01.09.2014 - 30.09.2018Završio935.115,65 KnPrirodne znanostiNatural sciencesGeologija, Geology, Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultetUniversity of Zagreb, Faculty of Mining, Geology and Petroleum Engineering2669, 4675, 6573, 2885, 2920, 624, 6464, 3252, 614, 4415, 3030, 6023, 20538, Goran Durn, Sonja Lojen, Mladen Juračić, Sibila Borojević Šoštarić, Marta Mileusnić, Neda Vdović, Srečo Davor Škapin, Uroš Barudžija, Irena Jurina Tokić, Maja Ivanić, Stanko Ružičić, Igor Felja, Tomislav Brenko, geochemistry, nanoparticles, nanominerals, sediments, soils The Project aims to investigate mineralogical, morphological, geochemical and surface physico-chemical properties of the naturally occurring inorganic nanomineral fraction separated from different modern marine and lacustrine sediments and soils developed on carbonate rocks along the Adriatic coast. The unique structural, chemical and surface properties of nanomineral phases and their role in cycling of trace elements in modern sediments and soils will be determined. The primary objectives of this project are: (1) to identify the size, the unique mineralogical, morphological, geochemical and surface physico-chemical properties of the naturally occurring inorganic nanomineral fractions; (2) to determine the early diagenetically driven formation and phase transformation of nanosized carbonate, sulfide and iron (hydr)oxide particles in modern lacustrine and marine sediments at the nanoscale; (3) to resolve pedogenetically driven formation of nanosized clay mineral and iron and manganese (hydr)oxide particles in soils at the nanoscale. Specifically, the role of iron (hydr)oxides, and humic materials on nanoscale agglomeration processes in soils will be also evaluated; (4) to determine the carbonate equilibrium, the origin of bulk and molecularly uncharacterized sedimentary organic matter, as well as dissolved inorganic matter in the sediments, soils and interstitial water using stable isotopes (13C/12C and 15N/14N) as natural tracers. Sources of DIC (carbonate dissolution vs. decomposition of sedimentary organic matter) in the pore water and in the DIC flux across the sediment – water interface, as well as in the sedimentary carbonate fraction will be appointed, so as to estimate the contribution of organically derived CO2 to the formation of authigenic nanocarbonate solids; and (5) to introduce and incorporate findings from “NanoMin” into the Croatian geosciences domain.
2247Inženjering kristalnih materijala pomoću metalnih kompleksa i nekovalentnih interakcijaEngineering crystalline materials using metal complexes and non-covalent interactions1229Marijana Đaković UIP2013-11UIP-2013-11-1809CRYSTIN01.09.2014 - 20.11.2017Završio692.715,50 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science713, 2648, 1327, 4669, 3881, 17739, Željka Soldin, Aleksandar Višnjevac, Boris-Marko Kukovec, Ivan Kodrin, Christer Aakeroy, Mladen Borovina, crystal engineering, non-covalent interactions, supramolecular architecture, synthons, metal complexesInterdisciplinary research at the interface of chemistry and materials science has been remarkably successful at producing technologies that have revolutionized all aspects of everyday life. However, there is still a great need for new solids with ‘improved’ physical properties (faster, cheaper, smarter or more responsive than current alternatives). Unfortunately, the ability to ‘dial-in’ a property or physical response remains a major challenge. Therefore, our goal is to establish reliable avenues for the design of crystalline metal-containing materials by encoding building-blocks with structural-preferences that lead to ‘programmable’ assembly, thus avoiding serendipity and chance when targeting new materials with specific and tunable properties. To achieve this, we first need to map out the structural landscape that controls how metal complexes communicate and subsequently assemble into 3-D architectures.We will explore and quantify the interrelationship between ligand-field splitting energy, coordination geometry, metal-ligand dimensionality, ligand flexibility, and supramolecular assembly, one variable at a time, using a combination of experiment and theory. This will enable us to map out the structural landscape defined by metal(II) complexes (Co, Ni, Cu and Cd) and custom-made ligands decorated with functionalities that are known to form reliable supramolecular synthons in organic solids.New structural and spectroscopic information will be complemented by data obtained by mining the CSD, while computational methods will inform both the planning as well as the interpretation of the experimental efforts. The results obtained in this systematic and multidisciplinary research program will create new avenues towards the design of crystalline metal-containing materials based on reliable structure-activity protocols.
2249Razvoj paketa računalskih programa za naprednu analizu štitova od gama i neutronskog zračenjaDevelopment of Code Package for Advanced Gamma and Neutron Shielding Analysis6070Krešimir Trontl UIP2013-11UIP-2013-11-3522DOCPAGANSA21.07.2014 - 20.10.2017Prekinut403.000,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing7255, 6980, 6827, 17764, Dubravko Pevec, Radomir Ječmenica, Mario Matijević, Paulina Dučkić, machine learning, active learning, parallel and distributed computing, gamma shielding, neutron shieldingRadiological safety analysis is equally important in all fields of peaceful application of nuclear energy, like industry or medicine, as well as for adequate radioactive waste management. In general, shielding analyses can be classified into two categories: preliminary analyses and final analyses. Preliminary analysis can be conducted using computer codes based on engineering methods, the most used one based on point-kernel method. Recent research indicated that a new approach can be used in determination of buildup factors as the key parameters of point-kernel method. The approach is based on machine learning technique, namely Support Vector Regression (SVR). For efficient training of the SVR models of a complex physical problem, an active learning procedure has to be defined. Final shielding analysis is usually conducted by computer codes based on either deterministic or statistic methods placing high time and hardware demands, but resulting in more accurate results. Advanced numerical procedures utilize advantages of both, deterministic approach as well as stochastic approach resulting in a hybrid deterministic-stochastic procedure increasing the efficiency of the overall analysis.The overall objective of the proposed project is the development of the synthesized calculational tool to enable all stages of a shield design to be performed within integrated environment. To accomplish this objective following activities are planned: definition of the optimal active learning procedure in regression framework to prepare data sets for SVR model creation, investigation of gamma and neutron buildup factors and preparation of SVR models, development of the computational tool for preliminary stage shielding design, optimization of hybrid deterministic-stochastic numerical procedure, development of the control module for automatic shielding analyses process control, preparation of front-end and back-end interface, testing of the final shielding analysis environment.
2255Biofizikalni dizajn antimikrobnih peptida i inovativni molekularni deskriptoriBiophysical Design of Antimicrobial peptides and Innovative Molecular Descriptors5542Damir Vukičević IP2013-11IP-2013-11-8481BioAmpMode15.09.2014 - 14.12.2017Završio382.754,08 KnPrirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Splitu, Prirodoslovno-matematički fakultetUniversity of Split, Faculty of Science3581, 3589, 3599, 87, 4882, 5478, 5373, 5545, 5591, 5636, 6123, 6627, 6630, 6633, 6683, 5731, 18995, 17844, 586, 3580, Juraj Simunić, Nada Ilić, Mario Novkovic, Goran Gajski, Frances Separovic, Alessandro Tossi, Anita Kriško, Jelena Sedlar, Bernarda Lovrinčević, Tomislav Došlić, Marija Raguž, Nataša Vučemilović-Alagić, Mara Kozić, Lara Romac, Lucija Krce, Ana Maravić, Luka Gujinović, Tomislav Rončević, Ivana Goić Barišić, Davor Juretic, Antimicrobial peptides, Molecular descriptors, Therapeutic index, Drug development, Design, Data-mining, Antibiotics, Multidrug resistanceThe starting point of this interdisciplinary project is bioinformatic and chemoinformatic data collection connecting molecular structure with physico-chemical and biological properties. In the case of antimicrobial peptides, measured biological activity and therapeutic index data will be collected from published papers with the goal of constructing robust and accurate predictive models. A large amount of data regarding the 20 natural amino acids attributes will also be collected and analysed. We plan to propose new scales of amino-acid attributes that may be a basis for a multitude of future studies. In our experience, construction of good predictive models is not possible without using biophysical insights to propose appropriate molecular descriptors crucial for data-mining procedure and model building. These models should be based on newly developed molecular descriptors. Study of molecular descriptors will be important part of this project, their extremal properties (as indicators of the most active compounds), their complexity of calculation (since exhaustive search for optimal compounds can be computationally demanding) and their interrelationships. Dedicated algorithms for in-silico identification or proposal of structures with the desired properties will be built and verified through synthesis, characterization and testing of predicted antimicrobials. The activity, selectivity, conformation and mechanism of action of lead compounds will be explored using biophysical, biochemical and microbiological techniques. Preliminary investigations by our group of graduate, doctoral and postdoctoral biophysics students has already led to the identification of two designed peptides as being very active against pan-resistant Acetinobacter baumanni, so that initial drug development is within the scope of this project with the aim of finding new classes of non-toxic peptide antibiotics active against multidrug resistant bacteria.
2258Karakterizacija reakcije osteoklastnih progenitora na artritisCharacterization of osteoclast progenitor responses to arthritis3075Danka Grčević IP2013-11IP-2013-11-5699COPERA01.09.2014 - 31.08.2017Završio699.336,77 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine3895, 4356, 2978, 3882, 3832, 3604, 5107, 5106, 5878, 5110, 5860, 17836, Alan Šućur, Frane Paić, Vedran Katavić, Nataša Kovačić, Elvira Lazić Mosler, Marina Ikić Matijašević, Zrinka Jajić, Asja Stipić Marković, Peter Ian Croucher, Ivo Kalajzić, Hector Leonardo Aguila, Darja Flegar, osteoclasts, arthritis, inflammation, progenitors, differentiation, cytokines, chemokinesChronic joint diseases affect more than a third of the world’s population and represent a major health problem. Several forms are classified in clinical practice, depending on the main pathogenic mechanism: osteoarthritis, rheumatoid arthritis (RA) and spondyloarthritis Collagen-induced arthritis (CIA) is a widely used mouse model of RA and is still an indispensible tool to study the disease pathogenesis. Through the production of osteoresorptive mediators by immune cells, chronic inflammation in arthritis creates a microenvironment that promotes osteoresorption by osteoclasts (OC). OCs are multinucleated bone-resorbing cells arising from myeloid hematopoietic lineage. A number of systemic and local stimuli, such as hormones and cytokines/chemokines, promote osteoclastogenesis by enhancing OC differentiation, migration, activation, lifespan and function, but the exact mechanisms of how the inflammatory network works in vivo in the context of arthritis are largely unclear. Particularly, the human osteoclast progenitor (OCP) populations are not precisely defined and it is, as yet, unknown which critical mediators have the potential to activate OCPs and attract them to produce joint lesions. Using the mouse model of CIA and samples from arthritic patients we propose to elucidate differentiation sequence of early progenitors into mature OCs, shifts in the frequency of discrete OCP subpopulations and their migration patterns during arthritis. We plan to identify distinct OCP subpopulations in the bone marrow, periphery and joint lesions, their migratory and homing patterns, and their functional links to bone loss in arthritis. We expect to define the properties of inflammatory microenvironment in the regulation of OC trafficking, differentiation and activity in arthritis. A better characterization of arthritis-induced OCP subpopulations could offer the potential to design therapeutic approaches to control their migration and curtail their osteoresorptive potential.
2259Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogeneziMolecular mechanisms of PVR(CD155) immunological pathways in viral and tumor pathogenesis4941Tihana Lenac Roviš UIP2013-11UIP-2013-11-1533PVRreg31.10.2014 - 30.04.2018Završio992.495,00 KnBiomedicina i zdravstvo, Prirodne znanosti, Biomedicine and health sciences, Natural sciences, Temeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine4958, 5361, 5312, 5204, 22539, Astrid Krmpotić, Hrvoje Šimić, Antonija Miletić, Paola Kučan, Ivana Stražić Geljić, poliovirus receptor, PVR, CD155, cytomegalovirus, CMV, immunoevasion, tumorThe project is focused on the role of PVR (poliovirus receptor) which serves as a ligand for both inhibitory (TIGIT) and activating (DNAM-1 and Tactile) receptors. The evidence has been accumulated indicating the role of PVR and its receptors in immune surveillance including the control of viral infections, tumors, as well as in pathogenesis of autoimmune diseases. Of note is that PVR is constitutively expressed on the majority of somatic cells, while its receptors are expressed on the majority of lymphocyte population. In many respects the interaction of PVR with its paired set of inhibitory and activating receptors resemble the interaction of paired co-stimulatory immune cell receptors and their cellular ligands (B7/CD28/CTLA-4). These co-stimulatory molecules have been the subject of intensive studies that resulted in immunoregulatory pharmaceutical agents for use in humans. The studies proposed here are based on the finding that human cytomegalovirus (HCMV) affects the surface expression of PVR (Nat Immunol. 2005) and on our preliminary results indicating that mouse cytomegalovirus (MCMV) also downregulates mouse PVR. Thus, we first focused on the identification of MCMV gene(s) (proteins) involved in the PVR regulation, but also on the consequence of this viral regulation on antiviral immune response in vivo. To that aim we will generate MCMV mutants lacking viral regulators and test their in vivo susceptibility to components of innate and acquired immune response. We expect that the results obtained will further broaden the knowledge of PVR regulation and its significance in immune control, which will eventually help to translate this knowledge to developing new immunotherapeutic tools. Namely, one aim of this project is to engineer antibody specific for human PVR in order to be used as a tool in targeted tumor therapy. This idea is based on the fact that many tumors over-express PVR, which could be used in antibody mediated uptake of anti-tumor compounds.
2260Moderne i suvremene umjetničke mreže, umjetničke grupe i udruženja: Organizacijski i komunikacijski modeli suradničkih umjetničkih praksi 20. i 21. stoljećaModern and Contemporary Artist Networks, Art Groups and Art Associations: Organisation and Communication Models of Artist Collaborative Practices in the 20th and 21st Century6142Ljiljana Kolešnik IP2013-11IP-2013-11-6270ARTNET01.09.2014 - 10.12.2018Završio537.298,00 KnHumanističke znanosti, Društvene znanosti, Tehničke znanosti, Humanities, Social sciences, Technological sciences, Povijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb2535, 5178, 6333, 5489, 4944, 4649, 6030, 4910, 21394, 17659, 23291, Petar Prelog, Jasna Galjer, Sanja ¸Horvatinčić, Dalibor Prančević, Željka Tonković, Tamara Bjažić Klarin, Ivana Meštrov, Irena Kraševac, Sanja Sekelj, Nikola Bojić, Artur Šilić, history of art, methodology, artist networks, art groups, social networks, data visualization, Croatian modern art, Croatian contemporary artResearch topics of this project are the organization and communication models embedded into artist networking and artist collaborative practices of the 20th and 21st century, as they are manifested in the Croatian art of that period. Project initial hypothesis is that artist networks, art groups and art associations form the most important platform of cultural exchange in modern and contemporary visual arts due to the similarity of underlying organization and communication models regardless of geo-cultural location at which they appear. A degree of their diversity in art practice of particular local community at particular historical moment is proportional to the dynamics and volume of its participation in the international/cross-cultural exchange. To prove our hypothesis and identify, describe and explain these organization and communication models as generally applicable – which is the main objective of the project - we shall investigate Croatian artist networking and collaborative practices on the background of similar phenomena in other European countries and with regard to poetic requirements of different periods in modern and contemporary art, conventions of social interactions and available techniques/technologies of communication. As the methodology of art history does not meet the complexity of the research topic, we shall develop interdisciplinary methodological apparatus combining knowledge and analytic tools of art history, sociology and information science. Considerable amount of data collected through the extensive infield research will be stored in Croatian Artists Networks Information System developed in the course of the project and supporting network visualization techniques as a cognitive research tool for experimental presentation of our research results framed with the appropriate structural narratives (textual, visual, GIS data). Project results will be also presented in 2 books, 7 articles and at the closing international conference.
2264Nastavničke emocije i strategije emocionalne regulacije: osobni i kontekstualni antecedenti i efekti na motivaciju, dobrobit i odnose sa studentimaTeachers’ emotions and emotion regulation strategies: personal and contextual antecedents and effects on motivation, well-being and relationships with students6118Irena Burić UIP2013-11UIP-2013-11-5065TEERS-ZD501.09.2014 - 31.08.2017Završio199.924,18 KnDruštvene znanostiSocial sciencesPsihologija, Psychology, Sveučilište u ZadruUniversity of Zadar6241, 5908, 6136, 6552, 21148, Izabela Sorić, Zvjezdan Penezić, Ana Slišković, Ivana Macuka, Enrica Ciucci, Teachers, emotion, emotion regulation strategies, personal antecedents, contextual antecedents, motivation, well-being, relationship with studentsAlthough cognition, motivation and emotion are recognized by psychologists as the three fundamental classes of mental operations (Mayer, Salovey and Caruso, 2000), most research in educational psychology has primarily focused on the first two classes. This is especially true regarding teachers’ emotional lives. The existing knowledge on teachers’ emotions indicates their influential potential on instructional practices, professional and personality development and well-being. By implication, emotions experienced by teachers in classroom settings and in relation to their professional activities, arise as a very important topic of research. Thus the main goal of this research proposal is to investigate the phenomena of teachers’ emotions and emotion regulation strategies as well as their personal and contextual antecedents and effects on various aspects of personal and professional functioning. In order to achieve this goal, the multimethod approaches will be implemented. More precisely, through the combination of qualitative and quantitative methods, cross-sectional and longitudinal research designs, and individual and nomothetic approach, relations between teachers’ emotions and emotion regulation strategies, their personal (e.g. temperament, personality, beliefs, goals, cognitive appraisals) and contextual antecedents (factors from teachers’ school environment), as well as their effects on motivation (e.g. intrinsic vs. extrinsic motivation, goal orientations, self-efficacy), well-being (e.g. emotional labour, emotional exhaustion, burnout, mental health and intention to leave the profession) and relationships with students (e.g. different aspects of student-teacher interaction) will be explored on the samples of elementary-school teachers.
2267Profesionalni razvoj tijekom adolescencije: Razvoj i provjera Modela tranzicije karijere u adolescencijiVocational Development in Adolescence: Setting the Adolescent Career Transition Model1178Iva Šverko UIP2013-11UIP-2013-11-1229VDAACTM01.07.2014 - 30.06.2017Završio293.434,58 KnDruštvene znanostiSocial sciencesPsihologija, Psychology, Institut društvenih znanosti Ivo PilarInstitute of Social Sciences Ivo Pilar in Zagreb6293, 6545, Toni Babarović, Vanja Međugorac, career transition, adolescence, career maturity, career identity, career decision makingThe aim of this project is to develop, postulate and evaluate an Adolescent Career Transition Model (ACTM). For most people the adolescence is the tipping point for career decision making. Last grade high-school students have to decide between further education on universities or entering the world of work and finding a job. To successfully overcome this important career transition period, adolescents have to become aware of their preferences and capabilities, to crystallize their career goals and to form their vocational identity. By implementing their vocational identity through engagement in their desired job or educational program, they should be able to achieve success and satisfactions in their careers, to fit in and adjust to their working environment and job demands, and to be motivated for their work and future advancement. The Adolescent Career Transition Model encompasses several career related behaviours, competences and traits that can influence positive career transition outcomes. We will assess approximately 1200 high school students at the beginning of the last grade of high-school (17-18 years) and follow their career development for the next 18 months. In three separate time points we will administer measures of career-related traits and social support, career self-guidance competencies, vocational development and career transition outcomes, through a secure online testing system that will be developed for this project. Statistical data analysis of the obtained data will be performed by adequate multivariate models to answer specific research objectives. Once the postulation and evaluation of the ACTM and the dissemination of the results are completed, the aim of the project is to create a new online career guidance system on the basis of the results of our research. This new online guidance system will be open and free for public use, and remain as a valuable and practically usefully legacy of the project.
2273Sveobuhvatni model istraživanja zabrinutosti za privatnost u online okruženjuExtended model of online privacy concern 177Jelena Budak IP2013-11IP-2013-11-7913PRICON01.07.2014 - 30.06.2018Završio497.806,82 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Ekonomski institut ZagrebInstitute of Economics in Zagreb189, 174, 3437, 674, 17736, Ivan-Damir Anić, Edo Rajh, Vatroslav Škare, Bruno Škrinjarić, Vedran Recher, online privacy concern, antecedents, internet, consumer protection, surveyThe research project will develop a comprehensive integrated model of privacy concern in the online environment and empirically test it in order to provide deeper understanding of various interactions between antecedents, concerns and consequences of online privacy. The research objectives will be achieved initially by identifying and developing (i) a comprehensive list of antecedents such as demographic factors (e.g. gender, education), experience factors (e.g. internet use experience, web expertise) and social-psychological factors (values, attitudes), and (ii) a comprehensive list of consequences of online privacy concern on individual-user level. These inputs will be used to develop an extended integrated model of online privacy concern in order to examine conceptual interrelations. Upon building a model, a customized survey questionnaire will be designed and measurement instruments for variables tested. The field research will consist of surveying 2,000 citizens in Croatia to assess their attitudes and behavior patterns when taking different roles and actions in the online environment. This core part of the research aims to empirically test the conceptualized model by employing adequate analytical tools to the large database collected in the survey. The research will result in the final definition of integrated theoretical framework of online privacy concern that will consolidate various streams of research in this field. The extended model of online privacy concern could be applied in future development in the related domain. The additional project outcomes are policy implications and recommendations for regulatory control, internet users policy and business strategies.
2277Poluvodički elementi visokih performansi za primjene u sklopovima za bežične komunikacije i optičke detektoreHigh-performance Semiconductor Devices for Wireless Circuit and Optical Detection Applications6955Tomislav Suligoj IP2013-11IP-2013-11-9006HiPerSemi25.08.2014 - 24.08.2018Završio903.000,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing7054, 5077, 6083, 6081, 7123, 7148, 7085, 17830, 6852, Mirko Poljak, Sanja Žonja, Tihomir Knežević, Josip Žilak, Igor Krois, Dubravko Babic, Boris Sviličić, Sabina Krivec, Marko Koričić, semicoductors, microelectronics, bipolar transistors, photodetectors, photodiodes, CMOS, modeling, MOSFET, RF circuitsThe objective of this project is to provide notable scientific contributions by designing and utilizing the advanced semiconductor devices for the wireless communication circuits and solid-state optical detection applications. Research in this project will be grouped in three major activities, which are: (i) Horizontal Current Bipolar Transistor (HCBT) for RF Wireless Circuits, (ii) Characterization and applications of solid-state photodetectors, and (iii) Modelling of MOS, photodetector and other advanced electron devices. The novel wireless RF communication circuits such as mixer, frequency divider, voltage-controlled oscillator, RF switch and power amplifier will be designed and fabricated in HCBT technology as the first such circuits using the HCBT as an active component. The measurements of noise, reliability and on-wafer uniformity as well as linearity, gain and efficiency will be performed on transistors and circuits. The characterization of material properties of pure amorphous boron (PureB) layers will be made in order to determine the composition, electrical and optical properties of the layer and to develop the model of charge carrier transport through it. They will be correlated with electrical measurements to find out currently-unknown physical mechanisms responsible for the current reduction and for the record-high performance of photodides with PureB layers. The investigation of the novel materials such as Ge, SiGe and GaN for ultra-scaled advanced CMOS structures, i.e. FinFETs, will be performed by the development of novel models and simulation environment. The analog/RF parameters and characteristics will be extracted for FinFETs with different geometries and materials in order to determine the optimum structure for future RF systems.
2281Metode deidentifikacije za meke i ne-biometrijske identifikatoreDe-identification Methods for Soft and Non-Biometric Identifiers6974Tomislav Hrkać UIP2013-11UIP-2013-11-1544DeMSI01.09.2014 - 31.08.2017Završio515.440,00 KnTehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing4290, 6564, 6814, 4584, 6563, Slobodan Ribarić, Zoran Kalafatić, Karla Brkić, Darijan Marčetić, Ivan Filković, De-Identification, Privacy Protection, Image Processing, Video Processing, Biometrics, MultimediaAdvances in audio and video recording devices, web technology and signal processing have highly facilitated the efficacy of audio and video acquisition. This capability is now widely exploited in a variety of scenarios to obtain audio-video recordings of people, raising serious privacy concerns. The protection of sensitive private data is required by EU’s Data Protection Directive (95/46/EC). De-identification in multimedia content can be defined as the process of concealing identities of individuals captured in a given set of data, for the purpose of protecting their privacy. Soft biometric and non-biometric characteristics such as tattoos, birthmarks, scars or dressing style also carry potentially identity-revealing information and have to be dealt with in the process of de-identification. This is an interdisciplinary challenge, involving such scientific areas as image processing, video tracking and biometrics. This project proposal aims to development of novel and robust methods for de-identification of soft and non-biometric identifiers in videos and images.
2283Arheološka istraživanja kasnog Pleistocena i ranog Holocena u Limskom kanalu, Istra Archaeological investigations into the Late Pleistocene and Early Holocene of the Lim Channel, Istria2764Ivor Janković UIP2013-11UIP-2013-11-7789ARCHAEOLIM15.06.2014 - 14.06.2017Završio598.000,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Institut za antropologijuInstitute for Antropological Research in Zagreb3839, 3871, 6897, 4112, 3711, 3440, 4229, 6754, 2993, 1371, 21180, James Ahern, Fred Smith, Darko Komšo, Sanjin Mihelić, Jacobo Weinstock, Katarina Gerometta, Rory Becker, Krunoslav Zubčić, Barbara Cvitkušić, Zrinka Premužić, Antonela Barbir, Paleolithic, Mesolithic, Neandertals, archaeology, caves, Croatia, prehistory, Pleistocene, Holocene The proposed project is aimed at archaeological research of four cave sites in the Lim Channel, Istria, where previous small-scale excavations and field survey documented human habitation during the Late Pleistocene and Early Holocene. It is expected that this work will provide data for understanding a number of important issues regarding behavioral and possibly biological aspects of human groups during a time when Late Glacial hunter gatherers were forced to change and adapt to a changing environmental and other pressures. Presence of Mousterian artefacts at one of the sites, and Upper Paleolithic tool types at another suggests two populations (i.e. Neandertals and anatomically modern humans) were present in the region during the Late Pleistocene. Data from the proposed excavations may provide a basis to test some of the highly debated questions regarding the relation of biological population to behavioral aspects (e.g. whether Neandertals or anatomically modern humans were responsible for Early Upper Paleolithic, is there a sharp distinction in behavior and anatomy between these groups etc. Furthermore, at one site early Mesolithic is documented, while at another Late Mesolithic is present, allowing similar issues regarding behavior and other aspects to be tested, including issues related to the transition to Neolithic (agricultural) lifestyle. A comparison of data between all four sites could provide us with a basis for testing of issues related to changing life ways, land use, movement patterns, site use, biological aspects (similarities and differences), contact zones, mobility, continuity, etc. at times of changing climatic and environmental conditions and thus help us to understand this crucial time period, in particular, and how humans respond to such changes, in general. Results from the project will also provide a basis for development of archaeology–based tourism and thus directly benefit the local community and Croatian economy in the long run.
2284Unaprijeđeno istraživanje općekorisnih funkcija šumaAdvanced Forest Environmental Services Assessment7009Ivan Pilaš IP2013-11IP-2013-11-1924AFORENSA01.07.2014 - 30.06.2018U tijeku842.000,00 KnBiotehničke znanosti, Tehničke znanosti, Biotechnical sciences, Technological sciences, Biotehnologija, Biotechnology, Hrvatski šumarski institutCroatian Forest Research Institute3207, 3290, 7002, 3272, 6337, 5644, 5659, 5655, 17863, 3478, Damir Medak, Ivan Medved, Dražen Odobašić, Ela Vela Bagić, Boris Vrbek, Jasnica Medak, SANJA PERIĆ, MARTINA TIJARDOVIĆ, Luka Rumora, Mario Miler, Forest environmental services, Remote sensing, Ecohydrology, Biodiversity, GIS, Climate change The main objective of AFORENSA is to generate relevant knowledge how the forest ecosystems in Croatia responds to observed extreme climatic variations, and what are possible future expectations in respect to the progression of climate change and disturbances of natural hydrologic cycle with intensification of drought frequency and severity. This objective is aimed to be resolved by implementing of the novel forest ecosystem assessment approach, applicable for the country scale, which incorporates: a) traditional in situ ecosystem survey (soil and vegetation), b) analysis of the functional state of the ecosystems by remote sensing, c) downscaling of the regional climatic models and d) coupling of scenario outputs with ecohydrological models on a site specific environmental settings. The core system on which AFORENSA activities will be build up, presents “Dynamical Geoinformation system of forest ecosystems in Croatia” (DYN-CROFOR), a technological project financed by the Ministry of Science and Education from 2003 to 2007. Aforensa is aiming at the inventory, and integration of terrestrial forest ecosystem research on the Web-Gis (DYN-CROFOR) platform incorporating automatized procedures for retrieving remote sensing data (such as MODIS and MERIS vegetation indices) and with the addition of incorporating Data mining procedures and the full power of R, a language and environment for statistical computing and graphics. Project workflow consists of four, interrelated, work packages: a) INVENTORY, b) AUTOMATIZATION, c) MINING, d) UPGRADING. AFORENSA will contribute with speeding-up of future exploratory forest ecosystem research, and with its capability of near real time data processing will present a basis for the development of “Forest watch”; an observatory for early determination of potentially harmful effects of Climate Change on forest ecosystem services such as biodiversity and water.
2291Tekstualne mreže ranonovovjekovne HrvatskeTextual networks of early modern Croatia2952Lahorka Plejić Poje IP2013-11IP-2013-11-4785TeMrežaH15.11.2014 - 15.11.2018Završio356.950,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište u ZagrebuUniversity of Zagreb1416, 5337, 3921, 4025, 4310, 5006, 5066, 5024, 4860, 3931, 6715, 7050, 4221, 7251, 7383, Neven Jovanović, Irena Bratičević, Tomislav Bogdan, Tamara Tvrtković, Violeta Moretti, Francesca Maria Gabrielli, Dolores Grmača, Bratislav Lučin, Šime Demo, Gorana Stepanić, Dunja Fališevac, Vladimir Rezar, Jasmina Lukec, Darko Novaković, Luka Špoljarić, scholarly edition, early modern Croatian literature, digital humanities, Renaissance, Baroque, 18th centuryWe propose to establish a collaborative framework for scholarly editions of Croatian early modern written heritage, regardless of its linguistic medium (Croatian, Latin, Italian, German) and its material manifestation (manuscripts, printed books, digital texts). A significant part of this heritage is still not easily or reliably accessible to modern scholarship. Leveraging current European and international achievements and initiatives, our project will solve textual and editorial problems through scholarly collaboration, in that way providing grounds and opportunity for further interpretative insights about the life of the texts. The project will prepare and publish both printed and digital editions; editorial work of team members will be submitted to early collective peer review and discussion. The proposed framework will also serve as a training ground for next generations of textual scholars studying early modern Croatian literature; researchers of all career stages (including undergraduate, graduate, and PhD students) will be offered an opportunity to make their first contributions, also peer-reviewed and carefully attributed. Through these innovative procedures we aim to reinterpret scholarly edition as a fruitful and exciting interpretative undertaking, without which there can be no real understanding of our intellectual history. The main outcome of our project will be 15 scholarly editions published over four years: six texts of Croatian authors in Croatian (Mršić, Primović, Palmotić Dionorić, Divković, the Kajkavian miscellany of Nikola Šafran, M. Zlatarić), an edition of three Croatian woman writers in Italian (G. and S. Bona, M. Gondola Gozze), and eight texts of Croatian authors in Latin (Nikola Modruški, Marulić, Beneša, V. Gučetić, Ritter Vitezović, Tomko Mrnavić, M. Zlatarić, the Macaronica Croatica).
2299Evlija Čelebi i Hrvati, nove perspektiveEvliya Chelebi and Croats, new perspectives98Nenad Moačanin IP2013-11IP-2013-11-9215EvliyaChelebi01.08.2014 - 30.11.2017Završio450.000,00 KnHumanističke znanostiHumanitiesPovijest, History, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences6011, 6202, 6728, 6807, 7081, Kornelija Jurin Starčević, Nataša Štefanec, Vjeran Kursar, Ekrem Čaušević, marta andrić, Evliya Chelebi, Travelouge, Croatia, History, Language, Critical Edition, Ottoman StudiesThirty years ago the autograph of the Evliya Chelebi's travelogue (SeyahatnameorBook of travels) was found. Evliya Chelebi is the most famous Ottoman traveller and writer and the worldwide cited Ottoman author. His Seyahatname in Ottoman was recently published in Istanbul in ten volumes. For Croatian history the volumes V, VI and partly VII have the paramount significence.A critical edition and translation of the autograph’ssections of the books V, VI and VII into Croatian language does not exist. HazimŠabanović made translation on the basis of a printed version from 1900 which was done upon an inaccurate, even censored copy. The translator himself had shortened the narrative in many places. Even a brief insight in original text shows dramatical differences and alterations in quantity of text (there is up to 35 percent more text in the autograph) and quality of informations (substantially new informations, thoroughly different from those in Šabanović's translation). The aim of the project is to investigate this „missing link“ among the narrative sources for Croatian history in Early Modern Period, i.e. to scrutinize the autograph, to translate parts of the V, VI and VII book with commentaries and footnotes, and to produce supporting articles. A picture of Croatian societies in different political frames which is given in the Seyahatname has never been a subject of scholarly research. This would lead toward the comprehensive explanation and interpretation of early modern national integration, ecohistorical determinants, social and ethnoconfessional structures and processes. Such a project is expected to contribute substantially to filling the gaps in the historiography, to establish a more balanced perception of the past, along with the improvement of mutual understanding between Croatia and Turkey, with positive effect in the Southeastern Europe. Also, this project can significantly contribute to the revitalization of the Ottoman heritage in Croatia.
2307Metakognicija kod kategorijalnog učenja, mišljenja i razumijevanjaMetacognition in Category Learning, Thinking and Comprehension4615Dražen Domijan IP2013-11IP-2013-11-4139METCALTHIC01.10.2014 - 30.09.2017Završio398.714,99 KnDruštvene znanostiSocial sciencesPsihologija, Psychology, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences4612, 6976, 568, 7004, 5747, 7169, 6968, 6882, 6892, 17886, Igor Bajšanski, Pavle Valerjev, Valnea Žauhar, Mia Šetić, Marija Šakić, Vladimir Takšić, Tanja Gulan, Maja Močibob, Nena Vukelić, Mateja Marić, metacognition, monitoring, dual processes, category learning, thinking, comprehensionThe fundamental problem of education is how to create a learning environment which will facilitate the acquisition of knowledge and skills. Psychology of education attempts to identify mental processes and mechanisms underlying our ability to learn. Research on self-regulated learning and metacognition is a topic of special importance for educational psychology. Self-regulated learning encompasses cognitive, motivational and behavioral processes which occur while learners undertake activities to accomplish a learning goal. Self-regulation is based on a cyclical process of monitoring and control. The learner monitors the efficiency of the applied learning strategies and responds to feedback obtained from the monitoring process. Metacognition is studied intensively in the areas of memory and text comprehension. The central aim of the project is to explore metacognitive processes of monitoring and control in the domains of: 1. Category learning, 2. Thinking, 3. Grounded (situated) comprehension. All of these domains have been studied extensively but in isolation from metacognition. Our goal is to bring together these disparate fields of study under the same research program. Unifying theme of the project is the distinction between Type 1 and Type 2 processes which can be identified in each domain and whose properties will guide metacognitive judgments. Project team consists of 5 established researchers in the field of experimental psychology and 5 doctoral students whose PhD theses are closely related to the project aims. The project team will utilize newly established Laboratory for experimental psychology equipped with facilities necessary to carry out the proposed project. The project will answer the important question of how accurate are the metacognitive judgments and how effective are the processes of monitoring and regulation in the cognitive domains where metacognition has not been studied in greater detail.
2314Višeagentno modeliranje velikih razmjera za MMORPG mrežne igre Large-scale Multi-Agent Modelling of Massively Multi-player On-line Role-Playing Games891Markus Schatten UIP2013-11UIP-2013-11-8537ModelMMORPG01.10.2014 - 30.09.2017Završio500.453,64 KnDruštvene znanostiSocial sciencesInformacijske i komunikacijske znanosti, Information and communication sciences, Sveučilište u Zagrebu, Fakultet organizacije i informatikeUniversity of Zagreb, Faculty of Organization and Informatics1428, 1412, 899, 918, 2900, 2725, 2508, 2577, 950, 17828, 21330, Mladen Konecki, Jurica Ševa, Joaquim Filipe, Pietro Terna, Nikola Ivković, Ivan Magdalenić, Igor Tomičić, Robert Kudelić, Marko Maliković, Bogdan Okreša Đurić, Mario Konecki, large-scale multi-agent systems, agent based modeling, mmorpg, organizational methods, organizational design, artificial intelligenceMassively multi-player on-line role playing games (MMORPGs) give us the opportunity to study two important aspects of computing: (1) large-scale virtual social interaction of people (players) and (2) the design, development and coordination of large-scale distributed artificial inteligence (AI). A common denominator for both aspects are the methods used to study them: social interaction can be descibed and simulated using agent-based models (ABM social science perspective) whilst distributed AI is commonly modelled in terms of multi-agent systems (MAS computer science perspective). The important question to ask in both perspectives is how do agents organize in order to perform their tasks and reach their objectives? Herein we will employ a combined empirical and theoretical approach towards finding the answer to this question.From the empirical side, we shall study the human behaviour on a number of venues across various gaming servers in order to find most suitable structures, cultures, processes, strategies and dynamics employed by most successful player communities. From the theoretical side, we shall test a multitude of organizational architectures from organization theory in various MMORPG settings, and compare them with methods found in empirical research.Our research is therefore aimed towards enriching the organizational design methods for the development of MMORPG to foster the development of self-organizing and adaptable networks of large-scale multi-agent systems.With this in mind, our main goals are:1) To identify and formalize adequate organizational design methods for developing LSMAS in MMORPGs.2) To couple them with real-life and future scenarios from industry.3) To provide open and accessible tools, which will allow for design, development, implementation, control, simulation and maintenance of LSMAS in MMORPG.
2317Ekonomski i socijalni učinci reformi energetskog sektora na održivi ekonomski rastEconomic and social effects of energy sector reforms on sustainable economic growth211Nela Vlahinić-Dizdarević IP2013-11IP-2013-11-2203ESEESRSEG01.06.2014 - 31.05.2018Završio517.093,73 KnDruštvene znanosti, Tehničke znanosti, Social sciences, Technological sciences, Ekonomija, Economy, Sveučilište u Rijeci, Ekonomski fakultetUniversity of Rijeka, Faculty of Economics2915, 2618, 7160, 1249, 4275, 6336, 19024, 6206, 7269, Saša Žiković, Pavle Jakovac, Sejid Tešnjak, Eraldo Banovac, Ivor Županić, Rafal Weron, Ivan Gržeta, Ana-Maria Boromisa, Đula Borozan, energy sector, reforms, economic effects, social effects, sustainable economic growth, Croatia, European UnionSustainable economic growth needs a sustainable energy supply. In order to accomplish this goal, good economic governance incorporating energy policy should implement reforms that will increase economic efficiency and social prosperity. The sector’s reform experience goes back to the beginning of 1990s, indicating that existing literature has been limited by a relatively short period of time, inadequate hypothesis cross-testing and without appropriate panel-data analysis. Therefore there is a strong need for the systematic analysis that would include EU countries and Croatia as the new EU Member State, a broader range of issues related to energy sector reforms within a longer time frame to examine whether the empirical evidence supports the logic of reforms and to compare the existing evidence on the reform determinants and performance. So far the findings on some issues have been limited and inconclusive. The goal of the research is to better understand the reform process by providing solid economic evidence on energy reform results and its economic and social impacts on sustainable growth. The aim of the research within this project is to address several related issues: 1) internal and external factors that will further influence the progress of reforms, especially in the EU; 2) macroeconomic performance, institutional settings, regulatory prudence and sector governance as the important wider framework; 3) measuring the economic impact of energy reforms in terms of economic efficiency, rate of investments, competitiveness and economic growth; 4) testing the existing risk management models and developing a novel approach to assessing and hedging the risks in the energy market; 5) measuring the social impact of energy reforms in terms of coverage of energy services and welfare; 6) evaluation of the energy reforms impact on long-term and sustainable economic growth. The research will be performed by combining economic and technical approach and research methods.
2322Istraživanje inovativnih zelenih tehnologija na kampusima za potrebe održivog društvaInnovative Green Building Research in the Campus Living Lab7223Bojan Baletić IP2013-11IP-2013-11-8596CampusLivingLAB01.09.2014 - 31.08.2017Završio741.000,00 KnTehničke znanostiTechnological sciencesArhitektura i urbanizam, Architecture and Urban Environment, Sveučilište u Zagrebu, Arhitektonski fakultetUniversity of Zagreb, Faculty of Architecture7216, 7232, 5972, 7319, 7503, 7540, 7520, 3715, Roberto Vdović, Morana Pap, Rene Lisac, Kristina Careva, Mladen Jošić, Ljubomir Miščević, Velimir Tolić, Zoran Veršić, Architecture, Campus, Green technology, Sustainable Development, Innovative DesignThe aim of the project is to research and develop an innovative model for a green building (based on student housing) on the campus that could be certified as A+ by applying new materials and technologies, the climate sensitive design approach and testing the possible alternatives with the future users in alignment with the Living laboratory principles.Our research is an extension of the present green campus multidisciplinary research and development. It belongs in the architecture domain, but it also includes interdisciplinary participation from other professions. We refer to the university campus Borongaj in Zagreb as an explicit framework of our research. The plan is to build it as a green campus with the highest level of energy efficiency. In its full form, that campus should be a place for studying, working, learning and living for about 20,000 academic citizens. For that reason, it was necessary to design a complex system and implement cutting-edge green technology and energy efficiency principles: bioclimatic principles of renewable energy sources, advanced technology, smart systems, and user adoptation of the new environment and technology within the methodology of the living laboratory concept.In the proposed three year project the team would research new materials, building elements and construction methods to define those appropriate for implementation. Using Building Information Management software and sustainable design principles the team will develop alternative building proposals that will be analyzed based on detailed energy, cost/benefit and quality of life simulations. The input from the construction industry is also planned. The third phase of the project is a testing phase in which, through student surveys and direct input from a selected group of students, the team expects to refine the proposals. In the end the research result needs to be evaluated within the high expectations of the green campus concept.
2330Primjena nusproizvoda prehrambene industrije za razvoj funkcionalnih i okolišno prihvatljivih ekstrudiranih proizvoda i aditiva Application of food industry by-products in development of functional and environmentally friendly extruded food products and additives6031Drago Šubarić IP2013-11IP-2013-11-1321FUNEXFOOD16.06.2014 - 15.06.2018U tijeku888.332,66 KnBiotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultetJosip Juraj Strossmayer University of Osijek, Faculty of Food Technology5709, 6520, 4090, 6811, 5095, 5982, 5097, 5093, 4578, 3836, 5723, 4879, 6084, 17789, Antun Jozinović, Marko Jukić, Indira Kosović, Daliborka Koceva Komlenić, Gordana Šimić, Dijana Miličević, Alojzije Lalić, Jurislav Babić, Đurđica Ačkar, Stela Jokić, Borislav Miličević, Biljana Pajin, Midhat Jasic, Jelena Panak, Functional food, extrusion, cereals, flours, by-products, environment-friendlyConsumers nowadays are seeking palatable food which has beneficial effect on health. At the same time, they are not ready to change their eating habits – reduce intake of bakery products, fast food etc. and increase intake of fresh fruit and vegetable, whole grain products etc. Therefore, food industry is challenged to create products that are consumed every day (bread, snacks etc.) by large population, which are both enriched with bioactive substances and have desired sensory properties.The aim of this project is to develop new functional and enriched products based on extrusion process. Enriched grains (wheat, maize) will be used as basic material. The improvement and supplementation with biologically active (antioxidants, minerals, vitamns, fibre) will be done by addition of by-products from food industry (fruit and vegetable pomaces, oil cakes) in extrusion process. Extrusion will be used to produce final products: expanded snack products and pasta, as well as modified flours which will be used in production of bakery products and biscuits.All processes - extrusion of snack products and pasta, extrusion for flour modification, pasta drying, baking) will be optimised using response surface methodology. All products will be tested for chemical, physical, thermophysical properties, and optimal products will be sensory analysed.The results of project will be array of flours and final products with defined recipes and optimal production conditions, along with defined application of food industry by-products that significantly load environment and are not currently exploited to satisfying extent.In the project multidisciplinary approach will be applied – from agronomist, over food technologist and process engineers to sensory experts. In addition, close academia-industry links will be developed through different activities.
2332Trehaloza: poboljšanje kvalitete proizvoda na bazi voćaTrehalose: fruit product quality improvement7246Mirela Kopjar UIP2013-11UIP-2013-11-6949TrehaMovement01.09.2014 - 31.08.2017Završio702.236,00 KnBiotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultetJosip Juraj Strossmayer University of Osijek, Faculty of Food Technology7296, 7330, 7400, 7405, 7410, Anita Pichler, Josip Simunovic, Nela Nedić Tiban, Ante Lončarić, Tomaž Požrl, trehalose, fruit products, colour, aroma, texture, trehalose action Trehalose is a nonreducing disaccharide which consists of two D-glucose units linked by a-a (1-1)-linkage and occurs widely in nature. Its unique hydration structure enables it to interact with both hydrophilic and hydrophobic molecules which probably contribute to the multifunctional character of trehalose. The major applications of trehalose have been in science, medicine and cosmetic sectors due to its natural functionality, mechanism of action and technical qualities. The limiting factor of trehalose use in the food industry used to be the ingredient cost but with development of a new manufacturing process, the cost of trehalose production has been dramatically reduced. It is about 45% as sweet as sucrose and very stable under processing and storage conditions. Texture, colour and aroma are the main quality attributes influencing consumer acceptability of fruit products. During formulation of fruit products different additives are often used to obtain desired properties of semi-products or final products. The aim of this project is investigation of the influence of trehalose on fruit product quality with emphasis on the explanation of trehalose mechanism of action in complex fruit product matrices. Practical application of project results would be valuable for new food product development. Through addition of trehalose to fruit product the retention of key aroma compounds, and prevention of colour degradation could be achieved, ensuring in this way more fresh-like characteristics of the final product. Also, through retention of phenols, especially pigments, such as anthocyanins, which are known for their antioxidant properties, obtained products would have higher nutritional value, as well as organoleptic properties.
2333Komparativnoslavističke lingvokulturalne temeComparative Slavic Linguocultural Themes3640Neda Pintarić IP2013-11IP-2013-11-2131KOMPAS01.09.2014 - 31.08.2018Prekinut466.100,00 KnHumanističke znanostiHumanitiesFilologija, Philology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences6803, 5453, 6916, 3642, 6906, 5457, 4124, 5183, 7079, 7046, 6970, 5456, 5554, 5446, 7052, 6367, 5365, 7341, 5571, 7361, Dubravka Sesar, Ivana Vidović, Aleksandra Welna, Miroslav Hrdlička, Jerzy Molas, Josip Lasić, Ivana Čagalj, Ana Vasung, Elżbieta Wrocławska, Slavomira Ribarova, Martina Grčević, Szerszunowicz Joanna, Oksana Timko Đitko, Borjana Prošev-Oliver, Lidija Cvikić, BARBARA POPIOŁEK, Anita Skelin Horvat, Ewa Komorowska, Marinela Aleksovski, Branko Kuna, Slavistics, Culturology, Pragmatics, Sociolinguistics, Phraseology, Lexicology, Stylistics, Language History, GtottodidacticsThe Project will include linguocultural themes from Slavic philology with an emphasis on Croatian language using a contrastive/comparative method of research. Languages included are: Polish, Czech, Slovak, Ukraine, Russian, Sorabian, Macedonian, Bulgarian and other Slavic languages.Linguocultural areas cover grammatical fields: phonology, inflexion, word- formation, lexicology, phraseology, micro -, macro- and suprasyntax and wider areas of interest are: pragmatics, paremiology, language history and semantics. Interdisciplinary areas, such as: ethno linguistics, sociolinguistics, psycholinguistics with a special emphasis on verbal and non-verbal communication are also taken into consideration. On the basis of this a connection of the language and culture in presenting the language world view will be presented.As a part of the Project specialized bilingual dictionary “Pragmaticon” and Quintilingual dictionary of Slavic etymons.
2335Napredni elektromotorni pogoni za primjene u vučiAdvanced Electric Drives for Traction Applications3873Damir Žarko IP2013-11IP-2013-11-7801ELTRAC01.10.2014 - 30.09.2018Završio971.500,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing1505, 1528, 2534, 2524, 2531, 2674, 2703, 2913, 3279, 3953, 3938, 5856, 6481, 7357, 18971, 17824, Goran Rovišan, Stjepan Stipetić, Marinko Kovačić, Željko Jakopović, Zlatko Maljković, Ivan Mrčela, Mario Vražić, Viktor Šunde, Tanja Poljugan, Zlatko Hanić, Ivan Gašparac, Neven Čobanov, Šandor Ileš, Fetah Kolonić, Ana Hanić, Tino Jerčić, electric traction, electric drives, energy efficiency, optimization, life cycle cost, control of electric drives, power electronics, electric machinesThe development of more efficient transport equipment and reduction of their environmental footprint is in the scope of the energy policy of the EU. The electrification of the transport equipment and the shift of the freight shipments from road to more efficient rail are some of the key elements for the overall increase of energy efficiency in transport and reduction of the greenhouse gas emissions. This project puts emphasis on development of advanced electric drives for traction vehicles for passenger and freight transport running on tracks. Traditional approach to the design of electric drives has an emphasis on components without insufficient insight into the interaction among them and thus it fails to deliver the optimal performance of the overall traction system. The main objective of this project is to enhance the general approach to design of electric drive systems for traction applications by utilizing a synergetic approach to component design accompanied with advanced control algorithms to maximize the system performance and efficiency and minimize the life cycle cost of the vehicle. This objective will be achieved through: (i) development of software tools for computer aided design of electric drive components for traction applications using multiphysics approach with consideration of component interaction with the rest of the system, (ii) development of different traction power converters topologies for evaluation of various modulation and control methods, (iii) development of software environment for dynamic simulation of traction system performance which couples complex nonlinear models of system components with the models of control algorithm and vehicle dynamics, (iv) development of the electric drive control system based on optimal control approach which ensures maximum efficiency of the system during entire drive cycle of the vehicle. The developed algorithms will be experimentally tested on the scaled model of the traction system.
2338ISTRAŽIVANJE JAVNE POTROŠNJE NA OBRAZOVANJE: UTJECAJ NA RAST, KONVERGENCIJA I EFIKASNOSTINVESTIGATING GOVERNMENT SPENDING ON EDUCATION: GROWTH EFFECTS, CONVERGENCE AND EFFICIENCY1210Lena Malešević Perović UIP2013-11UIP-2013-11-9558GOVSPENDEDU15.09.2014 - 14.09.2017Završio210.600,51 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Splitu, Ekonomski fakultetUniversity of Split, Faculty of Economics2515, 2526, Maja Mihaljevic Kosor, Silvia Golem, PUBLIC SPENDING, EDUCATION, GROWTH, CONVERGENCE, EFFICIENCYMore and more governments are increasingly recognising the importance of human capital for growth and prosperity of their countries; moreover, European Commission has stated education as one of its key 2020 goals. These plans are, however, in contrast with the EU fiscal policies which are faced with constraints as regards deficits and public debts. Public spending on education should, therefore, be given special attention. This research project, consequently, has three main goals, which are as follows: to analyse the relationship between public spending on education and GDP growth; to investigate whether there is a convergence between public spending on education among the EU countries and to analyse the efficiency of public spending on education in the EU countries.
2342Statističko modeliranje odgovora na krizu i ekonomskog rasta zemalja Zapadnog BalkanaStatistical Modelling for Response to Crisis and Economic Growth in Western Balkan Countries3292Ksenija Dumičić IP2013-11IP-2013-11-9402STRENGTHS01.09.2014 - 31.01.2019Završio388.297,97 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Zagrebu, Ekonomski fakultet u ZagrebuUniversity of Zagreb, Faculty of Economics and Business3929, 6268, 3738, 3373, 3372, 3492, 3285, 3464, 4258, 6350, 3528, 4043, 3608, 3669, 3727, Tunjo Perić, Vlasta Bahovec, Ivan Strugar, Anita Čeh Časni, Irena Palić, Berislav Žmuk, Dajana Cvrlje, Silvija Vig, Vesna Bucevska, Lea Bregar, Emina Resić, Mirna Dumičić, Ivan Huljak, Zrinka Marušić, Iris Mihajlović, Econometric Modelling, Panel Data Analysis, Mathematical Programming, Multivariate Analysis Methods, Survey Research DesignRecent economic downturn has forced policy makers to pay attention both not only on the economic growth, but as well on risk prevention. However, intelligent decision cannot be made without previous thorough analysis using appropriate methods. Project “STatistical modelling for Response to crisis and EcoNomic GrowTH in Western Balkan countrieS” (STRENGTHS) aims to support joint action of analysts, managers and policy makers, which is crucially needed in order to attain the goal of prosperity. Project team members are leading reserachers from Croatian, Slovenian, Bosnia and Herzegovina and Macedonian HEIs, researchers from the corporate world, and National Bank of Croatia. Prinicipal investigator and researchers have identified number of goals as significant for the crisis prevention and economic growth, which cannot be achieved without the insight acquired as a result of thoughtful statistical analysis. Crisis prevention topics will be investigated: Risk and financial management modelling, Commitment to business ethics and its influence on a corporation's performance, Efficiency of macroprudential measures and measuring financial stability, and Statistical modelling of the impact of macroeconomic shocks on small open economy. Economic growth topics will be investigated: Statistical modelling of housing wealth effect on personal consumption in selected WB countries, Modelling migration from the EU candidate countries, Impact of statistical methods usage to business performance, Estimating the value of public goods in tourism: Application of Contingent Valuation Method on the Case of Croatia, Strategic impact of the Internet usage on the tourism industry, and The net effect of bank market power in CEE countries. These goals will be achieved by the survey research, thoroughly prepared researched instruments, and usage of cutting-edge statistical methods (Econometric Modelling, Panel Data Analysis, Mathematical Programming, and Multivariate Methods).
2349Modeliranje toka podzemnih voda u krškim vodonosnicimaGroundwater flow modelling in karst aquifers6687Hrvoje Gotovac UIP2013-11UIP-2013-11-8103Karst modelling01.10.2014 - 31.01.2018Završio958.000,00 KnTehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezijeUniversity of Split, Faculty of Civil Engineering, Archtecture and Geodesy6169, 6989, 7099, 6856, 7030, 6042, 7164, 17887, 21318, Vedrana Kozulić, Blaž Gotovac, Roko Andricevic, Vinko Jovic, Veljko Srzić, Ivo Andrić, Srdjan Simunovic, Luka Malenica, Grgo Kamber, karst aquifers, groundwater flow modeling, multiresolution and multiscale approach, karst heterogeneity, distributive karst modelsKarst aquifers are very important groundwater resources around the world as well as in coastal part of Croatia. They consist of extremely complex structure defining by triple phases: slow porous medium, mostly laminar fractures and usually fast turbulent conduits/karst channels. Usually, karst aquifers have been analyzed by lumped hydrological models which ignore high heterogeneity of karst and consider only input (precipitation) and output (spring discharge) due to lack of extensive other input data and knowledge regarding the karst system. Last two decades full hydraulic (distributive) models have been developed exclusively by conventional finite elements considering karst heterogeneity structure that improves our understanding of complex processes in karst. Therefore, in this project we will develop novel “unique” flow model based on multi-resolution approach originally designed by Gotovac et al. (2007-2013) for 1-D and 2-D groundwater flow and transport simulations. Proposed approach is based on Fup basis functions with compact support and meshless collocation procedure enabling multi-scale representation of heterogeneity and other flow variables, closely related to the karst flow physical interpretation. Moreover, extending existing procedure to 3-D and constructing separate multi-scale solution for all three karst phases, proposed approach will enable the following impacts in comparison to conventional methods: desired spatial and temporal accuracy and high computational efficiency, modular model structure, incorporation of different heterogeneity scales related to existing measurements, enabling of transport and tracer test analysis and better understanding of karst aquifers due to solving of different engineering problems such as water usage and protection or contaminant pollution. Flow model will be verified by laboratory experiments and numerical synthetic benchmarks as well as real examples such as Jadro catchment and Ombla underground accumulation.
2351Upravljanje prostorno distribuiranim dinamičkim sustavimaControl of Spatially Distributed Dynamical Systems7315Andrej Jokić UIP2013-11UIP-2013-11-9354ConDis01.09.2014 - 31.08.2017Završio914.700,00 KnTehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture6421, 5441, 6544, 6498, 6493, 17859, Vladimir Milić, Marko Jokić, Josip Kasać, Mladen Crneković, Tihomir Žilić, Mihael Lobrović, control systems, distributed control, optimization, large-scale systems, vibrationsFollowing impressive developments in communication and information technologies, but also in sensor and actuator technologies, a whole set of novel products and systems has emerged, which only recently seemed unfeasible. Examples of such systems include the so-called smart structures composed of a large number of sensors and actuators mounted on constructive elements (beams/plates) with the goal to damp undesired vibrations or to control flow of fluids; adaptive optics with large amount of optical elements; smart electrical power systems; highways with automated cars driving in platoons. Common characteristic of all of the above mentioned systems is that they are composed of a large number of spatially distributed dynamical subsystems which operate under constant mutual interactions through some physical interconnections (network) and/or communication links (network). Today, it is widely acknowledged that the key challenge in development of such dynamical networks is synthesis of algorithms for their control. The main goal of this project is development of some of the key elements in fundamental theory of control for spatially distributed systems, together with constructive controller synthesis algorithms suitable for application in real-life problems. The research focus will be on distributed control solutions in which each dynamical system in the network is controlled by its local controller and each local controller communicates and coordinates its actions with a (usually small) set of directly neighboring controllers. Our approach will be based on innovative elements from the theory of dissipative systems, while both spatially invariant networks and generic dynamical networks with arbitrary interconnection graph will be considered. The developed control algorithms will be verified in laboratory experiments on groups of mobile robots and on a distributed vibration control platform.
2352Europska bioetika na djeluEuropean Bioethics in Action4099Amir Muzur IP2013-11IP-2013-11-7853EuroBioAct15.09.2014 - 14.09.2017Završio380.000,00 KnHumanističke znanosti, Društvene znanosti, Biomedicina i zdravstvo, Humanities, Social sciences, Biomedicine and health sciences, Filozofija, Philosophy, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine6036, 5496, 5108, 5105, 6779, 5129, 5896, 5503, 6539, 5594, 21391, Ante Čović, Robert Doričić, Igor Eterović, Nada Gosić, Željko Kaluđerović, Iva Rinčić, Tomislav Rukavina, Hans-Martin Sass, Vanja Vasiljev Marchesi, Valerije Vrček, Maja Miloš, Europe, integrative bioethics, Fritz Jahr, ecology, environment, Northern AdriaticThe „European Bioethics in Action (EuroBioAct)” project primarily aims at: 1. completing theoretical basis for the „new European bioethics“ (by rounding-up research on Fritz Jahr, Ignaz Bregenzer, and other thinkers and conceiving a common platform with integrated ideas of modern environment science and ethics) and 2. applying that theoretical basis in practice (by compiling a list of „bioethical standards“ for settlements, containing concrete general and specific norms for preservation and improvement of local eco-systems – i.e., human health, animal and plant welfare, etc.).In the first phase of the project realisation, the participants would continue with the broadening and deepening of the theoretical basis of the „new European bioethics“ primarily by completing the research of the life and work of Fritz Jahr and his most important models (Ignaz Bregenzer and others). In the second phase of the project, three focused workshops would be organised determining the status of the general and special ecological needs for the three local communities (Plomin, Bakar, and Mali Lošinj) from the Northern Adriatic region. The three communities selected to host the workshops have either been recently experiencing ecological threats (Plomin – thermo-electric power plant; Bakar – cokery), or represent a highly-valuable and vulnerable natural insular pocket (Mali Lošinj – health tourism, dolphin wildlife refuge, fragrant gardens programme, etc.). Based on the theoretical background and the insights provided by the workshops, in the third phase of the project, created would be the „bioethical standards“, that is, a set of principles and measures of the correct relation of men toward their own health, animals, plants, and the eco-system in total. A „bioethical standards“ charter might improve the level of local community environmental consciousness, and provide direction lines for its sustainable development (including a potential tourism-advertising ace card).
2353Znanstveno brendiranje svinjskog mesaScientifically Branded Pork1296Goran Kušec IP2013-11IP-2013-11-3396SciBra Pork01.07.2014 - 30.06.2018U tijeku849.277,50 KnBiotehničke znanosti, Prirodne znanosti, Biotechnical sciences, Natural sciences, Poljoprivreda (agronomija), Agriculture, Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti OsijekJosip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek2738, 6830, 4653, 7523, 1230, 7603, 7607, 7608, 3831, 19548, 21307, 13307, 13691, 20761, Boris Lukić, Vladimir Margeta, Kristina Budimir, Snježana Džijan, Zinka Bošnjak, Ivona Durkin, MARINA KRVAVICA, MARKO JELIĆ, Kristian Sabo, Miodrag Komlenić, Mane Medić, Ivan Kelić, Zdravko Tolušić, Polonca Margeta, indigenous pig breed, genomic identification, growth characteristics, carcass and meat quality, sensory traits, meat products, brandingBlack Slavonian pig is an autochthonous pig breed, established at the end of the 19th century near Osijek in eastern Croatia. The breed is black in color, resistant and convenient for keeping in extensive and half-extensive conditions. It is also characterized by good meat quality, suitable for producing typical traditional meat products. Recently, the traditionally produced food came into the focus which led to more often use of geographical indications (protected designation of origin-PDO, protected geographical indication-PGI and Traditional Specialties Guaranteed-TSG) as the valuable rural development strategy. Since Black Slavonian pig is a late maturing breed characterized by low lean meat percentage, meat processors tend to use the meat of modern pig breeds in production of traditional products. Therefore there is a need for scientifically developed methods in order to trace the origin of materials used in such production. First of all, molecular identification of breed will be performed by the use of MC1R gene and 18 microsatelite primers . Since the genotype, age and sex are possible sources of variation of the meat quality traits in pigs, the objective of proposed research is to determine the optimal time for slaughter with respect to these factors. The genetic influence on meat quality traits is nowadays well described by the use of molecular markers by which many of the candidate genes were discovered. In proposed research a special interest will be placed at some of them such as IGF2, MC4R, H-FABP3 and LEPR. The investigation of sensory traits and chemical analysis of meat and meat products will help to determine the typical physico-chemical characteristics and sensory profile of autochthonic Slavonian dry-cured meat products and fresh meat originated from Black Slavonian Pig meat. At the end, obtained polymorphisms at the microsatellite loci will be tested in identification of the origin of meat used in the production of traditional meat products.
2360Razvoj formulacija novih prirodnih insekticida na osnovi inertnih prašiva i botaničkih insekticida i njihovih kombinacija kao zamjena za sintetske konvencionalne insekticideDevelopment of new natural insecticide formulations based on inert dusts and botanicals to replace synthetic, conventional insecticides 4063Vlatka Rozman IP2013-11IP-2013-11-5570DIACROMIXPEST01.07.2014 - 30.06.2017Završio719.974,60 KnBiotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti OsijekJosip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek4202, 4081, 4365, 4414, 4277, 5109, Zlatko Korunic, Josip Halamić, Anita Liška, Pavo Lucić, Ines Galović, Renata Baličević, natural insecticides, inert dusts, botanical insecticides, stored pest, stored productsCroatia has a low tolerance for detectable insects in stored grain so stored pests must be controlled. The conventional choice, organosphosphates and pyrethroids, has many disadvantages due to considerable hazard of harmful residues, high cost, and the possible and already present appearance of insect resistance. The possible alternative, diatomaceous earth (DE), because of the needs to use high concentrations to control insects, is hindered by its effect on grain flow, bulk density and very high cost. Therefore, there is a great need for the development of a new, less toxic and less dangerous insecticide(s) to control insect pests of stored food and in Public Health/Pest Control field. Synergism of DE and botanicals allows effective control with much lower concentrations of active ingredients, in comparison when these components are used separately. The mode of action is a synergistic combination of desiccation, poisoning and (probably) starvation. Croatia has several sources of DE that are still not in use. These DEs have a potential to be used as natural insecticides or combining it with other natural substances to develop safe, effective and natural insecticide. Also, Croatia has a botanical diversity of indigenous plants. However, the country has not yet benefited from this wealth of knowledge on the use of plants as pesticides. These results make us confident that there is a possibility to develop the new natural synergized insecticide formulation(s) using Croatian DE and plant extract. The proposed project fits the goals and strategic priorities CSF because it encourages the international competitiveness of research groups,developing scientific field that provides the technological advances applicable to agriculture, food industry, public health, communal hygiene and veterinary medicine as well as the ability to obtain new Croatian natural products.
2361Prospektivno biopsihosocijalno istraživanje utjecaja seksualno eksplicitnih materijala na socijalizaciju i zdravlje mladihProspective Biopsychosocial Study of the Effects of Sexually Explicit Material on Young People's Sexual Socialization and Health5817Aleksandar Štulhofer IP2013-11IP-2013-11-9221PROBIOPS SEM STUDY01.09.2014 - 31.01.2019Završio450.360,76 KnDruštvene znanosti, Biomedicina i zdravstvo, Social sciences, Biomedicine and health sciences, Sociologija, Sociology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences7228, 5502, 4566, 2880, 7257, 18914, 17799, 21385, 24320, Vesna Buško, Ivan Landripet, Dea Ajduković, Jadranka Knežević Ćuća, Matija Sinković, Marija Brajdić Vuković, Goran Koletić, Ksenija Klasnić, Taylor Kohut, Prospective study, panel, young people, reproductive and sexual health, emotional intimacy, committed relationships, sexually explicit materialDigital technology has enabled an unprecedented availability and unrestricted use of sexually explicit material (SEM). As the first experiences with SEM almost invariably precede first sexual experiences, concerns have been raised about its potential impact on young people’s sexual socialization, subsequent reproductive and sexual health outcomes, as well as motivation and capacity for building and maintaining relationship intimacy. The field of socio-behavioural research on SEM has been marred by inability to distinguish between associations and causal links. The only available European panel study followed Dutch youth for only 12 months. To enable a more robust assessment of the links between SEM use and sexual socialization, health, and intimacy we propose to set up a 3-year panel sample with over 1,000 high-school students. The panel would be used to carry out biological testing on males (testosterone levels from saliva) and repeated online surveying in which the genre and the frequency of SEM use would be analyzed as predictors of subsequent sexual activity (particularly, sexual risk taking), the dynamics of attitudes toward women and committed relationships. We propose to test a conceptual model in which possible SEM influences on the outcomes are influenced by T levels, personality traits, family environment, characteristics of ego-centered social network, type of SEM used, and sexual experiences. Our biopsychosocial model aims to assess the contribution of SEM use to the process of young people’s sexual socialization, while controlling for the effects of biological makeup, intrapersonal characteristics, and interpersonal and group (family, peer group, partners) social influences.The proposed project is innovative in design and analytical conceptualization. The expected outcomes should be relevant not only in scientific terms but also in the context of public policy, particularly in the area of educational and public health interventions.
2366Optimiranje i modeliranje termalnih procesa materijalaOptimisation and modelling of thermal processes of materials1419Dario Iljkić IP2013-11IP-2013-11-5371OMOTPOM10.10.2014 - 09.10.2018Završio980.000,00 KnTehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Rijeci, Tehnički fakultetUniversity of Rijeka, Faculty of Engineering4865, 4866, 1419, 7533, 5169, 7373, 3783, 7443, 5116, 3042, 7621, 6646, 4849, 17778, 1422, 25054, Nikša Čatipović, Zvonimir Dadić, Dario Iljkić, Zvonimir Kolumbic, Branimir Lela, Mauro Maretić, Hrvoje Novak, Loreta Pomenić, Domagoj Rubeša, Goran Salopek, Sunčana Smokvina Hanza, NEVEN TOMAŠIĆ, Dražen Živković, Lovro Štic, Božo Smoljan, Milenko Jokić, materials processing, modelling, electroless plating, electroactive composites, optimisation, modellingPhenomena of physical processes during the thermal processes will be investigated. Methods for modeling and computer simulations of thermal processes of materials will be developed. Thermal processes, such as, heat treating processes of steel, hot pressing of powder metals and casting of alloys of light metals will be investigate. The study of heat treatment of steel will be focused on quench hardening and tempering, and control cooling during the hot working and steel casting. Thermal stability of electro-active composites will be analyzed. Optimization of electro-less Ni-P coating of stainless steel and thermo-diffusive heat treatment of layers will be studied. Methods of optimization of application of tools and dies in thermal processing of materials will be studied. Models and computer programs for simulation of behavior steel dies during casting of light metal alloys and hot pressing of metal powders will be developed.During the thermal processes primary will be studied physical processes and material properties such as: heat transfer, microstructure transformations, mechanical properties and distortions and residual stresses. Numerical model of physical phenomena will be preferable based on finite volume method (FVM). To solve these tasks, joined thermo-mechanic-metallurgical approach will be required. The computer program for 3-D simulation of heat transfer, microstructure transformations, mechanical properties, distortions and residual stresses during the thermal processes will be developed.
2368Dalmacija kao odredište europskog Grand Toura u 18. i 19. stoljećuDALMATIA - A DESTINATION OF EUROPEAN GRAND TOUR IN 18th AND 19th CENTURY3905Ana Šverko UIP2013-11UIP-2013-11-7091GRANDTOURDALMATIA01.07.2014 - 30.06.2017Završio295.500,00 KnHumanističke znanostiHumanitiesPovijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb5566, 4910, 3716, 5027, 5171, 5083, Ivica Covic, Irena Kraševac, Ivana Vlaić, Cvijeta Pavlović, Josip Vrandečić, Iva Raič Stojanović, Grand Tour, Dalmatia, Neoclassicism and Romanticism, Representation of Place, Contemporary UrbanscapeGrand Tour – an exceptional journey which reached its peak in the 18th C, thoroughly changed human perception of nature and society. From the 18 to the 19th C the revolution in natural, human and technical sciences marks the beginning of modern society and contemporary approach in arts and architecture.Although Grand Tour originally focused on Rome, the exploration of the Ancient World as the origin of Neolassicism widened its travelling radius onto further parts of the Roman Empire, among which Dalmatia held a prominent position. Drawings and literary works by travel artists and writers from that period are treasured in prestigious European museums and libraries and together constitute a priceless portion of European cultural heritage.For the first time, all known travelogues and drawings about Dalmatia from that period will be collected, analysed and evaluated in terms of literary theory and theory of architecture. The overall aim of the project is to identify, problematise and integrate the issues related to the phenomenon of recording the space, predominantly in Dalmatia. The specific goals of the project are: establishing a working group of young researchers; raising issues of international relevance related to description of Dalmatian space based on works of the 18th and 19th C artists and writers; advancing the development of research methodology; making applicable the research of contemporary cultural-spatial context for critical rethinking in contemporary approach to architecture; creating a platform for further research at international level; establishing a dissemination channel towards both European scientific circles and wider audience.In three years of research the following will be realised: the research of archival records; field research; project webpage; three international workshops; international scientific conference; public lectures; scientific papers and on-line proceeding book of workshops and conference.
2369Očuvanje mikrobne raznolikosti povezane s proizvodnjom tradicionalnih hrvatskih kobasica od mesa divljači: biotehnološka i sigurnosna karakterizacijaConservation of microbial diversity associated with the production of Croatian traditional game meat sausages: biotechnological and safety characterization4884Mirna Mrkonjić Fuka UIP2013-11UIP-2013-11-6640miCROgame01.10.2014 - 30.09.2017U tijeku844.988,34 KnBiotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture4971, 2954, 7343, 5628, 4419, 17813, 19027, 20375, 20430, Ivica Kos, Nikica Šprem, Vlatka Čubrić Čurik, Schloter Michael, Ana Beck, Ana Žgomba Maksimović, Nataša Hulak, Irina Tanuwidjaja, Blaz Stres, traditional game meat sausages, lactic acid bacteria, foodborn pathogens, antibiotic resistance, starter culturesDespite the fact that nowadays the utilization of starter cultures is a prerequisite for the meat industry, as product reproducibility, reduction of fermentation times and enhancement of organoleptic characteristics is achieved, small scale producers in Croatia still produce spontaneously fermented game meat sausages as they still surpass in sensorial properties. Such artisan products are increasingly appreciated because of their authenticity although of great consideration due to their variable microbiological and organoleptic quality. Overall monitoring of wildlife reservoir is needed in assessment its potential as sources for zoonosis agents exposures of humans as well as sources of bacterial strains relevant for enhancement and standardization of game meat sausages production. There are large variations in prevalence of microbial populations of game meat even within a single country and the published data for Croatia is limited and poorly documented which does not allow any related analysis. Especially the data on risk -based monitoring of zoonosis and antibiotic resistance genes transmission via game meat food chain in Croatia is missing and there is not authentic collection of indigenous bacterial strains that could act as a pool of novel genes and metabolic pathways relevant for high quality food production. MiCROgame focuses on the in situ diversity analysis as well as detailed characterization of lactic acid bacteria (LAB) isolated from traditional Croatian game meat sausages. Application of this autochthonous microbiota into the sausages production can influence the end-product quality and can accelerate maturation such helping producers to be more competitive on national or EU market. Special focus will be set towards identification and characterization of potential spoilage and pathogenic microflora and antibiotic resistance traits in order to estimate safety of locally produced game meat food and to identify sources of contamination.
2374Reforma računovodstva i financijskog izvještavanja kao sredstvo jačanja razvoja učinkovitog financijskog upravljanja u javnom sektoru RHAccounting and financial reporting reform as a means for strengthening the development of efficient public sector financial management in Croatia7294VESNA VAŠIČEK IP2013-11IP-2013-11-8509ACCFORPSFMINCRO20.08.2014 - 30.09.2018Završio417.735,76 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Zagrebu, Ekonomski fakultet u ZagrebuUniversity of Zagreb, Faculty of Economics and Business7069, 7230, 7334, 7095, 7182, 7212, 7096, 7104, 2956, 19004, 19001, Nives Botica Redmayne, SANJA BROZ TOMINAC, Verica Budimir, MARTINA DRAGIJA, Ivana Dražić Lutilsky, Maja Letica, MILENA PERŠIĆ, GORANA ROJE, Davor Vašiček, Tatjana Jovanović, Jelena Poljasevic, Croatia, EU, public sector, accounting, financial reporting, accounting basis, IPSAS, financial management, asset management, cost managementThe subject of the research addresses the need and ability to pursue budgetary accounting reform in Croatia, implying accrual accounting basis and International public sector accounting standards (IPSAS) implementation, with the aim to create quality accounting/financial reporting systems and sound financial management. Supporting that budgetary accounting reforms in Croatia are set as a necessity that arises from adjustments to comply with the EU regulations and the need for setting accounting system development in function of increasing the quality of accounting information as a basis for public management decision making, our research objectives broadly focus on: examining the possibilities for accruals and IPSAS appliance in Croatia, creation of public sector accounting (PSA) terminology framework, exploring the role of accounting in public sector asset management, examining the development of internal reporting system in the function of management decision making.Research objectives will be fulfilled through different activities, i.e.: exploring the adequacy of existing modified accrual basis model appliance and budgetary users’ financial statements qualitative characteristics comparison to the accruals appliance in chosen segments of the Croatian public sector; examining the level of Croatian budgetary accounting compliance with IPSAS on the path of international comparative studies on PSA harmonisation that would foster the creation of Croatian PSA terminology and interpretation on application of a selected number of IPSAS in Croatian PSA content; developing the methodology for a comprehensive government asset recording in central asset register and whole government balance sheet; empirically assessing accounting information system from the standpoint of its’ upgrading with managerial and cost accounting elements, by developing and testing the applicable internal reporting model resulting in providing sound information for public management decision making.
2379Tekstilne antene za pametno okruženjeTextile Antennas for Smart Environment6555Davor Bonefačić IP2013-11IP-2013-11-6198TexASE01.09.2014 - 31.08.2018Završio988.000,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing6808, 6535, 4646, 5165, 17757, Juraj Bartolić, Radovan Zentner, Željko Penava, Branimir Ivšić, Andrej Galoić, antenna, textile antenna, wearable antenna, on-body communications, body-centric communicationsThe smart environment consists of wired and wireless network of communication devices and sensors which communicate between themselves and with humans, and enable safer, more pleasant and energy efficient environment adaptable to the change of conditions and tasks. Any wireless device needs an antenna as the interface between the electronic circuits and the free space. Wireless communication modules, sensors and RFID devices are integrated in common objects like clothes, home appliances, toys, consumables, etc. The used antennas must be small and unobtrusive, yet energy efficient. The aim of this project is to investigate new materials and techniques for antenna fabrication including conductive textiles and threads. A textile antenna integrated into clothes must be lightweight, flexible, and comfortable to wear, but still must keep good radiation properties. Textile antennas are very interesting for military personnel on the field as well as for rescue teams. Another important application is healthcare, where wireless sensors in real time monitor the patients' health status and transmit data to the medical personnel. The broadest field of application of wearable antennas is in the entertainment and consumer electronics and mobile communications. Energy harvesting, and with it the associated antennas, can be used in all these fields to increase energy efficiency and enable operation of mobile devices. The aim of this project is to propose new and adapt existing antenna designs for integration into clothing and for new manufacturing techniques like embroidering or weaving. Another aspect to be considered in connection with wearable antennas is their operation in the proximity of human body which is a lossy dielectric. The second aim of this project is to study both theoretically and experimentally the propagation channel on the surface of the human body and off-body communications. The results will allow designing reliable on-body and off-body communication systems.
2381Utjecaj procesnih parametara na kinetiku heterogenih sustava koji se odvijaju u šaržnom reaktoru s miješanjemImpact of processing conditions on kinetics of heterogeneous systems in agitated batch reactors422Nenad Kuzmanić IP2013-11IP-2013-11-8959HETMIX01.09.2014 - 31.08.2018Završio924.850,00 KnTehničke znanostiTechnological sciencesKemijsko inženjerstvo, Chemical engineering, Sveučilište u Splitu, Kemijsko-tehnološki fakultetUniversity of Split, Faculty of chemistry and technology6051, 3364, 6053, 4537, 6047, Davor Rušić, Sandra Svilović, Marija Ćosić, Renato Stipišić, Antonija Kaćunić, heterogeneous process, batch reactor, process parameters, mixing, kinetics, crystallization, ion exchange, heavy metals, mathematical modelingFrom engineering point of view, heterogeneous system can be categorized as very complex. The presence of multiple phases causes a series of limitations, primarily connected to transport phenomena and actually those limitations are the ones that cause their distinct kinetic determination. Due to the complexity and the wide range of heterogeneous processes, research would be limited to solid-liquid systems, taking place in agitated batch reactors. Two heterogeneous processes are to be investigated simultaneously, one that includes and one that excludes a chemical reaction (a. Batch cooling crystallization; b. Ion exchange of heavy metals). The base intention of the proposed project is to find a link between process parameters, hydrodynamic conditions in agitated batch reactor, process kinetics and characteristics of the final product (that is, final process result). Furthermore, the intention is to examine the mentioned relation as a function of reactor scale size as well. Considering the kinetic determination of the process, special attention will be given to the investigation of the influence of hydrodynamic conditions, i.e. the influence of the mixing operation in a batch reactor on the kinetics of the investigated processes. Since one of the goals of this project is to contribute to the theory of reactor design, experimentally obtained insights could represent the criteria basis of heterogeneous solid-liquid process equipment scale up as well as the basis for the mathematical modeling of the impact of operating conditions on the heterogeneous process result. This way the functional relations between studied variables would be established.
2384Višeskalni model betona s identifikacijom parametaraMulti-scale concrete model with parameter identification4072Ivica Kožar IP2013-11IP-2013-11-9068ConcreteMuScID01.09.2014 - 31.08.2018Završio970.000,00 KnTehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište u Rijeci, Građevinski fakultet u RijeciUniversity of Rijeka, Faculty of Civil Engineering4673, 4880, 5624, 6013, 6135, 6912, 6843, 17853, Gojko Balabanić, Joško Ožbolt, Boris Podobnik, Neira Torić Malić, Silvija Mrakovčić, Natalija Bede, Anamarija Perušić, Tea Rukavina, multi-scale, concrete, system identification, dynamic loading, computer modelIn complex numerical models the calibration can only be achieved through interaction of measured data with the underlying mathematical model. Especially difficult situation occurs when loading is stochastic (e.g. wind, earthquake, traffic) since there is no direct relation between loading (input) and displacements (output). System parameter identification will be based on inverse mathematical formulation so to present a reliable and theoretically sound procedure for identification of required parameters. One of the main goals of the system identification procedure is representative volume identification. It will be necessary to consider non-Gaussian stochastic processes with heavy tails characterizing dangerous rare events. Regarding material parameters this project advocates the hypothesis that the fracture energy of a material is approximately constant and that the material constitutive law should not incorporate “rate effect”. The idea of (approximately) constant fracture energy for all loading rates is new and important in models of concrete under the dynamic loading. Also, the inclusion of the viscous parameter in the existing 3D microplane model for concrete is of vital importance for fatigue analysis since it connects creep and shrinkage (internal material loading) with dynamic loading (external structural loading). In the end the developed concrete model will account for corrosion by coupling the mechanical properties of concrete and properties affecting the transport of humidity, oxygen and chloride (chemo-hygro-thermo-mechanical model). The calibration of the 3D model and its verification will be performed based on the simulation of the corresponding experimental tests from the laboratory and the available literature according to the procedure for system parameter identification described above. Two main characteristics of the project: highly applicative and at the same time capable of producing high impact scientific results.
2399Sekundarno stanovanje i socijalna održivost lokalnih zajednica u HrvatskojSecond Homes and Social Sustainability of Local Communities in Croatia6867Geran-Marko Miletić UIP2013-11UIP-2013-11-1875SHSSLCC01.06.2014 - 15.09.2017Završio246.767,50 KnDruštvene znanostiSocial sciencesSociologija, Sociology, Institut društvenih znanosti Ivo PilarInstitute of Social Sciences Ivo Pilar in Zagreb6323, 6317, 2541, 5688, 6024, 1220, 6746, 6092, 6603, 18985, 18979, 18980, 18981, 18982, 18983, 18984, Anka Mišetić, Roko Mišetić, Krešimir Peračković, Saša Poljanec-Borić, Tomislav Smerić, Nenad Pokos, Sara Ursic, Mario Bara, Marica Marinović Golubić, Rašeljka Krnić, Srđana Urlić, Stanko Mirošević, Duje Radovniković, Mirjana Urlić, Katarina Mirošević, Boris Bučević, second homes, social sustainability, local communities, leisure, CroatiaThe planned project starts from the premise that second home use, i.e. occasional use of dwellings for vacation and recreation, is a strong factor in socio-spatial transformation. There is a constant growth of this trend in Croatia, whereby certain areas, or to be more precise, the coastal area is more exposed to second homes expansion. This increase in pressure of second homes and the tendency of this phenomenon to change and take new forms, especially under the influence of the expected growth of international second homes and disappearance of the hierarchy in the use of dwellings, have directed the planned project towards one question: are second homes only an obstacle, or could they be a source of opportunities, i.e. an additional impulse to the social sustainability of local communities in Croatia. The main objectives of the project are: 1) Identifying settlements in Croatia with an increased number of second homes; 2) Determining types of settlements in Croatia, and getting an insight into the connection of second homes to relevant sociodemographic and socioeconomic features of the settlers; and 3) Analysing how second homes affect the daily life of the local community, social structures and processes in it. These objectives direct the research towards combining secondary analysis of the census data and the analysis of the empirical data gathered through case studies. This will enable a deep insight into the way second homes affect the local social reality.
2402Pretvorba ostataka poljoprivredne proizvodnje i energetskih kultura u energiju i proizvode dodane vrijednosti – proizvodnja bioulja i biougljenaConverting waste agricultural biomass and dedicated crops into energy and added value products – bio-oil and biochar production5589Tajana Krička IP2013-11IP-2013-11-3328AgBiomassConversion15.10.2014 - 14.10.2018U tijeku785.620,00 KnBiotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture5606, 5600, 5604, 5608, 7403, 19075, 19643, Neven Voća, Vanja Jurišić, Ana Matin, Nikola Bilandžija, Ivan Kuže, Alan Antonović, Mateja Grubor, waste agricultural biomass, dedicated crops, conversion, pyrolysis, energy, added value products, bio-oil, biocharBiomass is one of the promising renewable energy resources and can be a partial alternate to fossil fuels. Common methods applied to make use of biomass energy potential are biochemical and thermochemical conversion methods. Pyrolysis is a thermo-chemical process carried out in the absence of oxygen that yields with three different end-products – bio-oil, biochar and syngas. Pyrolysis of agricultural residues can help meet renewable energy targets by displacing fossil fuels and, thereby, deal with concerns regarding the global warming. Unlike direct combustion, pyrolysis yields with more end-products. Bio-oil has environmental benefits as a clean fuel and causes less pollution as compared to fossil fuels, whereas biochar can be put on soil and act as a carbon-sequestering and climate-mitigating agent. Based on the above-mentioned, the overall objective of this project is to determine the potential of different types of biomass residues and waste, and dedicated crops, for bio-oil and biochar production via pyrolysis. Since the type of feedstock significantly influences the pyrolysis process and the yield of end-products, the specific objective of the proposed project will be to determine the potential of pyrolysis from different biomass feedstock collected in two climatically different regions, Mediterranean and Continental Croatia. Project will be split into three main phases, including feedstock collection and characterization, biomass pyrolysis, and end-products' (bio-oil and biochar) characterization. This will provide the most detailed database so far, speaking worldwide, and should result with the information on the optimum feedstock, concerning the available biomass in relation to the region.
2409Porezna politika i fiskalna konsolidacija u HrvatskojTax Policy and Fiscal Consolidation in Croatia82Helena Blažić IP2013-11IP-2013-11-8174TPFCC01.06.2014 - 31.05.2018Završio277.480,00 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Rijeci, Ekonomski fakultetUniversity of Rijeka, Faculty of Economics2759, 2716, 2754, 3265, 1250, 2822, 3555, 3370, 6318, 6361, 5230, Maja Grdinić, Ana Grdović Gnip, Maja Klun, Hrvoje Šimović, Ana Štambuk, Lejla Lazovic-Pita, Milan Deskar-Škrbić, Bojana Olgić Draženović, Žiga Kotnik, Saša Drezgić, Mario Pečarić, tax policy, tax system, tax structure, fiscal consolidation, CroatiaThe project is dealing with a tax policy problem Croatia has been tackling with in times of its fiscal consolidation as to ensure enough fiscal revenues, support long-term growth and maintain and even increase the equity of the tax system. The research starts with an extensive expert opinion survey about the state and perspectives of Croatian tax systems, which will be extended to Slovenia and Bosnia and Herzegovina in order to do relevant cross analysis of the obtained results. This survey will be followed by some public attitude surveys concerning relevant tax issues.The macroeconomic effects of fiscal consolidation measures in Croatia, with the emphasis on tax measures, will be analyzed at different government levels as well as the effects of tax structure on the economic growth. The research will be broadened to encompass other (mostly region) countries.It is expected that the research team with their in-depth tax policy analyses will pinpoint different aspects of crucial tax policy issues in Croatia with problem-solving recommendations regarding financial transaction tax, real estate tax, environmental taxation, flat tax and some other base broadening and tax expenditure issues.
2414Likovna umjetnost i komunikacija moći u razdoblju ranoga novoga vijeka (1450.-1800.) : povijesne hrvatske regije na razmeđi Srednje Europe i MediteranaVisual Arts and Communication of Power in the Early Modern Period (1450-1800): Historical Croatian Regions at the Crossroads of Central Europe and the Mediterranean1226Milan Pelc IP2013-11IP-2013-11-6827VACOP01.07.2014 - 30.06.2018Završio498.925,00 KnHumanističke znanostiHumanitiesPovijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb6665, 4903, 3408, 3742, 3481, 4586, 4663, Josip Belamarić, Višnja Bralić, Daniel Premerl, Ivana Prijatelj Pavičić, Mirjana Repanić-Braun, Petra Batelja, Maja Žvorc, Art, Politics, Communication, Croatia, Early Modern periodThis research will primarily focus on the analysis andinterpretation of the relation of pow er holders tow ard the visualarts in Croatian regions of the Early Modern Period, as w ell asthe places and the media of their transmission. In the spirit ofnew art history, the research w ill seek to answ er the follow ingquestions: 1. w hich media channels – including communicationmeans and strategies – did certain centres of pow er use tocreate and promote favourable responses among differenttypes of recipients in Croatia of the early modern period? 2.w hat w as the role of visual art in shaping public opinion and thesocial promotion and re(presentation) of pow er holders? Thepow er holders in Croatian regions w ho acted as artcommissioners w ere primarily from the ranks of the aristocracy(both secular and ecclesiastical) – representatives of the stateideologies of the Venetian Republic, the Kingdom of Hungary,the Habsburg Monarchy and the Dubrovnik Republic. In additionto them, there w ere also local corporate patrons and artcommissioners – confraternities – w hich mainly reflected theinterests of local communities. Those art commissioningchannels made possible cultural transfers in visual arts andarchitecture in the Croatian territory during the period from theearly Renaissance to the late Baroque. The research w illfacilitate the creation of a database containing relevant visualrecords of the aforementioned historical period, w hich w illenable a comparative analysis of the phenomenon from theperspective of the sociology of culture, critical iconology andsemiotics. Finally, this w ill result in the development of anappropriate model for the understanding and interpretation ofthe specific usage of visual arts as mediator in thecommunication of pow er in Croatia of 1450-1800.
2420Novi koncept primijenjene kognitivne robotike u kliničkoj neuroznanostiA new concept of Applied Cognitive RObotics in clinical Neuroscience7302Bojan Jerbić IP2013-11IP-2013-11-4192ACRON01.09.2014 - 31.08.2018Završio936.000,00 KnTehničke znanosti, Biomedicina i zdravstvo, Technological sciences, Biomedicine and health sciences, Strojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture7303, 3760, 7444, 7454, 7453, 7448, 7450, 7555, 7311, 7582, 7611, 17378, 22645, Darko Chudy, Gojko Nikolić, Tomislav Stipančić, Filip Šuligoj, Petar Ćurković, Marko Švaco, Bojan Šekoranja, vedran deletis, Dominik Romić, Gordan Grahovac, Domagoj Dlaka, Vladimira Vuletic, Josip Vidaković, robotics, artificial intelligence, cognitive models, medicine, neuroscienceThe research in this project leads to novel forms and uses of cognitive robotics applied in clinical neuroscience. Robot’s performances during the surgical procedures are investigated within the previously conducted technological project, RONNA - Robotic Neurosurgical Navigation. Results of RONNA suggest that the benefits of using robots in the operating room are enormous, e.g. increased accuracy and repeatability of the surgical procedures, flexible and tremor free operations, etc. During the RONNA realisation, it is recognized that certain new cognitive robot skills yet need to be developed.The long-term vision of the proposed ACRON project as a multi-disciplinary research arises from the recognition that a paradigm shift in human-robot-environment interaction is needed. Currently, technology robustness is achieved by restricting the interaction space, so that the region and the nature of the interaction can be controlled by the system. In ACRON, the cognitive fulcrum will therefore move from sensed data to the robot contextual anticipation.ACRON will advance the research providing a uniform scientific framework for the study, development and implementation of cognitive concepts, providing the robot to function in ICT enabled ubiquitous environment that can be shared by different kinds of agents. ACRON will therefore bring the new context-aware medical robot capable to anticipate the most appropriate actions respecting the phase of the medical procedure and spatial positions of the staff and objects. We will investigate the relationship between people, robots and the shared environment where they interact and work together. By moving throughout the discretized working space and while achieving the current assignment, the medical robot will become able to avoid all-possible spatial collisions and make the appropriate context-based decisions.
2432Uspostavni istraživački projekti o društvenom poduzetništvuInstallation Project for REsearch about Social ENTrepreneurship4514dražen šimleša UIP2013-11UIP-2013-11-5332iPRESENT15.09.2014 - 01.03.2018Završio375.823,74 KnDruštvene znanostiSocial sciencesSociologija, Sociology, Institut društvenih znanosti Ivo PilarInstitute of Social Sciences Ivo Pilar in Zagreb6323, 4720, 7578, 21224, Anka Mišetić, Filip Majetić, Jelena Puđak, Anita Bušljeta Tonković, social entrepreneurship, sustainability, social benefits, responsible, business modelThe main goal of iPRESENT (Installation Project for REsearch about Social ENTrepreneurship) project is to research capacities and potentials of social entrepreneurship as an environmentally friendly and socially responsible business model in Croatia. Social Entrepreneurship is one of the leading and growing phenomena, it has outcomes in social, economic and environmental fields, and as such is suitable and studious for scientific research. This is especially the case in a country such as Croatia, with longstanding economic crisis, rise of unemployment; decrease of social rights and trust, but at the same time quite a wealth of natural resources and tradition in cooperative business models. The project has a specific objective to initiate and secure long term scientific base and data for research on social entrepreneurship in Croatia; to set up a relevant and up to date published materials about social entrepreneurship open to science community and public; to test the level of 3BL (Triple bottom line) in social enterprises in Croatia; and to prepare guidelines and “advice book” for potential social entrepreneurs and recommendations for important and interested stakeholders. Through the three years of project duration, an already experienced scientist and researchers with young colleagues will explore and define the concept of social entrepreneurship, compare and elaborate EU perspectives and conditions regarding the subject of the project, but also place considerable emphasis on methodological approach that should provide us with reliable and operable scientific data. The project consists of a balanced and well suited mix of qualitative and quantitative scientific methods depending on applicability and specific needs within the project.It is worth mentioning that this is the first time in Croatia that the scientific community recognised social entrepreneurship as a valuable subject for long-term analytical work and research.
2441Mjerenje, modliranje i prognoziranje volatilnostiVolatility measurement, modelling and forecasting7589Josip Arnerić UIP2013-11UIP-2013-11-5199Volatility01.09.2014 - 31.08.2017Završio275.158,43 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Zagrebu, Ekonomski fakultet u ZagrebuUniversity of Zagreb, Faculty of Economics and Business3912, 4299, 4342, 6252, 4385, 4833, 21323, Blanka Škrabić Perić, Mirjana Čižmešija, Tea Poklepović, Ivana Lolić, Petar Sorić, Zdravka Aljinović, Danijel Mlinarić, OHLC volatility estimator, GARCH switching model, news impact curve, panel-GARCH models, high-frequency data, neural-networks, quasi-Newton algorithmVolatility of financial time series has become a key input to many important finance applications such as investment, portfolio selection and allocation, option pricing, hedging and risk management. The importance of accurate volatility estimates has become even more significant after the financial crisis. As volatility itself is not observable variable, many different volatility estimators have emerged in the literature to address this problem. This project proposal will explore some of methodologically complexities of volatility modelling and forecasting with respect to both the parametric and nonparametric approaches. Moreover, one of the objectives is to investigate news impact curve of different volatility models as well as to compare different types of Generalized Autoregressive Conditional Heteroscedascity models in terms of their ability to describe structural changes in returns and to explore if Markov regime switching GARCH models outperform uni-regime GARCH models in forecasting volatility when sudden switching occurs. According to previous commonly used aspects of volatility measurement and modelling, two relatively new approaches will be explored. First one relies on neural-networks as econometric tool. The second one combines panel methodology with GARCH models. It should be emphasized that new OHLC volatility estimator will be defined as the most efficient one when high frequency data is not available. The main contribution is to train doctoral and postdoctoral students within interdisciplinary areas of statistics, econometrics, financial econometrics, mathematics, operational research and their applications.
2445Hijerarhijska konsolidacija velikih potrošača temeljena na upravljanju za integraciju u napredne mrežeControl-based Hierarchical Consolidation of Large Consumers for Integration in Smart Grids7612Mario Vašak UIP2013-11UIP-2013-11-67313CON01.12.2014 - 30.11.2017Završio1.000.000,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing7616, 7618, 7624, 17458, 17455, 19265, 19325, Vinko Lešić, Mato Baotić, Nedjeljko Perić, Hrvoje Novak, Marko Gulin, Anita Martinčević, Antonio Starčić, optimal control, hierarchical control, building, railway traffic system, energy consumption, power flow optimisation, prosumer, smart gridBuildings and railway traffic systems are examples of complex technical systems that consume significant energy amounts so as to enable their inner processes to evolve as required. Thereby the requirements on dynamic functioning of these systems can be achieved by different system interactions, whereas some of them are more preferable than the others from the standpoints of energy consumption or other criteria like price of operation or equivalent pollution.The global objective of the project 3CON is to research and develop optimal control techniques on significantly different large consumers – building systems and railway traffic systems – in conceptually identical way: by applying the principle of hierarchical decomposition of systems and cooperative optimal controls between the hierarchy levels. In that way the computed energy consumption profile on the lower level directly maximizes the global economic gain of the system operation in the presence of system constraints (e.g. allowed temperatures or fixed train travelling time). This will enable the proactive role of these largest consumers in energy grids of the future (smart grids). It will make them responsive and in position to best exploit the imposed varying energy exchange terms. Thereby vast possibilities in energy grid management through dynamic pricing will be opened – foremost for reducing losses between generation and consumption points in the grid and increasing grid reliability. The secondary global objective of this installation grant is to build an internationally competent research group in control of energy-intensive systems on the Faculty which is also recognized and accepted by relevant domestic companies.The project developments will be verified through building and railway traffic case studies that will be supervised by relevant Croatian companies. This will ensure that all relevant system issues are taken care of in the design and that the design itself is close to exploitation.
2446Infektomika humanih jetrenih neparenhimskih stanica u kroničnom hepatitisu CInfectomics Study of Human Liver Non-parenchymal Cells in Chronic Hepatitis C6975Adriana Vince IP2013-11IP-2013-11-4241ILHNCHC01.07.2014 - 31.05.2019Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Ništa od navedenogNothing from this list4080, 3952, 3951, 7027, 7271, 3443, 7295, 7391, Snježana Židovec Lepej, Lana Gorenec, Ivana Grgić, Vjeran Čajić, Ivan Kurelac, Neven Papić, Davorka Dušek, Tajana Filipec Kanižaj, HCV, gene expression, Kupffer cells, LSEC, inflammation, immunotolerance Hepatitis C virus (HCV) is the leading cause of liver disease. HCV productively infects hepatocytes to impart liver inflammation and progressive tissue damage leading to fibrosis and cirrhosis. These processes underlie liver dysfunction and are thought to drive the onset of liver cancer. However, the molecular mechanism(s) by which HCV confers hepatic inflammation are not defined. Now, there is growing evidence that liver sinusoidal endothelial cells (LSEC) and Kupffer cells (KC), may play key roles in regulating immune responses and facilitating tolerance induction. These cells are playing a pivotal role in blood-borne virus clearance (>90%), leaving only a small fraction of infectious virus that escapes clearance in a manner peculiar to each individual pathogen. The biology of HCV, specifically regarding non-parenchymal liver cells, has been largely neglected. LSEC account for the 20% and KC for 15% of the hepatic cells, and are a unique organ-resident cell population with diverse functions, including degradation of bacterial by-products, antigen presentation and induction of tolerance. The hypothesis of the research is that HCV infection reprograms cellular gene expression of LSEC and KC, which results in the modulation of the inflammatory responses. Applying the infectomics approach, we plan to perform a series of next-generation sequencing experiments on LSEC and KC isolated and purified from healthy, mild and severe chronic hepatitis C liver biopsies. This will allow us to detect expression changes related with disease progression. Selected candidate genes will be comprehensively studied in in vitro systems in order to elucidate their role in modulation of inflammatory and adaptive immune responses. Through the development of this project it is expected that a series of high impact results will be obtained, which will facilitate the development of more significant biomarkers and effective interventions against HCV infection.
2447Komunikacije usmjerene čovjeku u pametnim mrežamaHuman-centric Communications in Smart Networks932Maja Matijašević IP2013-11IP-2013-11-8065HUTS01.10.2014 - 30.09.2017Završio750.000,00 KnTehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing2717, 2626, 2628, 2612, 4930, 5079, 2706, 2572, 2770, 2775, 4895, 6720, 6608, 2785, 5345, 5033, 5339, 17866, Ignac Lovrek, Igor Sunday Pandžić, Zeljka Car, Gordan Ježić, Mario Kušek, Ivana Podnar Žarko, Krešimir Pripužić, Ognjen Dobrijević, Tomislav Grgić, Mirko Sužnjević, Marin Vuković, Aleksandar Antonić, Šimo Brtan, Krunoslav Ivešić, Damjan Katušić, Nenad Markuš, Pavle Skočir, Martina Marjanović, smart network, big data, cloud communications, human computer interface, internet of thingsHuman-centric Communications in Smart Networks (HUTS) project will address open questions regarding smart networks and human-centric communication in which data is both gathered from – and provided to – humans, anywhere and at any time, responding to their current needs. Through its research objectives, the project will investigate networking aspects of human-centric communication, such as the allocation and optimization of cloud and network resources and also providing related quality of service guarantees. This research will be used as a building block for various smart services, which enable user and device adaptation based on learning from previous situations and communicating the results of these situations. This powerful concept relies on new methods in cloud computing for big data processing and Internet-connected objects, such as smart sensors and actuators, as well machine-to-machine communication between devices using self-organizing ad-hoc networks. Smart services are further built upon innovative complex-service composition methodology and intelligent mechanisms to be formulated by the project. The introduction of smart services will drive the changes in the way people interact with devices towards more intuitive and unconstrained means. In particular, contactless user interaction, considering various categories of users, and networked virtual worlds/environments will be studied. Network data traffic models and network management will be proposed, including online charging mechanisms for dynamic pricing and cost calculation of smart services. The research proposed in this project will create new knowledge, strengthen research mentoring and improve young scientist capacities in Croatia, contribute results to science in the area of Information and Communication Technology, and help develop Croatian scientific and research space as one of the long-term strategic priorities, enabling knowledge transfer to Croatian economy for the benefit of society.
24642708Mario Basletić DOK2014-06DOK-2014-06-6358-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Branimir Mihaljević
24654000Damir Sapunar DOK2014-06DOK-2014-06-5195-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine Doktorand: Tihana Repić
24661262Alan Filipin DOK2014-06DOK-2014-06-9078-Prekinut-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Građevinski fakultetUniversity of Zagreb, Faculty of Civil Engineering Doktorand: Marija Bliznac
246843Igor Jurak DOK2014-06DOK-2014-06-3295-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Rijeci, Odjel za biotehnologijuUniversity of Rijeka, Department of Biotechnology Doktorand: Marina Matešić
247092Dražen Adamović DOK2014-06DOK-2014-06-4322-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Ana Kontrec
247250Miroslav Požek DOK2014-06DOK-2014-06-9935-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Marija Došlić
2473242Filip Grgić DOK2014-06DOK-2014-06-7408-U tijeku-Humanističke znanostiHumanitiesFilozofija, Philosophy, Institut za filozofijuInstitute for Philosophy in Zagreb Doktorand: Anna Kocsis
2474747Sandra Bischof DOK2014-06DOK-2014-06-5072-Prekinut-Tehničke znanostiTechnological sciencesTekstilna tehnologija, Textile technology, Sveučilište u Zagrebu, Tekstilno-tehnološki fakultetUniversity of Zagreb, Faculty of Textile Technology Doktorand: Iva Matijević
2475984Hrvoje Kušić DOK2014-06DOK-2014-06-2343-U tijeku-Tehničke znanostiTechnological sciencesKemijsko inženjerstvo, Chemical engineering, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology Doktorand: Marin Kovačić
24764884Mirna Mrkonjić Fuka DOK2014-06DOK-2014-06-5664-U tijeku-Biotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture Doktorand: Ana Žgomba Maksimović
2479761Mirna Ćurković Perica DOK2014-06DOK-2014-06-8059-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Lucija Nuskern
2480510Marina Ilakovac Kveder DOK2014-06DOK-2014-06-9812-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Jurica Jurec
24815202Davor Zahradka DOK2014-06DOK-2014-06-3252-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Ana Hlevnjak
2482613Marijeta Kralj DOK2014-06DOK-2014-06-3177-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Iva Guberović
2483140Slobodan Milošević DOK2014-06DOK-2014-06-3950-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Institut za fizikuInstitute of Physics in Zagreb Doktorand: Dean Popović
24844121Luca Malatesti DOK2014-06DOK-2014-06-9522-U tijeku-Humanističke znanostiHumanitiesFilozofija, Philosophy, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences Doktorand: Marko Jurjako
2486162Slobodan Miko DOK2014-06DOK-2014-06-7454-U tijeku-Prirodne znanostiNatural sciencesGeologija, Geology, Hrvatski geološki institutCroatian Geological Survey Doktorand: Dea Brunović
248776Silvana Raić-Malić DOK2014-06DOK-2014-06-4842-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology Doktorand: Andrea Bistrović
2488504Željko Jakšić DOK2014-06DOK-2014-06-6175-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Maja Levak
2489105Petar Pervan DOK2014-06DOK-2014-06-6205-Prekinut-Prirodne znanostiNatural sciencesFizika, Physics, Institut za fizikuInstitute of Physics in Zagreb Doktorand: Ivan Jedovnicki
249158Nenad Antonić DOK2014-06DOK-2014-06-1949-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Marin Mišur
2492253Tomislav Jemrić DOK2014-06DOK-2014-06-5032-U tijeku-Biotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture Doktorand: Marko Vuković
24936497Igor Kuzle DOK2014-06DOK-2014-06-5507-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Kristina Jurković
24944290Slobodan Ribarić DOK2014-06DOK-2014-06-2427-U tijeku-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Martin Soldić
2495195Ivica Vilibić DOK2014-06DOK-2014-06-5127-U tijeku-Prirodne znanostiNatural sciencesGeofizika, Geophysics, Institut za oceanografiju i ribarstvoInstitute of Oceanography and Fisheries Doktorand: Natalija Dunić
24993207Damir Medak DOK2014-06DOK-2014-06-4224-U tijeku-Tehničke znanostiTechnological sciencesGeodezija, Geodesy, Sveučilište u Zagrebu, Geodetski fakultetUniversity of Zagreb, Faculty of Geodesy Doktorand: Luka Rumora
2501326David Smith DOK2014-06DOK-2014-06-6776-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Marko Hanževački
2502400Jelena Kuvač Kraljević DOK2014-06DOK-2014-06-3854-U tijeku-Društvene znanostiSocial sciencesLogopedija, Logopedics, Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultetUniversity of Zagreb, Faculty of Education and Rehabilitation Sciences Doktorand: Marina Olujić
25031419Dario Iljkić DOK2014-06DOK-2014-06-4469-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Rijeci, Tehnički fakultetUniversity of Rijeka, Faculty of Engineering Doktorand: Andrej Borić
25046687Hrvoje Gotovac DOK2014-06DOK-2014-06-4310-U tijeku-Tehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezijeUniversity of Split, Faculty of Civil Engineering, Archtecture and Geodesy Doktorand: Luka Malenica
25051458Mladen Obad Šćitaroci DOK2014-06DOK-2014-06-2984-Prekinut-Tehničke znanostiTechnological sciencesArhitektura i urbanizam, Architecture and Urban Environment, Sveučilište u Zagrebu, Arhitektonski fakultetUniversity of Zagreb, Faculty of Architecture Doktorand: Nikola Matuhina
2506243Davor Margetić DOK2014-06DOK-2014-06-1851-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Mateja Đud
2508927Jurica Sorić DOK2014-06DOK-2014-06-2938-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Filip Putar
250911149Joško Deur DOK2014-06DOK-2014-06-2348-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Vanja Ranogajec
25105962Nikola Mišković DOK2014-06DOK-2014-06-4651-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Filip Mandić
2511151Ivica Botički DOK2014-06DOK-2014-06-9536-U tijeku-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Tomislav Jagušt
25121081Mario Habek DOK2014-06DOK-2014-06-9971-Prekinut-Biomedicina i zdravstvoBiomedicine and health sciencesKliničke medicinske znanosti, Clinical sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Luka Crnošija
25135573Pavle Pandzic DOK2014-06DOK-2014-06-9187-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Karmen Grizelj
25142945Zlatko Drmač DOK2014-06DOK-2014-06-5570-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Ivana Šain
25164589Stjepko Fazinić DOK2014-06DOK-2014-06-4153-Prekinut-Prirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Roman Kosanović
251762Ivana Novak Nakir DOK2014-06DOK-2014-06-9538-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine Doktorand: Mija Marinković
25195694Sanja Kolaček DOK2014-06DOK-2014-06-7791-Prekinut-Biomedicina i zdravstvoBiomedicine and health sciencesKliničke medicinske znanosti, Clinical sciences, Ništa od navedenogNothing from this list Doktorand: Lana Njavro
2520442Šebojka Komorsky-Lovrić DOK2014-06DOK-2014-06-2282-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Lara Čižmek
2521527Gordan Jelenić DOK2014-06DOK-2014-06-9680-U tijeku-Tehničke znanostiTechnological sciencesTemeljne tehničke znanosti, Basic engineering sciences, Sveučilište u Rijeci, Građevinski fakultet u RijeciUniversity of Rijeka, Faculty of Civil Engineering Doktorand: Sara Grbčić
2522498Mariastefania Antica DOK2014-06DOK-2014-06-2010-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Josipa Skelin
25251480Mile Šikić DOK2014-06DOK-2014-06-2255-U tijeku-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Robert Vaser
25261211Andreja Ambriović Ristov DOK2014-06DOK-2014-06-9922-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Ana Dekanić
25277730Inga Tomić-Koludrović DOK2014-06DOK-2014-06-7620-U tijeku-Društvene znanostiSocial sciencesSociologija, Sociology, Institut društvenih znanosti Ivo PilarInstitute of Social Sciences Ivo Pilar in Zagreb Doktorand: Augustin Derado
2528961Zoran Mandić DOK2014-06DOK-2014-06-7033-U tijeku-Tehničke znanostiTechnological sciencesKemijsko inženjerstvo, Chemical engineering, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology Doktorand: Denis Sačer
25305416Vlatka Zoldoš DOK2014-06DOK-2014-06-1892-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Vanja Tadić
2532922Damir Kralj DOK2014-06DOK-2014-06-2469-Prekinut-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Lara Štajner
25345949Damir Sumina DOK2014-06DOK-2014-06-8519-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Tin Bariša
253519111Ivica Kopriva DOK2014-06DOK-2014-06-5945-U tijeku-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Maria Brbic
25371269Stewart Schultz DOK2014-06DOK-2014-06-2216-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u ZadruUniversity of Zadar Doktorand: Dubravko Pejdo
25384850Bojan Vršnak DOK2014-06DOK-2014-06-8294-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Geodetski fakultetUniversity of Zagreb, Faculty of Geodesy Doktorand: Mateja Dumbović
25401362Maja Buljan DOK2014-06DOK-2014-06-4610-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Nikolina Nekić
25415009Ivan Kokanovoć DOK2014-06DOK-2014-06-6755-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Filip Orbanić
25425998Danko Zelić DOK2014-06DOK-2014-06-6008-U tijeku-Humanističke znanostiHumanitiesPovijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb Doktorand: Matko Matija Marušić
25431128Davorin Kajba DOK2014-06DOK-2014-06-1443-U tijeku-Biotehničke znanostiBiotechnical sciencesŠumarstvo, Forestry, Sveučilište u Zagrebu, Šumarski fakultetUniversity of Zagreb, Faculty of Forestry Doktorand: Ivan Andrić
25443523Mario Vukšić DOK2014-06DOK-2014-06-1969-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Vinka Kovačević
25454828Silva Katušić Hećimović DOK2014-06DOK-2014-06-9815-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Kristina Dominko
2546287Irena Ciglenečki-Jušić DOK2014-06DOK-2014-06-7023-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Ana Cvitešić
2547480Ivo Piantanida DOK2014-06DOK-2014-06-9225-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Tamara Šmidlehner
25494668Hrvoj Vančik DOK2014-06DOK-2014-06-1051-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Petar Bibulić
25524960Hrvoje Kozmar DOK2014-06DOK-2014-06-5445-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Andrija Buljac
25533313Maro Cvitan DOK2014-06DOK-2014-06-2072-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Tamara Štemberga
2554227Robert Vianello DOK2014-06DOK-2014-06-8651-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Aleksandra Maršavelski
2555319Bojan Trkulja DOK2014-06DOK-2014-06-8561-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Ana Drandić
25565374Larisa Zoranić DOK2014-06DOK-2014-06-9740-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Splitu, Prirodoslovno-matematički fakultetUniversity of Split, Faculty of Science Doktorand: Martina Požar
25575817Aleksandar Štulhofer DOK2014-06DOK-2014-06-5015-U tijeku-Društvene znanostiSocial sciencesSociologija, Sociology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences Doktorand: Goran Koletić
2558118Tatijana Zemunik DOK2014-06DOK-2014-06-8198-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine Doktorand: Antonela Boljat
2559335Krešimir Kumerički DOK2014-06DOK-2014-06-6473-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Petar Čuljak
25605979Darko Koracin DOK2014-06DOK-2014-06-4724-U tijeku-Prirodne znanostiNatural sciencesGeofizika, Geophysics, Sveučilište u SplituUniversity of Split Doktorand: Slavko Radilović
25635054Zdenko Kovačić DOK2014-06DOK-2014-06-9417-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Frano Petric
25644941Tihana Lenac Roviš DOK2014-06DOK-2014-06-9006-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine Doktorand: Paola Kučan
256563Vesna Boraska DOK2014-06DOK-2014-06-6867-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine Doktorand: Luka Brčić
25665203Helena Otmačić Ćurković DOK2014-06DOK-2014-06-9683-U tijeku-Tehničke znanostiTechnological sciencesKemijsko inženjerstvo, Chemical engineering, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology Doktorand: Ekatarina Kristan
25673375Mirko Orlić DOK2014-06DOK-2014-06-3666-U tijeku-Prirodne znanostiNatural sciencesGeofizika, Geophysics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Maja Bubalo
2568131Vladimir Sigmund DOK2014-06DOK-2014-06-8930-Prekinut-Tehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet OsijekJosip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek Doktorand: Ervin Kožoman
25692974Sanja Tomić DOK2014-06DOK-2014-06-6802-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Marko Tomin
2570913Zlata Hrnjak-Murgić DOK2014-06DOK-2014-06-1233-U tijeku-Tehničke znanostiTechnological sciencesKemijsko inženjerstvo, Chemical engineering, Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologijeUniversity of Zagreb, Faculty of Chemical Engineering and Technology Doktorand: Vanja Gilja
25715854Dina Šimunić DOK2014-06DOK-2014-06-6634-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Antonija Marinčić
25722536Daniel Rolph Schneider DOK2014-06DOK-2014-06-6302-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Tihomir Tomić
25736555Davor Bonefačić DOK2014-06DOK-2014-06-6996-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Andrej Galoić
25754709Fabrizio Nesti DOK2014-06DOK-2014-06-3949-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Goran Popara
257611146Jasminka Popovic DOK2014-06DOK-2014-06-9951-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Sanja Brkić
2577361Siniša Šegvić DOK2014-06DOK-2014-06-4744-Prekinut-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Ivan Krešo
2580936DUBRAVKO FORČIĆ DOK2014-06DOK-2014-06-3771-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u ZagrebuUniversity of Zagreb Doktorand: Anamarija Slović
25814630Ivana Munitić DOK2014-06DOK-2014-06-4658-U tijeku-Biotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Sveučilište u Rijeci, Odjel za biotehnologijuUniversity of Rijeka, Department of Biotechnology Doktorand: Andrea Markovinović
25823305Domagoj Šimić DOK2014-06DOK-2014-06-6159-U tijeku-Biotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Poljoprivredni institut OsijekAgricultural Institute Osijek Doktorand: Vlatko Galić
258369Rozi Andretić Waldowski DOK2014-06DOK-2014-06-9244-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u RijeciUniversity of Rijeka Doktorand: Ana Filošević
25843388Kristina Štrkalj Despot DOK2014-06DOK-2014-06-6207-U tijeku-Humanističke znanostiHumanitiesFilologija, Philology, Institut za hrvatski jezik i jezikoslovljeInstitute of Croatian Language and Linguistics Doktorand: Ivan Pandžić
25861118Frano Barbir DOK2014-06DOK-2014-06-4783-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnjeUniversity of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture Doktorand: Ivan Pivac
2587177Jelena Budak DOK2014-06DOK-2014-06-7067-U tijeku-Društvene znanostiSocial sciencesEkonomija, Economy, Ekonomski institut ZagrebInstitute of Economics in Zagreb Doktorand: Vedran Recher
2588872Zrinka Kovarik DOK2014-06DOK-2014-06-4854-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut za medicinska istraživanja i medicinu radaInstitute for Medical Research and Occupational Health Doktorand: Tamara Zorbaz
258911142Maja Telišman Prtenjak DOK2014-06DOK-2014-06-6713-U tijeku-Prirodne znanostiNatural sciencesGeofizika, Geophysics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Andreina Belušić
259011164Vuko Brigljević DOK2014-06DOK-2014-06-8266-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Benjamin Mesić
25911243Verica Dragović-Uzelac DOK2014-06DOK-2014-06-9368-U tijeku-Biotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology Doktorand: Vanja Plazibat
25923481Mirjana Repanić-Braun DOK2014-06DOK-2014-06-7397-U tijeku-Humanističke znanostiHumanitiesPovijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb Doktorand: Petra Batelja
25934256Jasna Prpić-Oršić DOK2014-06DOK-2014-06-2582-U tijeku-Tehničke znanostiTechnological sciencesBrodogradnja, Naval architecture, Sveučilište u Rijeci, Tehnički fakultetUniversity of Rijeka, Faculty of Engineering Doktorand: Natalija Vitali
2594145Zoran Vondraček DOK2014-06DOK-2014-06-3394-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Hrvoje Planinić
25957459Gojko Bežovan DOK2014-06DOK-2014-06-7086-U tijeku-Društvene znanostiSocial sciencesSocijalne djelatnosti, Social work, Sveučilište u Zagrebu, Pravni fakultet u ZagrebuUniversity of Zagreb, Faculty of Law Doktorand: Josip Pandžić
25961294Klaudija Carović-Stanko DOK2014-06DOK-2014-06-2895-U tijeku-Biotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture Doktorand: Monika Vidak
25975506Iris Goldner Lang DOK2014-06DOK-2014-06-7630-U tijeku-Društvene znanostiSocial sciencesPravo, Law, Sveučilište u Zagrebu, Pravni fakultet u ZagrebuUniversity of Zagreb, Faculty of Law Doktorand: Nika Bačić
2599206Zoran Herceg DOK2014-06DOK-2014-06-3102-U tijeku-Biotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology Doktorand: VIŠNJA STULIĆ
26003576Maja Matulić DOK2014-06DOK-2014-06-9845-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Luka Horvat
2601102Beata Halassy DOK2014-06DOK-2014-06-8915-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u ZagrebuUniversity of Zagreb Doktorand: Dora Sviben
26062671Vjeran Pavlaković DOK2014-06DOK-2014-06-1936-U tijeku-Humanističke znanostiHumanitiesPovijest, History, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences Doktorand: Renato Stanković
26093406Nina Štirmer DOK2014-06DOK-2014-06-1679-U tijeku-Tehničke znanostiTechnological sciencesTemeljne tehničke znanosti, Basic engineering sciences, Sveučilište u Zagrebu, Građevinski fakultetUniversity of Zagreb, Faculty of Civil Engineering Doktorand: Martina Pezer
2610603Maruška Vizek DOK2014-06DOK-2014-06-9058-U tijeku-Društvene znanostiSocial sciencesEkonomija, Economy, Ekonomski institut ZagrebInstitute of Economics in Zagreb Doktorand: Petra Palić
261311160Darko Kozarac DOK2014-06DOK-2014-06-5314-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Mario Sremec
26144052Ivica Puljak DOK2014-06DOK-2014-06-2568-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnjeUniversity of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture Doktorand: Toni Šćulac
26151229Marijana Đaković DOK2014-06DOK-2014-06-9090-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Mladen Borovina
26164471Mario Štorga DOK2014-06DOK-2014-06-2035-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Marija Majda Perišić
26196650Ino Čurik DOK2014-06DOK-2014-06-8455-U tijeku-Biotehničke znanostiBiotechnical sciencesPoljoprivreda (agronomija), Agriculture, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture Doktorand: Vladimir Brajković
2620450Tonči Rezić DOK2014-06DOK-2014-06-4937-U tijeku-Biotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology Doktorand: Martina Andlar
26216564Zoran Kalafatić DOK2014-06DOK-2014-06-9838-U tijeku-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Ivan Filković
26224099Amir Muzur DOK2014-06DOK-2014-06-2024-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine Doktorand: Robert Doričić
2623572Magdalena Grce DOK2014-06DOK-2014-06-3542-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Ksenija Božinović
2624986Tvrtko Smital DOK2014-06DOK-2014-06-7922-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Jelena Dragojević
2625367Igor Jerković DOK2014-06DOK-2014-06-3039-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Splitu, Kemijsko-tehnološki fakultetUniversity of Split, Faculty of chemistry and technology Doktorand: Marina Kranjac
26264824Milan Sak-Bosnar DOK2014-06DOK-2014-06-8713-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemijuJosip Juraj Strossmayer University of Osijek, Department of Chemistry Doktorand: MATEJA HAJDUKOVIĆ
262711139Snježana Knezić DOK2014-06DOK-2014-06-6635-U tijeku-Tehničke znanostiTechnological sciencesTemeljne tehničke znanosti, Basic engineering sciences, Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezijeUniversity of Split, Faculty of Civil Engineering, Archtecture and Geodesy Doktorand: Toni Kekez
26286031Drago Šubarić DOK2014-06DOK-2014-06-5131-U tijeku-Biotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultetJosip Juraj Strossmayer University of Osijek, Faculty of Food Technology Doktorand: Jelena Panak
26295463Tihana Kraš DOK2014-06DOK-2014-06-4334-U tijeku-Humanističke znanostiHumanitiesFilologija, Philology, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences Doktorand: Maša Plešković
26316955Tomislav Suligoj DOK2014-06DOK-2014-06-2113-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Sabina Krivec
26325079Ivana Podnar Žarko DOK2014-06DOK-2014-06-9476-U tijeku-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Martina Marjanović
2633360Hrvoje Marjanović DOK2014-06DOK-2014-06-9721-U tijeku-Biotehničke znanostiBiotechnical sciencesŠumarstvo, Forestry, Hrvatski šumarski institutCroatian Forest Research Institute Doktorand: Mislav Anić
26347148Dubravko Babic DOK2014-06DOK-2014-06-7862-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Marko Šprem
26357315Andrej Jokić DOK2014-06DOK-2014-06-7947-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Mihael Lobrović
26363723Dunja Brozović Rončević DOK2014-06DOK-2014-06-4255-U tijeku-Humanističke znanostiHumanitiesFilologija, Philology, Sveučilište u ZadruUniversity of Zadar Doktorand: Ivana Gmižić
26413873Damir Žarko DOK2014-06DOK-2014-06-2238-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Tino Jerčić
26425244Stjepan Bogdan DOK2014-06DOK-2014-06-3174-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Tomislav Haus
2643891Markus Schatten DOK2014-06DOK-2014-06-1015-U tijeku-Društvene znanostiSocial sciencesInformacijske i komunikacijske znanosti, Information and communication sciences, Sveučilište u Zagrebu, Fakultet organizacije i informatikeUniversity of Zagreb, Faculty of Organization and Informatics Doktorand: Bogdan Okreša Đurić
26443209Milan Pernek DOK2014-06DOK-2014-06-9789-U tijeku-Biotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Hrvatski šumarski institutCroatian Forest Research Institute Doktorand: Ivan Lukić
26454958Astrid Krmpotić DOK2014-06DOK-2014-06-6481-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine Doktorand: Jelena Železnjak
26467808Vjera Katalinić DOK2014-06DOK-2014-06-5703-U tijeku-Humanističke znanostiHumanitiesZnanost o umjetnosti, Arts, Hrvatska akademija znanosti i umjetnostiCroatian Academy of Sciences and Arts Doktorand: Maja Milošević
26472825Nataša Šarlija DOK2014-06DOK-2014-06-6152-U tijeku-Društvene znanostiSocial sciencesEkonomija, Economy, Sveučilište Josipa Jurja Strossmayera, Ekonomski fakultet u OsijekuJosip Juraj Strossmayer University of Osijek, Faculty of Economics Doktorand: Ana Bilandžić
26484615Dražen Domijan DOK2014-06DOK-2014-06-2246-U tijeku-Društvene znanostiSocial sciencesPsihologija, Psychology, Sveučilište u Rijeci, Filozofski fakultet u RijeciUniversity of Rijeka, Faculty of Humanities and Social Sciences Doktorand: Tanja Gulan
26495748Nebojša Blanuša DOK2014-06DOK-2014-06-6078-U tijeku-Društvene znanostiSocial sciencesPolitologija, Political Science, Sveučilište u Zagrebu, Fakultet političkih znanostiUniversity of Zagreb, Faculty of Political Science Doktorand: Kosta Bovan
26504228Ozren Polašek DOK2014-06DOK-2014-06-8445-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesJavno zdravstvo i zdravstvena zaštita, Public health and health services, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine Doktorand: Andrea Gelemanović
2652801Vladimir Mrljak DOK2014-06DOK-2014-06-5716-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesVeterinarska medicina, Veterinary medicine, Sveučilište u Zagrebu, Veterinarski fakultetUniversity of Zagreb, Faculty of Veterinary Medicine Doktorand: Petra Nižić
26545255Aleksandra Sinđić DOK2014-06DOK-2014-06-3023-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Nikola Habek
265511173Mirjana Hruškar DOK2014-06DOK-2014-06-1031-Prekinut-Biotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology Doktorand: Saša Ajredini
265619875Jasna Puizina DOK2014-06DOK-2014-06-8371-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Splitu, Prirodoslovno-matematički fakultetUniversity of Split, Faculty of Science Doktorand: Tomislav Rončević
26577740Miloš Judaš DOK2014-06DOK-2014-06-3663-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Andrija Štajduhar
26584072Ivica Kožar DOK2014-06DOK-2014-06-5984-U tijeku-Tehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište u Rijeci, Građevinski fakultet u RijeciUniversity of Rijeka, Faculty of Civil Engineering Doktorand: Tea Rukavina
26627705Siniša Volarević DOK2014-06DOK-2014-06-3128-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine Doktorand: Deana Jurada
26633309Goran Turkalj DOK2014-06DOK-2014-06-9526-U tijeku-Tehničke znanostiTechnological sciencesTemeljne tehničke znanosti, Basic engineering sciences, Sveučilište u Rijeci, Tehnički fakultetUniversity of Rijeka, Faculty of Engineering Doktorand: Damjan Banić
26652829Zrinka Ljubešić DOK2014-06DOK-2014-06-5886-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Maja Mejdandžić
26665074Boris Muha DOK2014-06DOK-2014-06-4384-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Marija Galić
266781Blaženka Gašparović DOK2014-06DOK-2014-06-3224-U tijeku-Prirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Tihana Sesar
26682684Fran Borovečki DOK2014-06DOK-2014-06-9688-Prekinut-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Antonela Blažeković
26695935Vedran Krčadinac DOK2014-06DOK-2014-06-5387-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Renata Vlahović
2671820Goran Muić DOK2014-06DOK-2014-06-1470-U tijeku-Prirodne znanostiNatural sciencesMatematika, Mathematics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Sonja Žunar
26726070Krešimir Trontl DOK2014-06DOK-2014-06-6107-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Paulina Dučkić
2675810Joško Parunov DOK2014-06DOK-2014-06-5833-U tijeku-Tehničke znanostiTechnological sciencesBrodogradnja, Naval architecture, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture Doktorand: Ivana Gledić
267611143Vinko Zlatić DOK2014-06DOK-2014-06-5324-U tijeku-Prirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Andrea Kadović
26777618Mato Baotić DOK2014-06DOK-2014-06-6214-U tijeku-Tehničke znanostiTechnological sciencesTemeljne tehničke znanosti, Basic engineering sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Branimir Novoselnik
26783028Alan Uzelac DOK2014-06DOK-2014-06-2989-U tijeku-Društvene znanostiSocial sciencesPravo, Law, Sveučilište u Zagrebu, Pravni fakultet u ZagrebuUniversity of Zagreb, Faculty of Law Doktorand: Juraj Brozović
2679649Neda Slade DOK2014-06DOK-2014-06-1853-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Nikolina Hanžić
26805991Dražen Vouk DOK2014-06DOK-2014-06-6363-U tijeku-Tehničke znanostiTechnological sciencesGrađevinarstvo, Civil engineering, Sveučilište u Zagrebu, Građevinski fakultetUniversity of Zagreb, Faculty of Civil Engineering Doktorand: Domagoj Nakić
26814075Jasmina Lovrić DOK2014-06DOK-2014-06-5517-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesFarmacija, Pharmaceutical sciences, Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultetUniversity of Zagreb, Faculty of Pharmacy and Biochemistry Doktorand: Bisera Jurišić
26824910Irena Kraševac DOK2014-06DOK-2014-06-6881-U tijeku-Humanističke znanostiHumanitiesPovijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb Doktorand: Iva Raič Stojanović
26832921Ivica Veža DOK2014-06DOK-2014-06-2672-U tijeku-Tehničke znanostiTechnological sciencesStrojarstvo, Mechnical engineering, Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnjeUniversity of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture Doktorand: Ivan Peko
26856456Tomislav Pribanić DOK2014-06DOK-2014-06-8227-U tijeku-Tehničke znanostiTechnological sciencesRačunarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Matea Đonlić
26861396Ivica Rubelj DOK2014-06DOK-2014-06-6992-U tijeku-Prirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb Doktorand: Lucia Nanić
26877807Djuro Josic DOK2014-06DOK-2014-06-1373-U tijeku-Biotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Sveučilište u Rijeci, Odjel za biotehnologijuUniversity of Rijeka, Department of Biotechnology Doktorand: Tamara Martinović
26882612Gordan Ježić DOK2014-06DOK-2014-06-1586-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Matea Žilak
26903075Danka Grčević DOK2014-06DOK-2014-06-8382-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Darja Flegar
269111180Marija Ćurlin DOK2014-06DOK-2014-06-8752-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Marta Skelin
26925552Donatella Verbanac DOK2014-06DOK-2014-06-6863-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine Doktorand: Marina Panek
26934028Mirjana Sanader DOK2014-06DOK-2014-06-6088-U tijeku-Humanističke znanostiHumanitiesArheologija, Archeology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences Doktorand: Mirna Vukov
26943919Dean Konjević DOK2014-06DOK-2014-06-2264-U tijeku-Biomedicina i zdravstvoBiomedicine and health sciencesVeterinarska medicina, Veterinary medicine, Sveučilište u Zagrebu, Veterinarski fakultetUniversity of Zagreb, Faculty of Veterinary Medicine Doktorand: Miljenko Bujanić
269511144Vernesa Smolcic DOK2014-06DOK-2014-06-4630-Prekinut-Prirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science Doktorand: Nikola Baran
26967612Mario Vašak DOK2014-06DOK-2014-06-7386-U tijeku-Tehničke znanostiTechnological sciencesElektrotehnika, Electrical engineering, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing Doktorand: Hrvoje Novak
26975275Mladen Ivanković DOK2014-06DOK-2014-06-9784-U tijeku-Biotehničke znanostiBiotechnical sciencesŠumarstvo, Forestry, Hrvatski šumarski institutCroatian Forest Research Institute Doktorand: Sanja Mrmić
26986142Ljiljana Kolešnik DOK2014-06DOK-2014-06-5766-U tijeku-Humanističke znanostiHumanitiesPovijest umjetnosti, Art history, Institut za povijest umjetnostiInstitute of Art History, Zagreb Doktorand: Nikola Bojić
2820Znanstvena aktivnost, suradnja i orijentacija istraživanja u društvenim znanostima u Hrvatskoj i ostalim postsocijalističkim europskim zemljamaResearch activity, collaboration and orientation in social sciences in Croatia and other post-socialist European countries6932Marija Maja Jokić IP2014-09IP-2014-09-9351RACOSS15.09.2015 - 14.09.2019Završio528.790,00 KnDruštvene znanostiSocial sciencesInformacijske i komunikacijske znanosti, Edukacijsko-rehabilitacijske znanosti, Ekonomija, Pedagogija, Politologija, Pravo, Psihologija, Socijalne djelatnosti, Sociologija, Information and communication sciences, Economy, Law, Pedagogy, Physical education and rehabilitation sciences, Political Science, Psychology, Social work, Sociology, Institut za društvena istraživanjaInstitute for Social Research in Zagreb7722, 7451, 11177, 12381, 11224, 6920, 6939, 7724, 12373, 12341, 20965, 21215, Dejana Bouillet, Krešimir Zauder, Andrea Mervar, Krešimir Kufrin, Darja Maslić Seršić, Nikola Petrović, Srebrenka Letina, Sonja Špiranec, Dora Zgrabljić Rotar, Tonči Kursar, Stjepan Mateljan, Boris Stamenić, znanstvena aktivnost, citatne analize, znanstvena suradnja, analiza društvenih mreža¸ nacionalni časopisi, društvene znanosti, Hrvatska, EU zemljeresearch performance, citation analysis, collaboration, social network analysis, natioanl journals, social sciences, Croatia, EU countriesTemeljna funkcija znanosti, posebno društvenih, je utjecaj na razvoj društva. Status društvenih znanosti u društvu, kao i njihov utjecaj na razvoj, manje su istraživane teme u odnosu na prirodne i primijenjene znanosti.U Hrvatskoj se društvenim znanostima bavi približno četvrtina registriranih znanstvenika vezanih najvećim dijelom uz rad 7 instituta i svih 7 sveučilišta. Glavna istraživačka pitanja ovog projekta su: Kojim temama i kakvom problematikom se bave ti stručnjaci? Gdje objavljuju rezultate svojih istraživanja? Surađuju li međusobno unutar ustanova, na razini zemlje i na međunarodnoj razini? U kojoj mjeri su rezultati njihovih istraživanja dostupni i prepoznati kroz citiranost? Kakav je značaj i uloga nacionalnih časopisa iz društvenih znanosti u prijenosu i dostupnosti znanja? Postoje li razlike u obrascima znanstvenog komuniciranja u pojedinim poljima društvenih znanosti i koje su? Kako bi se dobila što cjelovitija slika stanja u Hrvatskoj, u projekt su uključene europske post-socijalističke zemlje, 10 EU zemalja i zemlje bivše Jugoslavije. Za ostvarivanje postavljenih ciljeva koristit će se kvantitativni (bibliometrija, upitnici, analiza društvenih mreža) i kvalitativni (intervjui) metodološki pristupi koje je osmislio i provodit će interdisciplinarni tim stručnjaka. Temeljni izvor podataka o produktivnosti, citiranosti, autorstvu, suradnji, časopisima, ustanovama i zemljama je baza Scopus. Za statističke podatke o zemljama koristi će se Eurostat i razni nacionalni izvori.Očekivani doprinosi projekta su teorijski i primijenjeni, od uvida u znanstveni potencijal u istraživanjima društvenih znanosti uključenih zemalja, preko razvoja i primjena kompleksne metodologije prikupljanja i obrade raznovrsnih podataka, do ponude relevantnih elementa hrvatskoj znanstvenoj politici i indikatora za razvoj i primjenu prihvatljivijih sustava za vrednovanje znanstvenog rada te pomoć pri donošenju vezanih odluka.A basic function of science, especially social science, is its influence on the development of society. The status of social science and its influence on the development of society are less researched themes in comparison with natural and applied sciences.Nearly a quarter of registered Croatian scientists are social scientists. Their work is, in most part, tied to the work of 7 scientific institutes and all 7 universities. The main research questions in this project are: Which themes and problematic are central to these experts? Where do they publish the results of their research? How much do they cooperate on institutional, country and international level and are there measurable effects of cooperation? To what extent are their results available and recognized through citations? What is the significance and role of national journals in social sciences? What are the differences between various fields of social sciences?To provide a rich comparative description of the state of social sciences in Croatia, the project includes 10 EU post-socialist countries as well as ex-Yugoslav countries. To attain its goals the project will use quantitative (bibliometry, survey, social network analysis) and qualitative (interviews) methods which have been planned and will be implemented by a multidisciplinary team of experts. The primary source for bibliometric data for productivity, impact, authorship, cooperation, journals, institutions and countries will be the Scopus citation index. The main source for statistical data about the included countries will be Eurostat and various national sources.The expected outcomes of the project are theoretical and applied, from insight in scientific potential of social science research in included countries, through the development of appropriate methods of collecting and analyzing different types of data, to offering the relevant elements and indicators for the evaluation of scientific output and as help in related decision making processes.
2834Patofiziološke posljedice promjena sastava lipidnih splaviPathophysiological consequences of lipid raft changes4409Marija Heffer IP2014-09IP-2014-09-2324RafTuning10.12.2015 - 09.12.2019U tijeku985.090,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Farmacija, Basic Medical Sciences, Pharmaceutical sciences, Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet OsijekJosip Juraj Strossmayer University of Osijek, Faculty of Medicine12600, 12492, 13131, 12890, 2737, 4439, 4511, 12488, 4384, 12475, 4379, 12468, 4417, 12977, 13292, 4420, 13221, 13217, 13317, 4473, 4739, 23157, 23158, 23159, 23162, 23166, 23167, 23165, 23171, Svjetlana Kalanj Bognar, Kristina Mlinac, Dragana Fabris, Marko Rožman, Jasenka Wagner, Barbara Viljetić, Vedrana Ivić, Ivana Škrlec, Marta Balog, Elizabeta Has-Schön, Senka Blažetić, Valentina Pavić, Robert Blažeković, Predrag Pale, Željka Vukelić, Irena Labak, Milan Mesić, Melita Čačić Hribljan, Zrinka Požgain, Stefan Mrđenović, Ana Amić, Alen Imširović, David Andrijevic, Kiš Ana, Tihana Mendeš, Martina Matanović, Tea Markulak, Mateo Čupić, Andrijana Včeva, lipidne splavi, gangliozidi, živčani sustav, inhibitori glikolipida, stres, epigenetikalipid rafts, gangliosides, nervous system, glycolipid inhibitor, stress, epigeneticsLipidne splavi su područja stanične membrane koja okupljaju lipide i 35% proteina membrane u dinamične strukture zvane signalosomi. Glavne molekule koje sudjeluju u izgradnji lipidnih splavi su kolesterol, sfingomijelin i glikosfingolipidi. Najmanje 11% transmembranskih proteina ovisi o glikosfingolipidima, posebice gangliozidima, koji osiguravaju pravilnu strukturu i funkciju lipidnih splavi. Promjene u sastavu glikosfingolipida moduliraju kritične korake u fiziološkim procesima kao što su adhezija, signalizacija, formiranje barijera, stanična migracija, vezikularni transport i apoptoza. Također, rani su pokazatelji neurodegenerativnih poremećaja (Alzheimer i Parkinson). Mehanizmi koji dovode do promjena nisu dovoljno istraženi i ne postoje terapije usmjereno na lipidne splavi kod liječenja neurodegenerativnih bolesti i pospješivanja regeneracije. Cilj istraživanja je testirati jeli sastav lipidnih splavi narušen kod genetički izmijenjenih miševa s nedostatkom u sintezi gangliozida, jeli se mijenja pod utjecajem stresa i u procesu starenja te može li se farmakološki manipulirati satavom lipidnih splavi. U svrhu dokazivanja postavljene hipoteze utvrditi će se promjene u sastavu lipidnih splavi i transkriptomu središnjeg i perifernog živčanog sustava kod miševa s nedostatkom u sintezi gangliozida odnosno na štakorskom modelu kroničnog stresa i starenja. Sintetizirati ćemo inhibitore ključnih enzima u metabolizmu glikolipida koji bi mogli poslužiti u farmakološkim intervencijama i dalje ih sistematizirati prema djelovanju na sastav lipidnih splavi u kulturama živčanih stanica i na mišjem modelu. Kombinacijom lipidomičkog i transkriptomičkog pristupa odabrat će se kritični signalni putovi i utvrditi njihov učinak na epigenetske promjene. Genetički, okolišem i farmakološki inducirane promjene u sastavu lipidnih splavi dati će uvid u njihovu funkciju i omogućiti razvoj lijekova namijenjenih finom ugađanju procesa kao što su reakcija na stres i regeneracija.Lipid rafts are liquid ordered sub-compartments of plasma membrane which co-cluster lipids and 35% of plasma-membrane proteins in dynamic structures called signalosomes. Cholesterol, sphingomyelin and glycosphingolipids are the major constituents and organizers of lipid rafts. At least 11% of transmembrane proteins depend on glycosphingolipids, particularly gangliosides, as lubricant enabling proper raft location and function. Changes in composition of glycosphingolipids interfere with fine tuning of critical physiological processes like adhesion, signaling, forming barriers, cell migration, vesicular transport and apoptosis. Although changes in the ganglioside content of lipid rafts are the first sign of neurodegenerative diseases like Alzheimer and Parkinson, mechanisms causing changes are not fully explored and there are no relevant clinical treatments targeting rafts in neurodegeneration or regeneration. With this proposal we aim to test whether the content of lipid rafts is disrupted in knockout mice for the key enzymes in ganglioside synthesis, affected in stress and aging and could it be successfully tuned by pharmacological manipulation. In order to test this hypothesis we will map the changes in lipid rafts and the transcriptome of CNS and PNS of ganglioside-deficient knockout mice and rat models of aging and chronic stress. Potential pharmacological substances, inhibitors of key enzymes in glycolipid metabolism, will be synthesized and further selected according to their efficacy to affect the composition of lipid rafts in cultured neurons and the mouse models. Combinations of lipidomic and transriptomic approaches will be used to select critical signaling pathways which would be tracked down to epigenetic changes. Genetically, environmentally and pharmacologically introduced changes in lipid rafts would give insight in their function and enable development of drugs for fine tuning of processes like stress responses and regeneration.
2841Uloga nekodirajućih RNA u regulaciji latencije herpes simplex virusa 1Roles of non-coding RNAs in regulation of herpes simplex virus 1 latency43Igor Jurak IP2014-09IP-2014-09-8790ON-OFF-IJ01.05.2015 - 30.09.2019U tijeku999.737,88 KnPrirodne znanostiNatural sciencesBiologija, Biology, Sveučilište u Rijeci, Odjel za biotehnologijuUniversity of Rijeka, Department of Biotechnology894, 12525, 858, 19184, 17801, 19177, 17845, Marko Hohšteter, Ivana Ratkaj, Hackenberg Michael, Maja Cokarić Brdovčak, Marina Matešić, Andreja Zubković, Maja Badurina, mikroRNA, miRNA, virus, latencija, herpesvirus, herpes simplex, regulacija genamicroRNA, miRNA, virus, latency, herpesvirus, herpes simplex, gene regulation, Herpes simplex virus 1 (HSV - 1) je važan patogen ljudi koji uzrokuje razna oboljenja, međutim usprkos intenzivnim istraživanjima i velikom broju iznimnih otkrića, mnogi temeljni aspekti HSV - 1 biologije su nepoznati. Nedavnim tehničkim postignućima koja su omogućila analize transkriptoma, postalo jasno da nekodirajuće RNA (ncRNA), koje između ostalih uključuju i miRNAs i duge ncRANs ( lncRNA ), imaju vrlo važnu ulogu u regulaciji genske aktivnosti životinja, biljaka i virusa. Naša grupa je otkrila brojne HSV -1 eksprimirane miRNA, no njihova funkcija je uglavnom nepoznata. S druge strane, već duže je poznato nekoliko HSV - 1 kodiranih lncRNAs, uključujući i intenzivno proučavan tzv. eng. latency associated transcript (LAT), glavni marker HSV - 1 latencije; ali i njihova funkcija je slabo poznata i uglavnom neistražena. Naša je hipoteza da ncRNAs imaju središnju ulogu u replikaciji ovog virusa i uspostavi latencije, posebice u regulaciji prijelaza iz latencije u litičku fazu (i.e. latentnog/litičkog prekidača). U našim nastojanjima odrediti ćemo nekodirajući transkriptom HSV-1 te odgonetnuti ulogu ncRNA u regulaciji genske aktivnosti tjekom litičke i latente faze HSV-1. Naše hipoteze temeljimo na preliminarnim podacima istraživanja funkcije miR-H1 i miR-H6, miRNA virusa koje su obilno izražena tijekom litičke i /ili latentne infekcije. U prethodnom istraživanju smo generirali virusnu mutantu koja ne eksprimira miRH1 i –H6 i preliminarni rezultati ukazuju na smanjenje patogenosti i smanjenu sposobnosti reaktivacije. U daljenjm radu ćemo uz pomoć bioinformatike i najsuvremenijih tehnika molekularne biologije utvrditi ciljne molekule ovih i drugih miRNAs , te odrediti njihovu ulogu u infekciji. Osim toga , kako bi omogućili primjenu visoko-protočnih tehnologija u proučavanju latencije, uspostaviti ćemo in vitro model HSV-1 latencije; koji temeljimo na našim prethodnim i preliminarnim istraživanjima u kojima smo karakterizirali ekspresiju HSV - 1 miRNAs u nekoliko takvih modela. Ovaj pristup također će nam omogućiti osjetljivo testiranje tzv. latentnog/litičkog prekidača i biokemijski pristup u proučavanju interakcije ncRNA-protein.Herpes simplex virus 1 (HSV-1) is an important human pathogen that causes a variety of diseases. However, in spite of intensive studies and remarkable discoveries, many fundamental aspects of the HSV-1 biology are unknown. Recently, with expansion of transcripome analyses, it become apparent that non-coding RNAs (ncRNA), including miRNAs and long ncRANs (lncRNA), have immense role in regulation of genes of animals, plants and viruses. We have discovered numerous miRNAs expressed by HSV-1, functions of which are mostly unknown. On the other hand, a few HSV-1 encoded lncRNAs have been discovered many years ago, including intensively studied latency associated transcript (LAT), but function of these remains largely elusive and not investigated. We hypothesize that miRNAs and other ncRNAs have a central role in virus gene regulation and efficient establishment of latency, particularly the control of the lytic-latent switch (reactivation from latency). We seek to determine the complete ncRNA transcriptome of HSV-1 and understand its roles in regulation of gene expression during lytic and latent HSV-1 infection. Our study is founded on preliminary data focusing on small set of miRNAs, i.e. functions of miR-H1 and miR-H6, HSV-1 miRNAs abundantly expressed during lytic infection and/or latent infection. We have generated the HSV-1 mutant with miR-H1/H6 locus deleted, and our results indicate that these miRNA are important for virus pathogenesis. Using bioinformatics and cutting-edge molecular biology techniques we will identify targets of this and other miRNAs and reveal their function in infection. Moreover, to enable high-throughput technologies in studying latency, we will establish an in vitro latency model. In preliminary attempts, we have characterized the expression of HSV-1 and host miRNAs in such models. This approach will also allow sensitive probing of the latent/lytic switch and biochemical approaches to study ncRNA-protein interactions.
2848Tranzicija i tradicija u špilji Vlakno: Model prijelaza paleolitika u mezolitik na području Sjeverne DalmacijeTransition and tradition in Vlakno cave: Modelling the Palaeolithic-Mesolithic transition in Northern Dalmatia499Dario Vujević UIP2014-09UIP-2014-09-1545Vlakno01.05.2015 - 30.04.2018Završio304.250,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Sveučilište u ZadruUniversity of Zadar2993, 12898, 12720, 6111, 2744, Barbara Cvitkušić, Mario Bodružić, Zlatko Perhoč, Mate Parica, Siniša Radović, Vlakno, paleolitik, mezolitik, epigravetijen, holocenVlakno, Palaeolithic, Mesolithic, Epigravettian, HoloceneProjekt „Tranzicija i tradicija u špilji Vlakno: Model prijelaza paleolitika u mezolitik na prostoru Sjeverne Dalmacije“ je nastavak interdisciplinarnih istraživanja paleolitičkog i mezolitičkog nalazišta Vlakno na Dugom otoku, kao i šireg područja samog otoka. Špilja Vlakno trenutno je jedino nalazište Sjeverne Dalmacije dostupno za proučavanje prijelaza paleolitika u mezolitik, kontinuiteta i diskontinuiteta naseljavanja prostora, kulture, te teritorijalne organizacije. Tijekom proteklih 10 godina istraživačke aktivnosti bile su inkorporirane u različite znanstvene projekte, a slijedeći cilj je dobiti dublji uvid u život i ponašanje prapovijesnih zajednica. Kombiniranjem terenskih istraživanja, kabinetskog rada i različitih analiza pokušat će se odrediti interakcija pećine s okolišem, s ciljem dobivanja podataka koji se mogu usporediti s drugim nalazištima jadranske obale. Nova istraživanja špilje Vlakno doprinijet će proučavanju gornjeg paleolitika i mezolitika Europe, na području koje je do sada bilo relativno slabo istraženo. Uz to Vlakno bi moglo poslužiti za izradu teorijskog modela prijelaza paleolitika u mezolitik, koji bi bio primjenjiv za šire područje.Predloženi projekt trebao bi obogatiti naše spoznaje o kulturi življenja i društvenim odnosima paleolitičkih i mezolitičkih zajednica. Pomoći će u definiranju načina na koji su ljudske zajednice mijenjale svoje ponašanje zbog globalnog zatopljenja, te predložiti teorijski i empirijski model prijelaza na drugačije klimatske i okolišne uvjete holocena. Projekt će pružiti važne informacije na temu naseljavanja i kretanja zajednica u jednom klimatski nestabilnom razdoblju.Project “Transition and tradition in Vlakno cave: Modelling the Palaeolithic-Mesolithic transition in Northern Dalmatia” will continue the interdisciplinary research of Palaeolithic and Mesolithic site of Vlakno on Dugi Otok. Vlakno cave is currently the only site in northern Dalmatia available for studying Palaeolithic/Mesolithic transition, continuity and discontinuity of settlement, Palaeolithic and Mesolithic culture, territorial organization, etc. Over the past 10 years research activities were incorporated in different scientific projects, but our primary objective is to get further insights into the way of life of prehistoric communities. Combination of field work, cabinet studies and analyses will be used to determine interaction of cave with environment in order to obtain data comparable with other sites on the Adriatic coast. New research of Vlakno cave will contribute new data to the study of the European Upper Palaeolithic and Mesolithic from a relatively understudied area. Also Vlakno cave could set a theoretical model of Paleolithic-Mesolithic transition, applicable to a wider area. The proposed project should significantly enrich the knowledge on the culture of living and social relations of Palaeolithic/Mesolithic communities. It will help define the ways in which humans modified their behaviour in response to global warming and sea-level rise and propose stronger theoretical and empirical model of transition to different climatic and environmental conditions of Holocene. Project will also provide important information on Adriatic human settlement and migration patterns during this climatically unstable period.
2872Generalizirana geometrija i simetrijeGeneralized Geometry and Symmetries52Larisa Jonke IP2014-09IP-2014-09-3258GGSymm01.09.2015 - 30.09.2019U tijeku596.000,00 KnPrirodne znanostiNatural sciencesFizika, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb5035, 5014, 471, 22491, 24502, 25067, 25315, Athanasios Chatzistavrakidis, Ivan Andrić, Danijel Jurman, Clay James Grewcoe, Fech Scen Khoo, Grgur Šimunić, Georgios Karagiannis, generalizirana kompleksna geometrija, nekomutativna geometrija, baždarne teorije, matrični modeli, fuzzy prostorirgeneralized complex geometry, non-commutative geometry, gauge theory, matrix models, fuzzy spacesUjedinjenje Einsteinove teorije opće relativnosti s kvantnom fizikom predstavlja jedan od najvećih izazova moderne teorijske fizike. Jedna pretpostavka zajednička svim istraživačkim smjerovima usmjerenih ka razumijevanja kvantne teorije gravitacije jest da za opis geometrije prostor-vremena nije dostatna klasična slika prostor-vremena kao diferencijabilne mnogostrukosti. U okviru ovog projekta smo zainteresirani za generalizirane geometrije motivirane fizikom teorije struna; generalizirana kompleksna geometrija i nekomutativna geometrija. Naš cilj jest bolje razumijevanje kako spomenute ideje generalizirane geometrije iskoristiti u generalizaciji načela simetrije. Konkretno, zainteresirani smo za proširenje baždarnog principa, ključne ideje koji se koristi u fizici za opis svih (poznatih) međudjelovanja materije, a u svjetlu ovih proširenja klasične geometrije. Želimo opisati učinke dualnosti u teoriji struna, nekomutativne baždarne teorije te viših baždarnih teorija u okviru učinkovne teorija polja koja nam je potrebne za obavljanje pouzdanih izračuna koje je moguće eksperimentalno provjeriti. Očekujemo da će nam geometrizacija ovih poopćenih simetrija pružiti, u dugogodišnjoj perspektivi, konzistentan okvir unutar kojeg bi se mogla riješiti neka od otvorenih pitanja u kozmologiji i fizici crnih rupa.The unification of Einstein's theory of general relativity with quantum physics represents one of the greatest challenges of modern theoretical physics. A hypothesis common to all research directions aiming at understanding the quantum theory of gravity is that our description of space-time geometry has to go beyond the classical picture of space-time as a differentiable manifold. Within this project we are interested in generalized concepts of geometry, physically motivated by string theory: generalized complex geometry and non-commutative geometry. We aim at improving our understanding on how these generalized notions of geometry could be utilized to obtain consistent extensions of symmetry principles. In particular, we are interested in extending the gauge principle, the key physical notion used to describe all (known) matter interactions, in view of the above generalizations of classical geometry. Our goal is to capture the effects of string duality symmetries, non-commutative gauge theory and higher gauge theories at the level of the effective field theory description, which is necessary in order to perform reliable calculations and yield experimentally testable predictions. We expect that geometrizing these generalized symmetries would provide us, as a long-term perspective, with a consistent framework within which one could address open issues in cosmology and black-hole physics.
2873Supramolekulska kontrola fotokemijskih reakcija eliminacijeSupramolecular control of photoeliminations376Nikola Basaric IP2014-09IP-2014-09-6312SupraPhotoE01.06.2015 - 31.08.2019Završio922.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb698, 3215, 2992, 3336, 2988, 2916, 3493, 3001, 566, 647, 1205, 20718, 22515, 22526, 24377, Kata Majerski, Marija Alešković, Tatjana Šumanovac Ramljak, Margareta Sohora, Marina Šekutor, Vesna Blažek Bregović, Đani Škalamera, Leo Mandić, Ivana Antol, Lidija Uzelac, Iva Dzeba, Matija Sambol, Matej Cindrić, Antonija Husak, Katarina Zlatić, fotokemija, supramolekulska kemija, karbeni, policikličke molekule, ftalimidi, kinon-metidi,photochemistry, supramolecular chemistry, carbenes, polycyclic molecules, phthalimides, quinone methidesDinamika supramolekulskih sustava omogućava kontrolu fotokemijske reaktivnosti i otvara mogućnosti za reakcije koje se konvencionalnim postupcima sinteze, termičkim reakcijama u izotropnoj otopini ne mogu provesti. Glavna strategija predloženog projekta je primijeniti različite supramolekulske sustave za kontrolu fotokemijske reaktivnosti. Očekuje se da će predloženo istraživanjo povećati fundamentalna znanja iz supramolekulske kemije, fotofizike i fotokemije policikličkih molekula u izotropnim medijima i supramolekulskim kompleksima. Istraživanje će biti usmjereno na tri reakcije fotoeliminacije: eliminaciju dušika iz diazirina i diazo prekursora uz nastajanje karbena, fotodekarboksilaciju različitih derivata aktiviranih s ftalimidnim kromoforom i fotodehidrataciju i deaminaciju kojom nastaju kinon-metidni intermedijeri. Aspekti kojima ćemo se baviti su učinak molekulske geometrije na reaktivnost i konstantu stabilnosti inkluzijskih kompleksa, kao i utjecaj kompleksiranja na fotofizička svojstva različitih kromofora, učinkovitost fotokemijskih reakcija i raspodjelu produkata. U vezi s predloženim istraživanjem bit će neophodno provesti sintezu velikog broja molekula, dobro definirane i u nekim slučajevima i iznimno složene strukture, što će sigurno zahtijevati značajne inovacije u sintetskoj metodologiji i razvoju postojećih tehnika. Znanstveni ciljevi projekta će ići dalje od trenutnih spoznaja kroz potragu za bio-medicinskim primjenama. Nizu spojeva će biti ispitana antiproliferativna aktivnost, pri čemu će se odrediti ''lead'' spojevi za daljnja istraživanja i potencijalni razvoj liječenja raka uz minimalne nuspojave.Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity. The proposed research should increase the fundamental knowledge in supramolecular chemistry, photophysics and photochemistry of the polycyclic molecules in isotropic media and the supramolecular complexes. The research will be focused on three photoelimination reactions: extrusion of nitrogen from diazirines and diazo precursors (giving carbenes), photodecarboxylation of different derivatives activated by phthalimides, and photodehydration and photodeamination giving quinone methide intermediates. The aspects which we will address include the effects of molecular geometry on reactivity and stability constants of the inclusion complexes, as well as influence of the complexation on the photophysical properties of different chromophores, efficiency of the photochemical reactions and product distribution. In connection with the proposed investigations it will be necessary to synthesize a large number of well defined and in some cases extremely complex molecules which will certainly ask for substantial innovations in the synthetic methodology and development of the existing techniques. The scientific goals of the project will go beyond the state of the art and search for bio-medical applications. A series of compounds will be screened for antiproliferative activity, providing lead molecules for further research and potential development of cancer treatment with minimal side effects.
2875Uloga oksidativnog stresa i opiorfina u temporomandibularnim poremećajimaThe role of oxidative stress and opiorphin in temporomandibular disorders 612Iva Alajbeg IP2014-09IP-2014-09-3070ROStrO-TMD01.10.2015 - 30.09.2019Završio873.225,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesDentalna medicina, Kliničke medicinske znanosti, Temeljne medicinske znanosti, Dental medicine, Basic Medical Sciences, Clinical sciences, Sveučilište u Zagrebu, Stomatološki fakultetUniversity of Zagreb, Faculty of Dentistry6409, 6340, 5987, 3288, 4284, 3378, 5175, 6162, 21042, 24296, Tomislav Badel, Dubravka Knezović Zlatarić, Ivan Alajbeg, Dunja Rogić, Dijana Zadravec, Lea Vuletić, Ana Andabak Rogulj, Maja Sabalić, Ema Vrbanović, Ivana Lapić, temporomandibularni poremećaji, oksidativni stres, opiorfin, orofacijalna bol, ELISA, HPLC MS, slinatemporomandibular disorders, oxidative stress, opiorphin, orofacial pain, ELISA, HPLC MS, salivaTemporomandibularni poremećaji (TMP) kronični su bolni poremećaji koji zahvaćaju čeljusni zglob, žvačne mišiće i okolna tkiva, s prevalencijom u populaciji od 3,6 do 7%. Patološki supstrat uglavnom izostaje, a uzrok je često nepoznat. Psihološki i mehanički stresni čimbenici mogu doprinijeti nastanku oksidativnog stresa (OS) i rezultirati TMP-om.Cilj je kvantificirati markere OS, totalni antioksidativni kapacitet (TAK) te nedavno izolirani endogeni peptid opiorfin (OP) u slini pacijenata s TMP-om i usporediti ih s kontrolnom skupinom. Kako kronična izloženost stresu može uzrokovati hiperalgeziju koja nastaje kao posljedica odgovora na stres u hipotalamičko-hipofizno-adrenalnoj (HHA) osi, cilj je istražiti ovaj mehanizam uspoređujući OP i markere OS s razinom salivarnog kortizola (SK).Hipoteze: OS ima ulogu u nastanku i održavanju TMP-a, stoga će markeri OS u slini rasti i/ili će se TAK smanjiti; opiorfin utječe na orofacijalne bolne sindrome kao što je TMP i njegove vrijednosti u slini će se razlikovati između bolesnika s TMP-om i kontrole. Poremećena HHA osovina je u podlozi povećanog OS i promjena razina OP u bolesnika s TMP-om.U 50 bolesnika s TMP-om (dijagnosticiranih pomoću kriterija i MRI nalaza) i 50 kontrolnih ispitanika sakupit će se slina. Za određivanje markera OS koristit će se ELISA sa spektrofotometrijom. Razine OP mjerit će se HPLC-MS/MS metodom koju smo sami razvili. Za određivanje SK koristit će se elektrokemiluminiscentna imunokemijska metoda s prethodnom ekstrakcijom.Pacijenti s TMP-om će biti randomizirani u 2 skupine (1:stabilizacijska udlaga + placebo tablete; 2:placebo udlaga + 1g vitamina C). Mjerenja će se ponoviti nakon 3 i 6 mjeseci. Praćenje OP, OS markera i SK tijekom tog razdoblja će, ovisno o promjenama simptoma TMP-a, dodatno rasvijetliti predloženi podliježeći mehanizam. Novi pristup u objašnjavanja neuroendokrinih mehanizama u TMP-u i uporaba sline kao neinvazivno pristupačne dijagnostičke tekućine predstavlja značajan napredak. Temporomandibular disorders (TMD) are chronic painful conditions involving joints, masticatory muscles and associated tissues that affect 3.6-7% of the population. Observable pathology is mostly absent, and the cause is unknown. Psychological and mechanical stress factors could contribute to oxidative stress (OS) and lead to TMD. Aims are to quantify salivary OS markers and total antioxidant capacity (TAC) and to quantify recently isolated endogenous peptide opiorphin (OP) in saliva of TMD patients and compare them to controls. As chronic exposure to stress may cause hyperalgesia as a result of the stress response in the hypothalamic-pituitary-adrenal (HPA) axis, aim is to test this as an underlying mechanism by correlating OP and OS markers to salivary cortisol (SC) levels. Hypotheses: OS has a role in TMD onset and maintenance, thus salivary markers of OS will increase and/or TAC will decrease; OP influences orofacial pain syndromes, such as TMD, and its salivary level will differ between TMD patients and controls. Disbalanced HPA axis underlies the increase of OS and OP level changes in TMD patients.Saliva of 50 TMD patients (diagnosed by validated diagnostic criteria and MRI) and 50 controls will be collected. OS markers will be assessed by ELISA with spectrophotometric detection and by spectrophotometric reagent kits. OP levels will be measured by HPLC-MS/MS method, developed by team members. The electrochemiluminescence immunoassay ECLIA will be used for measuring SC.TMD patients will be randomized in 2 treatment groups (1:stabilization splint + placebo pills; 2:placebo splint + 1g of vitamin C). Measurements will be repeated after 3 and 6 months of treatment. Monitoring of OP, OS markers and SC during that period will, in relation to TMD symptoms changes, further elucidate underlying proposed mechanism.Novel approach to understanding neuroendocrine mechanisms in TMD and use of saliva as non-invasively available biofluid represent significant advances.
2877Utjecaj magnetske anizotropije na kvantne spinske sustaveInfluence of Magnetic Anisotropy on Quantum Spin Systems11197Mirta Herak UIP2014-09UIP-2014-09-9775IMAQSS01.06.2015 - 15.09.2018Završio750.000,00 KnPrirodne znanostiNatural sciencesFizika, Kemija, Physics, Chemistry, Institut za fizikuInstitute of Physics in Zagreb2647, 12486, 4406, 21233, 2873, Dijana Žilić, Ivana Levatić, Zoran Džolić, Martina Dragičević, Nikolina Novosel, Kvantni spinski sustavi, niskodimenzionalni magneti, magnetska anizotropija, torque magnetometrija, elektronska spinska rezonancijaQuantum spin systems, low-dimensional magnets, magnetic anisotropy, torque magnetometry, esr spectroscopyProučavanje magnetskih materijala donijelo nam je razumijevanje mnogih fizikalnih pojava te doprinijelo razvoju novih tehnologija. Magnetizam je kvantna pojava koja dolazi od interakcija superizmjene među magnetskim momentima u materijalu. Razumijevanje utjecaja tih interakcija na formiranje materijala sa specifičnim magnetskim svojstvima jedan je od glavnih problema u znanosti o materijalima. U niskodimenzionalnim kvantnim spinskim sustavima interakcije među spinovima su često opisane izotropnim Heisenbergovim hamiltonijanom. Eksperimentalni rezultati ukazuju na važnost slabih anizotropnih interakcija te zahtijevaju nova teorijska istraživanja. Te interakcije induciraju nove zanimljive pojave s velikim potencijalom za primjenu te je nalaženje novih metoda osjetljivih na njihovu detekciju od velike važnosti.Cilj ovog projekta je eksperimentalno istraživanje utjecaja magnetske anizotropije na odabrane kvantne spinske sustave kombinacijom dviju iznimno osjetljivih tehnika: torque magnetometrije i spektroskopske metode elektronske spinske rezonancije (ESR). Istraživat ćemo uzorke čiji magnetizam dolazi od spinova S=1/2, a koji se mogu klasificirati kao male spinske nakupine, kvazi-jednodimenzionalni Heisenbergovi antiferomagneti i/ili magnetoelektrici. Kombinacija spomenutih tehnika dat će novu metodologiju za istraživanje utjecaja magnetske anizotropije na kvantne spinske sustave i druge magnetske materijale te doprinijeti razumijevanju pojava induciranih magnetskom anizotropijom.U ovom projektu ostvarit će se suradnja između fizičara i kemičara sa svrhom sinteze novih visokokvalitetnih magnetskih materijala. Istraživanja će biti fokusirana na te materijale i na uzorke dobivene iz inozemnih ekspertnih laboratorija. Glavni cilj ovog projekta je formiranje nove istraživačke grupe s ekspertizom u istraživanju pojava induciranih anizotropijom u novim magnetskim materijalima.Study of magnetic materials provides us with understanding many of physical phenomena and continues to provide us with new technologies. Magnetism is a quantum phenomenon emerging from the superexchange interactions between magnetic moments in the material. Understanding how these interactions bring forth a material with specific magnetic properties is one of the key questions in materials science. In low-dimensional quantum spin systems the interactions between the spins are often described by the isotropic Heisenberg Hamiltonian. The importance of weak anisotropic interactions emerges from experiments and requires new theoretical treatments. These interactions are found to induce new interesting phenomena with great potential for applications in emerging technologies. Exploiting new methods sensitive to these interactions is thus crucial. Aim of this project is to experimentally investigate the influence of magnetic anisotropy on chosen quantum spin systems by combining two highly sensitive techniques: torque magnetometry and electron spin resonance (ESR) spectroscopy. Our study is focused on samples with magnetism coming from electron spin S=1/2, which can be classified as weakly interacting small spin clusters, quasi one-dimensional Heisenberg antiferromagnets and/or magnetoelectrics. The combination of mentioned techniques allows a new methodology for investigation of the influence of magnetic anisotropy on quantum spin systems and other magnetic materials and will provide important input in understanding of anisotropy induced phenomena.Within this project a collaboration between physicists and a chemist will be established with the purpose of synthesising new high-quality magnetic materials. Our study will focus on these materials, and on samples synthesized in expert laboratories abroad. The main aim of this project is to form a new independent research group highly qualified to investigate the anisotropy induced phenomena in new promising magnetic materials.
2881Istraživanje bioaktivnih spojeva iz dalmatinskog bilja: njihov antioksidacijski karakter i utjecaj na enzimsku inhibiciju i zdravljeInvestigation of bioactive compounds from Dalmatian plants: their antioxidant, enzyme inhibition and health properties11165Mladen Miloš IP2014-09IP-2014-09-6897BioActCom01.09.2015 - 31.08.2019U tijeku790.000,00 KnPrirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, Natural sciences, Biotechnical sciences, Biomedicine and health sciences, Kemija, Biologija, Farmacija, Nutricionizam, Prehrambena tehnologija, Chemistry, Biology, Food technology, Nutrition, Pharmaceutical sciences, Sveučilište u Splitu, Kemijsko-tehnološki fakultetUniversity of Split, Faculty of chemistry and technology5297, 11213, 4634, 1227, 250, 100, 3823, 11269, 11267, 11168, 11169, Višnja Katalinić, Olivera Politeo, Mila Radan, Vida Šimat, Ivana Generalić Mekinić, Franko Burčul, Danijela Skroza, Ivana Carev, Maja Marasović, Safija Herenda, Jelena Ostojić, bioaktivni spojevi, inhibitori enzima, antioksidansi, oksidacijski stres, dalmatinsko biljebioactive compounds, enzyme inhibitors, antioxidants, oxidative stress, Dalmatian plants Reaktivni kisikovi spojevi (ROS), koji u živim stanicama nastaju tijekom prirodnih procesa aerobnog metabolizma, mogu znatno oštetiti vitalne makromolekule i promijeniti njihove funkcije. Kao rezultat oksidacijskog stresa i inhibicije pojedinih enzima, povećana je mogućnost nastanka kroničnih bolesti kao što su rak, ateroskleroza, neurodegenerativne bolesti, dijabetes itd. U živim organizmima razvijen je visoko sofisticirani i složeni sustav antioksidacijske zaštite, koji interaktivno i sinergijski neutralizira loš utjecaj ROS spojeva. Predloženi projekt treba skrenuti pozornost na činjenicu da dalmatinsko samoniklo bilje obiluje biološki aktivnim spojevima koje bi se moglo koristiti za prevenciju oksidacijskog stresa i liječenje različitih oboljenja. Identifikacija novih antioksidansa i inhibitora enzimskih aktivnosti mogla naći primjenu u prehrambenoj i farmaceutskoj industriji za pripremu zdrave hrane i prirodnih lijekova za sprječavanje štetnih oksidacijskih procesa.Reactive oxygen species (ROS), which are generated during the natural process of aerobic metabolism in living cells, can significantly damage their vital macromolecules and change functions. As a result of oxidative stress and inhibition of certain enzyme activities, it has increased the possibility of occurrence of chronic diseases such as cancers, atherosclerosis, neurodegenerative diseases, diabetes, etc. To protect the cells and organs of the body against ROS, human organisms have evolved a highly sophisticated and complex antioxidant protection system which involves a variety of components that interactively and synergistically could neutralize their bad influence. Identification of new antioxidant and inhibitor of the enzyme activities from Dalmatian plants could find application in the food and pharmaceutical industry for preparing healthy foods and natural remedies to prevent harmful oxidation processes.
2886Molekularna, epidemiolološka i klinička obilježja zaraze HIV-om u HrvatskojMolecular, epidemiological and clinical features of HIV infection in Croatia1084Josip Begovac IP2014-09IP-2014-09-4461MEKHH/MECHC01.10.2015 - 31.12.2019Završio955.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesKliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, Clinical sciences, Basic Medical Sciences, Public health and health services, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine1082, 12514, 1093, 4080, 12478, 1085, 1161, 3952, 3951, Klaudija Višković, George Rutherford, Šime Zekan, Snježana Židovec Lepej, Ana Planinić, Drago Turčinov, MARTA PEROVIĆ MIHANOVIĆ, Lana Gorenec, Ivana Grgić, HIV, AIDS, supklinička ateroskleroza, podtipovi HIV-a, rezistancija, antiretrovirusni lijekovi, preživljenjeHIV. AIDS, subclinical atherosclerosis, HIV subtypes, resistance, antiretrovirals, survivalHrvatska ima centraliziranu skrb za osobe zaražene HIV-om, svi bolesnici se liječe u Klinici za infektivne bolesti u Zagrebu. Opći cilj projekta je nastaviti dugotrajno prikupljati kliničke, molekularne, laboratorijske i terapijske podatke u skupini bolesnika zaraženih HIV-om iz Hrvatske te: (1) procijeniti čimbenike u svezi s kliničkim, imunološkim i virusološkim tijekom zaraze HIV-om i (2) nastaviti razvijati sustav molekularnog nadzora uz definiranje promejna koje se tijekom vremena događaju u zarazi HIV-om u Hrvatskoj. Opći istraživanja uključuje prospektivno istraživanje demografskih, kliničkih, terapijskih, virusoloških i laboratorijskih podatke u osoba zaraženih HIV-om u Hrvatskoj, u svrhu određivanja dugotrajnog virusološkog, imunološkog i kliničkog ishoda kao i trendove u molekularnoj epidemiologiji zaraze HIV-om. Specifični ciljevi istraživanja uključuju također: procjenu nazočnosti supkliničke ateroskleroze u bolesnika zaraženih HIV-om koji primaju ART te ispitanika koji nisu zaraženi HIV-om, analizirati učinak prehtrambenih navika, posebno mediteranske prehrane na supkliničku aterosklerozu, odrediti učestalost subtipova HIV-a u novodijagnosticiranih bolesnika koji su se uključili u kliničku skrb u razdoblju od 2014 do 2017.g., analizirati transmisijske klastere subtipa B i non-B subtipova HIV-a, te odrediti prevalenciju i obrasce mutacija povezanih s primarnom rezistencijom HIV-a na lijekove. U istraživanje će se uključiti sve osobe koje se liječe u KIB, a dale su pismenu privolu za istraživanje. Uključiti će se osobe koje su bile u skrbi u razdoblju 1997 do 2017. Procjenjuje se da će ukupno 700-800 osoba biti uključeno u analize. Očekujemo da će rezultati ovog projekta doprinijeti unaprjeđivanju kvalitete skrbi bolesnika zaraženih HIV-om kao i razvoju strategija uspješnije prevencije zaraze HIV-om.Croatia as a centralized system of care and all HIV infected persons are treated at the University Hospital of Infectious Diseases (UHID) in Zagreb. ln general terms, the objective of the project s to continue a long-term, prospective collection of biomolecular, clinical, laboratory and therapeutic data on a cohort of HIV infected patients from Croatia in order to (1) assess the factors associated with the clinical, immunological and virological course of HIV infection and (2) continue to provide and develop a molecular surveillance system to describe temporal changes of HIV-infection in in Croatia. The primary aim is to determine the long-term virological, immunological and clinical outcome as well as trends in the molecular epidemiology of HIV infection. We will also specifically address issues such as: subclinical atherosclerosis in both HIV-infected patients taking ART and non-HIV-infected participants; the influence of food habits, specifically adherence to the Mediterranean diet on subclinical atherosclerosis; the frequency of HIV subtypes among newly-diagnosed patients entering clinical care in the period 2014-2017; transmission clusters of B and non-B subtypes; prevalence and patterns of transmitted drug resistance (TDR) to different classes of antiretroviral drug resistance in newly-diagnosed HIV-infected persons in the period 2014-2017 with the impact of transmission clusters on the prevalence of TDR. The study population will include all patients in care at UHID who provided written consent. Patient eligible for analysis were or will be seen in care at UHID from 1997 to 2017. It is estimated that a total of about 700-800 will be included into the analyses. The results of this project are expected to significantly contribute to the improvement of HIV clinical care as well as to the development of improved strategies for prevention of HIV infection.
2887Životne strategije fitoplanktona u sjevernom JadranuPhytoplankton lifestrategies in the northern Adriatic3476Martin Pfannkuchen UIP2014-09UIP-2014-09-6563P-limit30.09.2015 - 29.09.2018Završio999.900,00 KnPrirodne znanostiNatural sciencesBiologija, Kemija, Biology, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb465, 547, 4424, 5284, 81, 543, 390, Ingrid Ivančić, Emina Pustijanac, Daniela Maric Pfannkuchen, Grozdan Kušpilić, Blaženka Gašparović, Mirta Smodlaka Tanković, Ana Baričević, Fitoplankton, aktivnost alkalina fosfatasa, sjeverni jadran, fosfat limitacija, životna strategijaPhytoplankton, alkaline phosphatase activity, northern Adriatic, phosphate limitation, life strategyU plitkim morima jednostanični organizmi su ključni za funkcioniranje ekosustava. Budući da je rast tih organizama uglavnom ograničen dostupnošću anorganskog dušika i fosfora, indukcijom ekstracelularnih enzima oni mogu koristiti organsku tvar kao izvor tih elementa. Mjerenja ukupne enzimatske aktivnosti su dobar pokazatelj metaboličke aktivnosti planktnonskih zajednica. Međutim da bi se shvatilo funkcioniranje ekosustava u cijelini, te kako planktonske zajednice reagiraju na prirodne promjene i antropogeni pritisak potrebno je poznavati odgovore na razini pojedine vrste unutar zajednice. Ta saznanja bi značajno doprinijela razumijevanju kako pojedine vrste utječu na funkcioniranje zajednice. Do sada takva detaljna istraživanja nisu sistematski provedena. Zbog neuravnoteženog slatkovodnog unosa hranjivih soli područje je uglavnom P limitirano. Stoga fitoplankton na tom području mora razviti strategije snalaženja da bi uspješno kompetirao za za taj element. Naša preliminarna istraživanja su pokazala da mikrofitoplankton može razviti čitav niz mehanizama prilagodbe da bi uspijevao u izrazito promjenjivoj dostupnosti hranjivih soli i uglavnom P limitiranim uvjetima. Cilj ovog projekta bio bi shvatiti metabolizam na nivou vrste te istražiti strategije koje omogućavaju najvažnijim vrstama da uspjevaju u kompleksnim uvjetima okoline. SJ je podesan za takva istraživanja jer na tom području postoje dugoročni podaci o oceanografskim i trofičkim uvjetima. Istraživanja bi bila usredotočena na mikrofitoplankton budući da je po biomasi to dominantna grupa fitoplanktonske zajednice. Osim toga njegovo je taksonomsko određivanje dobro uhodano, a metode dostupne našoj istraživačkoj grupi. Skup modernih i klasičnih metoda razvijenih i kombiniranih u ovom projektu značajno će doprinijeti napretku u ekološkim istraživanjima, kao i u klasičnom sustavu praćenja ekosustava.Unicellular organisms are the driving forces in shallow pelagic ecosystem functioning. Measurement of bulk enzymatic activity in water samples is a good proxy for the metabolic activity of planktonic communities. However the basis to understand how such ecosystems function and how planktonic communities react on natural and anthropogenic changes is detailed knowledge on how each functional unit (species) of the plankton community functions. Such knowledge will allow to understand how each component (species) contributes to the bulk community functioning and more important how changes in ecological conditions will change the community structure and subsequently the ecosystems functioning. So far such detailed analyses are not systematically undertaken. In this project we will achieve species resolution in metabolic analysis and understand the respective lifestrategies that make the most prominent phytoplankton species successful competitors in the P-limited system of the northern Adriatic (NA). We chose the NA as a well investigated and understood marine shallow ecosystem. This project investigates the metabolic adaptations to P-limitation as they are the most prominent adaptation in the NA. We will concentrate our investigations on microphytoplankton as it is taxonomically well defined and accesible to our research teams expertise and range of methods and as our preliminary results show the microphytoplankton to be the dominating component of the plankton community in the NA. Our preliminary research did uncover a variety of mechanisms that allow microphytoplankton to thrive in steep ecological gradients and generally P-limited conditions. A combination of modern and classical methodologies (ecology, oceanography, cell biology, advanced microscopy, taxonomy, phylogenetic analysis, molecular biology, biochemistry) as well as a comprehensive ecological (long term) database for the region will allow us to uncover the complex set of microphytoplankton lifestrategies.
2891Sklerokronologija kao alat za otkrivanje dugoročnih okolišnih promjena u JadranuSclerochronology as a tool for detecting long-term Adriatic environmental changes667Melita Peharda Uljević IP2014-09IP-2014-09-5747SCOOL01.06.2015 - 31.05.2019Završio880.150,00 KnPrirodne znanostiNatural sciencesBiologija, Geofizika, Geologija, Kemija, Biology, Chemistry, Geology, Geophysics, Institut za oceanografiju i ribarstvoInstitute of Oceanography and Fisheries195, 829, 670, 5215, 3031, 3525, 2530, 7600, 5837, 25078, Ivica Vilibić, Jadranka Šepić, Daria Ezgeta Balić, Krešimir Markulin, Žarko Kovač, Hrvoje Mihanović, Sanja Puljas, Miroslav Gacic, Ivan Župan, Hana Uvanović, klimatske promjene, sklerokronologija, Bivalvia, dinamička svojstva mora, ekologija moraclimate change, sclerochronology, Bivalvia, ocean dynamics, marine ecologyKlimatske promjene predstavljaju rastući problem sa aspekta okoliša, znanosti kao gospodarstva. Iako smo svjesni određenih promjena koje se događaju naše poznavanje njihovog porijekla i posljedica još uvijek je jako ograničeno. Dugoročni nizovi podataka su ključ za razumijevanje takvih promjena i čvrste strukture morskih organizama, uključujući ljušture školjkaša, predstavljaju važan arhiv podataka o okoliš koji potencionalno seže dekade ili čak stoljeća u prošlost. Sklerokonologija je novo interdisciplinarno područje znanosti koje omogućava dobivanje podataka o morskom okolišu iz strukturalnih elementa školjkaša i njihovog geokemijskog sastava. Takvi podatci su od velikog značaja za razumijevanje procesa na nivou ekosustava u morskom okolišu kao i njihovih odgovora na klimatske promjene.Motivacija i cilj ovog projekta jest je da primjenom recentnih sklerokronoloških metoda izgradimo kronologije za tri relativno dugo živuće vrste školjkaša (životni vijek oko pola stoljeća), koje obitavaju u istočnom Jadranu. Ciljane vrste uključuju školjkaše Glycymeris glycymeris, G. bimaculata i Callista chione. Kronologije će biti paralelno analizirane sa dugoročnim in situ podatcima kao i modeliranjem klimatoloških i oceanografskih parametara, sa ciljem kvantificiranje utjecaja okoliša na rast školjkaša. Nadalje, oceanografski podatci će se primijeniti za opisivanje dinamike oceana i procesa koji se odvijaju na višegodišnjim i dekadskim vremenskim skalama u Jadranko-Jonskom bazenu i koji su važni za rast svih morskih organizama. Projekt se razvija iz dvije nezavisne teme, sklerokronologije i fizičke oceanografije (znanosti o okolišu), koje se spajaju na interdisciplinarni način u kasnijim fazama implementacije projekta. Stoga je predloženi projekt izuzetno interdisciplinaran, dok je projektni tim transnacionalan. Climate change is a growing environmental, scientific as well as economic issue. However, although we are aware of certain changes our understanding of their origin and consequences is still very limited. Long-term data series are a key to this understanding and hard structures of marine organisms, including bivalve shells, present an important archive of environmental data potentially extending decades or even centuries into the past. Sclerochronology is an emerging interdisciplinary field that enables obtaining of marine environmental data from bivalve shell structural elements as well as their geochemical composition. These data are of great importance for understanding of the marine ecosystem-level process and responses to climate variability.Our motivation for the project is, by applying modern sclerochronological methods, to construct chronologies for three relatively long-lived bivalve species (longevity about half-century), living in the eastern Adriatic Sea. Target organisms include dog cockles Glycymeris glycymeris and G. bimaculata, and a smooth clam Callista chione. These chronologies will be analysed in parallel with long-term in situ and climate model oceanographic data, in order to quantify environmental effect on the bivalve growth. Further on, the oceanographic data will be used for portraying of ocean dynamics and processes that occur over interannual and decadal timescales in the Adriatic-Ionian basin and are important for growth of all marine organisms. The project will grow from two relatively independent topics, sclerochronology and ocean physical (environmental) sciences, merging them in an interdisciplinary manner in the later stage of the project execution. The project is highly interdisciplinary, while the project team is transnational.
2892Razvoj metodološkog okvira za rješavanje strateških problema u visokom obrazovanju – primjer implementacije otvorenog učenja i učenja na daljinuDevelopment of methodology and tools for multicriteria decision making in HE- case study of open and distant learning implementation12508Blazenka Divjak IP2014-09IP-2014-09-7854HigherDecision01.06.2015 - 31.05.2019Završio583.377,48 KnDruštvene znanosti, Prirodne znanosti, Tehničke znanosti, Social sciences, Natural sciences, Technological sciences, Informacijske i komunikacijske znanosti, Matematika, Računarstvo, Information and communication sciences, Computer sciences, Mathematics, Sveučilište u Zagrebu, Fakultet organizacije i informatikeUniversity of Zagreb, Faculty of Organization and Informatics12509, 12516, 12523, 5642, 12531, 12521, 12527, 12583, 12591, 121, 7751, 13731, 12590, 6087, 21076, 25090, Nina Begičević Ređep, Marcel Maretić, Katarina Pažur Aničić, Ivanka Đeri, Vjeran Strahonja, Nikola Kadoić, Sanjana Buć, Valentina Đurek, Tihomir Hunjak, Maja Ćukušić, Andrina Granić, Sandra Kučina Softić, Valentina Kirinić, Ana Ćorić Samardžija, Antonia Bralic, Mišo Džeko, odlučivanje, e-učenje, otvoreno učenje i učenje na daljinu, visoko obrazovanje, e-spremnost, procjena rizika, kauzalnost, AHPdecision making, e-learning, open and distant learning, higher education, e-readiness, risk assessment, portfolio, causality, AHPVisoko obrazovanje (VO) ima ključnu ulogu u razvoju ljudskih potencijala te u gospodarskom i društvenom razvoju. Stoga, donošenje odluka i praćenje njihove primjene u visokom obrazovanju postaje prvorazredno istraživačko i razvojno pitanje. Primarni istraživački cilj ovog projekta je razvoj cjelovite metodologije donošenja strateške odluke i praćenja njezine provedbe u VO. U svijetu se broj korisnika online edukacije rapidno povećava, a postoje i brojna izvješća koja govore o digitalnoj spremnosti te upotrebi informacijsko-komunikacijske tehnologije (IKT) u VO. Dvije osnovne komponente projekta:1. Razvoj metodološkog okvira donošenja strateških odluka u VO i praćenje njihove provedbe. 2. Primjena, prilagodba i provjera dane metodologije na primjeru implementacije odluke o uvođenju otvorenog učenja i učenja na daljinu.Istraživanje je interdisciplinarno i povezuje društveno područje (višekriterijsko odlučivanje, IKT, strateško planiranje) i matematiku (matematičko modeliranje, kvantitativne metode u odlučivanju, kauzalne modele i teoriju grafova). Istraživanje rješavanja strateških problema provodimo kroz ciklus strateškog odlučivanja u četiri faze: (1) prepoznavanje i istraživanje problema - identificirat će se i unaprijediti metodologije kao što su procjena spremnosti i difuzija inovacija.(2) razvoj metodologije odlučivanja i donošenja odluke - istražit će se primjena i unapređenje metodologije višekriterijske analize odluka u VO.(3) provedba i praćenje strateške odluke - identificirati će se ključni faktori koji utječu na uspješnost provedbe strateške odluke i njihove međuzavisnosti i razviti model za mjerenje zrelosti i uspješnosti implementacije strateških odluka u VO.(4) evaluacija učinaka provedbe odluke - istražit će se mogući pristupi, a posebno evaluacija upotrebom strukturalne teorije kauzalnosti. Higher education’s (HE) key mission is to develop human potential with beneficial effects for the social and economic development. HE as a system, along with HE institutions, must be innovative and strategically managed to be able to fulfill their mission. Therefore, the decision making accompanied by evaluation of its implementation in higher education is an issue of highest priority. Primary goal of this research proposal is to develop a complete methodology for strategic decision making and the monitoring of its implementation in HE. The enrollment rate within online education has skyrocketed worldwide and there are a number of reports on e-readiness and ICT use in HE. Two basic components of the project:1. Development of methodological framework for strategic decision making in HE and monitoring of its implementation. 2. Application, adjustment and evaluation of the methodology on the example of decision implementation on e-learning and distance learning.This is an interdisciplinary project connecting Social Sciences (ICT, multicriteria decision making, strategic planning) and Mathematics (mathematical modeling, quantitative methods in decision making, structural causal models and graph theory).The research is structured as a cycle of strategic decision making with four phases:(1) Intelligence - problem identification and research, advancement of methodologies such as readiness assessment, diffusion of innovation etc.(2) Design of methodology - design of decision making methodology and decision making, improvement of multicriteria decision analysis in HE.(3) Implementation and monitoring - research and identification of key factors that determine effectiveness of strategic decision, their correlation, design of measuring model for maturity and effectiveness of strategic decision implementation in HE(4) Evaluation - survey possible approaches and evaluation by application of J. Pearl’s structural causal models for identification of effects of strategic decision.
2899Procesi u morskoj mikrobnoj hranidbenoj mreži u perspektivi globalnog zatopljenjaMarine microbial food web processes in global warming perspective172Mladen Šolić IP2014-09IP-2014-09-4143MICROGLOB01.11.2015 - 31.10.2019U tijeku870.000,00 KnPrirodne znanostiNatural sciencesBiologija, Kemija, Biology, Chemistry, Institut za oceanografiju i ribarstvoInstitute of Oceanography and Fisheries203, 459, 531, 204, 437, 407, 207, STEFANIJA ŠESTANOVIĆ, Nada Krstulović, Ana Vrdoljak, Slaven Jozić, Danijela Šantić, Marin Ordulj, Natalia Bojanić, mikrobna zajednica, mikrobna hranidbena mreža, grazing, protok ugljika, globalno zatopljenje, fosfor, bakterijska respiracija, bakterijska efikasnost microbial community, microbial food web, grazing, carbon flux, global warming, phosphorus, bacterial respiration, bacterial growth efficiencyMikrobna zajednica uključuje jednostanične organizme koji pokrivaju široki veličinski raspon (od 0.02 do 200 µm) i s obzirom na trofički status uključuju autotrofne, heterotrofne i miksotrofne organizme. Ova je zajednica odgovorna za više od 50% primarne proizvodnje i proizvodnje kisika na Zemlji i ključni je pokretač biogeokemijskih ciklusa koji su ključni za ukupnu produktivnost mora. S obzirom na te značajke, vrlo je važno znati kako ova zajednica odgovara na poremećaje u morskom okolišu. Tijekom ovog projekta istraživat će se struktura mikrobne zajednice i mikrobna hranidbena mreža, te njeni kvantitativni, kvalitativni (strukturni) i funkcionalni odgovori na prirodne i antropogene promjene u morskom okolišu, te će se pokušati detektirati potencijalni pokazatelji tih promjena. U fokusu projekta biti će traženje odgovora na pitanje koje promjene u strukturi i funkcioniranju morske mikrobne hranidbene mreže u uvjetima globalnog zatopljenja možemo očekivati, te kako se ti utjecaji manifestiraju s obzirom na trofički status područja. Pri tome će se posebice istraživati uloga fosfora s obzirom da je Jadransko more općenito fosforom limitirano područje. Istraživanja će uključivati mjesečna terenska istraživanja koja će obuhvatiti estuarska, priobalna i otvorena područja mora, kao i laboratorijske i in situ eksperimente. Aktivnosti na Projektu odvijat će se kroz tri glavne teme: (1) Struktura mikrobne hranidbene mreže koja će biti istraživana na prostornoj (različiti morski okoliši), trofičkoj (trofički gradijent) i vremenskoj (mjesečna i međugodišnja) skali, te moguće temperaturnoj i salinitetnoj skali (usporedna analiza između prirodnih sustava s različitim temperaturnim i salinitetnim režimom), (2) Protok bakterijskog ugljika, koji uključuje eksperimente grazinga, te protok zgljika kroz mikrobnu hranidbenu mrežu, te (3) Eksperimentalni utjecaj porasta temperature i koncentracije fosfora na strukturu i funkcije mikrobne hranidbene mreže.Microbial community includes single-celled organisms that cover a wide size range (from 0.02 to 200 µm) and includes autotrophic, heterotrophic and mixotrophic organisms. This community is responsible for more than 50% of the primary production and oxygen production on Earth and are essential driving forces for biogeochemical cycles with established impacts on overall marine productivity. With respect to these properties it is very important to know how the community responds to disturbances and environmental changes. This project will study the structure of microbial community and microbial food web, as well as its quantitative, qualitative (structural) and functional responses to natural and man-induced changes in marine environment and will try to detect potential indicators of these changes. The main focus of the project will be to study what changes in the structure and functioning of marine microbial food web in terms of global warming we can expect, and how these influences are manifested with regard to the trophic status of the area. The role of phosphorus will be particularly studied with regard to the fact that Adriatic Sea is generally phosphorus limited area. Research will consist of monthly field sampling that will include estuary, coastal and open sea areas, as well as laboratory and in situ experiments. Project activities will be carried out through three main topics: (1) Structure of microbial food web on spatial (different marine environments), trophic (trophic gradient) and temporal (intra- and inter-annual) scales, and possibly temperature and salinity scales (cross comparisons between natural systems under different temperature and salinity regimes); (2) Bacterial carbon flux which include grazing experiments and study of bacterial carbon flux through the microbial food web; and (3) Experimental impact of temperature increase and phosphate additions on microbial community structure and carbon flux toward the higher trophic levels.
2904Razvoj sintetskih kimera vinove loze (Vitis vinifera L.)Development of grapevine (Vitis vinifera L.) synthetic chimeras 11198Darko Preiner UIP2014-09UIP-2014-09-8110ChimeraVitis16.06.2015 - 14.09.2018Završio283.333,33 KnBiotehničke znanostiBiotechnical sciencesBiotehnologija, Poljoprivreda (agronomija), Biotechnology, Agriculture, Sveučilište u Zagrebu, Agronomski fakultetUniversity of Zagreb, Faculty of Agriculture13517, 13508, 13506, 4418, 13543, 13509, 3132, 24336, Anita Mihovilović Bošnjak, Željko Andabaka, Domagoj Stupić, Silvio Šimon, Jasminka Karoglan Kontić, Zvjezdana Marković, Edi Maletić, Iva Šikuten, vinova loza, oplemenjivanje bilja, sintetske kimere, kultura biljnog tkiva, mikrosatelitski markerigrapevine, plant breeding, synthetic chimeras, plant tissue culture, microsatelite marcBiljne periklinalne kimere imaju tkiva najmanje dviju različitih genotipova u različitim slojevima apikalnog meristema što ima znatan utjecaj na svojstva ovakvih biljaka. Mnoge sorte i klonovi vinove loze koje su danas značajne u proizvodnji su periklinalne kimere koje su nastale spontano zbog mutacija u jednom od slojeva apikalnog meristema (Pinot crni, sivi i meunier). Za razliku od kimera koje su nastale mutacijama postoje i tzv. međuvrsne ili međusortne kimere koje su sastavljene od dvaju različitih genotipova koji pripadaju različitim vrstama ili sortama. Ovakve kimere mogu nastati spontano iz spojnog mjestu prilikom cijepljenja, a mogu se ciljano stvoriti što je osnovni preduvjet za razvoj kimeralnog oplemenjivanja, kao izuzetno zanimljive, ali zapostavljene metode oplemenjivanja bilja. U predloženom projektu istraživati će se mogućnosti dobivanja i detekcije sintetskih kimera različitih sorata vinove loze, ali i sintetskih kimera sorata vinove loze i američkih vrsta (otporne na filokseru, plamenjaću i pepelnicu). U početnoj fazi projekta istraživati će se uvjeti za uspješnu in vitro organogenezu 20 različitih genotipova (10 sorata, 5 podloga i 5 vrsta iz roda Vitis.). U slijedećoj fazi odabrati će se genotipovi koji imaju slične zahtjeve prema uvjetima za organogenezu te će se ona nastojati inducirati iz miješanog tkiva iz najmanje triju parova odabranih genotipova. Nakon organogeneze detektirati će se biljke sa kimeralnim statusom bilo koje vrste. Identifikacija i dokazivanje kimera provesti će se kombinacijom fenotipskih markera (npr. boja epiderme) i analizom genotipa primjenom mikrosatelitskih (SSR) markera. Pozicije genotipova u slojevima staničja periklinalnih kimera provest će se genetičkim analizom (SSR) adventivnog korijena. Rezultati ovog projekta o mogućnostima razvoja sintetskih međusortnih i međuvrsnih kimera uvelike će utjecati na daljnji razvoj kimeralnog oplemenjivanja kod vinove loze.Plant periclinal chimeras have tissues of at least two different genotypes in different layers of apical meristem and this has significant influence on properties of this plants. Many grapevine cultivars and clones used in production today are actually periclinal chimeras formed by spontaneous mutation of cells in certain layer of apical meristem (i.e. Pinot noir, gris and meunier). Many intervarietal and interspecific chimeras are also detected which are formed from two different genotypes (cultivars or species). This type of chimeras can arise spontaneously from graft tissue, but this process can also be controlled. This is the base for development of chimeral breeding, as a very interesting but underutilized plant breeding method. In project proposal research on the possibilities of in vitro methods of development and detection of grapevine intravarietal synthetic chimeras will be performed, but also chimeras of grapevine and other Vitis species (with resistance to phyloxera, downy and powdery mildew). In the first stage of the project research on conditions for in vitro organogenesis of 20 different genotypes (10 grapevine cultivars, 5 rootstocks and 5 genotypes of Vitis species). In next stage of the project genotypes with similar requirements for organogenesis conditions will be chosen, and organogenesis will be induced from mixed tissue of at least three pairs of genotypes. After organogenesis, detection of all chimeral plants will be performed. Identification and confirmation of chimeras will be performed using combination of phenotypic markers (i.e. color of epiderm ) and by analyzing genotypes using microsatellite marker (SSR). Position of different genotypes in cell layers of periclinal chimeras will be determined by adventive roots genotyping. Results of this research, on possibilities of grapevine synthetic chimeras development, will have a significant influence on future development of grapevine chimeral breeding.
2905Novootkrivene cirkulirajuće izoforme BMP1 proteina kao biomarkeri i terapijski ciljevi za humane bolestiNewly discovered BMP1 circulating isoforms as biomarkers and therapeutic targets for human diseases4108Lovorka Grgurević UIP2014-09UIP-2014-09-3509BMP1-IsoFor01.01.2016 - 31.12.2018U tijeku999.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine13196, 13183, 6237, 13232, 3289, 13334, 1278, 965, Morana Jankolija, Tatjana Bordukalo Nikšić, Vera Kufner, Ruđer Novak, Ivo Dumić-Čule, Hermann Oppermann, Mario Matijašić, Hana Čipčić Paljetak, metaloproteinaze, kronično bubrežno zatajenje, jetrena fibroza, izoforme, humanizirana protutijelametalloproteinases, chronic kidney disease, liver fibrosis, isoforms, humanized antibodiesPokušali smo identificirati i karakterizirati strukturu cirkulirajućih koštanih morfogenetskih proteina (BMP) u ljudskoj plazmi i izravno ih povezati uz patološka zbivanja u određenom organu. Umjesto toga, slučajno smo otkrili cirkulirajuće izoforme metaloproteinaza koji su proizvod Bmp1 gena: BMP1-3 (mTld) u zdravih muškaraca i pacijenata s kroničnom bubrežnom bolešću (CKD), BMP1-4 u pacijenata s cirozom jetre (LC), BMP1-5 u pacijenata s akutnim infarktom miokarda (AMI), i BMP1-7 u oboljelih od pankreatitisa. Kasnije smo pokazali da primjena BMP1-3 proteina pogoršavaju, dok BMP1-3 poliklonsko antitijela popravljaja bubrežnu funkciju i povećava preživljenje u štakora s CKD. Dodatno, inhibicija proteina BMP1-3 te kombinacija s neutralizacijom BMP1-4 proteina poboljšava funkciju jetre i srca nakon LC, odnosno AMI. Stoga pretpostavljamo da je molekula BMP1-3 ključna u signalnom putu koji regulira fibrozu te da njegova neutralizacija može ograničiti progresiju stvaranja ožiljka. U skladu s ovim rezultatima predlažemo novi znanstveni koncept u savladavanju fibroze preko glavnog te organ-specifičnih regulatornih puteva kroz sljedeće ciljeve: 1/ proizvesti izoforme BMP1 proteina i odgovarajuća monoklonska antitijela; 2/ odrediti specifične substrate za BMP1 izoforme; 3/ razviti novi osjetljivi biološki test za mjerenje BMP1 izoformi u različitim životinjskim eksperimentalnim modelima; 4/ istražiti ulogu BMP1 izoformi u životinja sa CKD i LC. Varijabilna domena najučinkovitijih monoklonskih antitijela će biti sekvencionirana i humanizirana s ciljem terapijske primjene i potencijalnog razvitka novog dijagnostičkog markera. Ovim novim pristupom pokušava se definirati ključna ciljna molekula za zaustavljanje progresije ili poboljšanje u CKD i LC. Naša hipoteza je da modulacija ili inhibicija BMP1 izoformi predstavlja budućnost terapijskih intervencija u spriječavanju fibrozeWe sought to identify and characterize the structure of circulating bone morphogenetic proteins (BMPs) in the human plasma directly associated with organ specific pathology. Instead, we unexpectedly discovered circulating Bmp1 gene metalloproteinase isoforms: BMP1-3 (mTld) in healthy men and in patients with chronic kidney disease (CKD), BMP1-4 in liver cirrhosis (LC), BMP1-5 in acute myocardial infarction (AMI), and BMP1-7 in pancreatitis. We then showed that injections of BMP1-3 protein deteriorate, while BMP1-3 neutralizing polyclonal antibody improves the kidney function and prevents death in rats with CKD. In addition, inhibition of BMP1-3 alone and in combination with a BMP1-4 antibody improved the organ function in LC and AMI. We assume that BMP1-3 represents a core regulatory pathway molecule essential in fibrosis, and its targeting may be sufficient to limit fibrosis progression. In line with these findings, in this project we propose a new scientific concept in combating fibrosis using core and organ specific regulatory pathways, through pursuing the following objectives: 1/ to produce recombinant BMP1 isoform proteins and related neutralizing isoform-specific monoclonal antibodies; 2/ to determine specific BMP1 isoform substrates; 3/ to develop new sensitive plasma bioassays for measuring BMP1 isoforms in different animal experimental models; 4/ to explore the role of BMP1 isoforms in the pathology and function of animals with CKD and LC. The most efficacious monoclonal antibodies variable domain will be sequenced, and than humanized for potential development of new diagnostic tools and therapeutic application. This novel approach aims to acquire the first candidate specific treatment for halting or reversing the progression of CKD and LC. We hypothesize that modulation and/or inhibition of BMP1 isoforms represents future of diagnostic and therapeutic interventions in the field of molecular and translational medicine of fibrosis.
2915Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojevaTau protein hyperphosphorylation, aggregation and trans-synaptic transfer in Alzheimer's disease: cerebrospinal fluid analysis and assessment of potential neuroprotective compounds11124Goran Šimić IP2014-09IP-2014-09-9730ALZTAUPROTECT12.10.2015 - 11.10.2019Završio1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Kliničke medicinske znanosti, Basic Medical Sciences, Clinical sciences, Sveučilište u Zagrebu, Medicinski fakultetUniversity of Zagreb School of Medicine8532, 5057, 12685, 3314, 2684, 13238, 3319, 6740, 20884, 25387, 26549, Mirjana Babić, Maja Jazvinšćak Jembrek, Danira Bažadona, Domagoj Đikić, Fran Borovečki, Vesna Benković, Nada Oršolić, Željka Petelin Gadže, Mirta Boban, Klara Zubčić, Ena Španić, Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S Alzheimer's disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine SZa Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. ''pre-tangle'' stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.
2916Satelitska DNA u genskoj regulaciji i ekološkoj adaptacijiSatellite DNA in gene regulation and environmental adaptation 183Đurđica Ugarković IP2014-09IP-2014-09-3733SatGenReg01.09.2015 - 30.11.2019U tijeku929.000,00 KnPrirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb3003, 559, 1280, 721, 475, 21311, 21338, Branka Bruvo Mađarić, Isidoro Feliciello, Zeljka Pezer Sakac, Ivana Akrap, Josip Brajković, Antonio Sermek, JURE SKEJIĆ, satelitska DNA, genska ekspresija, epigenetika, genska regulacija, adaptacija, Triboliumsatellite DNA, gene expression, epigenetics, gene regulation, adaptation, TriboliumPonovljena DNA kao npr. transpozoni, može biti izvor regulatornih sekvenci te doprinijeti raspršenju regulatornih elemenata unutar eukariotskog genoma. Međutim, utjecaj na gensku regulaciju druge skupine vrlo zastupljenih, uzastopno ponovljenih sekvenci DNA kao što je satelitska DNA, nije do sada pokazan. U crvenom brašnaru Tribolium castaneum (Coleoptera) satelitska DNA igra važnu ulogu u regulaciji i remodeliranju heterokromatina tijekom razvoja i odgovora na vanjski stres. Ekspresija glavne satelitske DNA je jako potaknuta termičkim stresom, a povećana razina malih interferirajućih RNA (siRNA) koje potječu od satelitske DNA je praćena povećanjem represivnih epigenetskih modifikacija na histonima u heterokromatinu. Uz prisustvo u heterokromatinu, kratki odsječci satelitske DNA su raspršeni u blizini protein-kodirajućih gena u eukromatinu. Transkripcija glavne satelitske DNA osjetljiva na okolišne uvjete kao i njena raspršenost u susjedstvu gena upućuje na moguću ulogu satelitskih elemenata u regulaciji genske aktivnosti i adaptaciji na uvjete u okolišu.Cilj predloženog projekta je ispitati ulogu satelitske DNA u regulaciji aktivnosti gena u kukcu T. castaneum. Mi pretpostavljamo da siRNA koja potječe od satelitskih DNA utječe na epigenetski status dijelova eukromatina koji sadrže raspršene satelitske elemente na način da specifično navodi kromatinske modifikatore, primarno histonske metiltransferaze, na te regije. To može dovesti do nastanka heterokromatina na raspršenim satelitskim DNA elementima i njegovog širenja na susjedna područja. Takova „heterokromatizacija“ može utjecati na ekspresiju susjednih gena, vjerojatno smanjujući njihovu aktivnost. Očekujemo da će naši rezultati po prvi put pokazati ulogu satelitskih DNA u podešavanju genske ekspresije i u ekološkoj adaptaciji.Repetitive elements such as transposons can be a source of regulatory sequences and could act to distribute regulatory elements throughout the genome. However, for the repetitive elements organized in tandem, known as satellite DNAs, role in gene regulation is not described till now. In the red flour beetle Tribolium castaneum (Coleoptera) satellite DNAs play an important role in heterochromatin regulation and remodelling during development and environmental stress response. Expression of a major satellite DNA is strongly induced by heat shock, and increased level of satellite-derived small interfering RNAs (siRNAs) is accompanied by increase of repressive epigenetic modifications of histones at heterochromatin. In addition to their presence in the heterochromatin, short stretches of satellite DNA have been mapped in the close vicinity of numerous genes within euchromatin. The environmentally susceptible transcription of a major satellite DNA as well as its distribution close to protein-coding genes provides strong support for the role of satellite DNA in gene regulation and adaptation to different environmental conditions.The aim of the proposed project is to investigate the gene-regulatory role of satellite DNAs in insect T. castaneum. We propose that satellite DNA-associated siRNAs could affect epigenetic state of euchromatic regions containing dispersed satellite elements by targeting these elements in a sequence-specific manner and by guiding chromatin modifiers, primarily histone methyltransferase. This could result in heterochromatin assembly at dispersed satellite DNA elements and its spreading to the flanking region. Such “heterochromatization” is expected to influence the expression of nearby genes, most probably by decreasing the level of gene expression. We expect that our results will for the first time demonstrate a role of satellite DNAs in the modulation of protein-gene expression and in environmental adaptation.
2920Model rasta aneurizme temeljen na biokemijskim i mehaničkim podražajima BioChemoMechanical Modeling of Aneurysmal Growth1010Igor Karšaj IP2014-09IP-2014-09-7382BCMModAneuGr01.10.2015 - 30.09.2019U tijeku872.100,00 KnTehničke znanosti, Biomedicina i zdravstvo, Technological sciences, Biomedicine and health sciences, Strojarstvo, Mechnical engineering, Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnjeUniversity of Zagreb, Faculty of Mechanical Engineering and Naval Architecture12954, 12791, 1012, 19003, 25392, Ivo Lovričević, Vedran Vindiš , Lana Virag, Nino Horvat, Josip Živić, aneurizma, abdominalna aorta, intraluminalni tromb, rast i promjena strukture, hiperelastičnost, naprezanja, prilagodba, razgradnja elastina, kolagenaneurysm, abdominal aorta, intraluminal thrombus, growth and remodeling, hyperelasticity, stress, adaptation, elastin degradation, collagen turnoverModeliranje biokemijskih kao i mehaničkih promjena tijekom razvoja intraluminalnog tromba (ILT) ima potencijal da pomogne nam odgovoriti na pitanje kako dolazi do rasta aneurizme i što uzrokuje njenu rupturu. Konačni cilj ovog istraživanja je utvrditi promjene koje s javljaju rastom aneurizme. Simulirat ćemo od početnog krvnog ugruška pa kasnog stadija aneurizme promjera većeg od 5 cm. Pretpostavljamo da povećanje AAA je izravna posljedica razvoja ILT. Predlažemo sljedeće ciljeve za ovaj projekt:Cilj 1: Razviti model rasta i promjene strukture fuziformne aneurizme koji je moguće koristiti u paketu za konačne elemente.Cilj 2: Potrebno je razviti trodimenzijski model rasta i promjene strukture sakularne aneurizme s uključenim intraluminalnim trombom.Cilj 3: Potrebno je ispitati različite hipoteze o tome kako dolazi do rupture ili stabilizacije AAA na realističnoj geometriji.Uspješno ostvarenje navedenih ciljeva bit će veliki napredak u polju biomehanike krvnih žila jer će omogućiti po prvi put praćenje kinetike razvoja intraluminalnog tromba unutar AAA i otkrivanje faktora koji utječu na rast i rupturu aneurizme.Proper biochemomechanical modeling of the development of an intraluminal thrombus (ILT) has the potential to help us answer the question about reasons for aneurysmal growth and to define parameters influencing potential for rupture?. The overall goal of this project, therefore, is to quantify the development of ILT from the initial blood clot to a mature formation, with special attention to changes in the clot structure. Our hypothesis is that AAA growth is a direct consequence of ILT development. We propose following aims for this proposal:Aim 1: To develop a finite element growth and remodeling model of thrombus-laden fusiform aneurysm from the moment of initiation.Aim 2: To develop a 3-D finite element growth and remodeling model of thrombus-laden saccular abdominal aortic aneurysm from the healthy aorta.Aim 3: To test different hypothesis on AAA rupture and stabilization on realistic geometry from Aim 2.Successful realization of these aims will advance the field of vascular mechanics by allowing for the first time quantification of kinetics of an intraluminal clot within AAA, and factors that significantly influence aneurysmal growth and risk of the rupture.
2921Raspad Habsburške Monarhije i transfomacije na istočnojadranskom prostoru (1917.-1923.)THE COLLAPSE OF HABSBURG MONARCHY AND TRANFORMATIONS OF EASTERN ADRIATIC REGION (1917-1923)1131Ante Bralić IP2014-09IP-2014-09-7822JADRANTRANSFORMACIJE15.05.2015 - 14.05.2019Završio395.495,00 KnHumanističke znanostiHumanitiesPovijest, History, Sveučilište u ZadruUniversity of Zadar3175, 1375, 2931, 4263, 2796, 2557, 13344, 2763, 2746, 22836, 914, Zlatko Begonja, Zdravka Jelaska Marijan, Andreas Guidi, Branko Kasalo, Sanda Uglešić, Ante Gverić, Hrvoje Ratkajec, Marko Trogrlić, Ante Batović, Matic Batič, BORUT KLABJAN, Istočni Jadran, Dalmacija, Habsburška Monarhija, Prvi svjetski rat, EliteEastern Adriatic, Dalmatia, Habsburg Monarchy, World War One, ElitesRazdoblje između sloma Austro-Ugarske Monarhije i stvaranja novih država bilo je iznimno turbulentno razdoblje u političkom, društvenom i nacionalnom pogledu. Istraživanje bi započelo Svibanjskom deklaracijom 1917. godine koja je potaknula političko gibanje na, do tada “zamrznutoj” političkoj sceni, a završilo bi se završetkom povlačenja talijanskih vojnih snaga 1923. godine iz III. okupacijske zone. Poseban fokus bit će posvećen prilikama u Dalmaciji, a komplementarno će se analizirati prilike u drugim krajevima Istočnog Jadrana.Ciljevi projekta:1. Objasniti utjecaj složenog sklopa uzroka koji su doveli do sloma Habsburške Monarhije i njihov utjecaj na javno mnijenje na istočnoj obali Jadrana, a posebno u Dalmaciji (1917.-1918.).2. Istražiti utjecaj vanjskih, međunarodnih čimbenika na političke i društvene procese koji se odvijaju u promatranom razdoblju na istočnoj obali Jadrana u kontekstu nedefiniranih državnih granica i konfliktnih situacija. 3. Proučiti promjene narativa u završnim procesima nacionalnih integracija (dalmatinskih Hrvata, Srba i Talijana, te tršćanskih Slovenaca) što je povezano s novim političkim i društvenim okruženjem.4. Istražiti transformaciju i prilagođavanje 'starih' elita novom društvenom okruženju.5. Objasniti nastanak i djelovanje novih političkih organizacija nakon 1918. godine, te njihov utjecaj u dalmatinskom društvu. Ova problematika je do sada, relativno slabo istražena. Jedan od najvećih problema je istovremeno i paraleno djelovanje više institucija na dalmatinskom i stičnojadranskom području u razdoblju od 1918. do 1923. što je osobito izraženo u prvom razdoblju do Rapallskog ugovora 1920.The period between the collapse of the Habsburg Monarchy and creation of new nation states was an exceptionally turbulent period in political, social and national sense. The research would begin with the May Declaration of 1917, which prompted political movement on previously “idle” political scene, and would end with final retreat of Italian military forces from the third occupation zone in 1923 in Dalmatia. Special focus will be devoted to the situation in Dalmatia, and complementary analysis will handle with the situation in other parts of the Eastern Adriatic.Project objectives:1. Analyze complex set of causes that led to the collapse of the Habsburg Monarchy and their influence on public opinion in Eastern Adriatic region, especially in Dalmatia (1917-1918)2. Explore the influence of external, international, factors on political and social processes in Dalmatia during the observed period, within the context of unidentified national borders and conflict situations.3. Study the narrative changes in final processes of national integrations (of Dalmatian Croats, Serbs, and Italians, and Slovenes from Trieste) in connection to new political and social environment.4. Investigate how the “old” elites transformed and adapted to new social environment.5. Explain formation and activities of new political organizations after 1918 and their influence on Dalmatian society.This topic has not yet been fully explored. One of the biggest research issues are simultaneous and parallel activities of various different institutions in Dalmatia and other Eastern Adriatic regions between 1918 and 1923, particularly during the first period, prior to the Treaty of Rapallo.
2923Mehanokemijska reaktivnost pod kontroliranim uvjetima temperature i atmosfere za čistu sintezu funkcionalnih materijalaMechanochemical reactivity under controlled temperature and atmosphere for clean synthesis of functional materials280Krunoslav Užarević UIP2014-09UIP-2014-09-4744MECHANOCONTROL01.04.2016 - 31.03.2019U tijeku981.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb196, 13070, 3012, 1007, 112, 625, 13224, 21253, 23293, 24360, Martina Tireli, Emmerling Franziska, Davor Gracin, Marina Juribašić Kulcsar, Manda Ćurić, Ivan Halasz, Tomislav Friscic, Stipe Lukin, Bahar Karadeniz, Tomislav Stolar, mehanokemijska sinteza, reaktivnost u čvrstom stanju, in situ monitoring, templatiranje i adsorpcija plinova, funkcionalizacija metal-ugljik vezemechanochemical synthesis, solid-state reactivity , in situ monitoring, gas-templation and adsorption, functionalization of metal-carbon bondMehanokemijske reakcije su se nametnule u posljednje vrijeme kao brza i ekološki prihvatljiva alternativa konvencionalnoj kemijskoj sintezi u velikom broju područja, od sinteze nanomaterijala i slitina do supramolekulskih organskih materijala i koordinacijskih mreža. Područje se posebno razvilo uvođenjem novih tehnika, tekućinom potpomognutog mljevenja ili ionima- i tekućinom potpomognutog mljevenja, koji uključuju dodatak aditiva u reakcijske smjese. Unatoč velikom broju objavljenih radova, načini kontrole osnovnih reakcijskih uvjeta, poput temperature i tlaka unutar mehanokemijskog reaktora, još uvijek nisu uvedeni u standardne mehanokemijske postupke. Štoviše, znanja o utjecaju reakcijskih uvjeta i aditiva na mehanizme reakcija mljevenja su još na spekulativnom nivou.Glavni cilj predloženog projekta je istraživanje fundamentalnih aspekata mehanokemijskih reakcija pod kontroliranom tlakom i u određenom rasponu temperatura. Okolišno relevantni plinovi (poput ugljikova(IV) oksida, metana, sumporovih i dušikovih oksida) će se koristiti kao templati ili reaktanti za sintezu poroznih koordinacijskih spojeva ili organskih spojeva. Također, ispitati će se vezanje plinova na neporozne koordinacijske spojeve, te funkcionalizacija ugljikovih atoma iz organometalnih spojeva.Da bismo uspješno ostvarili ciljeve projekta, razviti ćemo mehanokemijske reaktore u kojima će biti moguće kontrolirati temperaturu i tlak. Mehanistički aspekti mehanokemijskih reakcija između plinova i krutina biti će određeni in situ tehnikama praćenja nedavno razvijenih unutar naše grupe.Iskustvo i saznanja prikupljeni implementacijom ovoga projekta će se iskoristiti za istraživanja mehanokemijske sinteze ciljanih materijala, a s krajnjim ciljem stjecanja dubljeg uvida u mehanokemijske reakcije i proširenja potencijala za njihovu primjenu. Očekujemo da će rezultati projekta imati snažan utjecaj na korištenje reakcija u čvrstom stanju, kako u istraživačkim laboratorijima, tako i u kemijskoj industriji.Mechanochemical reactions by milling have recently emerged as excellent, rapid and cleaner alternative to conventional solution synthesis in a number of areas, from nanomaterials and alloys to supramolecular, organic materials and metal-organic frameworks. The area flourished after the introduction of new techniques, liquid-assisted grinding and ion- and liquid assisted grinding, involving additives in the reaction mixtures. Despite a growing rate of published articles, the means of controlling the basic milling reaction conditions, such as temperature and pressure in the vessel, is still not a part of standard milling procedures. Moreover, understanding of the effect of reaction conditions and additives on milling-reaction mechanisms is currently on speculative level.The main objective of this project proposal is to explore fundamental aspects of mechanochemical solid-state reactions under controlled pressure and in a range of temperatures. We will employ different gases (with special focus on environmentally relevant gases such as carbon dioxide, methane and sulfur- or nitric oxides) as reacting agents and templates for the synthesis of porous metal-organic and covalent organic frameworks, to selectively bind pollutant gases to nonporous coordination compounds or to functionalize carbon atoms in organometallic compounds. To successfully implement the objectives of this project proposal, we will develop milling vessels where the described reaction conditions can be achieved. Mechanistic aspects of gas-solid milling reactions will be studied by our novel in situ and real-time monitoring techniques.The experience and knowledge acquired by the project implementation will be applied to mechanochemical formation of target materials in order to broaden understanding and application scope of mechanochemical reactivity. The project results are expected to have a strong transformative effect on solid-state reactivity in a research laboratory as well as in chemical industry.
2933Modulacija metaboličkog, endokrinog i antioksidacijskog statusa u mliječnih krava dodavanjem zeolita u hranuModulation of metabolic, endocrine and antioxidative status in dairy cows by dietary zeolite supplementation11178Marko Samardžija IP2014-09IP-2014-09-6601ModZeCow15.09.2015 - 14.09.2019Prekinut1.000.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesVeterinarska medicina, Veterinary medicine, Sveučilište u Zagrebu, Veterinarski fakultetUniversity of Zagreb, Faculty of Veterinary Medicine2794, 11250, 11252, 11248, 12376, 11275, 11271, 11273, 11257, 5216, 11266, 12374, 11247, 11245, 3086, 11258, Miroslav Benić, Tomislav Dobranić, Vesna Dobranić, Dražen Đuričić, Zlata Flegar-Meštrić, Ivan Folnožić, Iva Getz, Damjan Gračner, Juraj Grizelj, Martina Lojkić, Nino Maćešić, Sonja Perkov, Paola Roncada, Romana Turk, Hrvoje Valpotić, Silvijo Vince, NEB, zeolit u hrani, plodnost, mastitis, mliječne kraveNEB, dietary zeolite, fertility, mastitis, dairy cowsNakon porođaja, naglo se povećaju hranidbene potrebe organizma zbog proizvodnje mlijeka i krave ulaze u razdoblje negativnog energetskog statusa (NEB) koji neposredno utječe na funkciju jajnika prouzrokujući izostanak pravilne ciklične aktivnosti jajnika tijekom puerperija i smanjenje plodnosti. NEB nije moguće izbjeći, ali je zato moguće umanjiti njegovo trajanje i jačinu. Reproduktivni poremećaji u krava mogu se pripisati značajnom smanjenju tjelesne kondicije tijekom puerperija kao i sistemskim promjenama metaboličkih, endokrinih i oksidacijskih pokazatelja zbog nedostatnog unosa hrane. Posljedično, energetska neravnoteža zbiva se zbog povećane mliječnosti nakon porođaja, periporođajnog stresa i/ili bolesti koje se javljaju tijekom puerperija. Te bolesti imaju značajan negativni ekonomski utjecaj tijekom puerperija i u razdoblju nakon njega zbog pojave trajne jalovosti. Jedna od najznačajnijih bolesti krava tijekom puerperija je mastitis koji prouzrokuje znatne ekonomske gubitke, zbog otežane dijagnostike subkliničkog oblika. Smatra se da zeolit klinoptilolit (KPL) može modulirati metabolički, endokrini i antioksidacijski status u mliječnih krava i stoga unaprijediti njihovo zdravlje, plodnost i mliječnost. Ciljevi projekta su vrednovati učinke nutritivne modulacije KPL u hrani na NEB, plodnost i produktivnost te pojavnost subkliničkog mastitisa radi rane dijagnostike oksidacijskog stresa i sistemskog/lokalnog upalnog odgovora povezanog s reproduktivnim i produktivnim poremećajima u mliječnih krava. Očekivani rezultati istraživanja na projektu uključit će dobro definirane pozitivne učinke nutritivne modulacije dodatkom KPL u hranu na: (1) NEB, plodnost i produktivnost s obzirom na tjelesnu kondiciju i paritet tijekom prijelaznog razdoblja i kasnog puerperija; (2) pojavnost/jačinu subkliničkog mastitisa u mliječnih krava. Sveukupno, ti će učinci u praksi doprinijeti unaprjeđenju zdravlja i ekonomskih pokazatelja u govedarskoj proizvodnji u Hrvatskoj i inozemstvu. Nutritional requirements of dairy cows are rapidly increasing following parturition due to milk production and thus animals inevitably enter into negative energy balance (NEB) which indirectly affecting ovaries function causing failure of regular ovarian activity during puerperium and consequently decreased fertility. The NEB could not be avoided by any known treatments but it is possible to decrease its duration and severity. Reproductive disorders in cows could be ascribed to significant decrease of body condition during puerperium and to systemic changes of metabolic, endocrine and oxidative parameters due to insufficient feed intake. Consequently, energy imbalance occurs due to increased milk production following parturition, peripartal stress and/or puerperal diseases. Such diseases have significant negative economic impact, during puerperium and afterwards by appearance of sterility. One of the most important puerperal diseases is mastitis which causes large economic losses particularly due to difficulties in diagnosis of its subclinical form. It is assumed that zeolite clinoptilolite (CPL) might modulate metabolic, endocrine and antioxidative status in dairy cows and thus improve their health, fertility and milk production. The objectives of the project are to evaluate effects of nutritive modulation by dietary CPL on: NEB, fertility, productivity and incidence of subclinical mastitis for early recognition of oxidative stress and systemic/local inflammatory responses involved in reproductive and productive disorders in dairy cows. The expected outcomes of the project will include well defined positive effects of nutritive modulation by dietary CPL on: (1) NEB, fertility and productivity regarding body condition and parity during transition period and late puerperium; (2) incidence/severity of subclinical mastitis in dairy cows. Altogether, these will contribute in practice to improve health and economical parameters in cattle production in Croatia and abroad.
2934JADRANSKA PRIČA - INTERDISCIPLINARNO ISTRAŽIVANJE JADRANSKIH NARATIVAADRIATIC TALE - INTERDISCIPLINARY RESEARCH OF ADRIATIC NARRATIVES8327Joško Božanić IP2014-09IP-2014-09-9300ADRIANA01.10.2015 - 30.09.2019Završio574.830,00 KnHumanističke znanostiHumanitiesFilologija, Etnologija i antropologija, Philology, Ethnology and anthropology, Sveučilište u Splitu, Filozofski fakultetUniversity of Split, Faculty of Philosophy12702, 12699, 11114, 12688, 12608, 13033, 13303, 13535, 13610, 12992, 7827, 13358, 24402, Anita Runjić-Stoilova, Inoslav Bešker, Eni Buljubašić, Marijana Tomelić Ćurlin, Marina Blagaić Bergman, Antonela Pivac, Filip Galović, Natalie Dupré, Elis Deghenghi Olujic, Ines Grgurinović, Danica Škara, Srecko Jurisic, Paula Jurišić, humorizam, književnost, usmenost, stilistika, Jadran, dijalekt, narativ, semiotikahumorism, literature, orality, stylistics, Adriatic, dialect, narrative, semiotics Atribut „jadranski“ ne pojavljuje se u hrvatskoj književnoj historiografiji ni znanosti o književnosti kao kvalifikativ koji bi definirao literarnu posebnost ni kao stilska, ni kao tematska, niti kao kulturološka odrednica. Zanemarivanje maritimnosti rezultira redukcijom kulturološkog diverziteta u recepciji nacionalne književnosti, umjetničke i usmene. Polazeći od teze da je kvalifikativ „jadranski“ bitna odrednica jednog od hrvatskih kulturnih identiteta, ovaj projekt želi doprinijeti istraživanju fenomena maritimnosti hrvatske kulture na području narativa oralne pripovjedne književnosti, kako fikcionalne tako i nefikcionalne, i njena refleksa u narativima umjetničke književnosti u sinkronijskoj i dijakronijskoj perspektivi. U tome je i specifičan doprinos ovoga projekta budući da on pokriva veliko neistraženo područje usmene književnosti i njena utjecaja na umjetničku književnost. Projekt se temelji na ideji sustavnog istraživanja usmene i zapisane građe oralne nefikcionalne i fikcionalne književnosti, izvan klasičnog folklorističkog okvira percepcije fenomena literarature kao žanrovski i poetološki definiranog diskursa. Ovo istraživanje nije strogo omeđeno granicama jezika jednog etnosa (hrvatskog), već uključuje i transetničke utjecaje i prožimanja zadana istom kulturalnom matricom adrianstva. To je dijaloška kultura čiji je temeljni princip humorizam. Zapisat će se i sistematizirati prikupljena građa te provesti sustavna analiza, valorizacija i interpretacija tekstova s različitih aspekata: literarnog, lingvističkog, etnološkog i kulturnoantropološkog, komparativnog i rodnog, a istraživanje će uključiti različite tipove interpretacije na područjima: stilistike, naratologije, književne teorije, dijalektologije, leksikologije / leksikografije, semiotike, retorike, etnografije i kulturne antropologije. Pragmatični dio istraživačkog programa realizirat će se dizajniranjem atraktivnih ambijentalnih narativa za potrebe jadranskih kulturnih itinerara.Within Croatian literary theory and historiography, the attribute ‘Adriatic’ does not signify any (relevant) determinant of literary quality, whether stylistic, thematic or cultural. The disregard of the maritime cultural aspects reduces the cultural diversity in the reception of national literature, both authored/written and oral. With the premise that the attribute 'Adriatic' is a significant determinant of one of Croatia's cultural identities, this project aims to contribute to the research of the phenomenon of Croatian culture's maritimity in the area of oral literature narratives, both fictional and non-fictional, as well as narratives of national written literature in its synchronic and diachronic perspective. The outstanding value and specific contribution of this project is in covering a field that has not yet been researched in Croatian literary studies. The project is based on the idea of definition, interpretation and valorisation of the Adriatic component of Croatian literature and the systematic research of oral and recorded stories of various narrative and protonarrative types related to specific areas of the Adriatic space. The collected data will be systematized and subjected to a detailed analysis and textual interpretation from various perspectives: literary, linguistic, ethnological, cultural, antropological, comparative and the perspective of gender. The research will include various types of interpretation in the areas of stylistics, narratology, literary theory, dialectology, lexicology / lexicography, semiotics, rhetoric, ethnography and cultural anthropology. Results will be dissaminated through the publication of books and research papers in internationally cited journals and proceedings of the international conference on the subject of this project. The practical side of this research project will be implemented through the creation of attractive ambient narratives as the basis of Adriatic cultural itineraries.
2936RIMSKI GROBNI SPOMENICI JUGOZAPADNE PANONIJE U SVOME MATERIJALNOM, DRUŠTVENOM I RELIGIJSKOM KONTEKSTUROMAN FUNERARY MONUMENTS OF SOUTH-WESTERN PANNONIA IN THEIR MATERIAL, SOCIAL, AND RELIGIOUS CONTEXT7449branka migotti IP2014-09IP-2014-09-4632RGSP/RFMP04.05.2015 - 03.05.2018Završio346.017,00 KnHumanističke znanosti, Prirodne znanosti, Humanities, Natural sciences, Arheologija, Geologija, Archeology, Geology, Hrvatska akademija znanosti i umjetnostiCroatian Academy of Sciences and Arts3706, 4660, 3255, 4105, 6682, Marjeta Šašel Kos, Ivan Radman-Livaja, Ljubica Perinić, Mirko Belak, Hana Ivezić, interdisciplinarno istraživanje, jugozapadna Panonija, sjeverna Hrvatska, grobni spomenici, provincijalno-rimsko društvointerdisciplinary research, south-western Pannonia, northern Croatia, funerary monuments, Romano-provincial societyInterdisciplinarno (arheologija, epigrafija, geologija) i cjelovito evidentiraju se, proučavaju i sistematiziraju kameni grobni spomenici triju jugozapadno-panonskih rimskih gradova na prostoru sjeverne Hrvatske: Andautonije (Ščitarjevo), Siscije (Sisak) i Akva Balisa (Daruvar). Aspekti proučavanja su povijesni, umjetnički i materijalni, a uključuju uvid u odabir vrste spomenika (tituli, stele, sarkofazi, urne, oltari i portretne niše) i odgovarajućeg grobnog rituala (spaljivanje ili tjelesno pokapanje), analize oblika i struktura spomenika, ikonografije i natpisa, te određivanju vrste kamena i kamenolomskog podrijetla. Sistematizacija navedenih podataka omogućit će bolji uvid u društveni i kulturni profil južno-panonskog provincijalnog društva: socijalnu stratifikaciju (statusnu i položajnu, te civilnu i vojničku), etničke identitete, religijsku pripadnost, te umjetničke trendove i gospodarske aspekte (nastanak domaćih radionica i trgovina mramornim i kamenim izrađevinama na prostoru Norika i Panonije). Prikupljanjem, sistematizacijom i analizom građe koja nikad prije nije bila razmatrana na taj način, osmislit će se svojevrstan pilot projekt, primjenjiv na druge gradove i regije Rimskog carstva.Funerary monuments of three south-western Pannonian Roman cities in the territory of northern Croatia (Andautonia, Siscia, and Aquae Balissae) are evidenced, compiled, studied, and systematised through an interdisciplinary (archaeological, epigraphic, and geological) and holistic approach. Aspects of the research are historical, artistic, and material, comprising the choice of the monument type (tituli, stelae, sarcophagi, ash-chests, altars, and portrait niches) and corresponding funerary rite (incineration or inhumation), analyses of the monument forms and structures, iconographies, epigraphy, and stone characterisation, that is, establishing the stone used and its quarry source. A systemisation of the acquired data will enable a better insight into the social and cultural profile of the south-Pannonian provincial society, concerning its social stratification (military and civil ranks and statuses), ethnic identities, religious affiliations, artistic trends, as well as economic and trade aspects (the establishment of local stonemasonry workshops and trade in marble and other stone funerary monuments in the Norico-Pannonian region). Through compiling, systematising and analysing of the evidence that had so far never been studied in this way, a kind of a pilot project will be produced, applicable to other towns or regions of the Roman Empire.
2949Novi metodološki pristup biogeokemijskim istraživanjima specijacije metala u tragovima u obalnim vodenim ekosustavimaNew methodological approach to biogeochemical studies of trace metal speciation in coastal aquatic ecosystems12557Dario Omanović IP2014-09IP-2014-09-7530MEBTRACE01.09.2015 - 31.12.2019U tijeku940.000,00 KnPrirodne znanostiNatural sciencesKemija, Geologija, Chemistry, Geology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb827, 101, 4198, 120, 75, 80, 691, 1423, 106, 12837, 5519, 5147, 13204, 13205, 20234, 19764, 21259, 23224, 20391, Ivanka Pižeta, Marina Mlakar, Neven Cukrov, Vlado Cuculić, Marta Plavšić, Stanislav Frančišković-Bilinski, Petra Vukosav, Vesna Žic, Slađana Strmečki Kos, Ana-Marija Cindrić, Sunčana Geček, Niko Bačić, Garnier Cédric, Lenoble Veronique, Jasmin Pađan, Nuša Cukrov, Matea Vrdoljak, Saša Marcinek, Filip Pošćić, metali u tragovima, specijacija, obalni vodeni ekosustavi, modeliranje, sedimenti, zagađivalatrace metals, speciation, coastal aquatic ecosystems, modeling, sediments, contaminantsPredloženo istraživanje ima za cilj razjasniti nekoliko pitanja vezanih za fizičko-kemijske procese koji reguliraju ponašanje tragova metala (TM) u čistim, ali i u potencijalno zagađenim prijelaznim i priobalnim vodenim ekosustavima. Pokretljivost, reaktivnost kao i bioraspoloživost MT-ova jako ovise o njihovoj kemijskoj specijaciji, bez obzira imaju li ulogu mikronutrijenata ili su izrazito toksični za organizme.Naša istraživanja usmjerena prema karakterizaciji međusobnog odnosa TM-ova s ostalim makro i mikro konstituentima prirodnih voda, posebno s prirodnom organskom tvari, bit će temeljena na korištenju najnovijih elektrokemijskih i složenih spektrometrijskih tehnika za specijaciju metala. Orijentirat ćemo se naročito na razvoj i usavršavanje metoda za specijaciju, mjernih protokola i mjernih senzora. Modele raspodjele metala razvijene u laboratorijskim uvjetima ispitat ćemo na uzorcima prirodne vode, a primijenit ćemo ih i kod on-site i in-situ mjerenja. Istraživanja će voditi do uspostavljanja niza specifičnih fizičko-kemijskih parametara, procedura i kriterija koja će omogućiti pouzdanu procjenu aktualnog stanja ali i predviđanje budućeg ponašanja TM-ova (specijaciju, mobilnost, biodostupnost/toksičnost) u slučaju lokalnih okolišnih nezgoda (npr. zagađenja) ili globalnih prijetnji (npr. “ocean acidification”).Istraživanja će se provoditi u vodnim područjima raznolikog kemijskog sastava gdje se očekuju promjene fizičko-kemijskih oblika TM-ova (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn), a uključivat će estuarijska, oksično/anoksična, eutrofička, te čista i zagađena područja, u kojima će se istraživati procesi koji se odvijaju kako na granicama faza, tako i u vodenom i sedimentnom stupcu.Teme istraživanja odabrane su tako da rezultati projekta budu od koristi ne samo široj znanstvenoj zajednici koja radi na problemima specijacije TM-ova nego i institucijama ovlaštenim za upravljanje priobalnim područjima.The proposed research aims at elucidating several issues related to the physico-chemical processes governing trace metals (TM) behaviour in pristine, but also in potentially contaminated transitional and coastal aquatic ecosystems. Whether the TMs behave as micronutrients or are highly toxic to organisms, their mobility, reactivity as well as bioavailability, strongly depends on chemical speciation.Our focus will be directed towards characterisation of interactions of TM with other macro and micro constituents of natural waters, particularly with natural organic matter, by employing the most recent approaches utilizing electrochemical and hyphenated spectrometric techniques. Particular effort will be invested in the development and improvement of speciation methods, measurement protocols and sensing electrodes. Methodologies developed under controlled laboratory conditions will be verified using natural water samples and applied in on-site and in-situ field-studies. The research will lead to the establishment of sets of specific measures and criteria which will allow reliable estimation of the actual state, but also the prediction of future behaviour of TMs (speciation, mobility, bioavailability/toxicity) in case of local environmental accidents (e.g. contamination) or global threats (e.g. ”ocean acidification”).Aquatic environments characterized by a variety of chemical compositions will be studied. In such conditions, variations in physical-chemical forms of the studied TMs (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn) are expected to occur. Study sites will be estuarine, oxic/anoxic, eutrophic and clean/contaminated areas, in which processes occurring at the phase boundaries, as well as in the sediment and water column will be explored.The specific subjects of the research are selected in a way to enable the outcome of the project be valuable not only to the broad scientific community working on TM speciation, but also to the authorities managing coastal zones.
2952Menadžment sportskih doživljaja u funkciji oblikovanja učinkovitih poslovnih modela u slabije razvijenim turističkim destinacijamaManagement of sports experiences in the function of designing effective business models in less developed tourist destinations2667Marko Perić UIP2014-09UIP-2014-09-1214SPORTBIZMODEL01.06.2015 - 31.05.2018U tijeku288.626,00 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Rijeci, Fakultet za menadžment u turizmu i ugostiteljstvuUniversity of Rijeka, Faculty of Tourism and Hospitality Managment4489, 3013, 2701, 3425, 2894, 6818, Nicholas Wise, Sanela Škorić, Daniel Dragičević, Nataša Kovačić, Jelena Đurkin, Vanja Vitezić, Poslovni model, menadžment, sportski doživljaji, sportski turizam, turistička destinacijaBusiness model, management, sports experiences, sports tourism, tourist destinationOpći cilj ovog istraživanja je predložiti učinkovite poslovne modele koji će omogućiti pružateljima usluga sportskog turizma u manje razvijenim turističkim destinacijama da se prilagode tržišnim izazovima te, usredotočujući se na pružanje sportskih doživljaja, održe i povećaju svoje tržišne udjele i pozitivne ekonomske učinke. Formulirano je nekoliko hipoteza: (1) sportski doživljaji koje turisti traže značajno se razlikuju jedni od drugih i mogu biti razvrstani u nekoliko karakterističnih skupina, (2) glavni elementi postojećih poslovnih modela u sportskom turizmu u slabije razvijenim destinacijama identični su glavnim elementima postojećih poslovnih modela najbolje prakse, ali se njihova primjena u praksi razlikuje; (3) analizom prikupljenih primarnih kvalitativnih podataka o karakteristikama postojećih poslovnih modela u sportskom turizmu, moguće je doći do spoznaja relevantnih za oblikovanje učinkovitih poslovnih modela sposobnih pružiti različite vrste sportskih doživljaja. Gorski kotar, kao jedna on slabije razvijenih destinacija u Hrvatskoj, prikladna je lokacija za istraživanje ovih teza. Identificirat ćemo i procijeniti ponudu sportskih sadržaja te provesti anketiranje sportskih turista u Gorskom kotaru kako bi generirali nekoliko vrsta sportskih doživljaja i utvrdili potencijalni odnos između vrsta sportskih doživljaja i izdataka turista. Radi usporedbe identična procedura će se primijeniti i na nekoliko odabranih primjera sportskih događaja i aktivnosti (najbolje prakse) izvan područja Gorskog kotara. Konačno, provest ćemo i interakcijsko istraživanje postojećih poslovnih modela u Gorskom kotaru i najboljih praksi izvan njega. Na taj način dobit ćemo bolji uvid u poslovne modele koji pružaju pojedine doživljaje i moći ćemo predložiti novu verziju konceptualnih poslovnih modela za sve vrste sportskih doživljaja. Spoznaje do kojih ćemo doći mogu biti od velike koristi pružateljima usluga sportskog turizma u Gorskom kotaru i drugim sličnim destinacijama. The overall objective of this research is to propose efficient business models which will allow sports tourism providers in less developed tourist destinations to adapt to the current market challenges and, being focused on providing sports experiences, to maintain and increase their market shares and positive economic impacts. Few hypotheses are formulated: (1) sports experiences that tourists seek differ significantly from one another and can be sorted in several characteristic groups; (2) the main elements of the existing business models of sports tourism in less developed tourist destinations are identical to the main elements of the existing business models of best practice, but their application in practice differ; (3) by analysing the collected primary qualitative data on the characteristics of the existing business models of sports tourism, it is possible to reach knowledge relevant to the design of effective business models capable to provide different types of sports experiences. Gorski kotar (GK) as one of the least developed tourist destinations in Croatia may be appropriate location to explore these issues. We will identify and assess the supply-side (sports events and activities) and conduct a survey on sports tourists in GK in order to generate several types of sports experiences and to determine potential relationship between the types of sports experiences and expenditure of tourists. For benchmarking purposes the same procedure will be applied on selected best practices outside the area of GK. Finally, we will conduct interaction research on existing business models in GK and external best practices. In this way we will get better insight into the business models that deliver different experiences and we will be able to propose the conceptual business models for all types of sports experience. New findings on business models could be of significant benefit for sports tourism providers in GK and other similar destinations.
2953Akumulacija, unutarstanično mapiranje i učinci metala u tragovima u akvatičkih organizamaAccumulation, Subcellular Mapping and Effects of Trace Metals in Aquatic Organisms724Marijana Erk IP2014-09IP-2014-09-4255AQUAMAPMET01.09.2015 - 31.12.2019U tijeku962.450,00 KnPrirodne znanostiNatural sciencesBiologija, Kemija, Biology, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb11261, 12330, 11251, 11253, 12349, 12871, 12351, 169, 12386, 12339, 12340, 12553, 21287, 24444, 25177, Zrinka Dragun, Vlatka Filipović Marijić, Dušica Ivanković, NESRETE KRASNIĆI, Renata Matoničkin Kepčija, Sanja Gottstein, Mirela Sertić Perić, Marko Miliša, Jasna Lajtner, Dirk Schaumlöffel, Julien MALHERBE, Etienne GONTIER, Tatjana Mijošek, Zuzana Redžović, Maria de los Angeles Subirana Manzanares, metali u tragovima, oslikavanje metala u stanici, unutarstanična raspodjela metala, biomarkeri, toksikologija okoliša, procjena utjecaja na okolištrace metals, cellular metal imaging, subcellular metal distribution, biomarkers, environmental toxicology, environmental impact assessmentCilj predloženog projekta je unaprjeđenje dosadašnjih i stjecanje novih spoznaja o tome kako se ribe, rakušci, školjkaši i nametnici riba (kukaši) nose s povišenim koncentracijama metala u slatkovodnim ekosustavima, što će se postići povezivanjem podataka o koncentracijama metala u vodi, akumuliranim metalima te o biomarkerima u bioti s podacima o unutarstaničnom mapiranju metala. Ovo pitanje će se istraživati na različitim biološkim razinama, od unutarstanične do razine organizma, što će omogućiti utvrđivanje načina suočavanja s metalima na različitim razinama biološke organizacije. Multielementna analitička tehnika primijenit će se za analizu metala/metaloida u vodi i u uzorcima biote. U odabranim akvatičkim organizmima istražiti će se i skup biomarkera, uključujući biomarkere općeg stresa te izloženosti i učinaka metala. Oslikavanje metala u stanici provest će se masenom spektrometrijom sekundarnih iona (NanoSIMS), koja trenutno predstavlja najnovije dostignuće tehnike, a omogućava određivanje, vizualiziranje i kvantificiranje raspodjele metala na unutarstaničnoj razini u biološkim materijalima. Primjena NanoSIMS-a u predloženom projektu omogućit će po prvi puta uvid u kretanje i raspodjelu metala u tkivima i stanicama akvatičkih organizama, koji žive u uvjetima povećane izloženosti metalima. Spoznaje, koje će biti rezultat projekta, omogućit će bolje razumijevanje procesa u stanicama i tkivima u kojima sudjeluju metali, kao i posljedica izloženosti akvatičkih organizama metalima. Dodatni cilj je procjena antropogenog utjecaja s obzirom na zagađenje metalima/metaloidima na odabrane slatkovodne ekosustave (rijeke Krka, Ilova), objedinjavanjem kemijskog, biokemijskog i biološkog pristupa, kao i procjena rizika po zdravlje ljudi. Nadalje, rezultati će doprinijeti razvoju planova upravljanja vodama te je stoga ovo istraživanje od strateškog značaja za Republiku Hrvatsku. Predloženi projekt će također omogućiti obrazovanje i usavršavanje nove generacije znanstvenika.The aim of the proposed project is to increase our understanding and gain new knowledge on how fish, crustaceans, bivalves and fish parasites (acantocephalans) cope with elevated metal concentrations in freshwater ecosystems by relating data on metal concentrations in water, accumulated metals and biomarker responses in biota to data on intracellular metal mapping. This issue will be tackled at different biological levels, from subcellular to organism, thus establishing how different levels of biological organisation cope with metal exposure. Multielemental analytical technique will be applied to analyse metals/metalloids in water and biota samples and the suit of biomarkers will be studied on selected aquatic organisms encompassing biomarkers of general stress and biomarkers of metal exposure and effect. Secondary ion mass spectrometry (NanoSIMS), as a new, state-of-the-art technique, will be applied for cellular metal imaging in order to measure, visualize and quantify the distribution of specific metals at the sub-cellular level in biological materials. The application of NanoSIMS in the proposed project will for the first time enable the insight into the circulation of metals within tissues and cells of aquatic organisms living under increased metal exposure. The resulting information of the proposed project will generally contribute to better understanding of metal processes in cells and tissues and consequences of metal exposure in aquatic organisms. Additional aim of the project is to evaluate anthropogenic impact on selected freshwater ecosystems (rivers Krka, Ilova) referring to metal/metalloid pollution and using integrated chemical, biochemical and biological approach, as well as to evaluate the risk for human health. In addition, it will contribute to development of water management plans and is therefore, of strategic importance for the Republic of Croatia. The proposed project will also provide capacity building of the next generation of scientists.
2959 HIBRIBRIDNE SILICIJSKE NANOSTRUKTURE ZA SENZORIKU HYBRID SILICON NANOSTRUCTURES FOR SENSING 3688Mile Ivanda IP2014-09IP-2014-09-7046NANOSENS01.06.2015 - 31.05.2019Završio996.000,00 KnPrirodne znanostiNatural sciencesFizika, Kemija, Physics, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb5237, 5879, 4750, 4964, 5104, 4985, 4963, 4632, 4296, 5395, 5187, 5190, 13452, 13039, Sanja Vidaček, Maurizio Ferrari, Vedran Đerek, Lara Mikac, Ozren Gamulin, Maja Balarin, Marin Kosović, Vedran Đurina, Davor Ristić, Miroslav Očko, Stjepan Lugomer, Tibor Janči, Niyazi Serdar Sariciftci, Marko Škrabić, SILICIJ, NANOSTRUKTURE, SENZORI, HIBRIDNE KOMPONENTE, ORGANSKI POLUVODIČISILICON, NANOSTRUCTURES, SENSORS, HYBRID COMPONENTS, ORGANIC SEMICONDUCTORSPrijedlog projekta temelji se na našim prethodnim aktivnostima kojima smo naučili pripraviti kvalitetne uzorke nanostrukturiranog silicija. Razvili smo i ideje te stekli znanja i iskustvo za daljnje eksperimentalne tretmane uzoraka kako bi se razvila nova svojstava s ciljem veće konkurentnosti kod određenih primjena. Projekt se bavi temeljnim fizikalnim i kemijskim svojstvima i primjeni hibridnih silicijevih nanostruktura pripravljanim elektrokemijskim jetkanjem i kemijskom depozicijom iz pare pod niskim tlakom (LPCVD). Projektni prijedlog sadrži četiri međusobno povezana istraživačka zadataka: silicijeve hibridne nanostrukture za plinske senzore; vrlo osjetljivi detektori za infracrvenu svjetlost; površinski pojačana Ramanova spektroskopija (SERS) u prehrambenoj tehnologiji i sferni optički mikrorezonatori u molekulskoj detekciji. Predloženi zadaci projekta su međusobno povezani preko priprave hibridnih materijala na temelju jeftinog silicija kompatibilnog CMOS tehnologiji u svrhu razvoja navedenih primjena. Za realizaciju predloženih istraživačkih zadataka organiziran je istraživački tim od 14 istraživača (9 znanstvenika i 5 doktorandada) sa 2 znanstvena instituta, 2 fakulteta, 1 instituta u privatnom sektoru i 2 instituta iz inozemstva. Elektrokemijski procesi jetkanja će se koristiti za pripravu silicija s porama odgovarajućih veličina i volumena s mogućom kontrolom od nanometarske do mikrometarske veličine. Različite kemijske metode biti će primjenjene za funkcionalizaciju poroznih silicijevih struktura pri istraživanjima i razvoju detekcije plina, IR senzora i SERS spektroskopije. Nove silicijeve heterostrukture pripravljene LPCVD metodom na sfernim kvarcnim optičkim microrezonatorima istraživati će se obzirom na mogućnosti primjene u detekciji molekula. Strukturna, optička i elektronska svojstva predloženih funkcionalnih silicijskih nanostruktura istraživati će se sa gledišta temeljnih spoznaja kao i u svrhu razvoja specifičnih proizvoda visoke tehnologije potrebnih hrvatskoj industriji.The project proposal is based on our prior research activities where we learned how to prepare high quality nanostructured silicon. We have also developed ideas and gained knowledge and experience for further experimental treatments of our samples aimed on development of new properties competitive for specific applications. The project addresses fundamental physics and chemistry, properties and application of silicon hybrid nanostructures prepared by electrochemical anodisation and low pressure chemical vapour deposition (LPCVD). The project proposal consists of four interrelated research tasks: silicon/hybrid nanostructures for gas sensing; low light infrared detection; surface enhanced Raman spectroscopy (SERS) in food technology and spherical optical microresonators in low concentration molecular detection. The proposed tasks are mutually interconnected by the CMOS technology compatible materials production based on inexpensive silicon, and by the search for their specific advanced applications. For the achievement of the proposed research tasks we have organized a team of 14 researchers (9 scientists and 5 PhD students) from 2 scientific institutions, 2 faculties and 1 institution in the private sector and 2 renowned institutions from abroad. Electrochemical processes will be used for construction of tailored pore sizes and volumes in silicon that are controllable on the scale from nano- to micrometers. A number of suitable chemistries will be applied for the functionalization of porous Si surfaces for gas sensing, IR sensors and SERS spectroscopy. The novel silicon heterostructures deposited by the LPCVD method on silica spherical optical microresonators will be investigated for possible applications in molecular sensing. The structural, optical and electrical properties of such functional silicon nanostructures will be examined from the fundamental science point of view as well as for development of specific high-tech products needed by the Croatian industry.
2963Fenotipski i epigenetski odgovor na sušni stres i prilagodljivost populacija hrasta lužnjaka (Quercus robur L.) uzduž gradijenta zemljopisne širine.Phenotypic and Epigenetic Response to Drought Stress and Adaptability of Quercus robur L. Populations along a Latitudinal Gradient11185Jozo Franjić IP2014-09IP-2014-09-4686PerdaQuercus15.06.2015 - 14.06.2019Završio967.264,00 KnBiotehničke znanostiBiotechnical sciencesŠumarstvo, Forestry, Sveučilište u Zagrebu, Šumarski fakultetUniversity of Zagreb, Faculty of Forestry11184, 11214, 11304, 44, 11167, 5275, 11179, 11312, 12638, 5607, Željko Škvorc, Ida Katičić Bogdan, Daniel Krstonošić, Saša Bogdan, Krunoslav Sever, Mladen Ivanković, Martina Temunović, Ivana Kovač, Ivica Čehulić, Maja Morić, fenotipska plastičnost, genetska raznolikost, klimatske promjene, ekološka niša, pozadinski rub rasprostranjenostiphenotypic plasticity, genetic variability, climate change, ecological nishe, rear distribution edgeHrast lužnjak (Quercus robur L.) je jedna od ekonomski najvrijednijih europskih vrsta šumskog drveća. To je ključna klimatogena vrsta u šumama visoke razine bioraznolikosti te stoga ima i neprocjenjivu ekološku i društvenu vrijednost. Opstanak populacija ove vrste u južnoj i jugoistočnoj Europi je ugrožen zbog predviđenih klimatskih ekstrema kao što su dugotrajne suše. Te populacije su dio tzv. ''pozadinskog ruba'' areala vrste, a njihov fenotipski odgovor i sposobnost prilagođavanja klimatskim promjenama nisu dovoljno istraživani. Istraživanje će se provesti na potomstvu i biljnim uzorcima iz europskih populacija uzorkovanih uzduž okolišnog gradijenta zemljopisne širine (sjever-jug). Žarište istraživanja bit će na populacijama iz južnog i jugoistočnog dijela rasprostranjenosti vrste. Cilj nam je usporediti prilagodljivost, epigenetski i fenotipski odgovor na sušni stres južnijih populacija s populacijama iz središnjeg i sjevernog dijela rasprostranjenosti.Glavni znanstveni ciljevi predloženog projekta su određivanje: 1) neutralne genetske raznolikosti i strukture odabranih populacija uzduž gradijenta zemljopisne širine; 2) njihove epigenetske raznolikosti i strukture; 3) njihovog epigenetskog odgovora na dugoročni sušni stres; 4) njihovog fiziološkog, fenološkog, morfološkog i biokemijskog (odnosno fenotipskog) odgovora na sušni stres; 5) njihove adaptivne genetske varijabilnosti, diferencijacije i fenotipske plastičnosti; 6) sadašnje ekološke niše i glavnih okolišnih varijabli koje određuju distribuciju ove vrste 7) buduće rasprostranjenosti vrste uvjetovane scenarijima klimatskih promjena na temelju modeliranja ekološke niše kao i koji će dijelovi sadašnje rasprostranjenosti biti zahvaćeni smanjenjem prikladnosti staništa; 8) razina prilagodljivosti istraživanih populacija usporedbom njihove adaptivne genetske varijabilnosti, fenotipske plastičnosti i epigenetskog odgovora.Pedunculate oak (Quercus robur L.) is one of the economically most valuable European forest tree species. It is the keystone climax species of forests which harbour high biodiversity and consequently has priceless ecological and social value. Survival of the specie’s populations in southern and southeastern Europe is endangered by predicted climate extremes such as prolonged drought. These populations are the “rear edge” of the species distribution range and their phenotypic response and adaptive capacity to climate change have not been well studied. Research will be carried out on progenies and plant samples derived from European populations sampled along a latitudinal environmental gradient. The focus of the research will be placed on populations from the southern and southeastern part of the specie’s distribution range. We aim to compare adaptability, epigenetic and phenotypic responses to drought stress of southernmost populations with the populations from the central and northern part of the specie’s distribution range.The main scientific objectives of the proposed project are to determine: 1) neutral genetic diversity and structure of selected pedunculate oak populations along a latitudinal gradient; 2) their epigenetic diversity and structure; 3) their epigenetic response to long-term drought stress; 4) their physiological, phenological, morphological, biochemical and growth (i.e. phenotypic) response to drought stress; 5) their adaptive genetic variability, differentiation and plasticity; 6) current ecological niche preferences and main environmental variables driving its distribution 7) its future distribution under climate change scenarios based on ecological niche modelling and which parts of the contemporary distribution will suffer from decreased habitat suitability induced by climate change; 8) levels of the studied populations adaptability by comparing their adaptive genetic variability, plasticity and epigenetic response.
2964Istraživanje utjecaja otpadnih voda iz farmaceutskih industrija na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica u slatkovodnim sedimentimaExploring the impact of wastewaters from pharmaceutical industries on the composition and antibiotic resistance profile of exposed microbial communities in freshwater sediments12566Nikolina Udiković Kolić UIP2014-09UIP-2014-09-9350WINAR01.09.2015 - 31.08.2018U tijeku983.100,00 KnBiotehničke znanosti, Prirodne znanosti, Biotechnical sciences, Natural sciences, Biotehnologija, Biologija, Kemija, Biotechnology, Biology, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb5324, 6257, 12589, 12743, 3674, 4621, 18946, 18989, 21182, Ines Petrić, Irena Vardić Smrzlić, Tamara Jurina, Fabienne Wichmann, Marijan Ahel, Ana Šimatović, Ana Bielen, Juan José González Plaza, Milena Milaković, antibiotička rezistencija, mikrobne zajednice, farmaceutska industrija, otpadna voda, sediment, antibiotici, teški metali, rezistomantibiotic resistance, microbial communities, pharmaceutical industry, wastewater, sediment, antibiotics, heavy metals, resistomeRastuća rasprostranjenost bakterija rezistentnih na antibiotike trenutno je jedna od najozbiljnijih prijetnji zdravlju. Istraživanja pokazuju da kontinuirani unos antibiotika i teških metala u okoliš doprinosi ovom problemu. Selekcijski pritisak nametnut od strane ovih zagađivala promovirao je razvoj i širenje antibiotičke rezistencije među okolišnim i patogenim bakterijama. Iako je otpad farmaceutske industrije prepoznat kao najvažniji točkasti izvor ovih zagađivala u prihvatnom vodenom okolišu, njegov utjecaj na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica nije poznat. Kako bi popunili ovaj važan istraživački jaz, predlažemo primijeniti interdisciplinarni pristup koji će se fokusirati na slatkovodne sedimente koji su pod utjecajem otpadnih voda iz dviju lokalnih farmaceutskih industrija. Procijenit ćemo rasprostranjenost antibiotika i teških metala u tim sedimentima i identificirati potencijalne ''vruće točke'' za razvoj rezistencije. Geni koji kodiraju za antibiotičku rezistenciju porijeklom iz ''vrućih točaka'' i referentnih mjesta bit će otkriveni primjenom funkcionalne metagenomike. Ovaj pregled bit će osnova za kvantitativnu studiju koja će uspostaviti prostorno-vremensku poveznicu između industrijskog ispusta i zastupljenosti antibiotičke rezistencije. Ovi podaci, u kombinaciji sa hvatanjem rezistentnih plazmida direktno iz bakterija sedimenta u modelni patogen, bit će kritični za donošenje zaključaka o širenju rezistencije među bakterijama. Kompletno sekvenciranje mobilnih plazmida će nadalje pomoći u identifikaciji novih plazmida koji nose grupirane gene za rezistenciju na antibiotike i teške metale. Konačno, utjecaj ispusta na dinamiku sastava bakterijskih zajednica u sedimentima bit će analiziran Ilumina sekvenciranjem 16S rRNA gena. Vjerujemo da će dobivena saznanja imati vitalne implikacije na razvoj učinkovitih strategija upravljanja kako bi se smanjilo širenje antibiotika i antibiotičke rezistencije preko okolišnih puteva.The increasing prevalence of antibiotic resistant bacteria is currently one of the most serious health threats. There is growing evidence that continuous environmental discharge of antibiotics and heavy metals contributes to this issue. The selection pressure imposed by these pollutants has promoted the development and spread of antibiotic resistance among environmental bacteria and pathogens. Although pharmaceutical waste is recognized as the most important point source of these pollutants in the receiving aquatic environment, its impact on the composition and antibiotic resistance profile of exposed microbial communities is not known. To fill this important research gap, we propose to take an interdisciplinary approach focusing on freshwater sediments impacted by wastewaters of two local pharmaceutical industries. We will assess the prevalence of antibiotics and heavy metals in these sediments and identify potential hot spots for resistance evolution. Antibiotic resistance genes from hot spots and reference sites will be discovered using functional metagenomics. This will lay the groundwork for a quantitative study that will establish spatio-temporal relationships between industrial discharge and the occurrence of antibiotic resistance. This, in combination with direct capturing of resistance plasmids from sediment bacteria to a model pathogen will be critical to draw conclusions about the spread of resistance genes among bacteria. Complete sequencing of transferable plasmids will furthermore assist in identifying novel plasmids that carry clustered antibiotic and heavy metal resistance gene loci. Finally, the impact of discharge on dynamics of sediment community composition will be analyzed by Illumina sequencing of 16S rRNA genes. We believe that the obtained knowledge will have vital implications for the development of effective management strategies to reduce the spread of antibiotics and antibiotic resistance determinants via environmental pathways.
2983Nutritivna modulacija metabolizma dokozaheksaenske kiseline kod dijabetičke dislipidemijeNutritive modulation of docosahexaenoic acid metabolism in diabetic dyslipidemia5392Tomislav Mašek IP2014-09IP-2014-09-8992dislipiDHA01.02.2016 - 31.01.2019Završio742.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesVeterinarska medicina, Veterinary medicine, Sveučilište u Zagrebu, Veterinarski fakultetUniversity of Zagreb, Faculty of Veterinary Medicine12663, 3601, 3611, 12946, 6444, 12484, 13016, 5271, 12628, 12528, 13235, 3257, 12450, Kristina Starčević, Marcela Šperanda, Mislav Đidara, Diana Brozić, Franjo Martinković, Krešimir Bošnjak, Maja Maurić, Snježana Kužir, Luka Krstulović, Miroslav Bajić, ivana stolić, Zvonko Stojević, Marina Vranić, dokozaheksaenska kiselina, dislipidemija, dijabetes, peroksisomi, oksidacija, prehranadocosahexaenoic acid, dyslipidemia, diabetes, peroxisomes, oxidation, nutritionDokozaheksaenske kiseline (DHA) je važna masna kiselina čiji je biokemijski put sinteze dugo vremena bio nejasan. Trenutni model pretpostavlja kako nakon serije desaturacija i elongacija u endoplazmatskoj mrežici nastaje C24:6n3 koja odlazi u peroksisom gdje se jednim ciklusom ß-oksidacije skraćuje u 22:6n3 (DHA) i zatim odlazi natrag u endoplazmatsku mrežicu gdje bude esterificirana u odgovarajuće fosfolipide. Količinu DHA u plazmi i tkivima određuje unos masnih kiselina hranom, natjecanje za enzime između n3 i n6 linije masnih kiselina i endogeni metabolizam. Svi ovi čimbenici mogu biti promijenjeni tijekom dijabetesa. Međutim, složenost sinteze trenutno onemogućava točno predviđanje razine DHA u tkivima dijabetičnih životinja. U projektu ćemo istražiti učinak n3/n6 omjera lipida hrane i direktnog dodatka DHA kod dijabetesa tipa 1 i 2 na metabolizam DHA, oksidaciju u mitohondrijima i peroksisomima i DHA metabolom. Naša pretpostavka je dokazivanje da hranidbena modulacija može umanjiti učinak inzulina kod dijabetičke dislipidemija što može imati veliko značenje u tretmanu dijabetesa. Dodatno ćemo istražiti koji enzimi, uključeni u mitohondrijsku i peroksisomsku ß-oksidaciju, mogu biti regulirani lipidima hrane. Istraživanja će biti provedena na štakorima kojima će biti induciran dijabetes tipa 1 i 2 te će dobivati hranidbene tretmane s varirajućih razinama n3/n6 i povećanom koncentracijom DHA. Integriranje rezultata pokusa objasnit će promjene u koncentracijama DHA kod različitih tipova dijabetesa. Istraživanja na subcelularnoj razini omogućit će utvrđivanje učinka dijabetesa na mitohondrijsku i peroksisomsku ß-oksidaciju i metabolizam DHA. Istraživanje metaboloma DHA povezat će prehranu, dijabetes i bioaktivne produkte DHA. Naposljetku, podaci iz cjelokupnog projekta rezultirat će integracijom znanja i boljim razumijevanjem biosinteze DHA.Docosahexaenoic acid (DHA) is an important fatty acid which biochemical pathway was enigmatic for a long time. Current model suggests that after the series of desaturation and elongation processes in endoplasmic reticulum C24:6n3 is synthesized, transported to the peroxisome and then shortened to 22:6n3 via one cycle of ß-oxidation and transported back to the endoplasmic reticulum for esterification into the appropriate phospholipids. Plasma and tissue DHA values are determined by dietary intake, competition for enzymes between n3 and n6 line and by the endogenous fatty acid metabolism, which could be dysregulated by diabetes. Nevertheless, the complexity of synthesis currently prevents correct prediction of DHA content in the tissues of diabetic animals.In this project, we will investigate the influence of n-3/n-6 ratio and DHA supplementation in insulin dependent and non-insulin dependent diabetes mellitus on DHA metabolism, mitochondrial and peroxisomal oxidation and DHA metabolome. Our assumption is that nutritional modulation can override insulin influence on diabetic dyslipidemia which could have profound influence on the treatment of diabetes. Additionally we will try to find enzymes of mitochondrial and peroxisomal ß-oxidation which could influence DHA metabolism by nutritional modulation. Trials will be performed on rats with induced diabetes which will receive dietary treatments with different n3/n6 ratios and increased DHA content. Integration of results from experiments will define the behavior of DHA in different types of diabetes. Investigations on subcellular level will allow us to determine the influence of diabetes on peroxisomal and mitochondrial beta oxidation and DHA metabolism. Investigation of DHA metabolome will link nutrition, diabetes and bioactive DHA products. Finally, data from the whole project will result in integration of knowledge and better understanding of DHA biosynthesis.
2984Genski polimorfizmi i ishemijski moždani udar u djeceGene polymorphisms and ischemic stroke in children3334Renata Zadro IP2014-09IP-2014-09-2047GENESTROKE01.10.2015 - 30.09.2019Završio799.440,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesTemeljne medicinske znanosti, Basic Medical Sciences, Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultetUniversity of Zagreb, Faculty of Pharmacy and Biochemistry4701, 4057, 4032, 5252, 4686, 13580, 21314, 1302, Marija Miloš, Margareta Radić Antolic, Ivana Horvat, Marina Pavić, Desiree Coen Herak, Jasna Leniček Krleža, Andrea Čeri, Vlasta Đuranović, ishemijski moždani udar, genski polimorfizmi, trombofilija, djeca, koagulacijaischemic stroke, genetic polymorphisms, thrombophilia, children, coagulationCerebrovaskularni poremećaji u djece, iako rijetki, rezultiraju značajnom smrtnošću i dugotrajnim morbiditetom. Pojavnost moždanog udara u djece prema podacima populacijskih studija iznosi 1,23-13,0/100.000 djece/godišnje. Iako je poznato više od 100 rizičnih faktora za nastanak moždanog udara, genetički faktori nisu potpuno istraženi. Za FV Leiden, FII 20210G>A, MTHFR677C>T, manjak protiena C i povišeni lipoprotein (a) pokazano je da igraju ulogu u moždanom udaru u djece. Moždani udar u djece vjerojatno nastaje kao posljedica interakcije više različitih gena i čimbenika okoliša koji zajedno s razlikama u cerebrovaskularnom, neurološkom i koagulacijskom sustavu ograničavaju izravnu ekstrapolaciju istraživanja s odraslih na djecu i opravdaju istraživanja polimorfizama ostalih trombofilijskih faktora. Cilj ovog istraživanja je odrediti prevalenciju genetičkih rizičnih čimbenika u skupini djece s ishemijskim moždanim udarom analizom polimorfizama u i) koagulacijskim faktorima FV (FV Leiden i FV H1299R), FII (20210G>A), FXIII (Val34Leu), beta-fibrinogen (-455G>A) i PAI-1 4G/5G; ii) trombocitni glikoproteinski receptori GPIa (807C>T/873G >A i 52T>C), GPIba (1018C>T, VNTR i (-5C/T Kozak), GPIIb/IIIa (1565T>C – PIA1/A2 i 2622T>G) i GPVI (13254T>C); iii) P-selektin (S290N, N562D, V599L, T715P) i iv) intermedijarni rizični faktori za moždani udar u djece, ACE I/D i Apo E2/E3/E4. Dobiveni rezultati unaprijedit će spoznaju o uključenosti ostalih genetičkih rizičnih čimbenika u etiologiji ishemijskog moždanog udara u djece. Razumijevanje genetičke osnove ishemijskog moždanog udara doprinijet će razvoju i primjeni standardiziranih protokola u dijagnostici, istraživanju, terapiji i procjeni ishoda moždanog udara u djece.Cerebrovascular disorders in children, although rare, result in significant mortality and long-term morbidity. The incidence of childhood stroke as reported by population based studies is 1.23-13.0/100 000 children/year. More than 100 risk factors for stroke are recognized but genetic factors are incompletely characterized. FV Leiden, FII 20210G>A, MTHFR 677C>T, protein C deficiency and elevated Lp(a) have been demonstrated to play a role in childhood stroke. It is likely that stroke in children occurs secondary to interactions between several genes and the environment that, together with age-related differences in cerebrovascular, neurological and coagulation systems limit the direct extrapolation of research from adults to children and justify research of polymorphisms of other thrombophilic factors. The aim of this investigation is to determine the prevalence of genetic risk factors in a cohort of children with ischemic stroke by analysis of polymorphisms in i) coagulation factors FV (FV Leiden and FV H1299R), FII (20210G>A), FXIII (Val34Leu), ß-fibrinogen (-455G>A) and PAI-1 4G/5G; ii) platelet glycoprotein receptors GPIa (807C>T/873G>A and 52T>C), GPIba (1018C>T, VNTR and (-5)C/T Kozak), GPIIb/IIIa (1565T>C – PIA1/A2 and 2622T>G) and GPVI (13254T>C); iii) P-selectin (S290N, N562D, V599L, T715P) and iv) intermediate risk factors for childhood stroke, ACE I/D and Apo E2/E3/E4. The obtained results will enhance knowledge about involvement of other genetic risk factors in the etiology of ischemic stroke in childhood. The understanding of genetic basis of ischemic stroke will contribute to the development and application of standardized protocols for the diagnosis, investigation, therapy and outcome assessment of ischemic stroke in children.
3000Definiranje mogućnosti uporabe mini dentalnih implantata (MDI) i njihovi rezultati u in vitro i u kliničkim prospektivnim istraživanjimaDefining possibilities of using Mini dental implants (MDI) and their outcomes in vitro and in clinical randomised prospective studies7709Asja Čelebić IP2014-09IP-2014-09-1218Mini implantati/ MDI17.11.2015 - 15.04.2020U tijeku945.000,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesDentalna medicina, Kliničke medicinske znanosti, Dental medicine, Clinical sciences, Sveučilište u ZagrebuUniversity of Zagreb13290, 13236, 7100, 11237, 13209, 13315, 13264, 13199, 13201, 5491, 6148, 13743, 21397, Denis Vojvodić, Robert Ćelić, Amir Ćatić, Ketij Mehulić, Renata Poljak-Guberina, Dražan Kozak, Damir Modrić, Sanja Peršić, Josip Kranjčić, Goran Batinjan, Irina Filipović Zore, Nikola Petričević, Dino Buković, Mini dentalni implantati, standardni implantati, mehanička teastiranja na modelima, klinička prospektivna istraživanja, određivanje indikacija za MDIMini dental implants, standard implants, mechanical testing on models, clinical prospective studies, MDI indicationsMini dentalni implantati (MDI) su jednokomadni uski implantati za privremenu (ortodoncija, privremeni mostovi) ili za dugoročnu kliničku upotrebu. Prednosti MDI za trajnu kliničku primjenu su u njihovoj niskoj cijeni i jednostavnoj proceduri. Iako na dentalnom tržištu postoje već 10 godina, dokazi o budućim kliničkim istraživanjima za definiranje njihovih kliničkih protokola i njihovom dugoročnom ishodu nedostaju. Stoga planiramo istraživati njihova mehanička svojstva na modelima s obzirom na moment sile prilikom insercije, mogućnost loma prilikom cikličkih opterećenja ili opterećenja prilikom naprezanja. Situacija slična stanju u ustima će se simulirati pomoću različitih kosti tvrdoće modela (guste vs kosti niske gustoće) s 2 vrste sluznice različite širine, te insercijom 1, 2, 3 ili 4 MDI različite širine i dužine za retenciju pokrovne proteze. 3 D printevi služiti će da bi se razvili modeli na kojima će se testirati. Nadalje, buduće kliničke studije koje će se temeljiti na pacijentovoj procjeni ishoda terapije (pomoću psihometrijski odobrenih upitnika) i kliničkih parametara (preživljavanje implantata, komplikacije, razina kosti oko implantata, resorpcija na stražnjim bezubim dijelovima ispod baze proteze, kortikalni indeksi na donjem rubu mandibule, vrijednosti gonion i antegonion udubina, gustoća kostiju u područjima interesa koji će biti izraženi u debljini stepwedga, mjerenje plak, gingiva i kalkulus indeksa, ISQ vrijednosti) će također biti predmetom istraživanja. Podaci će se upoređivati sa onima dobivenim nakon jedne i 3 godine. Rezulati dobiveni temeljem pacijentove procjene usporediti će se s kliničkim dobivenim parametrima. Nadalje, rezultati dobiveni s obzirom na kliničke parametre kod pacijenata sa MDI (kvaliteta kostiju, količina, gustoća) će se uspoređivati sa podacima kod pacijenata sa potpunim protezama, kod pacijenata sa pokrovnim proteze na 2-standardna implantata te kod osoba s prirodnim zubala. Također će se proučavati različite mogućnosti retencije proteza (mehanizmi).Mini dental implants (MDIs) are one piece slim implants for temporary (orthodontics, temporary bridges) or for a long term clinical use. Advantages of MDIs for a permanent clinical use are their low cost and simple procedures. Although they exist at the dental market for 10 years, evidence based prospective clinical studies for definition of their clinical protocols and long term outcomes are missing. Therefore we plan to study first their mechanical properties on models considering placement torque, fracture torque, possibility of fracture upon cycling loads or strain loads. A situation similar to real one will be simulated by using different bone hardness models (dense vs, low density bone) with 2 different oral mucosa widths, and with insertion of 1, 2, 3 or 4 MDIs of different width and length for overdenture retention. 3D prints will be helpful in model development. Further, prospective clinical studies based on both, patient based outcomes (assessed by psychometrically approved questionnaires) and clinical parameters (implant survival, any complications, bone level adjecent to implants, bone resorption at posterior edentulous sites under a denture base, cortical indices changes at the low border of the mandible, gonion angle and antegonion pitch values, bone density in the region of interest expressed as equvivalents of actual Cu stepwedge thickness attached during exposure, plaque, gingival and calculus indices, ISQ values) will be performed. Baseline data will be compared to a 1-year and 3-year outcomes. Patient based outcomes will be compared with clinical data. Results considering clinical parameters (bone quality, quantity, density) will be compared to similar data in complete denture wearers, in overdenture patients with dentures retained by 2-standard size implants and in individuals with natural dentition. Different denture retention options (mechanisms) will also be studied.
3001Postimperijalni narativi u srednjoeuropskim književnostima modernePostimperial narratives in Central European Literatures of the Modern Period7997Marijan Bobinac IP2014-09IP-2014-09-2307Postimperial01.06.2015 - 31.05.2019U tijeku469.770,00 KnHumanističke znanostiHumanitiesFilologija, Povijest, Philology, History, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences12586, 3566, 12609, 12579, 6503, 21419, 17727, 25305, 25194, 25245, 17728, Svjetlan Lacko Vidulić, Milka Car, Davor Dukić, Magerski Christine, Jelena Spreicer, Daniela Finzi, Endre Hars Hars, Wolfgang Müller-Funk, andrea seidler, Clemens Ruthner, Johann Georg Lughofer, Postimperijalni narativi, srednjoeuropske književnosti: hrvatska, austrijska, mađarska, moderna, dihotomija centar/periferija, Habsburg postcolonialPostimperial narratives, Central European literatures: Croatian, Austrian, Hungarian, modern period, dichotomy center/periphery, Habsb. postcolonialNaš projektni prijedlog, polazeći od teorijskog pristupa tzv. imperijalnih i postimperijalnih studija, istraživat će dodire i preklapanja u srednjoeuropskim kulturama sjećanja, a napose točke preklapanja u (zajedničkim) strukturama književne produkcije na tom području. Posebna će se pozornost pritom posvetiti Habsburškoj monarhiji, odnosno njezinim zemljama sljednicama u posljednjim dvama stoljećima, tj. u razdoblju od početaka procesa nastajanja modernih nacija pa sve do rasapa multietničkih državnih formacija, tj. starih imperija srednje i jugoistočne Europe, i nastanka novih nacionalnih država.Termin imperij, ključan pojam našeg istraživanja, preuzet je iz geopolitičke povijesti i može se primijeniti i na druge značajne državne strukture tog tipa (Osmansko, Rusko, Njemačko carstvo), relevantne u spomenutom vremenskom i prostornom kontekstu. Koncept implicira postojanje složene mreže društvenih, političkih i gospodarskih odnosa unutar tih državnih formacija, odnosa koji nastaju i posreduju se kroz konstrukcije 'kulturne razlike' i asimetričnih odnosa moći. Imperij se može shvatiti kao kompleksna kulturna 'priča' koju stvaraju političke i kulturne elite: kao neka vrsta narativnog konstrukta koji se u različitim kontekstima strukturira na različite načine, služeći pritom opisu ili objašnjenju određenih pojava ili odnosa. Stoga se ne samo nacionalne, nego i supranacionalne, tj. imperijalne kulture trebaju proučavati kao 'pripovjedne zajednice', strukture koje se međusobno razlikuju ponajprije po svome pripovjednom 'rezervoaru'.Osnova istraživanja bit će književnost, kulturni medij koji raspolaže jedinstvenim mogućnostima reprezentacije, afirmacije i subverzije konstrukcija kulturnog sjećanja i procesa stvaranja individualnih i kolektivnih identiteta. U tom kontekstu posebna će pažnja biti posvećena sljedećim pitanjima: 1) kako procesi nacionalne homogenizacije i imperijalne težnje funkcioniraju u mediju književnosti, 2) na koji se način oni prožimlju i sukobljavaju, te 3) kako se oni pritom instrumentaliziraju za konkretne političke, ideološke ili estetske ciljeve.Our research project situates itself in the field of Imperial and Post-Imperial Studies. It will investigate overlaps and interferences between different cultures of memory in Central Europe, along with possible points of convergence in (joint) structures of literary production. Special attention will be paid to the Habsburg Monarchy and its successor states in the last two centuries – from the beginnings of the modern nation building process to the subsequent disintegration of multi-ethnic state formations.The term ‘empire’, being key to our research, is borrowed from geopolitical historiography and also applies to other empires in the region, which are relevant in the aforementioned temporal and spatial context. The concept implies a complex network of social, political and economic relations within the state, established and ‘translated’ through constructions of ‘cultural difference’ and asymmetrical power relations. Thus, ‘empire’ can also be understood as a complex cultural ‘story’ told by the political and cultural stakeholders: a type of narrative construct structured differently in different contexts and often used to describe or explain certain social / historical facts. Accordingly, not only national, but also supranational, i.e. imperial, cultures should be studied as ‘narrative communities’ differing from each other mainly through their cultural story-telling reservoirs.In order to exemplify this, our research project will be based on the study of literature as a medium of culture with the unique capacity to represent, affirm and undermine constructions of cultural memory and processes of both individual and collective identity formations. For conclusive results, we will address the following research questions: 1) how processes of national homogenization and imperial claims function in the medium of literature, 2) how they come in contact and, 3) how they can be instrumentalized for concrete political, ideological or aesthetic purposes.
3002Imunosne i regenerativne implikacije korozije dentalnih materijala u djece i adolescenataImmunological and regenerative implications of corrosion of dental materials in children and adolescents 77Stjepan Špalj IP2014-09IP-2014-09-7500IMUNODENT01.12.2015 - 30.11.2019Završio962.420,00 KnBiomedicina i zdravstvo, Tehničke znanosti, Biomedicine and health sciences, Technological sciences, Dentalna medicina, Javno zdravstvo i zdravstvena zaštita, Kemijsko inženjerstvo, Kliničke medicinske znanosti, Strojarstvo, Dental medicine, Chemical engineering, Clinical sciences, Mechnical engineering, Public health and health services, Sveučilište u Rijeci, Medicinski fakultet u RijeciUniversity of Rijeka, Faculty of Medicine3799, 5203, 104, 99, 12407, 11286, 11287, 4798, 11283, 5125, 4260, 3866, 13366, 3810, 25209, Zorana Ivanković Buljan, Helena Otmačić Ćurković, Magda Trinajstić Zrinski, Višnja Katić, Elitza Petkova Markova-Car, Aleksandar Bulog, Sandra Peternel, Koviljka Matušan Ilijaš, Ines Musa Trolić, Andrej Pavlić, Marijana Rinčić Mlinarić, Jelena Prpić, Jasmina Primožič, Miranda Muhvić Urek, Martina Žigante, allergy, antibiotic resistance, nickel exposure, titan exposure, corrosionallergy, antibiotic resistance, nickel exposure, titan exposure, corrosionPomicanje zubi napravama baziranim na niklu i titanu ima veliki osteogeni potencijal i može regenerirati deficijentne dijelove alveolarne kosti i gingive te rehabilitirati narušene okluzijske odnose i žvačnu funkciju pacijenta. Zbog dugotrajnosti takve terapije paralelno se primjenjuju postupci i materijali za prevenciju te regeneraciju oštećene cakline i oralnih sluznica. Usna šupljina može se smatrati galvanskim člankom gdje su dentalne slitine elektrode, a elektrolit čine slina te oralni preventivni i regeneracijski agensi. Interakcija uzrokuje koroziju, smanjenje elastičnosti naprava, produkciju prevelikih sila, poremećaj regeneracije tikiva i nepopravljive štete na korijenu zuba, parodontu i kosti. Tijekom dugotrajne eksponiranosti otpušteni korozivni produkti u okolnim tkivima te transportirani slinom i krvlju mogu izazvati cijeli niz nusefekata. Alergije su danas sve češće i javljaju se sve ranije, a posebna skupina su djeca i mladi adolescenti u periodu pubertetskog rasta kada se razvija i imunološki sustav. Nikal je dugo poznati alergen i prisutan je u brojnim dentalnim legurama. Alergija na nikal događaje su u do 28.5% populacije i ne može se više smatrati niskim potencijalnim rizikom. U posljednje vrijeme reportira se i alergija na titan, za koji se smatralno da je biokompatibilan, a izloženi su mu brojni pacijenti s endoprotezama kuka, stentovima, dentalnim implantatima i ortodontskim napravama. Alergija na titan može biti odgovorna za neobjašnjene slučajeve neuspjeha i odbacivanja dentalnih implantata. Nikal i titan mogu uzrokovati rezistenciju bakterija na antibiotike što može stvarati probleme u terapiji niza infekcija koje su češće u djece i adolesceanta. Cilj je ovog projekta ispitati u kojoj mjeri i kojim mehanizmima korozija dentalnih materijala baziranih na niklu i titanu izaziva prethodno navedene biološke učinke.Tooth movement, based on nickel-titanium appliance, has great osteogenic potential, it can regenerate deficient alveolar bone sites and gingiva, rehabilitate deficient occlusal relationships and masticatory function. Due to prolonged therapy materials and techniques for prevention and regeneration of damaged enamel and oral tissues are concurrently used. Oral cavity can be considered as a galvanic cell, where saliva is electrolyte and dental alloys and oral agents are galvanic coupling components. Decreasing elasticity of orthodontic wires due to intraoral corrosion can produce excessive forces and therefore can disturb regeneration of tissues and irreparable damage to root and surrounding periodontium and bone. Due to long-term exposure corrosive products are released into adjacent tissues, saliva and blood. There from a number of undesired side effects can develop. Nowadays, the allergies occur more often and onset earlier during a lifetime. Children and young adolescents are undergoing pubertal growth, changes and maturation of immune system and particular attention should be paid to their exposure. Nickel has been well known allergen, present in many dental alloys. Nickel allergic hypersensitivity occurs in up to 28.5% of the population and it cannot be considered a low potential risk. Lately, allergic reactions to titanium were reported in patients with endoprosthesis and dental implants, contrary to the previously established biocompatibility. The occurrence of an allergy to titanium could be responsible for successive unexplained cases of failure of dental implants. Nickel and titan can enhance resistance of some bacteria to antibiotics which can produce problems in treatment of several infections that are more common in children and adolescents. The aim of this project is to explore to what extent and by which mechanisms does corrosion of dental materials based on nickel and titan produce above mentioned biological effects.
3004Razvoj evolucijskih postupaka za karakterizaciju ponašanja bioloških tkivaDevelopment of evolutionary procedures for characterization of biological materials behavior11229Marina Franulović IP2014-09IP-2014-09-4982BIOMAT01.10.2015 - 30.09.2019U tijeku717.500,00 KnTehničke znanosti, Biomedicina i zdravstvo, Technological sciences, Biomedicine and health sciences, Strojarstvo, Mechnical engineering, Sveučilište u Rijeci, Tehnički fakultetUniversity of Rijeka, Faculty of Engineering12834, 12813, 12820, 13022, 13078, 13011, 13337, 22633, 24813, Robert Basan, Kristina Marković, Tea Marohnić, Ivan Prebil, Ana Trajkovski, Senad Omerović, Simon Krašna, Stjepan Piličić, Robert Kunc, biološki materijali, karakterizacija materijala, materijalni model, materijalni parametri, genetski algoritambiological materials, material characterization, material model, material parameters, genetic algorithmU inženjerstvu sve se veća pažnja posvećuje poboljšanju značajki konvencionalnih i razvoju inovativnih materijala. Iako je istraživanje materijala uvelike usmjereno na metale, polimere, staklo, keramiku, kompozite itd., sve veći interes posvećuje se biološkim sustavima i materijalima (školjke, kosti, paukova svila, mišići itsl.) zbog njihovih svojstava koje uvelike nadvisuju one konvencionalnih materijala. Ponašanje i modeliranje bioloških materijala je kompleksno, ali se kao i modeliranje konvencionalnih materijala bazira na poznavanju i eksperimentalnom određivanju njihovih karakteristika. Pored materijalnog modela za opisivanje ponašanja materijala, osnovni preduvjet za modeliranje je identifikacija materijalnih parametara. Prethodno je ustanovljeno da je za identifikaciju parametara bioloških materijala potrebnih za modeliranje njihovog ponašanja preporučljivo primijeniti evolucijske metode, a posebno genetski algoritam. U okviru projekta karakterizirat će se i modelirati ponašanje vratnih ligamenata ljudske kralježnice na osnovi podataka dobivenih eksperimentima. Odabran je hiperelastični materijalni model koji se može koristiti i za kompresibilne i nekompresibilne materijale. Kako bi se na što efikasniji način dobile potrebne vrijednosti materijalnih parametara, razvit će se tehnika određivanja parametara temeljena na genetskom algoritmu. U cilju optimizacije procedure dobivanja parametara zadanog materijala, razvit će se procedura složenog genetskog algoritma te njegovi operatori, uz primjenu adekvatne funkcije cilja optimizacijskog postupka.Zbog fleksibilnosti i robusnosti predložene metodologije karakterizacije materijala, moguća je njena primjenjivost i na karakterizaciju ponašanja i drugih nekonvencionalnih i inovativnih materijala kompleksnog ponašanja. U tu svrhu prikupit će se i sistematizirati rezultati relevantnih publiciranih eksperimentalnih ispitivanja materijala te stvoriti pretpostavke za karakterizaciju drugih inovativnih materijala.In engineering great attention is paid to enhancing the properties of conventional and development of innovative materials. Although the research is largely focused on metals, polymers, glass, ceramics, composites, etc.., increasing interest is devoted to biological systems and materials (shells, bone, spider silk, muscle or similar) due to their characteristics that are significantly above those of conventional materials.Behavior and modeling of biological materials is complex, but as the modeling of conventional materials, it is based on the knowledge and experimental determination of their characteristics. To describe the behavior of materials, beside material model, the basic prerequisite is the identification of material parameters.It was found that for the identification of parameters of biological materials necessary for the modeling of their behavior, it is advisable to apply the evolutionary methods, especially genetic algorithm.In the project, the behavior of the neck ligaments of human spine will be characterized and modelled based on data obtained by experiments. A hyperelastic material model that can be used for compressible and incompressible materials is selected for that puprose. In order to more efficiently produce the required values of material parameters, a technique for determining the parameters based on genetic algorithm will be developed. In order to optimize the procedure to obtain the parameters specified materials, complex genetic algorithm and its operators will be developed, applying the appropriate objective function optimization procedure.Because of it's flexibility and robustness, the proposed methodology for the materials characterization is expected to be applicable to the characterization of other non-conventional and innovative materials of complex behavior. To this end, relevant published experimental results will be collected and systematized in order to create the basis for the characterization of other innovative materials.
3005Molekularni mehanizmi ugradnje homolognih i heterolognih proteina u staničnoj stijenci kvasca i njihova primjena u biotehnologijiMolecular mechanisms for incorporation of homologous and heterologous proteins in the yeast cell wall and their application in biotechnology359Vladimir Mrša IP2014-09IP-2014-09-2837CEWAPROT01.09.2015 - 31.08.2019U tijeku925.500,00 KnBiotehničke znanostiBiotechnical sciencesBiotehnologija, Biotechnology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology3258, 4377, 4323, 5726, 3284, 4764, 12966, 4031, 13195, 13087, 25089, Renata Teparić, Igor Stuparevic, Sanja Musladin, Slobodan Barbarić, Iva Grabarić Andonovski, Damir Iveković, Marina Palčić, Antonija Grbavac, Ksenija Lopandić, Krešimir Gjuračić, Mateja Lozančić, stančna stijenka kvasca, proteini stanične stijenke, lokalizacija proteina, heterologna ekspresija, izlaganje na staničnoj površini, genetička imobiliyeast cell wall, cell wall proteins, protein localization, heterologous expression, surface display, genetic immobilizationStanična stijenka kvasca sastoji se od unutrašnjeg sloja glukana na koji su s vanjske strane vezani manoproteini. Velika je raznolikost među proteinima stijenke, ne samo u strukturama i aktivnostima, nego i u načinu na koji su ugrađeni u stijenku. Neki od njih vezani su nekovalentno, neki kovalentno putem esterske veze nestabilne u lužinama, a neki također kovalentno, ali putem GPI-sidra i beta-1,6-glukana. Za najzastupljeniji nekovalentno vezani protein, Scw4p, nađeno je da je na glukan djelomično vezan i kovalentno, još nepoznatom vrste veze. Jedan od ciljeva ovog projekta je objasniti molekularnu prirodu te veze. Osim toga, za nekoliko proteina stijenke, uključujući i Scw4p nađeno je da su proteolitički procesirani. Drugi cilj ovog projekta bio bi ispitati koje proteaze cijepaju Scw4p i koji je fiziološki značaj te modifikacije.Poznavanje mehanizama ugradnje proteina u stijenku kvasca upotrijebit će se za ugradnju i izlaganje na površini heterolognih proteina eksprimiranih u kvascu. Pripremit će se novi plazmidi u tu svrhu, za ekspresiju i ugradnju proteina u stijenku kvasaca S. cerevisiae i P. pastoris. Analizirat će se i stanične stijenke više drugih kvasaca izoliranih iz različitih habitata kako bi se ispitala mogućnost da oni budu novi domaćini za izlaganje proteina.Kako već postojeći, tako i novoistraženi genetički sustavi upotrijebit će se za izlaganje na površini šest enzima biokemijskog puta za degradaciju S-triazina iz bakterije Pseudomonas ADP. Istražit će se primjena dobivenih kvaščevih sojeva za degradaciju ovog široko korištenog herbicida.Druga potencijalna primjena ove metodologije obuhvatit će izlaganje nekoliko ksiloza reduktaza iz različitih kvasaca i primjenu dobivenih sojeva u proizvodnji ksilitola iz ksiloze uz odgovarajuću elektrokemijsku regeneraciju potrebnog NAD(P)H. Ispitat će se i potencijal te metode za primjenu u biosenzorima.Yeast cell wall consists of an inner layer of beta-1,3-glucan to which mannoproteins are attached. There is a pronounced variability among yeast cell wall proteins not only in their structures and activities, but also in the way they are incorporated into the wall. Some of them are attached non-covalently, some are linked covalently through an alkali labile ester linkage, and some are attached through GPI anchors and beta-1,6-glucan. The most abundant non-covalently attached protein Scw4p was found to be partly also covalently attached to glucan by a so far unknown linkage. One of the goals of this project is to explain the molecular nature of this linkage. Several cell wall proteins including Scw4p were found to be proteolytically processed. The second goal of the proposed project is to investigate which protease cleaves Scw4p and what is the physiological significance of this modification.Our comprehension of molecular mechanisms for incorporation of proteins in the yeast cell wall can be used for surface display of heterologous proteins expressed in yeasts. New plasmids will be created for this purpose for expression and wall incorporation of proteins in S. cerevisiae and P. pastoris. Besides, cell walls of several other non-Saccharomyces yeasts isolated from different habitats will be analysed to search for other potential hosts for surface display of proteins.Both existing, and newly investigated genetic systems will be used for surface display of six enzymes of the S-triazine complete degradation pathway from Pseudomonas ADP. Application of obtained strains in degradation of this world-wide commonly used herbicide will be explored. Described methodology would be used for surface display of several xylose reductases from several yeasts and the application of the obtained strains for enzymatic production of xylitol, combined with electrochemical regeneration of the necessary NAD(P)H. Potential of this method for application in biosensing will also be explored.
3007Motorička znanja djece predškolske dobi: Osnivanje Nacionalnog centra za motorički razvojMotor skills in preschool children: Foundation of the National center for motor development12537Sanja Šalaj UIP2014-09UIP-2014-09-5428MZDPD01.09.2015 - 31.08.2019Završio137.100,00 KnDruštvene znanostiSocial sciencesKineziologija, Kinesiology, Sveučilište u Zagrebu, Kineziološki fakultetUniversity of Zagreb, Faculty of Kinesiology12731, 12593, 7521, 1493, 13377, 13467, 4051, Vatroslav Horvat, Milivoj Jovancevic, MAJA VUKELJA, Frane Žuvela, Dragan Milanović, Biljana Trajkovski, Vilko Petrić, temeljna kretna znanja, sposobnost, tjelesna aktivnost, vrtić, vježbanje fundamental movement, physical abilities, toddler, exercise, physical activity, kindergartenKompetencija u području temeljnih motoričkih znanja poput trčanja, skakanja i bacanja pridonosi dječjem tjelesnom, kognitivnom i socijalnom razvoju i smatra se temeljem za aktivan život. Pozitivno je povezana sa zdravstvenim dobrobitima, razinom tjelesne aktivnosti djece, a negativno s nepovoljnim težinskim statusom: prekomjernom težinom i pretilošću (Lubans i sur., 2010). cilj ovog projekta je osnivanje Nacionalnog centra za motorički razvoj pri Kineziološkom fakultetu Sveučilišta u Zagrebu. Postavljeni su znanstveni ciljevi i projektni zadaci po godinama koji će omogućiti: a) vrednovanje motoričkih znanja djece predškolske dobi u Republici Hrvatskoj, b) utvrđivanje razlika u motoričkim znanjima djece različitog stupnja tjelesne aktivnosti i uključenosti u programe vježbanja, c) definiranje povezanosti motoričkog razvoja sa ostalim domenama razvoja djeteta (socioemocionalni i govorno-jezični razvoj), d) utjecaj roditeljskog interesa prema sportu i stupnja njihove tjelesne aktivnosti na razinu motoričkih znanja djece i e) utvrđivanje utjecaja različitih trenažnih programa na motorička znanja i sposobnosti djece predškolske dobi. U istraživanju će sudjelovati 1500 dječaka i djevojčica u rasponu od 3 do 7 godina i njihovi roditelji iz različitih dijelova Republike Hrvatske. Mjerenje će se provoditi u dva dijela. Prvi dio predstavlja ispunjavanje anketnog upitnika od strane roditelja, a drugi dio testiranje motoričkih znanja putem dva seta testova za procjenu motoričkog statusa (“Test of Gross Motor Development“ i ˝Bruininks-Oseretsky Test of Motor Proficiency˝). Dobiveni podaci predstavljali bi temelj za definiranje normativnih vrijednosti i daljnja istraživanja motoričkog statusa djece u Republici Hrvatskoj te izradu strategije poticanja motoričkog razvoja kroz različite programe i znanstvene aktivnosti utemeljenog Nacionalnog centra za motorički razvoj.Competence in the field of fundamental movement skills such as running, jumping and throwing contributes to children's physical, cognitive and social development. It is considered to be the basis for an active lifestyle. Motor proficiency is positively associated with health benefits, level of physical activity of children, and negatively associated with body weight status (obesity) (Lubans et al., 2010). Final objective of this project is the establishment of the Croatian National Centre for Motor Development at the Faculty of Kinesiology, University of Zagreb. The set of scientific objectives and project assignments per year will allow: a) the evaluation of motor skills of preschool children in the Republic of Croatia, b) the determination of differences in motor skills of preschool children who are involved in different degrees of physical activity and exercise programs, c) the definition of the connection of motor development with the other domains of children development (socio-emotional and language), d) the determination of impact of parental interests in sports and their physical activity levels on children's motor skills, and e) the assessment of different training programs effects on motor skills and abilities of preschool children. The study will embrace 1,500 boys and girls aged 3 to 7 years and their parents from different areas of the Republic of Croatia. Subjects’ testing will be conducted in two parts. First, the parents will fill out the questionnaire, and second, the children’s motor skills will be measured through two sets of motor development and motor proficiency tests. The resulting data would represent a foundation for the normative values and further research on motor status of children in the Republic of Croatia. Also, the findings will be the starting point for the development of strategies promoting motor development through various programs and research activities of the newly established Croatian National Center for Motor Development.
3009Profesionalizam u zdravstvuProfessionalism in Health Care776Ana Marušić IP2014-09IP-2014-09-7672ProHealth01.10.2015 - 30.09.2019Završio750.855,00 KnBiomedicina i zdravstvoBiomedicine and health sciencesJavno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, Public health and health services, Clinical sciences, Sveučilište u Splitu, Medicinski fakultetUniversity of Split, Faculty of Medicine1016, 2713, 772, 12675, 5404, 874, 12670, 767, 4435, 12768, 5258, 12730, 937, 1046, 4935, 777, 4510, 1418, 25225, Lana Barać, Ana Jerončić, Mario Malički, Julije Meštrović, Tina Poklepović Peričić, Shelly Melissa Pranić, Dario Sambunjak, Davorka Vrdoljak, Elizabeth Wager, Ivančica Pavličević, Davor Lukšić, Karmela Krleža-Jerić, Ana Utrobičić, Irena Zakarija-Grković, Dalibora Behmen, Matko Marušić, Livia Puljak, Darko Hren, Marin Viđak, profesionalizam, zdravstvena skrb, profesionalci, integritet, izvrsnost, odgovornost, transparencijaprofessionalism, health care, students, professionals, integrity, excellence, accountability, transparencePredloženi projekt ima za cilj istraživanje izvrsnosti, odgovornosti i integriteta/transparencije kao atributa profesionalizma koji su relevantni za zdravstvenu skrb utemeljenu na dokazima, gdje je profesionalizam široko definiran kao predanost izvršavanju profesionalne zadaća, pridržavanju etičkih principa i osjetljivosti za pacijentovu dobrobit. Prva istraživačka tema projekta usmjerena je na profesionalizam u studenata. Istražit ćemo determinante profesionalnog razvoja studenata, kao i okružje za razvoj profesionalne izvrsnosti i integriteta. Temeljem nalaza iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poticanje razvoja profesionalizma tijekom studija. Druga istraživačka tema usmjerena je na profesionalizam u praksi zdravstvene skrbi. Prvo ćemo usporediti okvire za profesionalnu izvrsnost i integritet, uključujući i dokaze dostupne zdravstvenim profesionalcima i njihovu translaciju u praksi. Temeljem nalazi iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poboljšanje profesionalne prakse. Pristup svakom specifičnom cilj istraživanja uključit će 1) mapiranje trenutnog znanja i identifikacija područja s manjkavim znanjem, 2) uporabu adekvatnih istraživačkih ustroja i metodologija, 3) sinteza rezultata istraživanja u eksplanatorne teorije i modele i 4) razvoj i diseminacija aplikacija važnih za javnu politiku i pristup zdravstvenoj skrbi. Rezultati predloženih istraživanja pridonijet će boljem razumijevanju kako se profesionalizam razvija tijekom obrazovanja i prakse u zdravstvenoj skrbi. Razvojem i testiranjem novih intervencija za poticanje razvoja profesionalizma, projekt će donijeti dokaze za promicanje kurikularnog i cjeloživotnog učenja i za promjenu politike zdravstvene skrbi, kao i donijeti važne ekonomske i javnozdravstvene koristi.The proposed project aims to study excellence, accountability and integrity/transparency as attributes of professionalism which are most relevant for evidence-based healthcare, where professionalism is broadly defined as commitment to carrying out professional responsibilities, adherence to ethical principles and sensitivity to patient populations. The first research theme addresses professionalism in healthcare students. We will investigate the determinants of professional development in students, as well as the environment for the development of professional excellence and integrity. Based on the findings from this research, we will develop and test interventions for teaching professionalism in health curricula. The second research theme addresses professionalism in healthcare practice. We will first describe the framework for professional excellence and integrity, including the evidence available to healthcare practitioners and its translation to practice. Based on research results, we will develop and test interventions for professional practice. Each specific objective will include: 1) mapping of current research results and identification of knowledge gaps, 2) using appropriate research design and methodology, 3) synthesising research results into explanatory theories and models, and 4) developing and disseminating applications relevant for policy and public use. Results from the proposed research will contribute to better understanding of how professionalism develops during healthcare education and practice. By developing and testing new interventions for professionalism, the project will provide evidence for the advancement of curricular and life-long learning and policy changes in healthcare, as well as bring important economic and public health benefits.
3010Model mjerenja efikasnosti javno zdravstvenih uslugaA model for measuring the efficiency of public health services245Neda Vitezić IP2014-09IP-2014-09-8235MEPHS19.05.2015 - 18.05.2020U tijeku287.175,75 KnDruštvene znanostiSocial sciencesEkonomija, Economy, Sveučilište u Rijeci, Ekonomski fakultetUniversity of Rijeka, Faculty of Economics5114, 7120, 6438, 13419, 6371, 6035, 13765, 6723, 22832, 4913, 5391, 25556, 1068, 22489, Vladimir Mićović, Đulija Malatestinić, Lidija Pavica Pernar, Mirjana Grčić Fabić, Mirjana Zukić, Veronika Petkovšek, Stanka Setnikar Cankar, Alemka Šegota, Antonija Petrlić, Suzana Janković, Danijela Rabar, Danijela Čošić, Željko Linšak, Ana Bobinac, javno zdravstvene usluge, efikasnost, mjerenje, DEA,BSCpublic health services, efficiency, measurement, DEA, BSCPredmet istraživanja je mjerenje efikasnosti javno zdravstvenih usluga u Hrvatskoj koje se provodi kroz razne programe i projekte zavoda za javno zdravstvo (prevencija bolesti, ekologija, socijalna medicina, mikrobiologija i sl.). Osnovni cilj istraživanja je predložiti model za mjerenje efikasnosti tih usluga a koji bi bio primjenjiv i na ostale usluge u zdravstvu ali i na druge javne usluge. (npr. u bolnicama, lokalnoj samoupravi, sveučilištu i sl.). Model će se temeljiti na kombinaciji dviju metoda (DEA-BSC) koje su pogodne za mjerenje efikasnosti i efektivnosti raznovrsnih javnih usluga. DEA metoda se tradicionalno koristi za neprofitne organizacije gdje slične organizacijske jedinice djeluju s različitim ulaznim/izlaznim veličinama i gdje u pravilu nema zarade. BSC je metoda kojom se potiče strateško razmišljanje i ocjenjuje učinkovitost postavljenih ciljeva. Kombinacija DEA i BSC metode je relativno nova ideja i koristi se za utvrđivanje uzročno posljedičnih veza posebno kod neefikasnih jedinica. Model će se razraditi na primjeru Nastavnog zavoda za javno zdravstvo Primorsko goranske županije koje ima 48 organizacijskih jedinica. Ciljevi projektnog prijedloga su sljedeći: utvrditi relativnu efikasnost svake organizacijske jedinice i predložiti poboljšanja za neefikasne organizacijske jedince (projekcija na efikasnu granicu–DEA metoda), definirati cjelovit model (integracija DEA i BSC) za mjerenje efikasnosti po pojedinim perspektivama unutar BSC okvira sa svrhom mjerenja efektivnosti ostvarivanja postavljenih ciljeva. The subject of this research is to measure the efficiency of public health services in Croatia, which is carried out through various programs and projects of Public Health Institutes (prevention of diseases, ecology, social medicine, microbiology, etc.). The main goal of the research is to propose a model of measuring the efficiency of public health services that can also be applied to other activities in healthcare and other public services such as local government, universities etc. The model will be based on the combination of two methods (DEA and BSC) that are suitable for measuring the efficiency and effectiveness of various public services. DEA method is traditionally used for non profit organizations where similar units operate with different input/output basically without any income. BSC is a method that encourages strategic thinking and evaluates the effectiveness of set goals. The combination of DEA and BSC is relatively a new approach and is used to identify the cause and effect relationships especially within inefficient units. The model will be developed for the Teaching Institute of the Public Health of Primorje-Gorski Kotar County which has 48 organization units (DMUs). The objective of the project proposals are as follows: to determine relative efficiency of each organization unit and suggest improvements for the inefficient ones (projection on the efficient frontier-DEA method), to define an integrative model (integration of DEA and BSC) for measuring the efficiency of individual perspectives within BSC framework with the aim to assess the effectiveness of achieving goals.
3011Esencijalni metalni ioni u proteinima iz Helicobacter pylori i modelnim spojevima - struktura i funkcija/svojstvoEssential metal ions in Helicobacter pylori proteins and model complexes – structure and function/property593Dubravka Matković-Čalogović IP2014-09IP-2014-09-4274ProtModStruct01.06.2015 - 31.05.2019Završio970.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science1141, 358, 946, 4525, 4656, 12917, 11285, 3347, 1186, 3993, 3414, 4657, 19005, 20946, 19876, 23338, Draginja Mrvoš-Sermek, Biserka Prugovečki, Ivica Đilović, Nenad Judaš, Ivana Biljan, Neven Smrečki-Lolić, Marijana Marković, Marina Tašner, Ivana Pulić, Giuseppe Zanotti, Janez Plavec, Dalibor Milić, Darko Vušak, Kristina Smokrović, Mario Kekez, Mario Stojanović, essential metals, model compounds, structural characterization, H. pylori proteins, chemical synthesisesencijalni metali, modelni spojevi, strukturna karakterizacija, proteini iz H. pylori, kemijska sintezaU okviru istraživanja na ovom projektu želimo strukturno karakterizirati nekoliko proteina iz Helicobacter pylori (i odrediti njihovu funkciju) kao i modelne komplekse malih molekula sa esencijalnim metalnim ionima i biološki važnim ligandima (i odrediti njihova svojstva). Prioritetni će biti metali koji se nalaze u metaloproteinima iz H. Pylori.Svjetska zdravstvena organizacija proglasila je H. Pylori karcinogenom 1. klase te je važna meta istraživanja zbog svoje patogenosti. Proteini HypA i HypB su važni za pravilnu konstrukciju metalnog centra [Ni,Fe] hidrogenaze i urease. Proteini CrdA i CrdB potrebni su za održavanje koncentracije slobodnih iona bakra u citoplazmi ispod toksične razine. Namjeravamo klonirati, eksprimirati, pročistiti i karakterizirati kompleks HypA-HypB te proteine CrdA i CrdB biofizičkim i strukturnim metodama (termalna stabilnost, cirkularni dikroizam, određivanje konstante disocijacije bakrovog iona, rentgenska difrakcija, 3D NMR). Želimo odrediti funkciju metalošaperona u unutarstaničnoj regulaciji nikla (HypA-HypB) kao i mehanizam regulacije koncentracije bakra (CrdA, CrdB).Istraživati ćemo komplekse metala (bakra, nikla, željeza i drugih esencijalnih metala) s ciljem da odredimo preferirano koordinacijsko okruženje metala s aminokiselinama i derivatima aminokiselina (N-alkiliranih, amida, peptida, peptida bogatih metioninom i drugih) te dobijemo informaciju o specifičnosti aminokiselinskog ili peptidnog pokrajnjeg lanca prema različitim metalnim ionima. Komplekse ćemo sintetizirati te ih karakterizirati termičkim i spektroskopskim metodama i rentgenskom strukturnom analizom. Konstruirat ćemo konformacije bakrovih kompleksa s aminokiselinama te optimizirati njihovu geometriju pomoću kvantno-kemijskih proračuna da bismo istražili njihove moguće ravnotežne geometrije.Within this project we will structurally characterize several proteins from Helicobacter pylori (and reveal their functions) and small molecule model complexes of essential metal ions with biologically relevant ligands (and find their properties). The priority will be the essential metals involved in H. pylori metalloproteins.The World Health Organization has declared the H. pylori a Class 1 carcinogen and it is an important target for research due to its pathological relevance. H. pylori requires several accessory proteins such as HypA and HypB for the proper construction of the [Ni,Fe] hydrogenase and urease. The resistance determinants CrdA and CrdB are required for keeping the concentration of free copper ions in the cytoplasm below toxic levels. We plan to clone, express, purify and characterize the complex HypA-HypB and proteins CrdA and CrdB by biophysical and structural methods (thermal stability assay, circular dichroism, determination of copper ion dissociation constant, X-ray diffraction, 3D NMR). We hope to determine how the metallochaperones exert their functions in intracellular nickel delivery (HypA-HypB) and the mechanism of copper level regulation (CrdA, CrdB).The aim of the study of the model complexes (with copper, nickel, iron, zinc and other essential metal ions) is to determine how these metals template their coordination environment by amino acids and their derivatives (N-alkylated, amides, peptides, methionine-rich peptides and others) and to obtain information on the specificity of amino acid or short peptide side chains toward different metal ions. The complexes will be synthesized and structurally characterized by thermal and spectroscopic analysis and X-ray crystal structure diffraction experiments.The conformations of the copper complexes with amino acids will be constructed and the geometry optimized to study their possible equilibrium geometries by quantum chemical calculations.
3015Sveoubuhvatna procjena ponašanja i sudbine farmaceutski aktivnih tvari u okolišu: makrolidni antibiotici i opioidni analgeticiComprehensive assessment of the environmental behaviour and fate of pharmaceutically active contaminants: macrolide antibiotics and opioid analgesics 3673Senka Terzić IP2014-09IP-2014-09-7031COMPASS01.09.2015 - 28.02.2019Završio859.000,00 KnPrirodne znanostiNatural sciencesKemija, Biologija, Chemistry, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb5324, 5719, 5179, 5188, 3923, 5158, 3674, 21293, Ines Petrić, Marin Matošić, Ivona Krizman, Ivan Senta, Jovica Lončar, Iva Mikac, Marijan Ahel, Petra Kostanjevečki, makrolidni antibiotici, opioidni analgetici, transformacijski proizvodi, transformacija, ozonizacija, biološki efekti, otpadne vode macrolide antimicrobials, opioid analgesics, transformation products, degradation, ozonization, biological effects, wastewatersVećina studija farmaceutskih spojeva u okolišu usmjerena je na određivanje roditeljskih spojeva i uključuje samo jedan odjeljak okoliša. Takav pojednostavljeni pristup često podcjenjuje ekotoksikološku važnost neke farmaceutske skupine, bilo da se zanemaruje doprinos transformacijskih produkata (TP) ili tako da se previde neki kritični mehanizmi koji dovode do povećane opasnosti za okoliš i ljudsko zdravlje. Nasuprot tome, ovaj projekt ima za cilj ukazati na važnost sveobuhvatne evaluacije zagađivala voda na temelju istraživanja dviju skupina farmaceutskih spojeva, makrolidnih antibiotika (MA) i opioidnih analgetika (OA), pri čemu će biti uključeni njihovi glavni transformacijski produkti te će biti istražena uloga raspodjelnih procesa u procjeni izloženosti tim spojevima. Plan projekta predviđa razvoj visoko-specifičnih metoda za kvantitativno simultano određivanje ciljnih skupina spojeva i njihovih poznatih TP upotrebom tekućinske kromatografije povezane s tandemnom spektrometrijom masa(LC/MS/MS), dok će nepoznati TP biti identificirani upotrebom LC spregnute sa spektrometrijom masa visokog razlučivanja na temelju vremena leta (MS/TOF). Transformacijski procesi MA i OA bit će sustavno istraženi u kontroliranim laboratorijskim uvjetima, s posebnim naglaskom na biološku transformaciju i ozoniranje. Biotransformacija će biti provedena s dobro karakteriziranim mješovitim mikrobnim kulturama izoliranim iz uzoraka s kronično zagađenih staništa. Istraživanje transformacijskih procesa obuhvatit će određivanje kinetike roditeljskih spojeva kao i identifikaciju transformacijskih produkata. Ekotoksikološki značaj istraživanih transformacijskih procesa bit će procijenjen kombinacijom postupaka baziranih na određivanju intenziteta nastajanja TP i promjene bioloških učinaka u nastalim transformacijskim smjesama. Projekt, na kraju, predviđa i verifikaciju relativne važnosti TP u realnim uvjetima, uključujući uređaje za pročišćavanje otpadnih voda i zagađene površinske vode.Most of the environmental studies of pharmaceuticals are focused mainly on the determination of parent compounds and encompass only one environmental compartment. Such simplified approach often underestimates the ecotoxicological relevance of a contaminant class, either by neglecting the contribution of its transformation products or by overlooking some critical mechanisms that may pose a threat to the environmental safety and human health. As opposed to that, this project aims at demonstrating the importance of the comprehensive assessment of aquatic contaminants, based on the study of two important groups of pharmaceuticals, macrolide antibiotics (MAs) and opioid analgesics (OAs), by including their main transformation products (TPs) and addressing the issue of physico-chemical partitioning in the exposure assessment. The project work plan envisages development of class-specific methods for the concurrent quantitative analysis of the target contaminants and their known TPs using liquid chromatography- tandem mass spectrometry (LC/MS/MS), while identification of unknown TPs will be performed using LC coupled to high-resolution mass spectrometry employing time-of-flight (TOF) mass analyzer. The transformation processes of selected contaminant classes will be systematically studied in laboratory-controlled conditions with a special emphasis on biotransformation and ozonation. The biotransformation experiments will be performed using well-characterised mixed microbial communities isolated from contaminated natural habitats. The transformation studies will encompass the determination of dissipation kinetics of the parent compounds as well as identification of TPs. Ecotoxicological importance of the transformation processes will be evaluated using a combination of exposure-driven and effect-driven approaches. Finally, the project envisages verification of the relative importance of TPs in real systems, including wastewater treatment plants and ambient surface waters.
3016Fitohormoni u abiotskom stresu kupusnjača: mehanizam tolerancije i primjenaPhytohormones in abiotic stress of Brassica crops: mechanism of tolerance and application791Branka Salopek Sondi IP2014-09IP-2014-09-4359PhytoBraCro01.09.2015 - 31.12.2019U tijeku912.928,00 KnPrirodne znanostiNatural sciencesBiologija, Biology, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb12519, 998, 4217, 2689, 3827, 997, 3156, 3965, 2824, 5012, 3387, 3390, 17895, Ondřej Novák, Hrvoje Lepeduš, NATAŠA BAUER, Dunja Šamec, Iva Pavlović, Selma Mlinarić, Jutta Ludwig-Müller, Ana Smolko, Jasenka Antunović, Snježana Mihaljević, Sandra Radić Brkanac, VALERIJA VUJČIĆ, Ida Linić, kupusnjače, suša, solni stres, auksin, hormoni stresaBrassica crops, drought, salinity stress, auxin, stress hormonsBiljne vrste iz porodice Brassicaceae su široko rasprostranjene povrtne kulture. Abiotički stres poput suše i povećanog saliniteta tla su primarni uzroci gubitka u poljoprivrednoj proizvodnji. Fitohormoni su ključni za prilagodbu biljaka nepovoljnim uvjetima regulirajući procese kao što su fotosinteza, aktivnosti antioksidacijskih enzima, akumulacija sekundarnih metabolita, promjene u ekspresiji gena itd. Biljni hormoni auksini djeluju kao regulatori u većini odgovora biljaka na stres kroz složene interakcije s hormonima stresa: salicilnom (SA), abscizinskom (ABA), jasmonskom (JA) kiselinom i brazinosteroidima (BRA). Cilj ovog projekta je istražiti mehanizme odgovora odabranih biljaka iz porodice krstašica na stres uzrokovan sušom i povećanim salinitetom: kineski kupus (Brassica rapa), bijeli kupus (B. oleracea var. capitata) i raštika (B. oleracea var. acephala) kroz integrativni pristup koji podrazumjeva metode mjerenja fotosinteze, biokemijske metode dijagnostike stresa, metabolomiku (analize biljnih hormona i sekundarnih metabolita), molekularna funkcionalna te aplikativna istraživanja. Poseban naglasak će biti na ulozi fitohormona auksina i interakcijama s hormonima stresa (SA, ABA, JA, BRA) u odgovoru na sušu i povećani salinitet te potencijalnim mehanizmima tolerancije. Biljni hormoni biti će analizirani UHPLC-MS/MS metodom. Sekundarni metaboliti, polifenoli i glukozinolati biti će mjereni spektrofotometrijski i UHPLC-MS/MS metodama. Funkcionalna istraživanja će biti provedena na linijama uročnjaka (Arabidopsis thaliana) koje imaju mutacije u genima odgovornim za homeostazu auksina (gh3, ilr). Rezultati analiza bioaktivnih spojeva (hormona i sekundarnih metabolita) će biti korelirani s fiziološkim i biokemijskim podatcima (parametri fotosinteze, ROS, antioksidacijski enzimi, prolin, glutation, karbonili). Biljni hormoni stresa će biti ispitani kao potencijalni biostimulatori tolerancije na sušu i povećani salinitet aplikacijom na list i tretmanom korijena.Crops from the family of Brassicaceae are commercially widely spread vegetables. Abiotic stresses such as salinity and drought are the primary causes of crop loss worldwide. Phytohormones are crucial for the plant ability to adapt to abiotic stress by mediating a wide range of adaptive responses: photosynthesis modification, increased antioxidant activities, secondary metabolites accumulation, changes in gene expression. Phytohormone auxin regulates the majority of plant stress responses through interactions with stress hormones salicylic acid (SA), abscisic acid (ABA), jasmonic acid (JA), and brassinosteroids (BRA). The aim of this proposal is to investigate the abiotic stress responses of selected Brassica crops (Brassica rapa. ssp. pekinesis, Brassica oleracea var. capitata and Brassica oleracea var. acephala) to drought and salinity stress through integrative research approach comprising biophysical methods of photosynthesis measurements, biochemical methods of stress diagnostics, metabolomics (plant hormones and secondary metabolites) and molecular functional research. Particular focus will be placed to the role of auxin and its interactions with stress hormones (SA, ABA, JA and BRA) in stress responses and potential mechanisms of tolerance. Phytohormones auxin, SA, JA, ABA and BRA will be analyzed by UHPLC-MS/MS. Secondary metabolites, polyphenols and glucosinolates will be measured by spectrophotometry and UHPLC-MS/MS. In order to shed light on auxin homeostasis in abiotic stress, functional research will be performed by using Arabidopsis thaliana lines for genes of auxin reversible conjugation (GH3 and ILR). Results of hormonal analyses will be correlated with basic physiological and biochemical parameters (photosynthesis parameters, ROS level, antioxidant enzymes, proline, glutathione, protein carbonyl level). Finally, stress plant hormones will be investigate as potential biostimulator of abiotic stress tolerance by foliar spray and root treatment.
3019Molekularni aspekti oksidativnih procesa u stanicamaMolecular Aspects of Oxidative Processes in Cells440Mario Vazdar UIP2014-09UIP-2014-09-6090MolOxStress01.09.2015 - 31.12.2018U tijeku559.500,00 KnPrirodne znanostiNatural sciencesKemija, Biologija, Fizika, Chemistry, Biology, Physics, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb243, 373, 3569, 5002, 21289, 3618, Davor Margetić, Katarina Vazdar, Pavle Trošelj, Danijela Vojta, Sanja Škulj, Zlatko Brkljača, oksidativni stres, reaktivni aldehidi, membranski proteini, organska sinteza, molekulska dinamika, kvantnokemijski računioxidative stress, reactive aldehydes, membrane proteins, organic synthesis, molecular dynamics, quantum chemical calculationsCilj predloženog projekta je otkrivanje molekulskih detalja procesa vezanih za prijenos protona i oksidativni stres u mitohindrijima, organelima lociranim u stanicama koji služe za pretvorbu kisika i vanjskih izvora energije u adenozin trifosfat (ATP), u procesu oksidativne fosforilacije. Tijekom ovog procesa, osjetljiva energetska ravnoteža se održava pumpanjem protona izvan unutarnje mitohindrijske membrane uz pomoć lanca elektron-transport proteina te njihovog vraćanja unutra u procesu sinteze ATP-a pomoću ATP sintaze. Ova ravnoteža nije uvijek optimalna i posebna klasa proteina smještenih unutar unutrašnje mitohondrijske membrane, tzv. razvezujući proteini (''uncoupling proteins''), služe za kontrolu prijenosa protona kroz membranu.Posebna pažnja posvetit će se studiju reaktivnosti različitih reaktivnih aldehida koji se stvaraju tijekom oksidativnog stresa unutar fosfolipidnog dvosloja, prema razvezujućim proteinima. Ove štetne reakcije povećavaju aktivnost razvezujućih proteina koji dovodi i do povećanog protoka protona kroz unutrašnju mitohondrijsku membranu koja time mijenja energetsku ravnotežu unutar stanice što dovodi do raznih opasnih bolesti, poput raka, dijabetesa tipa 2 i pretilosti.Projekt će koristiti najnovije računske pristupe uz kombinaciju kvantnokemijskih računa i simulacija molekulske dinamike. Nadalje, teorijski proračuni će se nadopuniti modelnim eksperimentima gdje će se ispitati sintetizirani reaktivni aldehidi sa svrhom daljnjeg razumijevanja reaktvnosti, kao i dodatne provjere računskih rezultata.Ovo istraživanje će doprinijeti očuvanju zdravlja pružajući zajednici bolje razumijevanje osnovnih principa i mehanizama pomoću kojih opasni aldehidi reagiraju s razvezujućim proteinima. Predložit će se nove ideje s ciljem boljeg razumijevanja funkcije razvezujućih proteina, razvijanja lijekova za unaprijeđenje zdravlja te umanjivanju efekata oksidativnih procesa.The proposed project aims to unravel the molecular details of the processes connected with proton transfer and oxidative stress in mitochondria, organelles located in cells which convert oxygen and external energy supply into adenosine triphosphate (ATP) in the process of oxidative phosphorylation. During this process, a delicate energy balance is maintained between pumping of protons outside the inner mitochondrial membrane by the electron-transport chain proteins and transferring them back inside in the process of ATP synthesis by the ATP synthase. This balance is not always optimal and a special class of membrane proteins located inside inner mitochondrial membranes, called uncoupling proteins, serves as a control of the proton transfer rate through the membrane. Particular attention will be paid to the study of the reactivity of various reactive aldehydes generated during oxidative stress within phospholipid bilayers, towards uncoupling proteins. These deleterious reactions enhance the activity of uncoupling proteins resulting in the increased proton leak through inner mitochondrial membrane which in turn modifies energy balance inside the cell leading to various harmful diseases, such as cancer, type 2 diabetes and obesity. The project application uses the ''state of the art'' computational approach by combining quantum chemical calculations and molecular dynamics simulations. Also, the theoretical work is expanded with the experimental work where model compounds will be synthesized and used in model reaction systems to further understand and cross-check the simulation results. The research will endorse health by providing the community better understanding of the underlying principles and mechanisms by which deleterious aldehydes react with uncoupling proteins. The novel ideas will be proposed in order to better understand the function of uncoupling proteins, to develop drugs for improving health and to minimize effects due to oxidation processes.
3021SenseHive: Dinamički modeli za postepenu izgradnju leksičko-semantičkih resursa potpomognuti radom mnoštvaSenseHive: Dynamic Crowdsourcing Models for Incremental Construction of Lexico-Semantic Resources6211Jan Šnajder UIP2014-09UIP-2014-09-7312SenseHive01.10.2015 - 30.11.2018U tijeku710.000,00 KnTehničke znanosti, Humanističke znanosti, Technological sciences, Humanities, Računarstvo, Computer sciences, Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstvaUniversity of Zagreb, Faculty of Electrical Engineering and Computing6330, 6463, 6670, 1533, 7143, 7187, 7390, 7141, 13422, 18931, 22839, Sebastian Pado, Darja Fišer, Tomislav Stojanov, Željko Agić, Nikola Ljubešić, Bojana Dalbelo Bašić, Mladen Karan, Goran Glavaš, Luka Skukan, Domagoj Alagić, Abbas Akkasi, Natural language processing, language technologies, lexical semantics, semantic resources, word sense disambiguation, Croatian languageObrada prirodnog jezika, jezične tehnologije, leksička semantika, semantički resursi, razrješavanje višeznačnosti, hrvatski jezikLeksičko-semantički resursi igraju bitnu ulogu u obradi prirodnoga jezika i srodnih primjena poput pretraživanja informacija. Nažalost, njihova je izgradnja izuzetno skupa te je rijetko vođena praktičnim potrebama, što kod jezika sa slabije razvijenim resursima predstavlja naročit problem. Moguće rješenje jest izgradnja leksičko-semantičkih resursa potpomognuta radom mnoštva (engl. crowdsourcing). Premda se rad mnoštva pokazao izvedivim i znatno povoljnijim pristupom, još uvijek ne postoji cjelovita metodologija koja bi omogućila postepenu izgradnju vrlo velikih leksičko-semantičkih resursa. Cilj ovoga projekta jest upotpuniti ovu prazninu i istražiti računalne modele i metode za postepenu i učinkovitu izgradnju leksičko-semantičkih resursa potpomognutu radom mnoštva. Istraživanje će objediniti modele za dinamičan rad mnoštva, modele semantike temeljene na korpusu (distribucijske modele i tematske modele) te aktivno strojno učenje, te polučiti cjelovit i jezično neovisan radni okvir, tzv. SenseHive. SenseHive objedinjuje prilagodiv prikaz značenja i leksičko-semantičkih veza riječi temeljen na grafovima (SenseGraph) i postupke za njegovu postepenu izgradnju. Značenja riječi dinamički se razdjeljuju i stapaju na temelju analize ljudskih ocjena dobivenih nad podatcima ekstrahiranima iz korpusa. U prvoj fazi projekta izgradit ćemo prototip i upotrijebiti ga za ciljane eksperimente na podatcima na hrvatskom, slovenskom i engleskom jeziku s ciljem odgovaranja na relevantna istraživačka pitanja. Kao dokaz koncepta, u drugoj ćemo fazi primijeniti SenseHive za izgradnju leksičko-semantičkog resursa za hrvatski jezik umjerene veličine, proširivanjem i obogaćivanjem postojećih leksičko-semantičkih resursa. Predloženo će istraživanje unaprijediti stanje znanosti u području računalne semantike i poluatomatske izgradnje jezičnih resursa te rezultirati konkretnim leksičko-semantičkim resursom za hrvatski jezik od velike praktične vrijednosti.Lexico-semantic resources play an essential role in natural language processing and related applications such as information retrieval. Unfortunately, their construction is extremely costly and rarely guided by practical considerations, posing a problem especially for less-resourced languages. One possible solution is to rely on crowdsourcing of lexico-semantic resources. Although crowdsourcing has proven to be a viable option for reducing the overall costs, there still does not exists a comprehensive crowdsourcing methodology for incremental construction of large-scale lexico-semantic resources. This projects aims to fill this gap by investigating the computational models and methods for incremental and cost-efficient crowdsourcing of lexico-semantic resources. The research will combine dynamic crowdsourcing, corpus-based models of semantics (distributional semantics and topic models), and active machine learning methods into a comprehensible and language-independent crowdsourcing framework, the SenseHive. The SenseHive consists of a flexible, graph-based representation of senses and lexico-semantic relations (SenseGraph), coupled with an incremental construction methodology. In SenseGraph, senses are dynamically split up and merged based on the analysis of human judgments on corpus-extracted data. In the first phase, we will implement a prototype of the SenseHive framework and use it for focused evaluation experiments on Croatian, Slovene, and English data to answer the relevant research questions. As a proof of concept, in the second phase we will use SenseHive to construct a medium-sized lexico-semantic resource for Croatian by enlarging and enriching existing lexico-semantic resources. The proposed research will advance the state of the art in computational lexical semantics and semi-automated construction of linguistic resources, and yield a lexico-semantic resource for Croatian of great practical value.
3023Struktura i dinamika egzotičnih femto-sustavaStructure and Dynamics of Exotic Femtosystems11296Nils Paar IP2014-09IP-2014-09-9159STRUDEF01.06.2015 - 31.05.2019Završio999.471,00 KnPrirodne znanostiNatural sciencesFizika, Physics, Sveučilište u Zagrebu, Prirodoslovno-matematički fakultetUniversity of Zagreb, Faculty of Science780, 12567, 12568, 12577, 12571, 18998, 18999, 19023, 25237, 25236, Tamara Nikšić, Tomislav Marketin, Vaia Prassa, Jie Zhao, Deni Vale, Nato Popara, Yifei Niu, Kosuke Nomura, Petar Marević, Tomohiro Oishi, egzotične jezgre, energijski funkcional gustoće, kolektivno gibanje, fisija, beta raspad, gibanje velikih amplitudaexotic nuclei, energy density functional, nuclear collective motion, fission, beta decay, large amplitude motionOsnovni cilj ovog projekta je razviti i primijeniti novi teorijski pristup, zasnovan na relativističkom nuklearnom energijskom funkcionalu gustoće (RNEDF) koji omogućuje mikroskopski opis strukture i dinamike kvantnih sustava na femtometarskoj skali, te omogućuje precizan opis egzotičnih femto-sustava daleko od doline stabilnosti koji još nisu dostupni u eksperimentu. Radi se o jezgrama čija struktura i dinamika pokazuju egzotična svojstva, npr. veličinu i oblik vrlo različite od najbližih stabilnih jezgara, ili egzotične modove kolektivnog pubuđenja i raspada. Istraživački projekt uključuje razvoj teorijskog formalizma i pripadajućih modela na temelju RNEDF-a radi ostvarenja sljedećih ciljeva: (i) razviti pouzdanije funkcionale s unaprijeđenom efektivnom masom blizu Fermi površine i poboljšanim spin-orbit međudjelovanjem u izovektorskom kanalu, (ii) omogućiti kvantitativni opis statističke neodređenosti i korelacija između nuklearnih svojstava pomoću analize kovarijanci, (iii) opisati pobuđenja malih amplituda pomoću metode konačnih amplituda i vezanjima sa složenim konfiguracijama, (iv) nadograditi metodu generatorskih koordinata za gibanje velikih amplituda, (v) istražiti fenomene koegzistencije oblika i prijelaza između različitih oblika jezgara, (vi) proučiti strukturu i stabilnost superteških jezgara i proces fisije (vii) istražiti astrofizički značajne nuklearne procese koji uključuju slabu interakciju. Predviđen je razvoj naprednih teorijskih metoda za rješavanje izazova koje predstavljaju sadašnji i budući ubrzivači snopova nestabilnih iona, odnosno razumijevanje rijetkih jezgara daleko od stabilnosti koje igraju značajnu ulogu u sintezi svih stabilnih kemijskih elemenata koji danas postoje na Zemlji. Ključni pristup za ostvarenje znanstvenih ciljeva i povećanje prediktivne snage za opis egzotičnih femto-sustava je razvoj i primjena učinkovitih računalnih alata i metoda naprednog računarstva i njihova primjena na distribuiranim računalnim sustavima.The goal of this project is to develop and apply a novel theoretical framework, based on Relativistic Nuclear Energy Density Functional (RNEDF) that enables microscopic modeling of the structure and dynamics of quantum systems at the femtometer scale, and provides accurate predictions for exotic femtosystems far from stability that are not yet accessible in experiment. These nuclei have exotic or unusual structural and dynamical properties such as, for instance, sizes and shapes very different from their nearest stable nuclei, or exotic modes of collective excitation and decay by particle emission. The project research includes development of the framework based on the RNEDF with specific aims to (i) develop a more reliable functional with enhanced effective mass near the Fermi surface and improved spin-orbit interaction in the isovector channel, (ii) provide quantitative description of statistical uncertainties and correlations of nuclear properties using covariance analysis, (iii) to describe low-amplitude motion using finite amplitude method and couplings with complex configurations, (iv) upgrade the generator-coordinate method framework for large amplitude motion , (v) explore phenomena of shape coexistence and shape transitions, (vi) study the structure and stability of superheavy nuclei and fission process, (vii) explore astrophysically relevant nuclear processes including weak interaction. This will require the development of advanced theoretical methods to resolve the challenge posed by the current and future large-scale radioactive ion beam facilities, namely the understanding of rare nuclei far from stability that are precursors in the synthesis of all stable nuclear species on Earth. A key ingredient in achieving the theoretical goal of increased predictive power for exotic femtosystems is development and application of efficient computational tools and methods of scientific computing using distributed computer systems.
3024Procesna i poslovna inteligencija za poslovnu izvrsnost Process and Business Intelligence for Business Performance 1246Vesna Bosilj Vukšić IP2014-09IP-2014-09-3729PROSPER01.09.2015 - 31.08.2019U tijeku226.000,00 KnDruštvene znanosti, Tehničke znanosti, Social sciences, Technological sciences, Informacijske i komunikacijske znanosti, Ekonomija, Računarstvo, Information and communication sciences, Computer sciences, Economy, Sveučilište u Zagrebu, Ekonomski fakultet u ZagrebuUniversity of Zagreb, Faculty of Economics and Business1372, 3650, 1313, 3417, 3436, 3630, 1272, 3588, 3695, 4160, 3766, 3678, 3106, 4411, 2520, 22659, Mirjana Pejić Bach, Božidar Jaković, Jovana Zoroja, Ljubica Milanović Glavan, Mirta Baranović, Ljiljana Brkić, Katarina Tomičić-Pupek, Jurij Jaklič, Mojca Indihar Štemberger, Brina Hribar, Aleš Popovič, Tanja Grublješič, Amer Celjo, Jan Mendling, Dalia Suša, Ana-Marija Stjepić, procesna inteligencija, poslovna inteligencija, upravljanje poslovnim procesima, mjerenje i upravljanje performansama, rudarenje podataka, softverprocess intelligence, business intelligence, business process management, performance measurement and management, data mining, softwareSvrha projekta PROSPER je istražiti primjenu procesne (PI) i poslovne inteligencije (BI) u poduzećima i njihov utjecaj na uspješnost poslovanja, s posebnim fokusom na korištenje modernih tehnologija (kao što su sustavi za upravljanje poslovnim procesima, rudarenje podataka, simulacijski softver) pri implementaciji ovih koncepata. Primijenit će se odgovarajući istraživački pristup. Koristiti će se statističke metode (kao što su modeli strukturnih jednadžbi - SEM) i metode kvalitativnog istraživanja (na primjer kvalitativno istraživanje kulturalnih razlika primjene procesne i poslovne inteligencije u u Hrvatskoj, Sloveniji, Austriji i Bosni i Hercegovini). Projekt je multidisciplinaran i više-razinski, a njegovi su ciljevi hijerarhijski strukturirani.Na najvišoj razini (L1) istražit će se primjena i zrelost procesne i poslovne inteligencije u zemljama iz kojih dolaze suradnici na projektu. Provest će se empirijsko istraživanje, dobiveni rezultati analizirati će se kvantitativnim metodama (regresijska i faktorska analiza). Na drugoj razini (L2) istražit će se kritični faktori uspješnosti primjene koncepata procesne i poslovne inteligencije. U tu svrhu će se koristiti kvalitativne (studije slučaja, polu-strukturirani intervjui) i kvantitativne metode (modeli strukturnih jednadžbi). Rezultati istraživanja koristiti će se za razvoj modela za mjerenje procesnih performansi. Na trećoj razini (L3) testirati će se primjenjivost rezultata istraživanja iz prethodnih razina (L1 i L2), a u tu svrhu će se provesti kvalitativno istraživanje u poduzećima. Kroz studije slučaja testirati će primjena procesne i poslovne inteligencije i njihov utjecaj na uspješnost poslovanja. Razviti će se modeli iz područja poslovne inteligencije za neke specifične poslovne slučajeve i djelatnosti. Primjena ovih modela omogućiti će uspješnije poslovanje. The aim of the PROSPER project is to examine the adoption of the process intelligence (PI) and business intelligence (BI) in organizations, as well as to foresee their impact on business performance using cutting-edge technologies (e.g. business process management systems, data mining, simulation software) and research approach (e.g. cross-cultural research, structural equation modelling) with the assistance of multi-country (Croatia, Slovenia, Austria, Bosnia and Herzegovina) and interdisciplinary team of university researchers. The project is multidisciplinary and multi-levelled due to the hierarchical structure of its objectives.At the highest level (L1), the adoption and maturity of PI and BI will be explored in organizations in Croatia, Slovenia, Bosnia and Herzegovina and Austria. A quantitative empirical research results will be analysed using regression and factor analysis. At the middle level (L2), the impact of critical factors (e.g. organizational culture and structure) on PI and BI adoption will be analyzed. L2 research results will be explored using qualitative (e.g. case study, semi-structured interviews) and quantitative methods (e.g. structural equation modelling), the goal being development of the process performance measurement model. At the third level (L3), the practical applicability of the L1 and L2 research results will be tested and evaluated using specific business cases in PI and BI adoption for business performance. Models will be developed for the usage of BI in some specific business cases and industries, with the goal of increasing business performance.
3027Višekomponentne reakcije u sintezi peptidnih mimetikaThe assembly of peptidomimetics by multicomponent reactions66IVANKA JERIĆ IP2014-09IP-2014-09-3102MIMICRy01.09.2015 - 31.08.2019U tijeku948.000,00 KnPrirodne znanostiNatural sciencesKemija, Chemistry, Institut "Ruđer Bošković"Ruđer Bošković Institute in Zagreb558, 715, 717, 12506, 12613, 12635, 373, 2953, 21235, 21264, 24292, 25282, Matija Gredičak, Lidija Brkljačić, Josipa Suć, Kristina Vlahoviček-Kahlina, Lidija Varga-Defterdarović, Andreja Jakas, Katarina Vazdar, Lidija-Marija Tumir, Martina Kunštić, Mladena Glavaš, Ivana Kovačić, Mateja Matišić, peptidomimetici, višekomponentne reakcije, makrociklički spojevi, neprirodne aminokiseline, ugljikohidrati, endiinski spojevipeptidomimetics, multicomponent reactions, macrocycles, non-natural amino acids, carbohydrates, enediyne compoundsProbir biblioteka malih molekula je najčešće korišten pristup u otkriću novih lijekova u posljednih dvadeset godina. Međutim, glavni nedostatak biblioteka je mala raznovrsnost bioloških i kemijskih svojstva spojeva koje sadrže, tj. biblioteke pokrivaju vrlo mali «kemijski prostor». U posljednjih 15 godina, svega 15 % novih kemijskih spojeva zapravo pripadaju novim klasama spojeva. To predstavlja glavnu zapreku razvoju novih vodećih spojeva potrebnih za istraživanje novih bioloških meta. Cilj ovog projekta je proširiti kemijski prostor novim spojevima koji imaju slične karakteristike kao i prirodni spojevi, korištenjem višekomponentnih reakcija. To ćemo postići: (a) razvojem novih gradivnih jedinica temeljenih na neprirodnim aminokiselinama, ugljikohidratima i endiinskim spojevima, (b) provođenjem Passerinijeve i Ugijeve reakcije za dobivanje raznovrsnih linearnih i cikličkih produkata i (c) proučavanjem stereokemije višekomponentnih reakcija. Rezultati projekta i znanje o metodologiji, stereokemiji i svojstvima novih spojeva značajni su za istraživanja u više područja: medicinska kemija (nove strukture za obogaćivanje biblioteka spojeva), razvoj katalizatora (posebno makrociklički spojevi s endiinskom jedinicoma) i biomedicinska istraživanja (spojevi s ugljikohidratnim strukturnim elementom mogu se koristiti kao biološke probe). Projekt je usklađen s ciljevima Hrvatske zaklade za znanost: razvoj konkurentnog istraživačkog okruženja i stvaranje novih znanja za jačanje hrvatskog gospodarstva. Rezultati projekta će biti temelj za stvaranje bibliteka sa strukturno različitim malim molekulama i makrocikličkim spojevima, kao odgovor na potrebe farmaceutske industrije: identifikacija još nepoznatih bioloških ciljeva i razvoj novih vodećih spojeva. Stoga projekt doprinosi i jednom od ključnih ciljeva u Europskoj uniji: poboljšanju zdravlja građana EU-a za povećanje bogatstva i dobrobiti ljudi. Screening of small-molecule libraries has been the most commonly used tool in drug discovery over the past two decades. However, currently used libraries lack diversity in terms of biological and chemical properties, i.e. “chemical space” covered is infinitely small. In the past 15 years, only 15 % of the emerging novel chemical entities have been novel classes of compounds. This limitation significantly hampers development of novel lead compounds needed to tackle new generations of biological targets. The project goal is to expand the chemical space of natural product-like compounds by using multicomponent reactions. This will be achieved by: (a) developing novel non-natural amino acid-, carbohydrate- and enediyne-based building blocks; (b) performing Passerini and Ugi multicomponent reactions to obtain structurally diverse linear and macrocyclic compounds and (c) studying the stereochemistry of multicomponent reactions. Project results, and the knowledge about methodologies, stereochemistry and properties of novel compounds, are highly relevant for the following fields: medicinal chemistry - novel structures to fill the libraries; catalyst development – particularly enediyne-based macrocycles; and biomedical studies – carbohydrate-based compounds can be used as biological probes. Project is aligned with the goals of the Croatian Science Foundation: development of competitive research environment, and creation of new knowledge for the strengthening the Croatian economy. Project results will be the base for the generation of libraries with structurally diverse peptide-like small molecules and macrocyclic compounds, as an answer to the pharmaceutical industry needs: identification of yet undisclosed biological targets and the development of novel lead compounds. Therefore, project contributes to one the key objectives in the European Union: improving the health of EU citizens for generation of wealth and public wellbeing.
3030Internet stvari - okvir interoperabilnostiInternet of Things – Interoperability Framework 12678Neven Vrček IP2014-09IP-2014-09-3877IoTIF01.06.2015 - 31.05.2019Završio590.123,91 KnDruštvene znanostiSocial sciencesInformacijske i komunikacijske znanosti, Information and communication sciences, Sveučilište u Zagrebu, Fakultet organizacije i informatikeUniversity of Zagreb, Faculty of Organization and Informatics12786, 5699, 12796, 202, 12805, 12793, 13514, 13611, 13612, 2508, Sandro Gerić, Renata Mekovec, Darko Andročec, Boris Tomaš, Igor Pihir, Tonimir Kišasondi, Mate Boban, Dragutin Kermek, Matija Novak, Igor Tomičić, internet stvari, energetska učinkovitost, interoperabilnost, automatsko konfigurabilne arhitekture, pitanja sigurnosti i privatnostInternet of Things, energy efficiency, large scale interoperability, automated architecture reconfiguration, security and privacy issuesInternet stvari je „dinamična globalna mrežna infrastruktura koja ima mogućnost automatske konfiguracije i bazirana je na standardnim interoperabilnim komunikacijskim protokolima gdje fizičke i virtualne stvari posjeduju identitete, fizičke atribute i virtualne osobnosti, koriste inteligentna sučelja, te su integrirani u informacijsku mrežu“ (Vermesan, 2014). Općenito, Internet stvari (IoT) se opisuje kao globalna mreža međusobno povezanih entiteta poput ljudi, računala, knjiga, vozila koji mogu ostvariti otvorenu komunikaciju s bilo kojim drugim entitetom i mjestom na bilo koji način (Roman, Zhou i Lopez, 2013). IoT mreža je iznimno heterogena, te kako bi se iskoristili njezini potencijali potrebno je ostvariti visoku razinu interoperabilnosti između uređaja u IoT mreži. Istraživanja interoperabilnosti u IoT okruženju su još u početnim fazama. U okviru projekta usmjerit ćemo se na interoperabilnost na razini usluga, te upotrebom semantičkog jezika i AI algoritama pokušati riješiti probleme konfigurianja i interoperabilnosti u IoT okruženju. Ideja je predstaviti IoT uređaje kao usluge (servise) te ih opisati semantičkim jezikom (SA-WSDL). Pri tome će se razviti OWL ontologija za opis elemenata IoT okruženja. Uključeni IoT uređaji će biti opisani, njihove funkcije i operacije također, što će omogućiti razvijenom algoritmu umjetne inteligencije da kombinira i dinamički u IoT okruženje uključuje i povezuje one uređaje koji doprinose rješavanju zadanog problema. Uz to će se ostvariti integracija IoT uređaja sa cloud platformom, čiji kapaciteti se mogu iskoristiti kao podrška i dodatna funkcionalnost IoT okruženju.Internet of Things (IoT) is “a dynamic global network infrastructure with self configuring capabilities based on standard and interoperable communication protocols where physical and virtual things have identities, physical attributes, and virtual personalities; use intelligent interfaces; and are seamlessly integrated into the information network”. It is highly-heterogeneous, so to unleash its full value we must to achieve interoperability among various things. Research on the interoperability of IoT is in the initial stage. We will focus on service-level interoperability and we will use lightweight semantic language and AI planning methods to resolve found problems of heterogeneous things abstracted in form of semantic web services. Our idea is to represent things as services and semantically annotate them by using lightweight semantic language such as SA-WSDL. OWL Ontology for describing the things and their most important operations will be developed. Things as services will be annotated using the developed ontology, together with their main operations and operations’ input and output. AI planning problem and domain will be formulated to enable composition of various things as services. Then an AI tool together with web interface will be developed to enable users to achieve more complex tasks composing various things and their capabilities. We will investigate how we can integrate our approach with existing cloud computing services, i.e. we will develop a framework for integration of clouds and Internet of Things. Cloud services can enrich things as service with storage, application and resource capabilities. Therefore, cloud services will be semantically annotated using similar approach as semantically annotated smart things. This will enable us to create compositions of different things as services and cloud services to support more complex interoperability scenarios by using common ontology and AI planning method.
3031Novi enološki postupci kao alternativa sumporovom dioksidu u proizvodnji visokokvalitetnih vinaNew enological tools for the reduction of sulfur dioxide and production of high-quality wine6224Karin Kovačević Ganić IP2014-09IP-2014-09-3796LOWSULF-HQWINE01.09.2015 - 31.08.2019Završio939.150,00 KnBiotehničke znanostiBiotechnical sciencesPrehrambena tehnologija, Food technology, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultetUniversity of Zagreb, Faculty of Food Technology and Biotechnology13101, 13272, 493, 13352, 222, 13282, 2653, 469, 453, 206, 1307, 21313, Ksenija Marković, Natka Ćurko, Tomislava Vukušić, Tomislav Bosiljkov, Marina Đapić, Leo Gracin, Stela Križanović, Anet Režek Jambrak, Jasna Mrvčić, Zoran Herceg, Damir Stanzer, Katarina Lukić, Vino, SO2, antimikrobno djelovanje, kvaliteta vina, ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP), hladna plazma (NTP)wine, SO2, antimicrobial activity, wine quality, high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP)Suvremeni zahtjevi za povećanjem sigurnosti i kvalitete vina utjecali su na preporuke o smanjenju, ali i na nove zakonske restrikcije u upotrebi sumporovog dioksida. Naime, zbog svojih antimikrobnih i antioksidacijskih karakteristika, sumporov dioksid jedan je od najučinkovitijih aditiva u proizvodnji vina. Međutim, uslijed potencijalnih pseudo-alergijskih reakcija koje kod osjetljivih pojedinaca dovode do zdravstvenih problema, korištenje sumporovog dioksida danas je pod razmatranjem. Stoga su i znanstvena istraživanja u posljednjem desetljeću intenzivno usmjerena na pronalaženje alternativa sličnih antiseptičkih i antioksidacijskih svojstava, kojima bi se zamijenila/smanjila upotreba sulfita u proizvodnji vina; što i danas predstavlja jedan od najznačajnijih enoloških izazova. U posljednje vrijeme, tehnologije kao ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP) te hladna plazma (NTP) otvorile su nove mogućnosti u kontroli mikrobiološke kvalitete hrane te su stoga našle sve veću primjenu u prehrambenoj industriji. Međutim, primjena ovih novih, netermalnih postupaka u proizvodnji vina i njihov utjecaj na mikrobiološku stabilnost vina do sada nije istražen. Cilj projekta je istražiti mogućnosti primjene HPU, HHP i NTP sa svrhom smanjenja upotrebe sumporovog dioksida u proizvodnji visokokvalitetnih crnih, bijelih i desertnih vina. Ispitat će se utjecaj ovih netermalnih postupaka na cjelokupnu kvalitetu vina, u prvom redu na sastav polifenola, arome te senzorske karakteristike vina. Također, istražit će se mogućnosti ovih postupaka u kontroli mikrobiološke stabilnost vina. Nadalje, ispitat će se i sinergijski učinak navedenih postupaka te dodatka antioksidansa (niži udio sumporovog dioksida i glutation) tijekom dozrijevanja vina u bocama. Rezultati ovog projekta pokazat će kako primjenom novih netermalnih tehnologija samostalno ili u kombinaciji s antioksidansima proizvesti vina poboljšane kvalitete s nižim udjelom sumporovog dioksida.Modern increasing requirements for wine safety and quality led to very restrictive legislation regarding sulfur dioxide addition recommending limitations or even complete suppressing. In fact, sulfur dioxide is one of the most efficient additives used in winemaking due to its antimicrobial and antioxidant properties. However, as a result of potential pseudo-allergenic health problems in sensitive individuals use of sulfur dioxide has recently come under the review. Hence, in recent decades, alternatives to reducing/replacing sulfites in winemaking have been extensively studied. However, finding promising substitutes with similar antiseptic and antioxidant characteristics still remains major challenge. Recently, emerging technologies such as high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP) have entered the field of food science and technology offering, as novel tools, new opportunities for managing food microbiology. Their opportunities in wine microbiology have not been examined. The aim of this project is to study the potential usage of HPU, HHP and NTP in production of high quality red, white and dessert wine as sulfur dioxide reducing strategies, and furthermore to optimize their application. Impact on overall wine quality, particularly chemical and sensory characteristic will be studied. Possibilities of these new technologies in controlling microbiological stability of wine will be investigated. In addition, synergistic practices of these physical technologies with antioxidants (lower content of sulfur dioxide and glutathione) during long period of aging in the bottles will be studied. The results of this project are expected to provide information how application of new physical technologies on its own or in combination with antioxidant addition can lead to wines with lower levels of sulfur dioxide and improved quality.
3041Pogrebni običaji starijeg željeznog doba u južnoj Panoniji - raskrižja identitetaBurial Customs of the Early Iron Age in Southern Pannonia - Crossroads of Identity3432Hrvoje Potrebica IP2014-09IP-2014-09-1234BC-CrossId01.06.2015 - 31.05.2019Završio600.000,00 KnHumanističke znanostiHumanitiesArheologija, Archeology, Sveučilište u Zagrebu, Filozofski fakultetUniversity of Zagreb, Faculty of Humanities and Social Sciences12745, 12736, 12812, 11263, 12982, 12742, 25275, Petra Stipančić, Janja Mavrović Mokos, Borut Križ, Branko Mušič, Renata Šoštarić, Andrijana Pravidur, Julia Katarina Fileš Kramberger, starije željezno doba, pogrebni običaji, identitet, halštatska kultura, pogrebne gomile, elite, kneževski grobovi, Alpe, PanonijaEarly Iron Age, burial customs, identity, Hallstatt Culture, burial mounds, elites, princely burials, Alps, PannoniaCilj ovog projekta jest utvrditi način na koji željeznodobne zajednice izražavaju svoj identitet kroz pogrebni ritual. Pri istraživanju bi se u najvećoj mjeri primjenjivao kontekstualni pristup: materijalna kultura se neće promatrati isključivo kao tipološka kategorija nego će biti povezana s kontekstom pogrebnog inventara i rituala. Namjera nam je pokazati da je mobilnost bila daleko intenzivnija i veća na razini pojedinaca i manjih skupina nego na razini čitavih zajednica. Smatramo da pogrebni ritual i materijalna kultura vezana uz takve cjeline jasno ukazuje da se pitanju identiteta željeznodobnih kulturnih skupina treba pristupiti analitički na razini pojedinih zajednica. Provest ćemo poredbenu analizu istovremenih i koncepcijski sličnih grobnih inventara koje pronalazimo u različitim kulturnim skupinama u različitim kontekstima pogrebnog rituala. Na taj način pokušali bismo na razini pojedinih zajednica razložiti i definirati pojedine aspekte materijalne kulture i ritualnog konteksta koji tvore identitet pokojnika. Koristeći te rezultate mogli bismo utvrditi koje od utvrđenih elemenata koristimo pri definiranju identiteta na razini pojedine zajednice, kulturne skupine ili šire, i koliko je takav pristup opravdan i univerzalno primjenjiv. Korelacijom podataka o materijalnoj kulturi, prostornoj organizaciji i ritualnom kontekstu, utvrdit ćemo pojedine elemente koji definiraju identitet pokojnika na temeljnoj razini (spol, dob, status, vrijeme ukopa) kao i na razini zajednice (status i uloga). Usporedbom podataka za pojedine zajednice provjerit ćemo postoji li specifičan skup elemenata kojima se pojedine zajednice izdvajaju unutar kulturnih skupina, odnosno postoje li poveznice između zajednica koje definiraju identitet pojedinih kulturnih skupina i izdvajaju ih jedne od drugih. Rezultat će biti set markera koji bi unutar definiranih razdoblja željeznog doba određivao identitet pokojnika u odnosu na njegovu osnovnu zajednicu i/ili kulturnu skupinu.The goal of this project is to identify the way in which the Iron Age communities expressed their identity through the burial ritual. The proposed project will research the burial ritual as a reflection of identity of Iron Age communities, mostly by applying the contextual approach. The material culture will not be viewed only as a typological category, but rather it will be linked to the context of the grave inventory and the burial ritual. The burial ritual and material culture associated with graves clearly suggest that the issue of identity of the Iron Age cultural groups should be analysed at the level of individual communities. We will carry out a comparative analysis of contemporary and conceptually similar grave inventories discovered in different burial contexts and belonging to different cultural groups. By doing so, we will attempt to examine and define some aspects of the material culture and ritual context which make up the identity of the deceased, at the level of individual communities. Such results would enable us to establish which of the identified elements are used when defining the identity at the level of a community, cultural group or a wider unit, and whether such an approach is justifiable and universally applicable. A co-relation of data concerning the material culture, spatial organization and ritual context will be used to identify elements which determine the deceased’s identity at the basic level (sex, age, time of burial) and at the level of the community (status and role). By comparing data on different communities we will check if there is a specific group of elements that sets apart some communities within a cultural group, and whether there are links between communities which define the identity of certain cultural groups. The result will consist of a set of identification markers, which will de